Cholera and Immigration: 1840s Ireland
48 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What was a major consequence of the potato crop devastation in 1840s Ireland?

  • A flood of Irish immigrants fleeing famine. (correct)
  • An increase in the population of Ireland.
  • Improved crop yields of alternative crops.
  • A decrease in immigration to the U.S.
  • What was one of the reasons why cholera was perceived as a threat during the time of the Irish immigrants?

  • It was easily cured by antibiotics.
  • The cause and transmission of cholera were unknown. (correct)
  • It only affected individuals with weak immune systems.
  • Cholera was well understood and easily managed.
  • Which of the following is a potential pathogen humans are exposed to?

  • Minerals
  • Viruses (correct)
  • Vitamins
  • Carbohydrates
  • What is one strength of natural immunity?

    <p>It develops naturally after exposure to infections. (D)</p> Signup and view all the answers

    During the cholera outbreak, where were the Irish immigrants quarantined?

    <p>On a small island. (A)</p> Signup and view all the answers

    What was a major downfall of the quarantine measures implemented for immigrants?

    <p>They led to increased mortality rates. (B)</p> Signup and view all the answers

    How quickly can cholera lead to death from dehydration due to diarrhea?

    <p>Within 24 hours. (A)</p> Signup and view all the answers

    What is one aspect that the immune system helps to manage?

    <p>Protecting the body from pathogens. (C)</p> Signup and view all the answers

    What is the role of the cholera toxin in the spread of Vibrio bacteria?

    <p>It binds to a G protein and causes an influx of ions into the intestines. (D)</p> Signup and view all the answers

    Which of the following organisms are prokaryotic pathogens mentioned in the content?

    <p>Tuberculosis and cholera. (D)</p> Signup and view all the answers

    What are viruses unable to do independently?

    <p>Replicate outside of a host cell. (B)</p> Signup and view all the answers

    Which characteristic defines prions as pathogens?

    <p>They are self-replicating proteins. (D)</p> Signup and view all the answers

    Which of the following best describes the first line of defense of the immune system?

    <p>It stops pathogens from entering the body through nonspecific barriers. (A)</p> Signup and view all the answers

    In which form do multiceular eukaryotic pathogens generally exist?

    <p>Fungi that can cause infections. (B)</p> Signup and view all the answers

    What is a key function of chlorine and sodium ions rushing into the intestines as described?

    <p>They facilitate the transmission of Vibrio bacteria. (A)</p> Signup and view all the answers

    How do protozoan pathogens differ from prokaryotic pathogens?

    <p>Protozoans have a nucleus; prokaryotes do not. (D)</p> Signup and view all the answers

    What was the main cause of the cholera outbreak in London in 1854 identified by John Snow?

    <p>Polluted water from a pump (B)</p> Signup and view all the answers

    Which bacterium was identified by Robert Koch as responsible for cholera?

    <p>Vibrio cholerae (A)</p> Signup and view all the answers

    How does the body respond to the loss of water and electrolytes due to cholera?

    <p>It enters a state of shock (A)</p> Signup and view all the answers

    What physiological change occurs in patients' intestines during cholera infection?

    <p>Fluid accumulation leading to severe dehydration (B)</p> Signup and view all the answers

    What is the role of the toxin secreted by Vibrio cholerae in the cells of the intestine?

    <p>It interferes with water balance regulation (C)</p> Signup and view all the answers

    What happens to the heart rate as cholera leads to a drop in blood pressure?

    <p>It accelerates to compensate (C)</p> Signup and view all the answers

    How do Vibrio bacteria survive the acidic environment of the stomach?

    <p>By sheer numbers (B)</p> Signup and view all the answers

    What key factor contributes to multiple organ failure in cholera patients?

    <p>Dehydration and electrolyte loss (B)</p> Signup and view all the answers

    Which type of barrier does skin represent in the immune system?

    <p>Nonspecific barrier (A)</p> Signup and view all the answers

    What role do macrophages play in the immune system?

    <p>They 'eat' microbes. (B)</p> Signup and view all the answers

    Which of the following is categorized as a defensive protein?

    <p>Interferons (B)</p> Signup and view all the answers

    What characterizes the inflammatory response?

    <p>It leads to red, warm, and painful swelling. (B)</p> Signup and view all the answers

    What initiates the antibody-mediated response?

    <p>B cells binding to a foreign antigen. (D)</p> Signup and view all the answers

    Which process do B cells undergo after recognizing an antigen?

    <p>They produce and secrete more antibodies. (C)</p> Signup and view all the answers

    Natural killer cells function primarily by:

    <p>Destroying virus-invaded cells. (A)</p> Signup and view all the answers

    What is the primary function of complement proteins in the immune system?

    <p>To coat bacteria and facilitate their removal. (A)</p> Signup and view all the answers

    What role do cytotoxic T cells play in the immune system?

    <p>They specialize in killing infected cells or pathogens. (C)</p> Signup and view all the answers

    Which type of T cell assists in coordinating the immune response?

    <p>Helper T cells (C)</p> Signup and view all the answers

    What happens when the immune system fails due to B and T cells attacking the body's own cells?

    <p>Autoimmune disease (D)</p> Signup and view all the answers

    What does the immune system do when it detects a foreign organ during transplantation?

    <p>It attacks the foreign organ. (D)</p> Signup and view all the answers

    Which component of the immune response is primarily associated with memory cells?

    <p>Antibody-mediated immunity (D)</p> Signup and view all the answers

    How did Bruce Glick contribute to the understanding of the immune response in chickens?

    <p>He studied the bursa of Fabricius and its importance. (C)</p> Signup and view all the answers

    Which immune system deficiency is characterized by weak B and T cell responses?

    <p>Immunosuppressive disease (D)</p> Signup and view all the answers

    What is the primary function of memory cells in the immune system?

    <p>To remain in the body for long-term immunity. (A)</p> Signup and view all the answers

    What is the main goal of organ and tissue transplantation?

    <p>To improve the availability of organs through regenerative medicine. (B)</p> Signup and view all the answers

    What type of immunity is developed after recovering from an infectious disease?

    <p>Natural immunity (B)</p> Signup and view all the answers

    How does vaccination work in the immune system?

    <p>By using weakened forms of pathogens to stimulate memory cells. (D)</p> Signup and view all the answers

    What is the role of antibodies in passive immunity?

    <p>They are transferred temporarily from one individual to another. (C)</p> Signup and view all the answers

    What is antivenom and how is it related to immunity?

    <p>A temporary form of immunity using antibodies from animals. (B)</p> Signup and view all the answers

    What is a characteristic of monoclonal antibodies?

    <p>They specifically target diseased cells. (C)</p> Signup and view all the answers

    Which option describes the source of antibodies provided through passive immunity in infants?

    <p>Antibodies from the mother through breast milk. (C)</p> Signup and view all the answers

    What is a primary reason why immunosuppressive drugs are required during organ transplantation?

    <p>To prevent the body's rejection of the transplanted organ. (C)</p> Signup and view all the answers

    Flashcards

    Cholera

    A serious intestinal infection caused by the bacterium Vibrio cholerae, resulting in severe dehydration due to diarrhea, potentially leading to death within 24 hours.

    Infectious Disease

    A disease caused by the presence and multiplication of a pathogenic organism in a host organism.

    Pathogens

    Disease-causing microorganisms such as bacteria, viruses, fungi, and parasites.

    Immune System

    The body's defense mechanism against infection and disease, composed of specialized cells and organs.

    Signup and view all the flashcards

    Natural Immunity

    The innate immune system of a host, recognizing and attacking harmful organisms through natural defense mechanisms.

    Signup and view all the flashcards

    Vaccination

    A method of conferring immunity to a disease by injecting a weakened or inactivated form of the pathogen.

    Signup and view all the flashcards

    Passive Immunity

    Temporary immunity achieved through the transfer of antibodies from one individual to another.

    Signup and view all the flashcards

    Antibiotics

    Drugs that inhibit the growth or kill bacteria.

    Signup and view all the flashcards

    Cholera Outbreak, 1854

    John Snow traced the cause of the cholera outbreak in London to contaminated water from a specific pump. Removing the pump handle stopped the spread of the disease.

    Signup and view all the flashcards

    What causes cholera?

    Robert Koch discovered the bacteria responsible for cholera, Vibrio cholerae, by examining the feces of cholera patients under a microscope.

    Signup and view all the flashcards

    How cholera affects the body?

    Cholera causes dehydration and electrolyte loss, leading to shock due to insufficient blood circulation. The intestines fill with fluid, causing low blood pressure and rapid heart rate.

    Signup and view all the flashcards

    What is electrolyte loss?

    Loss of electrically charged substances needed for muscle function. This loss is a major consequence of cholera.

    Signup and view all the flashcards

    Vibrio cholerae is pathogenic

    Pathogenic means that the bacteria can cause disease. Vibrio cholerae is a pathogenic bacteria that leads to cholera.

    Signup and view all the flashcards

    How does Vibrio cholerae survive in the stomach?

    The bacteria survive the acidic environment of the stomach by sheer numbers. They then attach to cells in the small intestine and release a toxin.

    Signup and view all the flashcards

    Vibrio cholerae toxin

    The toxin produced by Vibrio cholerae enters the intestinal cells and disrupts the water balance, leading to dehydration.

    Signup and view all the flashcards

    Multiple organ failure

    When cholera leads to severe dehydration and electrolyte loss, it can cause multiple organs to stop functioning properly.

    Signup and view all the flashcards

    Prokaryotic Organisms

    Single-celled organisms that lack a membrane-bound nucleus and other organelles. Examples include bacteria and archaea.

    Signup and view all the flashcards

    Cholera Toxin's Effect

    Cholera toxin binds to a G protein, activating it and causing chlorine and sodium ions to rush into the intestines. This influx of ions draws water, resulting in diarrhea.

    Signup and view all the flashcards

    Protozoans

    Single-celled eukaryotic organisms. Examples include giardia, amoeba, and plasmodium.

    Signup and view all the flashcards

    What are some eukaryotic examples of pathogens?

    Fungi (like those that cause yeast infections, athlete's foot, and ringworm) are multicellular eukaryotic organisms that can cause disease.

    Signup and view all the flashcards

    What are Viruses?

    Non-living pathogens that require a host cell to replicate. They are composed of genetic material (DNA or RNA) encased in a protein coat.

    Signup and view all the flashcards

    What are Prions?

    Misfolded proteins that can cause disease by converting normal proteins into their misfolded form.

    Signup and view all the flashcards

    First Line of Defense

    Mechanical and chemical barriers that prevent pathogens from entering the body. These barriers are nonspecific, meaning they don't target specific pathogens.

    Signup and view all the flashcards

    What are some examples of non-specific barriers?

    Examples include skin, mucous membranes, stomach acid, and the normal flora of the body. They are not designed to target one specific type of pathogen.

    Signup and view all the flashcards

    Organ Transplantation

    The process of transferring organs from one person to another to replace damaged or non-functional organs.

    Signup and view all the flashcards

    Immunosuppressive Drugs

    Medicines that suppress the immune system, preventing it from attacking the transplanted organ.

    Signup and view all the flashcards

    Memory Cells

    Specialized immune cells that "remember" a specific pathogen and can quickly mount a defense if re-exposed.

    Signup and view all the flashcards

    Cytotoxic T Cells

    Immune cells that directly kill infected cells or pathogens by releasing toxins.

    Signup and view all the flashcards

    Why are donors matched?

    Donors and recipients are matched based on blood type and tissue compatibility to reduce the chance of the recipient's immune system rejecting the transplanted organ.

    Signup and view all the flashcards

    Helper T Cells

    Immune cells that activate other immune cells, like cytotoxic T cells, and coordinate the immune response.

    Signup and view all the flashcards

    What is regenerative medicine?

    A field of medicine focused on developing therapies to repair or regenerate damaged tissues or organs.

    Signup and view all the flashcards

    Autoimmune Disease

    A condition where the immune system mistakenly attacks the body's own cells and tissues.

    Signup and view all the flashcards

    Immunosuppressive Disease

    A condition where the immune system is weakened, making the body more susceptible to infections.

    Signup and view all the flashcards

    Bursa of Fabricius (BF)

    A special organ in birds that is involved in the development of B cells, which produce antibodies.

    Signup and view all the flashcards

    How does antivenom work?

    Antivenom contains antibodies that neutralize snake venom, providing temporary immunity.

    Signup and view all the flashcards

    Cell-mediated Immunity

    An immune response that involves T cells directly attacking infected cells or pathogens.

    Signup and view all the flashcards

    Antibody-mediated Immunity

    An immune response where antibodies produced by B cells bind to pathogens, marking them for destruction.

    Signup and view all the flashcards

    Nonspecific Barriers

    The first line of defense against pathogens, which act generally against a wide range of invaders. Examples include skin and mucous membranes.

    Signup and view all the flashcards

    Macrophages

    Specialized immune cells that engulf and destroy pathogens by phagocytosis. They are part of the second line of defense.

    Signup and view all the flashcards

    Natural Killer Cells

    Immune cells that target and destroy virus-infected cells and cancer cells. They are part of the second line of defense.

    Signup and view all the flashcards

    Interferons

    Proteins produced by infected cells that help signal other cells to resist viral infection. They are part of the second line of defense.

    Signup and view all the flashcards

    Complement Proteins

    Proteins that coat bacteria, making them easier for macrophages to engulf and destroy. They are part of the second line of defense.

    Signup and view all the flashcards

    Inflammation

    The body's response to injury or infection, characterized by redness, warmth, swelling, and pain. It brings immune cells to the affected area.

    Signup and view all the flashcards

    Antigens

    Foreign molecules that trigger an immune response. They are recognized by the immune system as 'non-self'.

    Signup and view all the flashcards

    Study Notes

    Chapter 14: Infectious Disease and the Immune System

    • This chapter explores how the immune system repels, evades, or kills invaders.
    • Learning objectives include describing cholera's history and biology, detailing potential pathogens humans encounter daily, explaining the human immune system's function and the impact of system removal, assessing natural, vaccination, and passive immunity, describing antivenom, antibodies, and antibiotics production, and predicting the impact of personal choices on health.

    Case Study: The Summer of Sorrow

    • Irish farmers relied heavily on the potato crop.
    • A fungal disease emerged in the 1840s, devastating the potato crop.
    • A massive influx of Irish immigrants migrated to the U.S. to escape the famine.
    • These immigrants faced quarantine on an island due to cholera outbreaks.
    • Cholera is a severe and rapidly fatal intestinal infection.

    What Causes Cholera?

    • Cholera sufferers experience severe dehydration from diarrhea, often dying within 24 hours.
    • Lack of understanding about its spread and cause was a major concern initially.
    • John Snow, during a London outbreak in 1854, traced the source to a water pump contaminated by sewage.
    • Removal of the pump handle stopped the outbreak.
    • Robert Koch identified Vibrio cholerae as the causative bacterium.

    How Cholera Affects the Body

    • Dehydration and loss of electrolytes due to diarrhea lead to shock.
    • The small intestine loses water due to high salt concentration.
    • The lack of water and electrolytes causes shock and multiple organ failure.
    • The amount of blood flowing decreases

    How Vibrio Bacteria Survive and Spread Cholera

    • Vibrio bacteria are pathogenic, causing cholera.
    • They travel to the small intestine, tolerating stomach acid.
    • They attach to intestinal cells and secret toxins that causes diarrhea.
    • The toxin impacts water balance, causing massive water loss..
    • This loss of water carries the bacteria to new hosts.

    14.2 What Invaders Do We Face?

    • Humans encounter various microorganisms.
    • Some are prokaryotic (lacking membrane-bound organelles).
    • Examples include bacteria that can help (digestion) or harm (cholera, tuberculosis).
    • Other microorganisms include protozoans (single-celled eukaryotes).
    • Examples include those that cause giardiasis and amoebic dysentery.
    • Multicellular eukaryotes like fungi are also present, known to cause athlete's foot and yeast infections.
    • Viruses, such as HIV and prions, are another class of pathogens.
    • Prions are self-replicating proteins that cause diseases like mad cow disease (BSE).

    14.3 How Does the Immune System Protect Us?

    • The first line of defense includes mechanical and chemical barriers, such as skin and mucous membranes.
    • The second line of defense employs nonspecific cells (macrophages and natural killer cells).
    • Macrophages engulf pathogens by phagocytosis.
    • Natural killer cells destroy virus-infected cells.
    • Defensive proteins such as interferons and complement proteins are part of the second line.
    • Inflammation is a key response associated with the second line.
    • Antibody-mediated responses are part of the third line of defense and are achieved through B lymphocytes (B cells).
    • Each B cell produces antibodies that recognize specific antigens—foreign molecules.
    • B cells multiply, creating memory cells.
    • Cell-mediated immunity involves cytotoxic and helper T cells.
    • Cytotoxic T cells target and destroy infected or cancerous cells.
    • Helper T cells coordinate the immune response.

    14.3 How Does the Immune System Protect Us? (Continued)

    • When the immune system fails, autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis) can result, where the immune system attacks the body's own cells.
    • Immunosuppressive diseases like AIDS can also occur, hindering the immune system's ability to respond effectively.

    How Do We Know? The Immune Response Is Two-Fisted

    • Bruce Glick and Timothy Chang's studies on chickens revealed the presence of two immune response components.
    • Removing the bursa of Fabricius in chickens displayed a clear relationship between the immune system's presence and the ability to fight and develop antibody responses during these experiments.

    Life Application: Organ and Tissue Transplantation

    • Organ transplantation poses challenges for the recipient.
    • Immune systems treat transplanted organs as foreign tissue.
    • Organ donors are carefully matched, aiming to reduce incompatibility risks.
    • Immunosuppressive drugs are given to prevent organ rejection.

    14.4 How Can We Harness the Immune System?

    • Natural immunity refers to immunity gained after recovering from a specific infection.
    • Vaccination involves using a weakened or modified pathogen to induce immunity.
    • This allows the immune system to recognize and target the actual pathogen, in the case of an infection, by recognizing and destroying the virus.

    14.5 What Can Help If Our Immune System Fails?

    • Antivenom contains antibodies prepared by exposing animals to snake venom and isolating the antibodies.
    • Monoclonal antibodies (MAbs) are laboratory-produced antibodies targeting precise and particular cells.

    Technology Connection: Monoclonal Antibodies

    • Scientists identified flaws in B-cell lifespan, leading them to create immortal B cells.
    • This involves fusing B cells with cancer cells to generate hybrid cells in the lab.

    14.5 What Can Help If Our Immune System Fails? (Continued)

    • Antibiotics are chemicals that kill or inhibit the growth of microorganisms.
    • The overuse of antibiotics has contributed to antibiotic resistance in some microorganisms.

    14.6 How Can We Prevent the Spread of Infectious Disease?

    • Maintaining good health, encouraging hygiene practices, and ensuring access to clean water and sanitation can reduce infectious disease transmission.
    • Proper vaccination and antibiotic use can limit the spread of infectious diseases.

    Scientist Spotlight: Anthony S. Fauci

    • Anthony Fauci played a crucial role in fighting HIV and AIDS.
    • His response to demonstrations and commitment to community engagement are notable aspects of his career.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Chapter 14 Lecture Notes PDF

    Description

    Test your knowledge on the impacts of the potato crop failure in 1840s Ireland and the related cholera outbreaks among Irish immigrants. This quiz covers public health responses, natural immunity, and the consequences of quarantine measures. Discover the intricate connection between agriculture, disease, and immigration during this critical period.

    More Like This

    Cholera
    10 questions

    Cholera

    AdoringRoseQuartz avatar
    AdoringRoseQuartz
    Dr. John Snow and Cholera Research
    10 questions

    Dr. John Snow and Cholera Research

    AffectionateElectricOrgan avatar
    AffectionateElectricOrgan
    Use Quizgecko on...
    Browser
    Browser