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Chlorhexidine Gluconate in Healthcare

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Questions and Answers

What is the main mechanism of action of aldehydes such as glutaraldehyde and OPA?

Denaturation of proteins

Inhibition of DNA, RNA, and other macromolecules (correct)

Disruption of cell membrane structure

Binding to nucleic acids

What is the primary advantage of using OPA over glutaraldehyde?

OPA is more bactericidal

OPA is more virucidal

OPA is less toxic (correct)

OPA is more sporicidal

Which of the following is NOT a characteristic of alcohols?

Denaturation of proteins

Inactivation of viruses

Effective in the absence of water (correct)

Used for cleaning and disinfection

What is the optimal concentration range for alcohol disinfectants?

60-80% Signup and view all the answers

Which of the following microorganisms is killed in 10 seconds by a concentration of 30-100% ethanol?

Pseudomonas aeruginosa Signup and view all the answers

What is the primary advantage of using hydrogen peroxide as a disinfectant?

It is non-corrosive and safe on plastics Signup and view all the answers

What percentage of chlorhexidine gluconate is used in high risk applications such as hospital surgical scrubs?

0.5% to 4% Signup and view all the answers

What is the spectrum of activity of biguanides against Gram-positive and Gram-negative bacteria?

Rapid action against Gram-positive and Gram-negative bacteria Signup and view all the answers

What is a disadvantage of using hypochlorites as disinfectants?

They can cause oropharyngeal, esophageal and gastric burns Signup and view all the answers

What should cleaning personnel use when handling some disinfectants to prevent occupational exposure?

Personal Protective Equipment (PPE) Signup and view all the answers

What is a type of chlorine compound that is commonly used as a disinfectant?

Sodium Hypochlorite Signup and view all the answers

What is the percentage of sodium hypochlorite usually found in household bleach?

5.25% - 6.15% Signup and view all the answers

What is the level of effectiveness against Liphophilic viruses like herpes, vaccinia, and influenza?

60-95% Signup and view all the answers

What viruses show variable efficacy against alcohol-based disinfectants?

Non-enveloped viruses Signup and view all the answers

What is the main disadvantage associated with repeated use of alcohol-based disinfectants on skin and surfaces?

Irritation, drying, and surface damage Signup and view all the answers

What ligand is contained in Biguanides?

C2H7N5 Signup and view all the answers

What is a notable advantage of alcohol-based disinfectants for compatibility with skin?

Good compatibility with skin Signup and view all the answers