Chlorhexidine Gluconate in Healthcare

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Questions and Answers

What is the main mechanism of action of aldehydes such as glutaraldehyde and OPA?

  • Denaturation of proteins
  • Inhibition of DNA, RNA, and other macromolecules (correct)
  • Disruption of cell membrane structure
  • Binding to nucleic acids

What is the primary advantage of using OPA over glutaraldehyde?

  • OPA is more bactericidal
  • OPA is more virucidal
  • OPA is less toxic (correct)
  • OPA is more sporicidal

Which of the following is NOT a characteristic of alcohols?

  • Denaturation of proteins
  • Inactivation of viruses
  • Effective in the absence of water (correct)
  • Used for cleaning and disinfection

What is the optimal concentration range for alcohol disinfectants?

<p>60-80% (B)</p> Signup and view all the answers

Which of the following microorganisms is killed in 10 seconds by a concentration of 30-100% ethanol?

<p>Pseudomonas aeruginosa (B)</p> Signup and view all the answers

What is the primary advantage of using hydrogen peroxide as a disinfectant?

<p>It is non-corrosive and safe on plastics (A)</p> Signup and view all the answers

What percentage of chlorhexidine gluconate is used in high risk applications such as hospital surgical scrubs?

<p>0.5% to 4% (C)</p> Signup and view all the answers

What is the spectrum of activity of biguanides against Gram-positive and Gram-negative bacteria?

<p>Rapid action against Gram-positive and Gram-negative bacteria (C)</p> Signup and view all the answers

What is a disadvantage of using hypochlorites as disinfectants?

<p>They can cause oropharyngeal, esophageal and gastric burns (B)</p> Signup and view all the answers

What should cleaning personnel use when handling some disinfectants to prevent occupational exposure?

<p>Personal Protective Equipment (PPE) (D)</p> Signup and view all the answers

What is a type of chlorine compound that is commonly used as a disinfectant?

<p>Sodium Hypochlorite (A)</p> Signup and view all the answers

What is the percentage of sodium hypochlorite usually found in household bleach?

<p>5.25% - 6.15% (D)</p> Signup and view all the answers

What is the level of effectiveness against Liphophilic viruses like herpes, vaccinia, and influenza?

<p>60-95% (C)</p> Signup and view all the answers

What viruses show variable efficacy against alcohol-based disinfectants?

<p>Non-enveloped viruses (B)</p> Signup and view all the answers

What is the main disadvantage associated with repeated use of alcohol-based disinfectants on skin and surfaces?

<p>Irritation, drying, and surface damage (C)</p> Signup and view all the answers

What ligand is contained in Biguanides?

<p>C2H7N5 (B)</p> Signup and view all the answers

What is a notable advantage of alcohol-based disinfectants for compatibility with skin?

<p>Good compatibility with skin (B)</p> Signup and view all the answers

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