Chlamydiae: Structure and Diseases
25 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary form of Chlamydia that infects host cells?

  • Infectious body
  • Elementary body (correct)
  • Reticulate body
  • Mature body

    • Which disease is caused by Chlamydia trachomatis?

  • Lymphogranuloma venereum
  • Acute bronchitis
  • Atypical pneumonia
  • Nongonococcal urethritis (correct)

    • Which of the following methods is NOT typically used for diagnosing Chlamydiae infections?

  • Fluorescent antibody-stained smear
  • PCR
  • NAAT
  • Blood culture (correct)

    • What type of serology is responsible for causing blindness from follicular conjunctivitis in resource-limited areas?

    <p>Type A, B, C</p> Signup and view all the answers

    Which antibiotic is preferred for treating Chlamydiae infections during pregnancy?

    <p>Azithromycin</p> Signup and view all the answers

    What is a characteristic of the cell wall of Chlamydiae?

    <p>It makes Chlamydiae resistant to β-lactam antibiotics.</p> Signup and view all the answers

    Which mode of transmission is associated with Chlamydophila pneumoniae and Chlamydophila psittaci?

    <p>Aerosol.</p> Signup and view all the answers

    What is the function of the reticulate body in Chlamydiae?

    <p>It undergoes replication within the cell.</p> Signup and view all the answers

    Which disease is NOT commonly associated with Chlamydia trachomatis?

    <p>Atypical pneumonia.</p> Signup and view all the answers

    What is the recommended treatment for lymphogranuloma venereum caused by Chlamydia serotypes L1, L2, L3?

    <p>Doxycycline.</p> Signup and view all the answers

    Which characteristic of Chlamydiae makes them resistant to β-lactam antibiotics?

    <p>Lack of classic peptidoglycan due to reduced muramic acid</p> Signup and view all the answers

    What is the primary role of the elementary body in the Chlamydiae life cycle?

    <p>Transform into a reticulate body</p> Signup and view all the answers

    Which condition is associated with Chlamydia trachomatis infection?

    <p>Follicular conjunctivitis</p> Signup and view all the answers

    Which serological type of Chlamydia is primarily responsible for causing lymphogranuloma venereum?

    <p>Type L1, L2, L3</p> Signup and view all the answers

    What is a common diagnostic method for detecting Chlamydiae infections?

    <p>Cytoplasmic inclusions identified on a smear</p> Signup and view all the answers

    Which characteristic of Chlamydiae contributes to their classification as obligate intracellular organisms?

    <p>Their requirement for host cells for replication</p> Signup and view all the answers

    What is the primary role of the elementary body in the life cycle of Chlamydiae?

    <p>To initiate infection by entering host cells</p> Signup and view all the answers

    Which disease is commonly associated with Chlamydia trachomatis infection?

    <p>Reactive arthritis</p> Signup and view all the answers

    What is a distinguishing feature of the serology types A, B, and C of Chlamydia?

    <p>Leads to blindness from follicular conjunctivitis</p> Signup and view all the answers

    How is treatment for lymphogranuloma venereum typically administered?

    <p>Doxycycline only</p> Signup and view all the answers

    Which form of Chlamydia is characterized as being small, dense, and infectious?

    <p>Elementary body</p> Signup and view all the answers

    What is a common complication associated with Type D-K Chlamydia infections?

    <p>Ectopic pregnancy</p> Signup and view all the answers

    Which of the following methods is least effective for treating Chlamydiae infections due to their cell wall structure?

    <p>Ceftriaxone</p> Signup and view all the answers

    Chlamydia traachomatis is known to cause which of the following conditions?

    <p>Follicular conjunctivitis</p> Signup and view all the answers

    Which serological type of Chlamydia is primarily linked to chronic infections causing blindness?

    <p>Type A, B, C</p> Signup and view all the answers

    Study Notes

    Chlamydiae Overview

    • Obligate intracellular organisms that cannot synthesize their own ATP.
    • Cause mucosal infections; ineffective against β-lactam antibiotics due to the absence of classic peptidoglycan in the cell wall.

    Forms of Chlamydiae

    • Elementary Body: Small and dense; acts as the infectious form, entering host cells via endocytosis.
    • Reticulate Body:
      • Replicates within the host cell through fission.
      • Reorganizes back into elementary bodies for transmission.

    Associated Diseases

    • Chlamydia trachomatis:
      • Causes neonatal and follicular adult conjunctivitis, nongonococcal urethritis, and pelvic inflammatory disease (PID).
      • Linked to reactive arthritis.
    • Chlamydophila pneumoniae and Chlamydophila psittaci:
      • Associated with atypical pneumonia.
      • Mainly transmitted through aerosol routes.

    Diagnosis

    • Detection methods include PCR and nucleic acid amplification tests (NAAT).
    • Cytoplasmic inclusions (reticulate bodies) detectable via Giemsa or fluorescent antibody-stained smears.

    Treatment Options

    • First-line treatment includes doxycycline.
    • Azithromycin is recommended for pregnant patients.
    • Ceftriaxone may be added to cover for possible co-infections.

    Serology Types

    • Type A, B, C:
      • Associated with chronic infection leading to blindness caused by follicular conjunctivitis, particularly in resource-limited areas.
    • Type D-K:
      • Causes urethritis, PID, ectopic pregnancy, neonatal pneumonia (characterized by staccato cough and eosinophilia), and conjunctivitis in neonates occurring 1-2 weeks after birth.
    • Type L1, L2, L3:
      • Responsible for lymphogranuloma venereum, presenting as small, painless genital ulcers and swollen, painful inguinal lymph nodes (buboes).
      • Treatment includes doxycycline.

    Chlamydiae Overview

    • Obligate intracellular organisms that cannot synthesize their own ATP.
    • Cause mucosal infections; ineffective against β-lactam antibiotics due to the absence of classic peptidoglycan in the cell wall.

    Forms of Chlamydiae

    • Elementary Body: Small and dense; acts as the infectious form, entering host cells via endocytosis.
    • Reticulate Body:
      • Replicates within the host cell through fission.
      • Reorganizes back into elementary bodies for transmission.

    Associated Diseases

    • Chlamydia trachomatis:
      • Causes neonatal and follicular adult conjunctivitis, nongonococcal urethritis, and pelvic inflammatory disease (PID).
      • Linked to reactive arthritis.
    • Chlamydophila pneumoniae and Chlamydophila psittaci:
      • Associated with atypical pneumonia.
      • Mainly transmitted through aerosol routes.

    Diagnosis

    • Detection methods include PCR and nucleic acid amplification tests (NAAT).
    • Cytoplasmic inclusions (reticulate bodies) detectable via Giemsa or fluorescent antibody-stained smears.

    Treatment Options

    • First-line treatment includes doxycycline.
    • Azithromycin is recommended for pregnant patients.
    • Ceftriaxone may be added to cover for possible co-infections.

    Serology Types

    • Type A, B, C:
      • Associated with chronic infection leading to blindness caused by follicular conjunctivitis, particularly in resource-limited areas.
    • Type D-K:
      • Causes urethritis, PID, ectopic pregnancy, neonatal pneumonia (characterized by staccato cough and eosinophilia), and conjunctivitis in neonates occurring 1-2 weeks after birth.
    • Type L1, L2, L3:
      • Responsible for lymphogranuloma venereum, presenting as small, painless genital ulcers and swollen, painful inguinal lymph nodes (buboes).
      • Treatment includes doxycycline.

    Chlamydiae Overview

    • Obligate intracellular organisms that cannot synthesize their own ATP.
    • Cause mucosal infections; ineffective against β-lactam antibiotics due to the absence of classic peptidoglycan in the cell wall.

    Forms of Chlamydiae

    • Elementary Body: Small and dense; acts as the infectious form, entering host cells via endocytosis.
    • Reticulate Body:
      • Replicates within the host cell through fission.
      • Reorganizes back into elementary bodies for transmission.

    Associated Diseases

    • Chlamydia trachomatis:
      • Causes neonatal and follicular adult conjunctivitis, nongonococcal urethritis, and pelvic inflammatory disease (PID).
      • Linked to reactive arthritis.
    • Chlamydophila pneumoniae and Chlamydophila psittaci:
      • Associated with atypical pneumonia.
      • Mainly transmitted through aerosol routes.

    Diagnosis

    • Detection methods include PCR and nucleic acid amplification tests (NAAT).
    • Cytoplasmic inclusions (reticulate bodies) detectable via Giemsa or fluorescent antibody-stained smears.

    Treatment Options

    • First-line treatment includes doxycycline.
    • Azithromycin is recommended for pregnant patients.
    • Ceftriaxone may be added to cover for possible co-infections.

    Serology Types

    • Type A, B, C:
      • Associated with chronic infection leading to blindness caused by follicular conjunctivitis, particularly in resource-limited areas.
    • Type D-K:
      • Causes urethritis, PID, ectopic pregnancy, neonatal pneumonia (characterized by staccato cough and eosinophilia), and conjunctivitis in neonates occurring 1-2 weeks after birth.
    • Type L1, L2, L3:
      • Responsible for lymphogranuloma venereum, presenting as small, painless genital ulcers and swollen, painful inguinal lymph nodes (buboes).
      • Treatment includes doxycycline.

    Chlamydiae Overview

    • Obligate intracellular organisms that cannot synthesize their own ATP.
    • Cause mucosal infections; ineffective against β-lactam antibiotics due to the absence of classic peptidoglycan in the cell wall.

    Forms of Chlamydiae

    • Elementary Body: Small and dense; acts as the infectious form, entering host cells via endocytosis.
    • Reticulate Body:
      • Replicates within the host cell through fission.
      • Reorganizes back into elementary bodies for transmission.

    Associated Diseases

    • Chlamydia trachomatis:
      • Causes neonatal and follicular adult conjunctivitis, nongonococcal urethritis, and pelvic inflammatory disease (PID).
      • Linked to reactive arthritis.
    • Chlamydophila pneumoniae and Chlamydophila psittaci:
      • Associated with atypical pneumonia.
      • Mainly transmitted through aerosol routes.

    Diagnosis

    • Detection methods include PCR and nucleic acid amplification tests (NAAT).
    • Cytoplasmic inclusions (reticulate bodies) detectable via Giemsa or fluorescent antibody-stained smears.

    Treatment Options

    • First-line treatment includes doxycycline.
    • Azithromycin is recommended for pregnant patients.
    • Ceftriaxone may be added to cover for possible co-infections.

    Serology Types

    • Type A, B, C:
      • Associated with chronic infection leading to blindness caused by follicular conjunctivitis, particularly in resource-limited areas.
    • Type D-K:
      • Causes urethritis, PID, ectopic pregnancy, neonatal pneumonia (characterized by staccato cough and eosinophilia), and conjunctivitis in neonates occurring 1-2 weeks after birth.
    • Type L1, L2, L3:
      • Responsible for lymphogranuloma venereum, presenting as small, painless genital ulcers and swollen, painful inguinal lymph nodes (buboes).
      • Treatment includes doxycycline.

    Chlamydiae Overview

    • Obligate intracellular organisms that cannot synthesize their own ATP.
    • Cause mucosal infections; ineffective against β-lactam antibiotics due to the absence of classic peptidoglycan in the cell wall.

    Forms of Chlamydiae

    • Elementary Body: Small and dense; acts as the infectious form, entering host cells via endocytosis.
    • Reticulate Body:
      • Replicates within the host cell through fission.
      • Reorganizes back into elementary bodies for transmission.

    Associated Diseases

    • Chlamydia trachomatis:
      • Causes neonatal and follicular adult conjunctivitis, nongonococcal urethritis, and pelvic inflammatory disease (PID).
      • Linked to reactive arthritis.
    • Chlamydophila pneumoniae and Chlamydophila psittaci:
      • Associated with atypical pneumonia.
      • Mainly transmitted through aerosol routes.

    Diagnosis

    • Detection methods include PCR and nucleic acid amplification tests (NAAT).
    • Cytoplasmic inclusions (reticulate bodies) detectable via Giemsa or fluorescent antibody-stained smears.

    Treatment Options

    • First-line treatment includes doxycycline.
    • Azithromycin is recommended for pregnant patients.
    • Ceftriaxone may be added to cover for possible co-infections.

    Serology Types

    • Type A, B, C:
      • Associated with chronic infection leading to blindness caused by follicular conjunctivitis, particularly in resource-limited areas.
    • Type D-K:
      • Causes urethritis, PID, ectopic pregnancy, neonatal pneumonia (characterized by staccato cough and eosinophilia), and conjunctivitis in neonates occurring 1-2 weeks after birth.
    • Type L1, L2, L3:
      • Responsible for lymphogranuloma venereum, presenting as small, painless genital ulcers and swollen, painful inguinal lymph nodes (buboes).
      • Treatment includes doxycycline.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Explore the unique characteristics of Chlamydiae, including their inability to produce ATP and their role as obligate intracellular pathogens. This quiz covers the lifecycle of Chlamydiae, focusing on the elementary and reticulate body forms and the associated diseases they cause.

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser