Chirality and Enantiomers
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Questions and Answers

Why does the failure to observe optical activity not necessarily mean that no chiral compound is present?

Each compound with an asymmetric C-atom has two enantiomers, each rotating light in opposite directions.

What happens when we have a 50-50 mixture of enantiomers?

No rotation is observed at all.

How are amino acids generally in terms of chirality?

Amino acids are generally homochiral.

Why is it important to consider chirality in pharmaceuticals?

<p>Any synthetic substance interacting with a chiral environment needs to be considered due to chirality.</p> Signup and view all the answers

What does optical activity establish in a sample?

<p>Chirality</p> Signup and view all the answers

What is the property of light when it oscillates in all planes perpendicular to its direction of propagation?

<p>Ordinary light</p> Signup and view all the answers

Does a lack of optical activity prove a lack of chirality in a sample?

<p>No</p> Signup and view all the answers

How do optical isomers affect plane-polarized light?

<p>Rotate the plane</p> Signup and view all the answers

Define optical isomerism and provide an example.

<p>Optical isomerism is a type of stereoisomerism where isomers differ in their effect on the rotation of polarized light. Example: lactic acids.</p> Signup and view all the answers

What are enantiomers?

<p>Enantiomers are non-congruent mirror images of each other, with the ability to rotate plane polarized light by equal amounts but in opposite directions.</p> Signup and view all the answers

How do diastereomers differ from enantiomers?

<p>Diastereomers are stereoisomers that are not mirror images of each other and can have different physical properties and reactivity.</p> Signup and view all the answers

Why are molecules with one tetrahedral stereogenic center always chiral?

<p>Molecules with one tetrahedral stereogenic center are always chiral because they have non-superimposable mirror images.</p> Signup and view all the answers

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