Chemotherapy for Malaria: Chloroquine Pharmacokinetics
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Questions and Answers

What is the exact mechanism of action of Primaquine?

  • Exact mechanism remains undetermined (correct)
  • Inhibition of enterohepatic circulation
  • Inhibition of ATP and pyrimidine biosynthesis
  • Inhibition of mitochondrial processes
  • Which adverse effect is NOT commonly associated with Mefloquine?

  • Abdominal pain (correct)
  • Depression
  • Hallucinations
  • Disorientation
  • What is a characteristic of Chloroquine's pharmacokinetics?

  • Well absorbed after oral administration
  • Rapid metabolism and excretion through urine
  • Long half-life due to enterohepatic circulation
  • Primarily excreted via the bile into the feces (correct)
  • Which statement is true about Atovaquone's mechanism of action?

    <p>Inhibits electron transport in mitochondria (D)</p> Signup and view all the answers

    What adverse effect can occur if Mefloquine is taken concurrently with quinine or quinidine?

    <p>Cardiac arrest (A)</p> Signup and view all the answers

    Which statement is true regarding the pharmacokinetics of Primaquine?

    <p>Well absorbed after oral administration (B)</p> Signup and view all the answers

    What is the main mechanism of action of chloroquine in treating malaria?

    <p>Damaging phospholipid membranes in the parasite and red blood cell (A)</p> Signup and view all the answers

    Where does chloroquine concentrate in the body according to the text?

    <p>Erythrocytes, liver, spleen, kidney, lung, and melanin-containing tissues (B)</p> Signup and view all the answers

    What is a common adverse effect of chloroquine at high doses?

    <p>Blurred vision (C)</p> Signup and view all the answers

    How is chloroquine primarily excreted from the body?

    <p>Urine (C)</p> Signup and view all the answers

    Which statement best describes the pharmacokinetics of chloroquine?

    <p>Rapid absorption and large volume of distribution in various tissues (B)</p> Signup and view all the answers

    What adverse effect should be monitored with routine ophthalmologic examinations during chronic chloroquine administration?

    <p>Blurred vision (A)</p> Signup and view all the answers

    Which of the following statements regarding primaquine's mechanism of action is correct?

    <p>Primaquine's metabolites are believed to act as oxidants responsible for its schizonticidal action and toxicities. (D)</p> Signup and view all the answers

    Which of the following statements about primaquine's pharmacokinetics is incorrect?

    <p>Primaquine is concentrated in tissues. (D)</p> Signup and view all the answers

    Which of the following is not a known adverse effect associated with primaquine?

    <p>Increased risk of birth defects when used during pregnancy. (A)</p> Signup and view all the answers

    Which of the following statements about chloroquine is incorrect?

    <p>Chloroquine is more effective against P. vivax malaria than P. falciparum malaria. (D)</p> Signup and view all the answers

    What is the mechanism of action of chloroquine?

    <p>Chloroquine binds specifically to heme, preventing its polymerization to hemozoin. (D)</p> Signup and view all the answers

    Which of the following statements regarding drug resistance is true?

    <p>All Plasmodium species may develop resistance to primaquine. (C)</p> Signup and view all the answers

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