18 Questions
What is the exact mechanism of action of Primaquine?
Exact mechanism remains undetermined
Which adverse effect is NOT commonly associated with Mefloquine?
Abdominal pain
What is a characteristic of Chloroquine's pharmacokinetics?
Primarily excreted via the bile into the feces
Which statement is true about Atovaquone's mechanism of action?
Inhibits electron transport in mitochondria
What adverse effect can occur if Mefloquine is taken concurrently with quinine or quinidine?
Cardiac arrest
Which statement is true regarding the pharmacokinetics of Primaquine?
Well absorbed after oral administration
What is the main mechanism of action of chloroquine in treating malaria?
Damaging phospholipid membranes in the parasite and red blood cell
Where does chloroquine concentrate in the body according to the text?
Erythrocytes, liver, spleen, kidney, lung, and melanin-containing tissues
What is a common adverse effect of chloroquine at high doses?
Blurred vision
How is chloroquine primarily excreted from the body?
Urine
Which statement best describes the pharmacokinetics of chloroquine?
Rapid absorption and large volume of distribution in various tissues
What adverse effect should be monitored with routine ophthalmologic examinations during chronic chloroquine administration?
Blurred vision
Which of the following statements regarding primaquine's mechanism of action is correct?
Primaquine's metabolites are believed to act as oxidants responsible for its schizonticidal action and toxicities.
Which of the following statements about primaquine's pharmacokinetics is incorrect?
Primaquine is concentrated in tissues.
Which of the following is not a known adverse effect associated with primaquine?
Increased risk of birth defects when used during pregnancy.
Which of the following statements about chloroquine is incorrect?
Chloroquine is more effective against P. vivax malaria than P. falciparum malaria.
What is the mechanism of action of chloroquine?
Chloroquine binds specifically to heme, preventing its polymerization to hemozoin.
Which of the following statements regarding drug resistance is true?
All Plasmodium species may develop resistance to primaquine.
Test your knowledge on the pharmacokinetics of Chloroquine, a drug used in the chemotherapy for malaria. Learn about its absorption, distribution, and tissue concentration.
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