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Chemotherapy for Malaria: Chloroquine Pharmacokinetics

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Questions and Answers

What is the exact mechanism of action of Primaquine?

Exact mechanism remains undetermined (correct)
Inhibition of enterohepatic circulation
Inhibition of ATP and pyrimidine biosynthesis
Inhibition of mitochondrial processes

Which adverse effect is NOT commonly associated with Mefloquine?

Abdominal pain (correct)
Depression
Hallucinations
Disorientation

What is a characteristic of Chloroquine's pharmacokinetics?

Well absorbed after oral administration
Rapid metabolism and excretion through urine
Long half-life due to enterohepatic circulation
Primarily excreted via the bile into the feces (correct)

Which statement is true about Atovaquone's mechanism of action?

Inhibits electron transport in mitochondria (D) Signup and view all the answers

What adverse effect can occur if Mefloquine is taken concurrently with quinine or quinidine?

Cardiac arrest (A) Signup and view all the answers

Which statement is true regarding the pharmacokinetics of Primaquine?

Well absorbed after oral administration (B) Signup and view all the answers

What is the main mechanism of action of chloroquine in treating malaria?

Damaging phospholipid membranes in the parasite and red blood cell (A) Signup and view all the answers

Where does chloroquine concentrate in the body according to the text?

Erythrocytes, liver, spleen, kidney, lung, and melanin-containing tissues (B) Signup and view all the answers

What is a common adverse effect of chloroquine at high doses?

Blurred vision (C) Signup and view all the answers

How is chloroquine primarily excreted from the body?

Urine (C) Signup and view all the answers

Which statement best describes the pharmacokinetics of chloroquine?

Rapid absorption and large volume of distribution in various tissues (B) Signup and view all the answers

What adverse effect should be monitored with routine ophthalmologic examinations during chronic chloroquine administration?

Blurred vision (A) Signup and view all the answers

Which of the following statements regarding primaquine's mechanism of action is correct?

Primaquine's metabolites are believed to act as oxidants responsible for its schizonticidal action and toxicities. (D) Signup and view all the answers

Which of the following statements about primaquine's pharmacokinetics is incorrect?

Primaquine is concentrated in tissues. (D) Signup and view all the answers

Which of the following is not a known adverse effect associated with primaquine?

Increased risk of birth defects when used during pregnancy. (A) Signup and view all the answers

Which of the following statements about chloroquine is incorrect?

Chloroquine is more effective against P. vivax malaria than P. falciparum malaria. (D) Signup and view all the answers

What is the mechanism of action of chloroquine?

Chloroquine binds specifically to heme, preventing its polymerization to hemozoin. (D) Signup and view all the answers

Which of the following statements regarding drug resistance is true?

All Plasmodium species may develop resistance to primaquine. (C) Signup and view all the answers

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