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Questions and Answers
Which compounds penetrate the CNS and inhibit replication?
Which compounds penetrate the CNS and inhibit replication?
- Nitrosoureas (correct)
- Hemorrhagic cysts
- Phosphoramide mustard
- Acrolein
What are the active compounds of cyclophosphamide and ifosfamide that react with DNA?
What are the active compounds of cyclophosphamide and ifosfamide that react with DNA?
- Phosphoramide mustard and acrolein (correct)
- Nitrosoureas and hemorrhagic cysts
- Carmustine and lomustine
- Acrolein and bladder toxicity
Which compound is associated with bladder toxicity?
Which compound is associated with bladder toxicity?
- Carmustine
- Acrolein (correct)
- Phosphoramide mustard
- Lomustine
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Study Notes
Anticancer Compounds and CNS Penetration
- Certain compounds can penetrate the CNS (Central Nervous System) and inhibit replication of cancer cells.
Active Metabolites of Cyclophosphamide and Ifosfamide
- The active compounds of cyclophosphamide are aldophosphamide and phosphoramide mustard, which react with DNA to inhibit cancer cell growth.
- The active compounds of ifosfamide are aldophosphamide and isophosphoramide mustard, which also react with DNA to inhibit cancer cell growth.
Compounds Associated with Bladder Toxicity
- Ifosfamide is associated with bladder toxicity, which can lead to hemorrhagic cystitis.
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