Podcast
Questions and Answers
Which compounds penetrate the CNS and inhibit replication?
Which compounds penetrate the CNS and inhibit replication?
What are the active compounds of cyclophosphamide and ifosfamide that react with DNA?
What are the active compounds of cyclophosphamide and ifosfamide that react with DNA?
Which compound is associated with bladder toxicity?
Which compound is associated with bladder toxicity?
Study Notes
Anticancer Compounds and CNS Penetration
- Certain compounds can penetrate the CNS (Central Nervous System) and inhibit replication of cancer cells.
Active Metabolites of Cyclophosphamide and Ifosfamide
- The active compounds of cyclophosphamide are aldophosphamide and phosphoramide mustard, which react with DNA to inhibit cancer cell growth.
- The active compounds of ifosfamide are aldophosphamide and isophosphoramide mustard, which also react with DNA to inhibit cancer cell growth.
Compounds Associated with Bladder Toxicity
- Ifosfamide is associated with bladder toxicity, which can lead to hemorrhagic cystitis.
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Description
Test your knowledge of chemotherapy drugs and their mechanisms of action with this quiz. Learn about the active compounds, toxicities, and penetration of certain drugs into the central nervous system.