47 Questions
Which class of drugs binds to tubulin in cells and disrupts the mitotic spindle?
Anti tumour antibiotics
Which class of drugs inhibits the use of cell metabolites used in growth and cell division?
Anti Metabolites
Which class of drugs inhibits various TK receptors, such as KIT and VEGFR?
Tyrosine kinase inhibitors
Which class of drugs binds platinum to DNA causing cross linkage and cell death?
Platinum analogues
Which class of drugs inhibits topoisomerase-II causing breakage of DNA and cell death?
Anti tumour antibiotics
Which class of drugs binds to and cross-links DNA?
Alkylating Agents
Which route of administration is not helpful for vets when using chemotherapeutic agents?
Topical
Which type of treatment involves the use of chemotherapeutic drugs along with radiography and/or surgery?
Adjuvant treatment
What is the definition of a chemotherapeutic agent?
A drug used to treat cancers by causing cell death or stopping cells from dividing
What is the specific definition of chemotherapy in most first opinion practices?
The use of chemotherapeutic agents to treat cancers
What is the main purpose of using chemotherapeutic drugs as part of treatment for lymphoma in dogs and cats?
To cause cell death or stop cell division
Which type of tumours should be treated with a high growth fraction?
Tumours with high growth fraction
What is the purpose of using cell cycle specific drugs?
To target a limited number of cells with each dose
Why is it important to use combinations of drugs in chemotherapy?
To target cancer cells in different phases of the cell cycle
How should quality of life be maintained during chemotherapy?
By assessing the side effects of chemotherapy
What can chemotherapy drugs do to people who come into direct contact with them?
Cause adverse effects
What is the purpose of using antiemetic drugs during chemotherapy?
To treat symptoms of nausea and vomiting
How do we know when to start treatment for small tumours?
By monitoring the tumour growth rate
Which class of drugs is known for causing peripheral neuropathy as an adverse event?
Plant Alkaloids
Which class of drugs is associated with cumulative cardiotoxicity in dogs and nephrotoxicity in cats?
Anti tumour antibiotics
Which class of drugs is used to treat lymphoma with CNS involvement?
Anti Metabolites
Which class of drugs is used to treat osteosarcoma and carcinomas?
Platinum analogues
Which class of drugs is used to inhibit various TK receptors, such as KIT and VEGFR?
Tyrosine kinase inhibitors
Which route of administration is not recommended for vets when using chemotherapeutic agents?
Topical
Which type of treatment involves the use of chemotherapeutic drugs along with radiography and/or surgery?
Adjuvant treatment
What is the main purpose of using chemotherapeutic drugs as part of treatment for lymphoma in dogs and cats?
To stop cell division
What types of chemotherapeutic agents do vets primarily use?
Cytotoxic drugs
What is the specific definition of a chemotherapeutic agent in most first opinion practices?
A drug used to treat cancers by causing cell death or stopping cell division
What do cytotoxic drugs primarily do as chemotherapeutic agents?
Inhibit mitosis and/or damage DNA
Which type of cells are targeted when treating small tumors with a high growth fraction?
Rapidly dividing cells
What is the recommended approach for dosing cell cycle specific drugs?
Repeat dosing as often as possible
Why is it important to use combinations of drugs in chemotherapy?
To target different phases of the cell cycle
What is the purpose of using antiemetic drugs during chemotherapy?
To treat adverse effects like nausea and vomiting
How should quality of life be maintained during chemotherapy?
By effectively communicating with owners
What can chemotherapy drugs do to people who come into direct contact with them?
Cause direct exposure to the drugs
What is the main purpose of using chemotherapeutic drugs as part of treatment for lymphoma in dogs and cats?
To target and kill cancer cells
Which class of drugs inhibits various TK receptors, such as KIT and VEGFR?
Tyrosine kinase inhibitors
What is the definition of a chemotherapeutic agent?
A chemotherapeutic agent is a drug used to treat cancers by causing cell death or stopping cells from dividing.
How are chemotherapeutic agents used?
Chemotherapeutic agents can be administered orally, by injection, by IV infusion (given slowly), or topically (though not recommended for cats and dogs).
What do cytotoxic drugs primarily do as chemotherapeutic agents?
Cytotoxic drugs primarily inhibit mitosis and/or damage DNA, targeting both healthy cells and cancer cells.
What are the limitations of cytotoxic drug treatments?
Palliative, not curative; toxicity limits dose or frequency of dose; maximum tolerated dose
What are the different classes of therapeutic agents used by vets?
Alkylating Agents, Plant Alkaloids, Anti Metabolites, Anti tumour antibiotics, Platinum analogues, Tyrosine kinase inhibitors
What are the adverse events associated with the use of anti tumour antibiotics?
Myelosuppression, GI signs, Extreme irritation if leaks from vein, Alopecia, Cumulative cardiotoxicity (dogs), Nephrotoxic (cats)
What are some strategies for maximizing the benefit of chemotherapy treatment for small tumors with a high growth fraction?
Repeat dosing as often as possible and use combinations of drugs to target different phases and work in different ways.
How can the harm of chemotherapy treatment be minimized?
By being aware of adverse effects and providing symptomatic treatment, monitoring the patient, and communicating with owners.
What is the importance of maintaining quality of life during chemotherapy treatment?
Quality of life must be maintained to ensure the well-being of the patient.
How can chemotherapeutic drugs potentially affect people who come into contact with them?
Chemotherapeutic drugs can potentially enhance people either through direct exposure to the drugs or metabolites excreted by the pets.
Test your knowledge on chemotherapeutics and learn about the definition and use of chemotherapeutic agents in treating cancer. Explore how these drugs work to induce cell death or halt cell division. Discover the broad spectrum of drugs that fall under the category of chemotherapeutic agents and their applications in human medicine.
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