Chemical Filters in Sunscreens

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Questions and Answers

What is the primary function of Mexoryl SX in sunscreens?

  • To reflect UV rays
  • To enhance skin penetration
  • To provide UVA2 protection only
  • To absorb UV rays and release them as thermal energy (correct)

What is the limitation of Mexoryl SX in terms of UV protection?

  • It is not water-soluble
  • It only provides protection against UVA1
  • It is not photostable
  • It doesn't protect against the entire UV spectrum (correct)

What is the main difference between Mexoryl SX and Mexoryl XL?

  • Mexoryl XL is not photostable
  • Mexoryl XL is not approved by the FDA
  • Mexoryl XL is used synergistically with Mexoryl SX (correct)
  • Mexoryl XL is water-soluble

Why is Mexoryl SX not sufficient as a single ingredient in sunscreens?

<p>It doesn't provide protection against the entire UV spectrum (C)</p>
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What is the benefit of Mexoryl SX being water-soluble?

<p>It makes it easier to formulate in sunscreens (A)</p>
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What is the current status of Mexoryl XL in the US market?

<p>It is not approved by the FDA (D)</p>
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What is the primary advantage of using Mexoryl SX and Mexoryl XL together?

<p>It provides better broad-spectrum protection (A)</p>
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What is the patent status of Mexoryl SX?

<p>It is patented by L'Oréal (A)</p>
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What is the primary difference between Mexoryl SX and other chemical filters?

<p>It is more photostable (B)</p>
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Why is Mexoryl SX used in combination with other filters?

<p>To provide broad-spectrum protection (B)</p>
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Study Notes

Chemical Filters

  • Avobenzone: absorbs full UVA spectrum, oil-soluble, tends to be unstable when combined with octinoxate, but can be stabilized by octocrylene, 4-MBC, Tinosorb, Meroxyl SX, and other UV filters or photo-stabilizers.
  • Helioplex: a combination of avobenzone and oxybenzone, offering broad-spectrum protection and stability, but not water-resistant, held by Neutrogena, and FDA-approved.

Octinoxate

  • Octinoxate: absorbs UVB rays, water-insoluble, degrades over time when exposed to sunlight, can be stabilized by other UV filters such as Tinosorb M.
  • Also known as octyl methoxy-cinnamate (OMC), ethylhexyl methoxycinnamate (EHMC), and other names.

Octocrylene

  • Octocrylene: absorbs UVB and UVA2 rays, oil-soluble, absorbed by skin, can increase skin's photosensitivity to the sun, increasing free radicals.
  • Photostable and helps stabilize other UV filters.

Mexoryl SX

  • Mexoryl SX: absorbs UV rays, releases thermal energy, doesn't protect against the entire UV spectrum, and has to be combined with other filters for good protection.
  • Also known as terephthalylidene dicamphor sulfonic acid (TDSA) and ecamsule, FDA-approved.

Mexoryl XL

  • Mexoryl XL: absorbs UV rays, oil-soluble, photostable, used synergistically with Mexoryl SX, not yet FDA-approved.

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