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Questions and Answers
What is the main focus of the current Discovery Grant project?
What is the main focus of the current Discovery Grant project?
What is the total funding amount of the DNAPrint grant over its duration?
What is the total funding amount of the DNAPrint grant over its duration?
Which of the following best describes the relationship between the Discovery Grant and the SPG proposal?
Which of the following best describes the relationship between the Discovery Grant and the SPG proposal?
What specific application does the SPG proposal focus on?
What specific application does the SPG proposal focus on?
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Which individuals are funded by the Discovery Grant?
Which individuals are funded by the Discovery Grant?
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What is the applicant's family name?
What is the applicant's family name?
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Which department is associated with the grant application?
Which department is associated with the grant application?
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How many hours per month is the applicant planning to devote to the proposed research?
How many hours per month is the applicant planning to devote to the proposed research?
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What is the title of the proposal submitted by the applicant?
What is the title of the proposal submitted by the applicant?
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Which of the following keywords is not included in the proposal?
Which of the following keywords is not included in the proposal?
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What personal identification number (PIN) is assigned to the applicant?
What personal identification number (PIN) is assigned to the applicant?
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Which institution will administer the grant?
Which institution will administer the grant?
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Which research subject code is identified as primary in this application?
Which research subject code is identified as primary in this application?
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What is the activity time for Anbuhi Jahanshahi as stated in the document?
What is the activity time for Anbuhi Jahanshahi as stated in the document?
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Which organization is associated with Amyn Sayani?
Which organization is associated with Amyn Sayani?
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Who is listed as a collaborator with the Family name 'Filipe'?
Who is listed as a collaborator with the Family name 'Filipe'?
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How many hours per month does Ashkar dedicate to research activities?
How many hours per month does Ashkar dedicate to research activities?
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What does the PIN stand for in the context of the document?
What does the PIN stand for in the context of the document?
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Which of the following individuals is not listed as a co-applicant?
Which of the following individuals is not listed as a co-applicant?
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What is the relationship between GSK Canada and Amyn Sayani?
What is the relationship between GSK Canada and Amyn Sayani?
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What is the full name of the organization abbreviated as NSERC?
What is the full name of the organization abbreviated as NSERC?
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What is the total in-kind contribution from Advanced Theranostics?
What is the total in-kind contribution from Advanced Theranostics?
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What role will Kevin Pennings have in the project?
What role will Kevin Pennings have in the project?
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What percentage of fringe benefits is included in Kevin Pennings' salary?
What percentage of fringe benefits is included in Kevin Pennings' salary?
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How much is Marianne Chew expected to dedicate to the project?
How much is Marianne Chew expected to dedicate to the project?
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Which of the following is NOT mentioned as part of the materials and supplies budget?
Which of the following is NOT mentioned as part of the materials and supplies budget?
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What is the total cost allocated for materials and supplies?
What is the total cost allocated for materials and supplies?
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What is a key strength of Kevin Pennings as highlighted in the budget justification?
What is a key strength of Kevin Pennings as highlighted in the budget justification?
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What funding does the organization hope to receive through their Idea to Innovation grant application?
What funding does the organization hope to receive through their Idea to Innovation grant application?
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What is the total estimated value of in-kind contributions from Advanced Theranostics Inc. for salaries and equipment?
What is the total estimated value of in-kind contributions from Advanced Theranostics Inc. for salaries and equipment?
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What is the primary goal of Advanced Theranostics Inc. as stated in the letter?
What is the primary goal of Advanced Theranostics Inc. as stated in the letter?
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Which technology is Advanced Theranostics Inc. interested in integrating with their diagnostic systems?
Which technology is Advanced Theranostics Inc. interested in integrating with their diagnostic systems?
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What is the significant characteristic of the reagent stabilization technology developed by Dr. Filipe?
What is the significant characteristic of the reagent stabilization technology developed by Dr. Filipe?
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What type of diseases is Advanced Theranostics Inc. currently focusing on detecting?
What type of diseases is Advanced Theranostics Inc. currently focusing on detecting?
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How long is the desired time for obtaining a test result using the new POC test device?
How long is the desired time for obtaining a test result using the new POC test device?
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What has Advanced Theranostics Inc. agreed to provide for the research collaboration?
What has Advanced Theranostics Inc. agreed to provide for the research collaboration?
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What is the in-kind value of research time expected from Advanced Theranostics Inc.?
What is the in-kind value of research time expected from Advanced Theranostics Inc.?
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What is a key benefit of moving to a capsule/tablet format for vaccines?
What is a key benefit of moving to a capsule/tablet format for vaccines?
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Which of the following methods can the technology integrate with?
Which of the following methods can the technology integrate with?
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What is the approximate cost of producing 1000 tablets of the GMP pullulan mixture?
What is the approximate cost of producing 1000 tablets of the GMP pullulan mixture?
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How much does the stabilization mixture add per vaccine?
How much does the stabilization mixture add per vaccine?
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What is a significant cost-saving advantage of the proposed system?
What is a significant cost-saving advantage of the proposed system?
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What type of patent applications have been filed for the pullulan-based tablets?
What type of patent applications have been filed for the pullulan-based tablets?
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What does the Freedom to Operate assessment reveal?
What does the Freedom to Operate assessment reveal?
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What is a potential market application for the technology besides vaccines?
What is a potential market application for the technology besides vaccines?
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Study Notes
Application for a Grant
- Applicant: Filipe Carlos
- Grant Type: Idea to Innovation
- Institution: McMaster University
- Department: Chemical Engineering
- Date: 2016/07/04
- PIN: 256630
Proposal Details
- Title: Validation and Scale Up of Vaccine Stabilization for Ambient Handling Using a Pullulan/Trehalose Formulation
- Keywords: vaccine stabilization, in vitro validation, in vivo validation, scale up, optimization, ambient handling
- Total Amount Requested: $125,000
Collaborators
- Jahanshahi Anbuhi: PIN: 501309, McMaster University, 80 hours/month
- Ashkar, A: McMaster University, 30 hours/month
- Co-Applicants' Organizations: GSK Canada - GlaxoSmithKline, Advanced Theranostics Inc.
Activity Schedule
- Optimization of pullulan molecular weights & casting method: 2016-10-03 to 2016-12-30
- Formulation (vaccine trials in vitro): 2016-11-01 to 2017-04-30
- Vaccine Trials (in vivo): 2016-12-01 to 2017-06-30
- Characterization of performance under varying conditions: 2017-03-01 to 2017-06-15
- Scale-up methods for large-scale manufacturing: 2017-04-01 to 2017-06-30
- Develop/source additional partners for licensing technology: 2017-04-01 to 2017-08-31
- Final Report: 2017-08-01 to 2017-10-02
Proposed Expenditures
- Salaries and Benefits: $80,500 (Year 1), $15,000 (Year 1)
- Equipment: $5,000 (Year 1), $0 (Year 2, 3, 4, 5)
- Materials and supplies: $25,000 (Year 1), $2,000 (Year 1), $10,000 (Year 1)
- Technology Transfer Activities: $7,500 (Year 1)
- Total Proposed Expenditures: $125,000
Intellectual Property
- Patent Application: Filed for "Method for Stabilizing Various Molecules without Refrigeration Using Water Soluble Polymers" (US provisional patent application, 61/901,784, 2013-11-08)
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Description
This proposal outlines the validation and scale-up process of a novel vaccine stabilization formulation using a pullulan/trehalose approach. The goal is to facilitate ambient handling and optimize vaccine stability through rigorous in vitro and in vivo trials. Collaborators from McMaster University and other organizations will be involved in this significant project.