Chemical Engineering Grant Proposal 2016

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Questions and Answers

What is the main focus of the current Discovery Grant project?

Surface modification of paper substrates to prevent non-specific binding of molecules (correct)

Creating pathogen-tracking paper sensor platforms

Funding research for Legionella detection in water towers

Developing functional nucleic acids for bacterial detection

What is the total funding amount of the DNAPrint grant over its duration?

$517,000

$757,000

$687,000 (correct)

$229,000

Which of the following best describes the relationship between the Discovery Grant and the SPG proposal?

They have minimal conceptual overlap and no budgetary overlap. (correct)

They have a significant budgetary overlap.

They focus on the same materials and concepts.

They are both aimed at developing new nanomaterials.

What specific application does the SPG proposal focus on?

Detection of Legionella in water towers. (A) Signup and view all the answers

Which individuals are funded by the Discovery Grant?

One Ph.D. student and one undergraduate student. (B) Signup and view all the answers

What is the applicant's family name?

Filipe (B) Signup and view all the answers

Which department is associated with the grant application?

Chemical Engineering (B) Signup and view all the answers

How many hours per month is the applicant planning to devote to the proposed research?

30 (B) Signup and view all the answers

What is the title of the proposal submitted by the applicant?

Validation and Scale Up of Vaccine Stabilization (A) Signup and view all the answers

Which of the following keywords is not included in the proposal?

clinical trials (C) Signup and view all the answers

What personal identification number (PIN) is assigned to the applicant?

256630 (A) Signup and view all the answers

Which institution will administer the grant?

McMaster (C) Signup and view all the answers

Which research subject code is identified as primary in this application?

1800 (A) Signup and view all the answers

What is the activity time for Anbuhi Jahanshahi as stated in the document?

80 hours/month (A) Signup and view all the answers

Which organization is associated with Amyn Sayani?

GSK Canada - GlaxoSmithKline (B) Signup and view all the answers

Who is listed as a collaborator with the Family name 'Filipe'?

Ashkar (A) Signup and view all the answers

How many hours per month does Ashkar dedicate to research activities?

30 hours/month (D) Signup and view all the answers

What does the PIN stand for in the context of the document?

Personal Identification Number (A) Signup and view all the answers

Which of the following individuals is not listed as a co-applicant?

Amyn Sayani (B) Signup and view all the answers

What is the relationship between GSK Canada and Amyn Sayani?

Signing officer (D) Signup and view all the answers

What is the full name of the organization abbreviated as NSERC?

National Science and Engineering Research Council (C) Signup and view all the answers

What is the total in-kind contribution from Advanced Theranostics?

$20,000 (B) Signup and view all the answers

What role will Kevin Pennings have in the project?

Research Assistant (C) Signup and view all the answers

What percentage of fringe benefits is included in Kevin Pennings' salary?

22% (B) Signup and view all the answers

How much is Marianne Chew expected to dedicate to the project?

Half of her time (A) Signup and view all the answers

Which of the following is NOT mentioned as part of the materials and supplies budget?

Reagents (D) Signup and view all the answers

What is the total cost allocated for materials and supplies?

$37,000 (C) Signup and view all the answers

What is a key strength of Kevin Pennings as highlighted in the budget justification?

His exclusive experience with pullulan (A) Signup and view all the answers

What funding does the organization hope to receive through their Idea to Innovation grant application?

Research and development (A) Signup and view all the answers

What is the total estimated value of in-kind contributions from Advanced Theranostics Inc. for salaries and equipment?

$20,000 (B) Signup and view all the answers

What is the primary goal of Advanced Theranostics Inc. as stated in the letter?

To develop rapid point-of-care tests for infectious diseases (A) Signup and view all the answers

Which technology is Advanced Theranostics Inc. interested in integrating with their diagnostic systems?

Isothermal DNA amplification (B) Signup and view all the answers

What is the significant characteristic of the reagent stabilization technology developed by Dr. Filipe?

It enhances storage and transport viability (C) Signup and view all the answers

What type of diseases is Advanced Theranostics Inc. currently focusing on detecting?

Infectious diseases (A) Signup and view all the answers

How long is the desired time for obtaining a test result using the new POC test device?

20 minutes (C) Signup and view all the answers

What has Advanced Theranostics Inc. agreed to provide for the research collaboration?

Equipment and facilities (C) Signup and view all the answers

What is the in-kind value of research time expected from Advanced Theranostics Inc.?

$15,000 (C) Signup and view all the answers

What is a key benefit of moving to a capsule/tablet format for vaccines?

It eliminates the need to handle the vaccine in its sensitive form. (B) Signup and view all the answers

Which of the following methods can the technology integrate with?

Rolling circle amplification (RCA) (D) Signup and view all the answers

What is the approximate cost of producing 1000 tablets of the GMP pullulan mixture?

$23 (C) Signup and view all the answers

How much does the stabilization mixture add per vaccine?

2.3 cents (C) Signup and view all the answers

What is a significant cost-saving advantage of the proposed system?

Elimination of the lyophilization process. (A) Signup and view all the answers

What type of patent applications have been filed for the pullulan-based tablets?

Utility patents. (D) Signup and view all the answers

What does the Freedom to Operate assessment reveal?

Only one US patent which requires licensing from a specific university. (C) Signup and view all the answers

What is a potential market application for the technology besides vaccines?

Molecular diagnostics. (A) Signup and view all the answers

Study Notes

Application for a Grant

Applicant: Filipe Carlos
Grant Type: Idea to Innovation
Institution: McMaster University
Department: Chemical Engineering
Date: 2016/07/04
PIN: 256630

Proposal Details

Title: Validation and Scale Up of Vaccine Stabilization for Ambient Handling Using a Pullulan/Trehalose Formulation
Keywords: vaccine stabilization, in vitro validation, in vivo validation, scale up, optimization, ambient handling
Total Amount Requested: $125,000

Collaborators

Jahanshahi Anbuhi: PIN: 501309, McMaster University, 80 hours/month
Ashkar, A: McMaster University, 30 hours/month
Co-Applicants' Organizations: GSK Canada - GlaxoSmithKline, Advanced Theranostics Inc.

Activity Schedule

Optimization of pullulan molecular weights & casting method: 2016-10-03 to 2016-12-30
Formulation (vaccine trials in vitro): 2016-11-01 to 2017-04-30
Vaccine Trials (in vivo): 2016-12-01 to 2017-06-30
Characterization of performance under varying conditions: 2017-03-01 to 2017-06-15
Scale-up methods for large-scale manufacturing: 2017-04-01 to 2017-06-30
Develop/source additional partners for licensing technology: 2017-04-01 to 2017-08-31
Final Report: 2017-08-01 to 2017-10-02

Proposed Expenditures

Salaries and Benefits: $80,500 (Year 1), $15,000 (Year 1)
Equipment: $5,000 (Year 1), $0 (Year 2, 3, 4, 5)
Materials and supplies: $25,000 (Year 1), $2,000 (Year 1), $10,000 (Year 1)
Technology Transfer Activities: $7,500 (Year 1)
Total Proposed Expenditures: $125,000

Intellectual Property

Patent Application: Filed for "Method for Stabilizing Various Molecules without Refrigeration Using Water Soluble Polymers" (US provisional patent application, 61/901,784, 2013-11-08)

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Description

This proposal outlines the validation and scale-up process of a novel vaccine stabilization formulation using a pullulan/trehalose approach. The goal is to facilitate ambient handling and optimize vaccine stability through rigorous in vitro and in vivo trials. Collaborators from McMaster University and other organizations will be involved in this significant project.