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is the process of formation of a stable
complex, which may be covalent , but is
commonly formed through noncovalent
interactions between two or more
compounds.
is the process of formation of a stable complex, which may be covalent , but is commonly formed through noncovalent interactions between two or more compounds.
COMPLEXATION
The molecule that interacts with a central
molecule/metal ion, that is, substrate, is
called a _________
The molecule that interacts with a central molecule/metal ion, that is, substrate, is called a _________
LIGAND
It is the combination of 2 different species forming a new compound with different physicochemical properties than the original compounds
It is the combination of 2 different species forming a new compound with different physicochemical properties than the original compounds
COMPLEXATION
It alters the solubility, stability, partitioning, energy absorption, and conductance of drug.
It alters the solubility, stability, partitioning, energy absorption, and conductance of drug.
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It optimizes drug delivery systems and affects distribution of drug to body.
It optimizes drug delivery systems and affects distribution of drug to body.
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also known as coordination compounds
product of donor- acceptor mechanism,
specifically Lewis acid-base reactions
also known as coordination compounds product of donor- acceptor mechanism, specifically Lewis acid-base reactions
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attachments of the central ion/atom.
donate lone pairs to the central ion
act as Lewis bases
attachments of the central ion/atom.
donate lone pairs to the central ion
act as Lewis bases
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substrate for ligands
accepts lone pairs from ligands
acts as Lewis acid
substrate for ligands
accepts lone pairs from ligands
acts as Lewis acid
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number of ligands binding to the central ion.
number of ligands binding to the central ion.
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these are substances containing 2 or more
donor groups that may combine with a
metal.
bonds involved in this type of
complex may either be ionic, covalent, or
both.
these are substances containing 2 or more donor groups that may combine with a metal.
bonds involved in this type of complex may either be ionic, covalent, or both.
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Chelates are classified as monodentate, bidentate, tri,
tetra,penta, .... depending on the number
of lone pairs donated by the ligand.
Chelates are classified as monodentate, bidentate, tri, tetra,penta, .... depending on the number of lone pairs donated by the ligand.
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provide steric hindrance.
provide steric hindrance.
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complexes are metal
complexes bound to a metal species.
complexes are metal complexes bound to a metal species.
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Unlike typical ligands that form sigma bonds, alkene
complexes are also bound by a pi back-bond.
Unlike typical ligands that form sigma bonds, alkene complexes are also bound by a pi back-bond.
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The first olefin complex and organometallic
complex discovered was ________
The first olefin complex and organometallic complex discovered was ________
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________ is a model in organometallic chemistry that explains the chemical bonding in transition metal alkene complexes.
________ is a model in organometallic chemistry that explains the chemical bonding in transition metal alkene complexes.
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Held together by weak forces of donor-acceptor type interaction or by hydrogen bonds.
Held together by weak forces of donor-acceptor type interaction or by hydrogen bonds.
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difficult to detect by chemical and physical means because they are so weak that they cannot be separated from their solutions as definite compounds.
difficult to detect by chemical and physical means because they are so weak that they cannot be separated from their solutions as definite compounds.
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They form complexes with other
substances due to architecture of the
molecules and not by chemical affinity.
They form complexes with other substances due to architecture of the molecules and not by chemical affinity.
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They trap compounds inside their
architecture
They trap compounds inside their architecture
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This type of complex involves a metal ion and an alkene bound through both sigma and pi bonds.
This type of complex involves a metal ion and an alkene bound through both sigma and pi bonds.
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These complexes are formed due to the structural arrangement of molecules rather than chemical affinity.
These complexes are formed due to the structural arrangement of molecules rather than chemical affinity.
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A molecule that interacts with a central metal ion or molecule
A molecule that interacts with a central metal ion or molecule
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Substances with multiple donor groups that can bind to a metal
Substances with multiple donor groups that can bind to a metal
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In the complex [PtCl3(C2H4)]-, what is the ligand?
In the complex [PtCl3(C2H4)]-, what is the ligand?
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This process can alter various properties of a drug, including its solubility, stability, partitioning, energy absorption, and conductance. It also plays a role in optimizing drug delivery systems and influencing drug distribution within the body
This process can alter various properties of a drug, including its solubility, stability, partitioning, energy absorption, and conductance. It also plays a role in optimizing drug delivery systems and influencing drug distribution within the body
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These complexes are held together by attractive forces such as Van Der Waals, H bonding, coordinated covalence, electrostatic forces, charge transfers, and hydrophobic forces
These complexes are held together by attractive forces such as Van Der Waals, H bonding, coordinated covalence, electrostatic forces, charge transfers, and hydrophobic forces
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These substances have two or more donor groups that can combine with a metal. The bonds in chelates can be ionic, covalent, or both. They are classified by the number of lone pairs donated by the ligand (e.g., monodentate, bidentate) and provide steric hindrance
These substances have two or more donor groups that can combine with a metal. The bonds in chelates can be ionic, covalent, or both. They are classified by the number of lone pairs donated by the ligand (e.g., monodentate, bidentate) and provide steric hindrance
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These complexes involve a metal species bound to an alkene. The Dewar-Chatt-Duncanson model explains the chemical bonding in these complexes, which involves both sigma and pi back-bonds
These complexes involve a metal species bound to an alkene. The Dewar-Chatt-Duncanson model explains the chemical bonding in these complexes, which involves both sigma and pi back-bonds
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These complexes are formed through weak donor-acceptor interactions or hydrogen bonds. They are challenging to detect chemically or physically due to their weak nature
These complexes are formed through weak donor-acceptor interactions or hydrogen bonds. They are challenging to detect chemically or physically due to their weak nature
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hese materials can form complexes with drugs, potentially leading to precipitation, changes in bioavailability, and altered solubility
hese materials can form complexes with drugs, potentially leading to precipitation, changes in bioavailability, and altered solubility
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These compounds form complexes by trapping other substances within their molecular architecture rather than through chemical affinity
These compounds form complexes by trapping other substances within their molecular architecture rather than through chemical affinity
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Study Notes
Complex Formation Process
- Formation of stable complexes occurs through noncovalent interactions between compounds, often involving a central molecule or metal ion.
- The interacting molecule/substrate is referred to as a ligand, which can either act as a Lewis base or a Lewis acid depending on its role in bonding.
Properties Alteration
- Formation of complexes can lead to significant changes in physicochemical properties such as solubility, stability, partitioning, energy absorption, and conductance of drugs.
- Optimization of drug delivery systems is influenced by these alterations, affecting how drugs distribute within the body.
Types of Complexes
- Coordination compounds are formed by a donor-acceptor mechanism typical of Lewis acid-base reactions.
- Ligands, consisting of multiple donor groups, bind to metal ions, forming chelates which may exhibit ionic or covalent bonding patterns.
- Chelates are classified based on the number of donor lone pairs contributed by ligands, including monodentate, bidentate, and higher categories.
Bonding Characteristics
- Complexes can have bonds that are ionic, covalent, or both. Additionally, pi back-bonding occurs in alkene complexes, differentiating them from typical ligands that exhibit sigma bonding.
- Attractive forces binding these complexes include Van der Waals forces, hydrogen bonds, coordinated covalence, electrostatics, charge transfers, and hydrophobic interactions.
Detection and Characteristics
- Weak forces make complexes difficult to detect using chemical or physical methods; they are not easily separated from their solutions.
- Complex formation is determined by molecular architecture rather than solely by chemical affinity; these materials can encapsulate other compounds.
Specific Complex Examples
- [PtCl3(C2H4)]- features an alkene ligand bonding with platinum, showcasing the interaction of metal ions with organic compounds.
- The Dewar-Chatt-Duncanson model describes chemical bonding in transition metal-alkene complexes, which involves both sigma and pi interactions.
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Description
This quiz explores the process of forming stable complexes through various interactions, primarily focusing on noncovalent bonds. Understand the significance of these interactions in the context of chemical compounds.
