CHEM358 Pharmacodynamics Chapter 2 Quiz

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What is the primary focus of the Dose-Effect model?

The theory behind receptor-drug interactions

The association/dissociation of drugs at equilibrium

The relationship between dose and effect (correct)

Comparisons between medications for the same indication

Which statement best describes the necessity of understanding dose-effect relationships?

Facilitate comparisons between drugs for different indications

Predicting the rate of drug degradation in the body

Ability to predict the effects of changing dose of a drug (correct)

Enhance understanding of how drugs are synthesized

In the Dose-Effect model, what is the response proportional to at equilibrium?

Plasma concentration of the drug

Rate of drug elimination

Number of receptors occupied (correct)

Frequency of drug administration

What does 'Max response = 10 a.u.' indicate in the context of drug-receptor interactions?

Maximum receptor occupancy reached by the drug Signup and view all the answers

Which factor primarily determines the magnitude of response in the Dose-Effect model?

Number of receptors occupied Signup and view all the answers

What role does equilibrium play in drug-receptor interactions?

Balances the association and dissociation of drugs with receptors Signup and view all the answers

In the context of drug-receptor interactions, what does Ntot represent?

Total number of receptors present in the tissue Signup and view all the answers

What is the equilibrium constant for association (K) defined as?

The ratio of free drug to free receptor concentrations at equilibrium Signup and view all the answers

How do pharmacologists define the equilibrium constant for dissociation (KA)?

As the reciprocal of the ratio of drug-receptor complex to free drug and receptor Signup and view all the answers

What does the magnitude of response at equilibrium depend on in drug-receptor interactions?

The number of receptors occupied by the drug Signup and view all the answers

How does the dose-effect model describe the relationship between receptor occupancy and response?

It is non-linear and inversely proportional Signup and view all the answers

What is the purpose of defining the equilibrium constant for dissociation in terms of reciprocal units (mol/L)?

To make it easier to understand by using simpler units Signup and view all the answers

In the context of receptor occupancy, what does a lower KA value signify?

Higher drug affinity for the receptor Signup and view all the answers

What can be inferred about the response from the fractional occupancy equation pA = A [A] / (A [A] + KA)?

Response increases with higher fractional occupancy Signup and view all the answers

How is the relationship between free agonist [A] and fractional occupancy (pA) visualized?

Sigmoidal plot Signup and view all the answers

What is the significance of pA = A [A] / (A [A] + KA) in pharmacology?

Describing drug-receptor affinity Signup and view all the answers

How does maximum possible response relate to receptor occupancy?

Maximum response is achieved at 50% occupancy Signup and view all the answers

Why is a sigmoidal plot preferred for extracting information in pharmacology over a hyperbolic plot?

Sigmoidal plots are easier to interpret Signup and view all the answers