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Questions and Answers
What is the purpose of suppositories?
What is the purpose of suppositories?
- They are used to deliver medications through intramuscular injection
- They are used to deliver medications orally
- They are used to deliver medications through inhalation
- They are used to deliver both systemically and locally acting medications (correct)
How are rectal suppositories usually inserted?
How are rectal suppositories usually inserted?
- With the fingers (correct)
- By compression
- With the aid of an appliance
- Inserted high in the tract
What is the typical weight of adult rectal suppositories?
What is the typical weight of adult rectal suppositories?
- 3 g
- 4 g
- 1 g
- Varies depending on the medicaments (correct)
What is the shape of rectal suppositories?
What is the shape of rectal suppositories?
What is the primary requisite for a suppository base?
What is the primary requisite for a suppository base?
What is the advantage of using cocoa butter as a suppository base for water-soluble drugs?
What is the advantage of using cocoa butter as a suppository base for water-soluble drugs?
Why is cocoa butter considered the superior base for relieving irritation or inflammation in anorectal disorders?
Why is cocoa butter considered the superior base for relieving irritation or inflammation in anorectal disorders?
Which type of suppository bases dissolve slowly in body fluids?
Which type of suppository bases dissolve slowly in body fluids?
Which type of base is Witepsol?
Which type of base is Witepsol?
What is the main ingredient in glycerinated gelatin suppositories?
What is the main ingredient in glycerinated gelatin suppositories?
Why are glycerinated gelatin-based suppositories prone to absorbing moisture?
Why are glycerinated gelatin-based suppositories prone to absorbing moisture?
Why is the glycerinated gelatin base commonly used in vaginal suppositories?
Why is the glycerinated gelatin base commonly used in vaginal suppositories?
What is the purpose of adding water to the suppositories prior to insertion?
What is the purpose of adding water to the suppositories prior to insertion?
What is the purpose of using various combinations of polyethylene glycols in suppositories?
What is the purpose of using various combinations of polyethylene glycols in suppositories?
At what temperature do polyethylene glycol 8000 (PEG 8000) suppositories dissolve in the body's fluids?
At what temperature do polyethylene glycol 8000 (PEG 8000) suppositories dissolve in the body's fluids?
Why do polyethylene glycol (PEG) suppositories not need to be formulated to melt at body temperature?
Why do polyethylene glycol (PEG) suppositories not need to be formulated to melt at body temperature?
Rectal and vaginal routes are commonly used for systemic purposes.
Rectal and vaginal routes are commonly used for systemic purposes.
Drugs that are destroyed by portal circulation may bypass the liver after rectal administration.
Drugs that are destroyed by portal circulation may bypass the liver after rectal administration.
The rectal route is not convenient for patients who are unable or unwilling to swallow medication.
The rectal route is not convenient for patients who are unable or unwilling to swallow medication.
The rectal route is ineffective in the treatment of patients with vomiting.
The rectal route is ineffective in the treatment of patients with vomiting.
Suppository molds are generally not opened for cleaning before and after preparation of a batch of suppositories
Suppository molds are generally not opened for cleaning before and after preparation of a batch of suppositories
Plastic molds are less prone to scratching compared to stainless steel, aluminum, or brass molds
Plastic molds are less prone to scratching compared to stainless steel, aluminum, or brass molds
Suppositories may be prepared by forcing the mixed mass of the base and the medicaments into special molds using suppository-making machines
Suppositories may be prepared by forcing the mixed mass of the base and the medicaments into special molds using suppository-making machines
Hand rolling and shaping is a modern method of preparing suppositories
Hand rolling and shaping is a modern method of preparing suppositories
The pharmacist no longer needs to shape suppositories by hand due to the availability of molds.
The pharmacist no longer needs to shape suppositories by hand due to the availability of molds.
The pharmacist must calculate the amounts of materials needed for the preparation of exactly the number prescribed of suppositories.
The pharmacist must calculate the amounts of materials needed for the preparation of exactly the number prescribed of suppositories.
The volume of base required can be determined by subtracting the volume of drug substances from the total volume of the mold.
The volume of base required can be determined by subtracting the volume of drug substances from the total volume of the mold.
If the added amounts of medicaments are slight, they are always considered to be negligible in suppository preparation.
If the added amounts of medicaments are slight, they are always considered to be negligible in suppository preparation.
The displacement value (D.V) is defined as the quantity of base that displaces one part of the drug.
The displacement value (D.V) is defined as the quantity of base that displaces one part of the drug.
If the density of the drug is less than the density of the base, the drug will displace a low amount of base.
If the density of the drug is less than the density of the base, the drug will displace a low amount of base.
To calculate the quantity of base that the active medication will occupy, the method used is called Density factor.
To calculate the quantity of base that the active medication will occupy, the method used is called Density factor.
If the density of the drug equals the density of the base, the drug will displace a higher amount of base.
If the density of the drug equals the density of the base, the drug will displace a higher amount of base.
What is the main constituent of cocoa butter?
What is the main constituent of cocoa butter?
At what temperature does cocoa butter melt, making it an ideal suppository base?
At what temperature does cocoa butter melt, making it an ideal suppository base?
What is the result of carelessly melting cocoa butter at a temperature greatly exceeding the minimum required temperature?
What is the result of carelessly melting cocoa butter at a temperature greatly exceeding the minimum required temperature?
Why does cocoa butter exhibit marked polymorphism?
Why does cocoa butter exhibit marked polymorphism?
What is a major advantage of using the rectal route for systemic effects over oral therapy?
What is a major advantage of using the rectal route for systemic effects over oral therapy?
Why is the rectal route advantageous for drugs destroyed or inactivated by the pH or enzymatic activity of the stomach or intestines?
Why is the rectal route advantageous for drugs destroyed or inactivated by the pH or enzymatic activity of the stomach or intestines?
What permits the absorption of many soluble drugs for systemic effects in the rectal and vaginal routes?
What permits the absorption of many soluble drugs for systemic effects in the rectal and vaginal routes?
Why is the rectal route not frequently used for systemic purposes?
Why is the rectal route not frequently used for systemic purposes?
What is the primary requisite for a suppository base?
What is the primary requisite for a suppository base?
Why is cocoa butter considered the superior base for relieving irritation or inflammation in anorectal disorders?
Why is cocoa butter considered the superior base for relieving irritation or inflammation in anorectal disorders?
What is the property of glycerinated gelatin and polyethylene glycol bases in relation to fat-soluble drugs?
What is the property of glycerinated gelatin and polyethylene glycol bases in relation to fat-soluble drugs?
What is the displacement value (D.V) defined as?
What is the displacement value (D.V) defined as?
What are the emulsifying properties of cocoa butter primarily useful for?
What are the emulsifying properties of cocoa butter primarily useful for?
How is the displacement value (D.V) used to calculate the amount of base needed for suppository preparation?
How is the displacement value (D.V) used to calculate the amount of base needed for suppository preparation?
In suppository preparation, if the density of the drug is more than the density of the base, what is likely to happen?
In suppository preparation, if the density of the drug is more than the density of the base, what is likely to happen?
How can the displacement value for liquids be described?
How can the displacement value for liquids be described?
What is the main purpose of the rectal route for drug administration?
What is the main purpose of the rectal route for drug administration?
Which property is NOT listed as a characteristic of the ideal suppository base in the text?
Which property is NOT listed as a characteristic of the ideal suppository base in the text?
What is the potential consequence of a base that irritates the mucous membranes of the rectum?
What is the potential consequence of a base that irritates the mucous membranes of the rectum?
Why is it important to ascertain the absence of any drug interaction between the suppository base and medicinal agent?
Why is it important to ascertain the absence of any drug interaction between the suppository base and medicinal agent?
What role does the interaction between the base and drug play in drug absorption?
What role does the interaction between the base and drug play in drug absorption?
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