Chapter 12: Suppositories and Inserts - Bases Category Quiz
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Questions and Answers

What is the purpose of suppositories?

  • They are used to deliver medications through intramuscular injection
  • They are used to deliver medications orally
  • They are used to deliver medications through inhalation
  • They are used to deliver both systemically and locally acting medications (correct)

    • How are rectal suppositories usually inserted?

  • With the fingers (correct)
  • By compression
  • With the aid of an appliance
  • Inserted high in the tract

    • What is the typical weight of adult rectal suppositories?

  • 3 g
  • 4 g
  • 1 g
  • Varies depending on the medicaments (correct)

    • What is the shape of rectal suppositories?

    <p>Cylindrical with both ends tapered</p> Signup and view all the answers

    What is the primary requisite for a suppository base?

    <p>It should remain solid at room temperature</p> Signup and view all the answers

    What is the advantage of using cocoa butter as a suppository base for water-soluble drugs?

    <p>It leads to good release results</p> Signup and view all the answers

    Why is cocoa butter considered the superior base for relieving irritation or inflammation in anorectal disorders?

    <p>It has a spreading action</p> Signup and view all the answers

    Which type of suppository bases dissolve slowly in body fluids?

    <p>Glycerinated gelatin bases</p> Signup and view all the answers

    Which type of base is Witepsol?

    <p>Fatty base</p> Signup and view all the answers

    What is the main ingredient in glycerinated gelatin suppositories?

    <p>Glycerin</p> Signup and view all the answers

    Why are glycerinated gelatin-based suppositories prone to absorbing moisture?

    <p>Because of the hygroscopic nature of glycerin</p> Signup and view all the answers

    Why is the glycerinated gelatin base commonly used in vaginal suppositories?

    <p>For prolonged local action of medicinal agent</p> Signup and view all the answers

    What is the purpose of adding water to the suppositories prior to insertion?

    <p>To reduce the initial tendency of the base to draw water from the mucous membranes</p> Signup and view all the answers

    What is the purpose of using various combinations of polyethylene glycols in suppositories?

    <p>To achieve a suppository base of desired consistency and characteristics</p> Signup and view all the answers

    At what temperature do polyethylene glycol 8000 (PEG 8000) suppositories dissolve in the body's fluids?

    <p>-40°C - -63°C</p> Signup and view all the answers

    Why do polyethylene glycol (PEG) suppositories not need to be formulated to melt at body temperature?

    <p>Because they are not intended to melt but dissolve slowly in the body's fluids</p> Signup and view all the answers

    Rectal and vaginal routes are commonly used for systemic purposes.

    <p>False</p> Signup and view all the answers

    Drugs that are destroyed by portal circulation may bypass the liver after rectal administration.

    <p>True</p> Signup and view all the answers

    The rectal route is not convenient for patients who are unable or unwilling to swallow medication.

    <p>False</p> Signup and view all the answers

    The rectal route is ineffective in the treatment of patients with vomiting.

    <p>False</p> Signup and view all the answers

    Suppository molds are generally not opened for cleaning before and after preparation of a batch of suppositories

    <p>False</p> Signup and view all the answers

    Plastic molds are less prone to scratching compared to stainless steel, aluminum, or brass molds

    <p>False</p> Signup and view all the answers

    Suppositories may be prepared by forcing the mixed mass of the base and the medicaments into special molds using suppository-making machines

    <p>True</p> Signup and view all the answers

    Hand rolling and shaping is a modern method of preparing suppositories

    <p>False</p> Signup and view all the answers

    The pharmacist no longer needs to shape suppositories by hand due to the availability of molds.

    <p>True</p> Signup and view all the answers

    The pharmacist must calculate the amounts of materials needed for the preparation of exactly the number prescribed of suppositories.

    <p>False</p> Signup and view all the answers

    The volume of base required can be determined by subtracting the volume of drug substances from the total volume of the mold.

    <p>True</p> Signup and view all the answers

    If the added amounts of medicaments are slight, they are always considered to be negligible in suppository preparation.

    <p>False</p> Signup and view all the answers

    The displacement value (D.V) is defined as the quantity of base that displaces one part of the drug.

    <p>False</p> Signup and view all the answers

    If the density of the drug is less than the density of the base, the drug will displace a low amount of base.

    <p>False</p> Signup and view all the answers

    To calculate the quantity of base that the active medication will occupy, the method used is called Density factor.

    <p>False</p> Signup and view all the answers

    If the density of the drug equals the density of the base, the drug will displace a higher amount of base.

    <p>False</p> Signup and view all the answers

    What is the main constituent of cocoa butter?

    <p>Oleopalmito-stearin</p> Signup and view all the answers

    At what temperature does cocoa butter melt, making it an ideal suppository base?

    <p>30°C to 36°C</p> Signup and view all the answers

    What is the result of carelessly melting cocoa butter at a temperature greatly exceeding the minimum required temperature?

    <p>Formation of metastable crystalline form (alpha crystals) with a lower melting point</p> Signup and view all the answers

    Why does cocoa butter exhibit marked polymorphism?

    <p>Due to its triglyceride content</p> Signup and view all the answers

    What is a major advantage of using the rectal route for systemic effects over oral therapy?

    <p>Drugs irritating to the stomach may be given without causing such irritation.</p> Signup and view all the answers

    Why is the rectal route advantageous for drugs destroyed or inactivated by the pH or enzymatic activity of the stomach or intestines?

    <p>Drugs destroyed or inactivated by the pH or enzymatic activity of the stomach need not be exposed to these destructive environment.</p> Signup and view all the answers

    What permits the absorption of many soluble drugs for systemic effects in the rectal and vaginal routes?

    <p>The mucous membranes of the rectum and vagina</p> Signup and view all the answers

    Why is the rectal route not frequently used for systemic purposes?

    <p>Vaginal route is more effective for systemic purposes.</p> Signup and view all the answers

    What is the primary requisite for a suppository base?

    <p>Softens, melts, or dissolves readily at body temperature</p> Signup and view all the answers

    Why is cocoa butter considered the superior base for relieving irritation or inflammation in anorectal disorders?

    <p>It has soothing, spreading action</p> Signup and view all the answers

    What is the property of glycerinated gelatin and polyethylene glycol bases in relation to fat-soluble drugs?

    <p>They release fat-soluble drugs more readily</p> Signup and view all the answers

    What is the displacement value (D.V) defined as?

    <p>The amount of base that displaces one part of the drug</p> Signup and view all the answers

    What are the emulsifying properties of cocoa butter primarily useful for?

    <p>Relieving irritation and inflammation</p> Signup and view all the answers

    How is the displacement value (D.V) used to calculate the amount of base needed for suppository preparation?

    <p>By dividing the weight of the drug by the displacement value</p> Signup and view all the answers

    In suppository preparation, if the density of the drug is more than the density of the base, what is likely to happen?

    <p>The drug will displace a high amount of base</p> Signup and view all the answers

    How can the displacement value for liquids be described?

    <p>Equals 1.0</p> Signup and view all the answers

    What is the main purpose of the rectal route for drug administration?

    <p>To allow quick and complete drug release and absorption</p> Signup and view all the answers

    Which property is NOT listed as a characteristic of the ideal suppository base in the text?

    <p>Incompatible with medicaments</p> Signup and view all the answers

    What is the potential consequence of a base that irritates the mucous membranes of the rectum?

    <p>Colonic response and bowel movement</p> Signup and view all the answers

    Why is it important to ascertain the absence of any drug interaction between the suppository base and medicinal agent?

    <p>To maintain stability and bioavailability of the drug</p> Signup and view all the answers

    What role does the interaction between the base and drug play in drug absorption?

    <p>Impairs or prevents drug absorption</p> Signup and view all the answers

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