Channel Capacity and Discrete Memoryless Channels

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Questions and Answers

What potential effect can morphine sulfate have on clients with CNS depression, toxic psychosis, acute alcoholism, or delirium tremens?

  • It can provide a calming effect, reducing psychosis-related anxiety.
  • It can exacerbate these conditions, potentially worsening the client's state. (correct)
  • It can counteract the effects of alcohol, aiding in detoxification.
  • It can alleviate the symptoms of CNS depression.

Why should morphine be avoided in clients with gastrointestinal obstruction, especially paralytic ileus?

  • Morphine reduces inflammation in the gastrointestinal tract.
  • Morphine decreases propulsive peristaltic waves and may prolong the obstruction. (correct)
  • Morphine enhances propulsive peristaltic waves, relieving the obstruction.
  • Morphine helps to diagnose the underlying cause of the obstruction.

A client with a head injury is prescribed morphine for pain relief. What is a significant risk associated with morphine use in this client?

  • Masking of neurological signs due to increased intracranial pressure (correct)
  • Enhanced pupillary response.
  • Improved respiratory function.
  • Reduced intracranial pressure.

What is the primary risk factor associated with morphine sulfate?

<p>Respiratory depression. (A)</p> Signup and view all the answers

In light of the opioid crisis, what action is important for nurses to provide safe and equitable care for clients experiencing pain?

<p>Implementing clinical practice guidelines to ensure safer, effective pain treatment. (D)</p> Signup and view all the answers

What is the significance of the concept of "no ceiling effect" in the context of morphine's analgesic properties?

<p>Higher doses of morphine provide higher levels of analgesia. (D)</p> Signup and view all the answers

How does morphine impact clients with biliary tract disease?

<p>Morphine sulfate may cause spasming and diminished biliary and pancreatic secretions. (C)</p> Signup and view all the answers

Why is it important to provide accurate information to clients about how to safely use opioids?

<p>To alleviate concerns about addiction, especially in opiate-naive clients. (D)</p> Signup and view all the answers

Clients with which condition should generally have morphine dosages reduced?

<p>A client with renal impairment. (B)</p> Signup and view all the answers

A client taking morphine is also prescribed a phenothiazine. What should be the primary concern regarding this combination?

<p>Potential combined CNS depressant effects. (C)</p> Signup and view all the answers

Which of the following factors increases the likelihood of respiratory depression in clients receiving morphine?

<p>Concurrent upper airway obstruction. (C)</p> Signup and view all the answers

When is morphine indicated?

<p>Moderate to severe pain and pulmonary edema. (B)</p> Signup and view all the answers

A client is prescribed morphine while also consuming alcohol regularly. What is a potential risk of this combination?

<p>Additive central nervous system depression, leading to coma or death. (D)</p> Signup and view all the answers

What strategies should clients be taught to prevent opioid dependency?

<p>Clients need to recognize dependency is possible even after short-term use. (D)</p> Signup and view all the answers

Why should caution be exercised when administering morphine sulfate to clients in circulatory shock?

<p>Because it may exacerbate vasodilation, further reducing cardiac output and blood pressure. (B)</p> Signup and view all the answers

Flashcards

Special Risk Groups for Morphine

Use morphine with caution and in reduced dosages in clients with severe renal or hepatic impairment, Addison's disease, hypothyroidism, prostatic hypertrophy, or urethral stricture, and in elderly or debilitated clients.

Morphine and Operating Machinery

Morphine can impair mental and physical abilities needed for potentially hazardous activities like driving or operating machinery.

Hypotensive Effect of Morphine

Morphine may cause severe hypotension, especially in those with compromised blood pressure or those receiving certain anesthetics.

Morphine's GI Effects

Do not administer morphine to clients with gastrointestinal obstruction, as it diminishes propulsive peristaltic waves. Doing so may obscure diagnosis.

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Morphine and Biliary/Pancreatic Disease

Use morphine with caution in clients with biliary tract disease or acute pancreatitis, as it may cause spasms and diminished secretions.

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Misuse of Morphine

Morphine sulfate is an opioid agonist and a controlled substance, posing a risk of misuse.

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Morphine Interactions

Morphine has additive effects with alcohol or illicit drugs, causing respiratory depression, hypotension, sedation, coma, or death.

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Morphine and Head Injury

In head injuries, morphine's respiratory depressant effects and potential to increase cerebrospinal fluid pressure may be markedly exaggerated.

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Morphine and Respiratory Depression

Respiratory depression is the primary risk of morphine sulfate, especially in the elderly or those with certain conditions.

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Effects of Long-Term Morphine Use

Long-term morphine use may result in drug tolerance, dependence, and/or misuse. Naloxone is used to reverse opioid overdoses.

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Morphine Side Effects

Adverse effects include respiratory depression, hypotension, light-headedness, dizziness, sedation, constipation, nausea, vomiting, sweating, and pruritus.

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Morphine's Mechanism

Morphine binds to opioid receptors in the CNS, altering perception and response to painful stimuli while producing generalized CNS depression.

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Morphine Indications

Morphine is indicated for the relief of moderate to severe acute and chronic pain and for pulmonary edema.

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Opioid Potency vs Morphine

Hydromorphone is five times more potent than morphine. Fentanyl is 80-100 times more potent than morphine.

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Morphine Routes

Morphine is administered via PO & Rectal, SubQ, IM, & IV routes.

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Study Notes

Lecture 19: Channel Capacity

  • Channel capacity is the maximum amount of information that can be reliably transmitted over a channel, with arbitrarily small error probability.
  • Memoryless channels are considered.

Discrete Memoryless Channel (DMC)

  • Defined by conditional probabilities $p(y|x)$, where $x \in \chi$, $y \in \gamma$.
  • $\chi$ is the input alphabet, $\gamma$ is the output alphabet.
  • Memoryless: $p(y_1, y_2, \dots y_n|x_1, x_2, \dots x_n) = \prod_{i=1}^{n} p(y_i|x_i)$.

Channel Capacity Formula

  • $C = \max_{p(x)} I(X;Y)$ bits per transmission.
  • The maximum is taken over all possible input distributions $p(x)$.
  • C is a fixed property of the channel.

Binary Symmetric Channel (BSC)

  • Binary input and output.
  • Probability of error: p.
  • $p(y=0|x=0) = p(y=1|x=1) = 1-p$
  • $p(y=0|x=1) = p(y=1|x=0) = p$
  • $I(X;Y) = H(Y) - H(Y|X) = H(Y) - H(p)$
  • $H(Y) \le 1$, $H(p)$ is fixed.
  • $H(Y)$ is maximized when $Y$ is uniform, i.e., $p(y=0) = p(y=1) = 1/2$
  • $p(y=0) = (1-p)\alpha + p(1-\alpha)$ where $\alpha = p(x=0)$.
  • Achieved $p(y=0) = 1/2$ by setting $\alpha = 1/2$.
  • For $p(x=0) = p(x=1) = 1/2$, $I(X;Y) = 1 - H(p)$.
  • $C = 1 - H(p)$ bits.

Lecture 15: October 24, 2023 - Geometry of Linear Programs

Introduction

  • Review of the geometry of linear programs.

Reading

  • Section 4.7

Example 1

  • Maximizing $x_1 + x_2$ subject to constraints.
  • Constraints include $4x_1 - x_2 \le 8$, $2x_1 + x_2 \le 10$, $-5x_1 + 6x_2 \le 30$, $x_1, x_2 \ge 0$
  • Feasible region is a five-sided polygon.
  • Vertices are $(0, 0), (2, 0), (3, 4), (0, 5), (60/34, 30/34)$.
  • Optimal solution is found with the vertex $(3, 4)$ as objective value $3 + 4 = 7$.

Vertices

  • Standard form LP: maximize $c^T x$, subject to $Ax = b$, $x \ge 0$.
  • $A \in \mathbb{R}^{m \times n}$ has rank $m$.
  • A vector $x \in \mathbb{R}^n$ is a basic solution if $Ax = b$, and $m$ indices $B(1), ..., B(m)$ which includes:
    • The columns $A_{B(1)},..., A_{B(m)}$ are linearly independent.
    • If $i \notin {B(1),..., B(m)}$, then $x_i = 0$.
  • The columns $A_{B(1)},..., A_{B(m)}$ are called the basis.
  • Let $B = (A_{B(1)},..., A_{B(m)})$ be the $m \times m$ matrix formed by the basis columns, then $x_B = B^{-1}b$.
  • A vector $x \in \mathbb{R}^n$ is a basic feasible solution if $x$ is a basic solution and $x \ge 0$.

Algoritmos de Busca

  • Do not have information about the search space beyond that inherent in the definition of the problem.
  • Apply a fixed strategy.
  • All nodes at a level are expanded before any node at the next level.
  • Implementation: queue (FIFO).
  • Complete: Yes (if the branching factor b is finite).
  • Optimal: Yes (if the cost is 1 per step).
  • Time complexity: $O(b^d)$.
  • Space complexity: $O(b^d)$.
  • Expand the lowest cost node g(n).
  • Implementation: priority queue.
  • Complete: Yes (if the cost is greater than a positive value $\epsilon$).
  • Optimal: Yes.
  • Time complexity: $O(b^{\lceil C*/\epsilon \rceil})$.
  • Space complexity: $O(b^{\lceil C*/\epsilon \rceil})$.
  • Expand the deepest node in the current frontier.
  • Implementation: stack (LIFO).
  • Complete: No (fails in spaces with infinite depth, may enter a loop).
  • Optimal: No.
  • Time complexity: $O(b^m)$.
  • Space complexity: $O(bm)$.
  • Depth-first search with a depth limit l.
  • Complete: Yes, if l $\ge$ d.
  • Optimal: No.
  • Time complexity: $O(b^l)$.
  • Space complexity: $O(bl)$.
  • Executes a sequence of depth-limited searches with increasing limits.
  • Complete: Yes.
  • Optimal: Yes, if the cost is 1 per step.
  • Time complexity: $O(b^d)$.
  • Space complexity: $O(bd)$.

Busca Informada (Heurística - Informed Search (Heuristic))

  • Use problem-specific knowledge to guide the search.
  • Heuristic function h(n): estimate of the cost of a path from node n to a goal node.
  • Expand the node that seems to be closest to the goal.
  • Evaluated using the heuristic: h(n) (lowest estimated cost to the goal).
  • Implementation: priority queue.
  • Complete: No (may enter loops).
  • Optimal: No.
  • Time complexity: $O(b^m)$.
  • Space complexity: $O(b^m)$.
  • Minimizes the total path cost: $f(n) = g(n) + h(n)$.
    • g(n) = cost to reach node n.
    • h(n) = estimated cost from node n to the goal.
  • Implementation: priority queue.
  • Complete: Yes (unless there are infinite nodes with $f \le f(G)$).
  • Optimal: Yes.
  • Time complexity: $O(b^m)$.
  • Space complexity: $O(b^m)$.

Fonction Exponentielle

Définition

  • La fonction exponentielle, notée $exp(x)$ ou $e^x$, est l'unique fonction définie et dérivable sur $\mathbb{R}$.
    • $f'(x) = f(x)$ pour tout $x \in \mathbb{R}$
    • $f(0) = 1$

Propriétés

  • $e^0 = 1$
  • $e^1 = e \approx 2.718$
  • $e^{a+b} = e^a \cdot e^b$
  • $e^{a-b} = \frac{e^a}{e^b}$
  • $e^{-x} = \frac{1}{e^x}$
  • $(e^a)^b = e^{ab}$
  • $e^x > 0$ pour tout $x \in \mathbb{R}$

Limites

  • $\lim_{x \to +\infty} e^x = +\infty$
  • $\lim_{x \to -\infty} e^x = 0$
  • $\lim_{x \to +\infty} \frac{e^x}{x} = +\infty$
  • $\lim_{x \to -\infty} xe^x = 0$
  • $\lim_{x \to 0} \frac{e^x - 1}{x} = 1$

Dérivée

  • La dérivée de $e^x$ est $e^x$.
  • Si $u(x)$ est une fonction dérivable, alors la dérivée de $e^{u(x)}$ est $u'(x)e^{u(x)}$.

Variations

  • La fonction exponentielle est strictement croissante sur $\mathbb{R}$.

Représentation Graphique

  • La représentation graphique de la fonction exponentielle est une courbe croissante qui passe par le point $(0, 1)$. Elle s'approche de l'axe des abscisses lorsque $x$ tend vers $-\infty$, et tend vers $+\infty$ lorsque $x$ tend vers $+\infty$.

Bernoulli's Principle

  • Bernoulli's principle states that for an inviscid flow, an increase in the speed of the fluid occurs simultaneously with a decrease in pressure or a decrease in the fluid's potential energy.
  • The principle was discovered by Daniel Bernoulli in the 18th century.

How Wings Generate Lift

  • Airplane wings are designed to direct air to travel faster over the top of the wing than under the wing.
  • Faster moving air exerts less pressure.
  • The air moving over the top of the wing exerts less pressure than the air moving under the wing.
  • The higher pressure from below pushes the wing up, creating lift.

Airfoil

  • The cross-sectional shape of a wing is called an airfoil.

Pressure and Velocity

  • Faster-moving fluids exert less pressure.

Lift

  • The upward force on a wing caused by the pressure difference between the top and bottom of the wing is called lift.

Air Pressure

  • The force exerted by the weight of air on a surface.

Parts of an Airplane

  • A: Wing
  • B: Fuselage
  • C: Empennage (Tail)
  • D: Engine
  • E: Cockpit
  • F: Propeller

The Poisson Process

Definition

  • $N(t)$ counts the number of events that occur in the interval $[0, t]$.
  • A counting process ${N(t), t \geq 0}$ is a Poisson process with rate $\lambda > 0$ if:
    • $N(0) = 0$
    • Independent increments
    • The number of events in any interval of length $t$ is Poisson with mean $\lambda t$.
  • $P{N(t+s) - N(s) = n} = e^{-\lambda t} \frac{(\lambda t)^n}{n!}, \quad n = 0, 1, \dots$

Interarrival Times

  • $T_i$ is the time between event $i-1$ and event $i$.
  • The interarrival times $T_1, T_2, \dots$ are i.i.d. exponential random variables with parameter $\lambda$.
  • $T_i \sim Exp(\lambda), \quad i = 1, 2, \dots$

Properties

  • If $N_1(t)$ and $N_2(t)$ are independent Poisson processes with rates $\lambda_1$ and $\lambda_2$, then $N_1(t) + N_2(t)$ is a Poisson process with rate $\lambda_1 + \lambda_2$.
  • Conditional on $N(t) = n$, the $n$ event times are distributed as $n$ independent uniform random variables on $[0, t]$.

Nonhomogeneous Poisson Process

  • A counting process ${N(t), t \geq 0}$ is a nonhomogeneous Poisson process with rate function $\lambda(t), t \geq 0$ if:
    • $N(0) = 0$
    • Independent increments
    • $P{N(t+h) - N(t) = 1} = \lambda(t)h + o(h)$
    • $P{N(t+h) - N(t) \geq 2} = o(h)$
  • $o(h)$ is a function such that $\lim_{h \rightarrow 0} \frac{o(h)}{h} = 0$.

Mean Value Function

  • The mean value function is given by:
    • $m(t) = \int_0^t \lambda(s) ds$
  • The number of events in the interval $(s, t]$ is Poisson distributed with mean $m(t) - m(s)$:
    • $P{N(t) - N(s) = n} = e^{-(m(t) - m(s))} \frac{(m(t) - m(s))^n}{n!}, \quad n = 0, 1, \dots$

Lecture 14: Sequential Estimation

Definition (Sequential Estimation)

  • Estimator is sequential if the number of observations $n$ is not fixed in advance, but is determined by the observations as they are taken.

Definition (Stopping Rule)

  • A stopping rule is a criterion for deciding when to stop sampling, based on the observations.

Theorem

  • Let $X_1, X_2,...$ be i.i.d. random variables with density $f(x;\theta)$, $\theta \in \Omega$.
  • Let $\hat{\theta}_n = \hat{\theta}_n(X_1,..., X_n)$ be a sequence of estimators.
  • If $N$ is a stopping rule, then ${\hat{\theta}_n, N}$ is a sequential estimation procedure.

Example

  • $X_1, X_2,... \stackrel{iid}{\sim} Bernoulli(p)$, $p \in (0,1)$.
  • $N = \min{n: \sum_{i=1}^n X_i = r }$, $r \geq 1$ is fixed.
  • $N \sim NB(r, p)$. Estimator of $p$ given $N = n$ is $\hat{p}_n = \frac{r}{n}$.
  • $E[\hat{p}_n] = E[\frac{r}{N}] = r E[\frac{1}{N}]$.
  • $E[\frac{1}{N}] \neq \frac{1}{E[N]}$, then $\hat{p}_n$ is biased.
  • $\lim_{r \to \infty} \hat{p}_n = p$, then $\hat{p}_n$ is consistent.

Definition (Sufficient Statistics)

  • A statistic $T(\mathbf{X})$ is sufficient for $\theta$ if the conditional distribution of the sample $\mathbf{X}$ given $T(\mathbf{X})$ does not depend on $\theta$.

Theorem (Factorization Theorem)

  • $f(\mathbf{x}; \theta)$ denotes the joint p.d.f. or p.m.f. of the sample $\mathbf{X} = (X_1,..., X_n)$.
  • A statistic $T(\mathbf{X})$ is sufficient for $\theta$ if and only if there exist functions $g(t, \theta)$ and $h(\mathbf{x})$ such that for all $\mathbf{x}$ and $\theta$: $f(\mathbf{x}; \theta) = g(T(\mathbf{x}), \theta) h(\mathbf{x})$.

Properties of Sufficient Statistics

  • If $T(\mathbf{X})$ is a sufficient statistic for $\theta$, then any one-to-one function of $T(\mathbf{X})$ is also a sufficient statistic for $\theta$
  • If $T(\mathbf{X})$ is a sufficient statistic for $\theta$, then the maximum likelihood estimator (MLE) of $\theta$ is a function of $T(\mathbf{X})$

Theorem

  • If $T(\mathbf{X})$ is a sufficient statistic for $\theta$, then any estimator based on $T(\mathbf{X})$ will have a smaller variance than any estimator not based on $T(\mathbf{X})$

Pressure Drop Correlations

Friction Factor

  • Laminar Flow (Re $\leq$ 2100):

    • $f = \frac{16}{Re}$
  • Turbulent Flow (Re > 4000):

    • Smooth Tubes (Blasius): $f = 0.0791 Re^{-0.25}$
    • Smooth Tubes (Nikuradse): $\frac{1}{\sqrt{f}} = 2.0 \ log (Re \sqrt{f}) - 0.8$
    • Rough Tubes (Nikuradse): $\frac{1}{\sqrt{f}} = 1.74 - 2.0 \ log (\frac{\epsilon}{D})$
    • Colebrook: $\frac{1}{\sqrt{f}} = -2.0 \ log (\frac{\epsilon}{3.7D} + \frac{2.51}{Re \sqrt{f}})$
    • Swamee-Jain: $f = \frac{0.25}{[log (\frac{\epsilon}{3.7D} + \frac{5.74}{Re^{0.9}})]^{2}}$

Pressure Drop

  • $\Delta P = f \frac{L}{D} \frac{\rho V^{2}}{2}$
    • f = Fanning friction factor
    • L = Length of pipe
    • D = Diameter of pipe
    • $\rho$ = Density of fluid
    • V = Average velocity of fluid

Reynolds Number

  • $Re = \frac{D V \rho}{\mu}$
    • D = Diameter of pipe
    • V = Average velocity of fluid
    • $\rho$ = Density of fluid
    • $\mu$ = Viscosity of fluid

Darcy Friction Factor

  • $f_{Darcy} = 4f_{Fanning}$

Notes

  • $\epsilon$ = roughness of the pipe
  • Use consistent units.
  • Empirical correlations have limitations.
  • The Moody chart is a graphical representation of the Colebrook equation.

Lecture 14: Data Models

Data Model

  • A set of concepts to describe the structure of a database.
  • The operations for manipulating structures, and constraints that the database should obey.
    • Structure: Data types, relationships, and constraints
    • Operations: For specifying database retrievals and updates
    • Constraints: Rules that data must adhere to

Categories of Data Models

  • Conceptual (high-level, semantic) data models: Concepts close to how users perceive data.
  • Physical (low-level, internal) data models: Describe details of how data is stored.
  • Implementation (representational) data models: Balance user views with computer storage.

Data Model Schema vs. Instance

  • Schema: The description of a database.
    • Includes data element descriptions, relationships, and constraints.
  • Instance: The actual data stored in a database at a moment in time.
  • Database systems support multiple schemas:
    • Database schema: The overall design.
    • External schema: User views.
    • Conceptual schema: Logical structure.
    • Internal schema: Physical storage structure.

Data Independence

  • The capacity to change the schema at one level without changing the schema at the next higher level.
  • Two Types:
    • Logical Data Independence: Change conceptual schema without changing external schemas.
    • Physical Data Independence: Change internal schema without changing the conceptual schema.
  • When is a schema at a lower level changed, only the mapping between these and higher levels schemas needs to be changed.

Database Languages

  • Data Definition Language (DDL): Used by designers to define each database schema (e.g., SQL).
  • Data Manipulation Language (DML): Used to specify database retrievals and updates (i.e., "Query language").
    • High-level (Non-procedural) DML: Specify what data is needed (e.g., SQL).
    • Low-level (Procedural) DML: Specify how to get the data. Rarely used directly.

Database System Architecture

  • Centralized Database Systems: Use a single computer site, all functions are performed on one machine.
  • Client/Server Database Systems: Specialized servers with specialized functions, clients can access the servers via SQL.
    • Two-Tier Architecture: The application resides at the client, directly invoking database access.
    • Three-Tier Architecture: The application server resides between the client and database server.
    • Benefits include increased security, improved concurrency, and simpler updates.

Classification of Database Management Systems

  • Based on the data model: Relational, object-oriented, object-relational, hierarchical, network.
  • Based on the number of users: Single-user, multi-user.
  • Based on the number of sites: Centralized, distributed.
  • Based on the purpose: General-purpose, special-purpose.

Entity-Relationship (ER) Model

  • ER Model: A popular high-level conceptual data model.
  • ER diagrams: a graphical notation for representing ER model.

ER Model Concepts

  • Entity: A "thing" with independent existence.
  • Attribute: Property of an entity or a relationship type.
  • Relationship: Association among two or more entities.

Entities

  • Entities are represented by a set of attributes. Key attribute's value is distinct for each individual entity in the entity set
  • Entity Set: A set of entities of the same type.
  • Each entity set has a key attribute.

Attributes

  • Simple vs. Composite attributes. Composite attributes can be divided into smaller subparts.
  • Single-valued vs. Multi-valued attributes. An employee can have multiple college degrees.
  • Stored vs. Derived attributes. The value of derived attributes can be derived from other attributes.

Relationship Types

  • Relationship Type R among n entity types $E_1, E_2,..., E_n$: a set of associations among entities from these entity types.
  • Relationship Set: The current set of relationship instances represented in the database.

Relationship Degree

  • Degree of a relationship type: The number of participating entity types.
    • Unary relationship: degree is one.
    • Binary relationship: degree is two.
    • Ternary relationship: degree is three.

Cardinality Constraints

  • Cardinality ratio for binary relationships.
    • Specifies the maximum number of relationship instances that an entity can participate in.
    • one-to-one (1:1).
    • one-to-many (1:N).
    • many-to-one (N:1).
    • many-to-many (M:N).
  • Participation constraint: Total participation (existence dependency).
    • Partial participation.

Weak Entity Types

  • An entity that does not have a key attribute of its own.
  • Identified by being related to another entity type (identifying owner).
  • Identifier of a weak entity is the combination of:
    • Partial key of the weak entity.
    • Key of the identifying owner entity.

ER Diagram Notation

  • Entities are represented as rectangles.
  • Attributes are represented as ovals.
  • Relationships are represented as diamonds.
  • Entity sets are connected to relationship sets via straight lines.
  • Multi-valued attributes are represented as double ovals.
  • Derived attributes are represented as dashed ovals.
  • Composite attributes are represented as ovals with ovals inside.
  • Weak entity types are represented as double rectangles.
  • Identifying relationship types are represented as double diamonds.
  • Total participation is represented as a double line connecting the entity type to the relationship type.
  • Cardinality ratios are written on each line connecting entity sets to the relationship set. 1, N, M.

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