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Questions and Answers
If a patient exhibits difficulty coordinating rapid, alternating movements (dysdiadochokinesia) and demonstrates intention tremors, which area of the cerebellum is MOST likely affected?
If a patient exhibits difficulty coordinating rapid, alternating movements (dysdiadochokinesia) and demonstrates intention tremors, which area of the cerebellum is MOST likely affected?
- Flocculonodular lobe
- Vermis
- Spinocerebellum
- Cerebrocerebellum (correct)
A researcher is investigating the effects of a novel drug on cerebellar function. They discover that the drug selectively blocks the release of GABA from Purkinje cells. What would be the MOST likely consequence of this drug's action?
A researcher is investigating the effects of a novel drug on cerebellar function. They discover that the drug selectively blocks the release of GABA from Purkinje cells. What would be the MOST likely consequence of this drug's action?
- Increased excitation of deep cerebellar nuclei (correct)
- Reduced climbing fiber input to Purkinje cells
- Decreased activity of mossy fibers
- Enhanced long-term depression (LTD) at parallel fiber synapses
A patient presents with gait ataxia, nystagmus, and postural instability. Imaging reveals a lesion affecting a specific cerebellar pathway. Which of the following pathways is MOST likely involved, given the patient's symptoms?
A patient presents with gait ataxia, nystagmus, and postural instability. Imaging reveals a lesion affecting a specific cerebellar pathway. Which of the following pathways is MOST likely involved, given the patient's symptoms?
- Cerebellothalamocortical pathway
- Corticopontocerebellar pathway
- Spinocerebellar tract
- Vestibulocerebellar pathway (correct)
A researcher selectively stimulates the inferior olive in an animal model. What direct effect would this stimulation have on the cerebellar cortex?
A researcher selectively stimulates the inferior olive in an animal model. What direct effect would this stimulation have on the cerebellar cortex?
A person is standing still on a moving bus. Which vestibular organs are MOST active in this scenario?
A person is standing still on a moving bus. Which vestibular organs are MOST active in this scenario?
A patient reports brief episodes of vertigo triggered specifically by looking upwards. Which semicircular canal is MOST likely affected by BPPV in this case?
A patient reports brief episodes of vertigo triggered specifically by looking upwards. Which semicircular canal is MOST likely affected by BPPV in this case?
During a Caloric reflex test, cold water is irrigated into a patient's left ear. If the vestibulo-ocular reflex (VOR) is functioning normally, what would be the expected eye movement?
During a Caloric reflex test, cold water is irrigated into a patient's left ear. If the vestibulo-ocular reflex (VOR) is functioning normally, what would be the expected eye movement?
If the stapedius muscle is paralyzed due to damage to the facial nerve, how would this affect a person's hearing?
If the stapedius muscle is paralyzed due to damage to the facial nerve, how would this affect a person's hearing?
Which of the following BEST describes the role of outer hair cells in the cochlea?
Which of the following BEST describes the role of outer hair cells in the cochlea?
A genetic mutation causes a complete absence of tip links in hair cells of the cochlea. What would be the MOST likely consequence?
A genetic mutation causes a complete absence of tip links in hair cells of the cochlea. What would be the MOST likely consequence?
A drug selectively blocks phosphodiesterase (PDE) activity in rod photoreceptors. What immediate effect would this have on the rods in dark conditions?
A drug selectively blocks phosphodiesterase (PDE) activity in rod photoreceptors. What immediate effect would this have on the rods in dark conditions?
A patient has damage to the magnocellular layers of the lateral geniculate nucleus (LGN). Which visual function would be MOST affected?
A patient has damage to the magnocellular layers of the lateral geniculate nucleus (LGN). Which visual function would be MOST affected?
A lesion completely severs the optic radiation in the left temporal lobe. What specific visual field deficit would result?
A lesion completely severs the optic radiation in the left temporal lobe. What specific visual field deficit would result?
A person with blindsight can accurately point to the location of a light stimulus in their blind field, even though they report not consciously seeing it. Which pathway is MOST likely mediating this behavior?
A person with blindsight can accurately point to the location of a light stimulus in their blind field, even though they report not consciously seeing it. Which pathway is MOST likely mediating this behavior?
Which cellular mechanism is MOST directly responsible for light-induced hyperpolarization of photoreceptors?
Which cellular mechanism is MOST directly responsible for light-induced hyperpolarization of photoreceptors?
How would the loss of the left superior oblique muscle impact vision?
How would the loss of the left superior oblique muscle impact vision?
A patient has a lesion that damages the right parietal lobe's contribution to the dorsal stream. Which symptom would you MOST expect?
A patient has a lesion that damages the right parietal lobe's contribution to the dorsal stream. Which symptom would you MOST expect?
What specific impairment would result from bilateral damage restricted only to area V4 of the visual cortex?
What specific impairment would result from bilateral damage restricted only to area V4 of the visual cortex?
What pattern of hearing loss would follow damage limited only to the right medial geniculate nucleus?
What pattern of hearing loss would follow damage limited only to the right medial geniculate nucleus?
Conduction deafness can result from all of the following EXCEPT
Conduction deafness can result from all of the following EXCEPT
If the left flocculonodular lobe of the cerebellum is lesioned, what other signs and symptoms would MOST likely be apparent?
If the left flocculonodular lobe of the cerebellum is lesioned, what other signs and symptoms would MOST likely be apparent?
A patient presents with uncoordinated gait, intention tremor, and difficulty performing rapid alternating movements with their right arm and leg, but not their left. Where is the MOST likely location of the causative lesion?
A patient presents with uncoordinated gait, intention tremor, and difficulty performing rapid alternating movements with their right arm and leg, but not their left. Where is the MOST likely location of the causative lesion?
Following a stroke, a patient exhibits a combination of sensorineural hearing loss and vestibular dysfunction. Which single arterial structure was MOST likely occluded?
Following a stroke, a patient exhibits a combination of sensorineural hearing loss and vestibular dysfunction. Which single arterial structure was MOST likely occluded?
A patient reports difficulty perceiving the location of objects in space after suffering a stroke. Which area is MOST likely affected?
A patient reports difficulty perceiving the location of objects in space after suffering a stroke. Which area is MOST likely affected?
A 60-year-old patient presents with progressive difficulty recognizing familiar faces, even those of close family members. Neuroimaging reveals atrophy primarily in the anterior temporal lobe. This condition is MOST likely associated with:
A 60-year-old patient presents with progressive difficulty recognizing familiar faces, even those of close family members. Neuroimaging reveals atrophy primarily in the anterior temporal lobe. This condition is MOST likely associated with:
Which of the following correctly pairs a structure of the eye with its primary function?
Which of the following correctly pairs a structure of the eye with its primary function?
A patient has damage to the left optic nerve. What resulting sign is MOST apparent?
A patient has damage to the left optic nerve. What resulting sign is MOST apparent?
Compared to rods, cone photoreceptors...
Compared to rods, cone photoreceptors...
What would happen if a patient with unilateral damage to the vestibular nerve experienced loud sounds?
What would happen if a patient with unilateral damage to the vestibular nerve experienced loud sounds?
How is motion detected at the sensory level of hair cells in the ear?
How is motion detected at the sensory level of hair cells in the ear?
How does the basilar membrane function in hearing?
How does the basilar membrane function in hearing?
A patient exhibits deficits in smooth pursuit eye movements and experiences difficulty maintaining gaze stability when tracking a moving object. Damage to which cerebellar region is MOST likely contributing to these symptoms?
A patient exhibits deficits in smooth pursuit eye movements and experiences difficulty maintaining gaze stability when tracking a moving object. Damage to which cerebellar region is MOST likely contributing to these symptoms?
A researcher discovers a novel neurotoxin that selectively destroys granule cells in the cerebellar cortex. What cascade of events would MOST likely follow this exposure?
A researcher discovers a novel neurotoxin that selectively destroys granule cells in the cerebellar cortex. What cascade of events would MOST likely follow this exposure?
A patient reports experiencing vertigo and nystagmus immediately after a forceful sneeze. What is the MOST plausible underlying mechanism for these symptoms, considering the anatomy of the inner ear?
A patient reports experiencing vertigo and nystagmus immediately after a forceful sneeze. What is the MOST plausible underlying mechanism for these symptoms, considering the anatomy of the inner ear?
A new drug selectively enhances the activity of prestin, a motor protein in outer hair cells. What would be the MOST likely effect of this drug on auditory function?
A new drug selectively enhances the activity of prestin, a motor protein in outer hair cells. What would be the MOST likely effect of this drug on auditory function?
A patient with a history of migraines presents with transient vision loss described as a shimmering, zigzagging pattern that obscures a portion of their visual field. This is MOST likely due to:
A patient with a history of migraines presents with transient vision loss described as a shimmering, zigzagging pattern that obscures a portion of their visual field. This is MOST likely due to:
Flashcards
Flocculonodular lobe function?
Flocculonodular lobe function?
Involved in balance and posture. Receives information from the pons and vestibular nuclei and CN VIII.
Purkinje cell function?
Purkinje cell function?
The only efferent (output) neuron of the cerebellar cortex.
Spinocerebellar tracts function?
Spinocerebellar tracts function?
Carry proprioceptive information from the body to the cerebellum.
Cerebrocerebellum function?
Cerebrocerebellum function?
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Dentate nucleus function?
Dentate nucleus function?
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Deep pontine nuclei function?
Deep pontine nuclei function?
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Cerebellar damage location impacts?
Cerebellar damage location impacts?
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Semicircular canals function?
Semicircular canals function?
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Utricle and Saccule function?
Utricle and Saccule function?
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Vestibulo-ocular reflex (VOR) function?
Vestibulo-ocular reflex (VOR) function?
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Vestibular 'push-pull' relationship?
Vestibular 'push-pull' relationship?
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Benign Paroxysmal Positional Vertigo (BPPV) cause?
Benign Paroxysmal Positional Vertigo (BPPV) cause?
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Cochlea function?
Cochlea function?
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Sensorineural hearing loss cause?
Sensorineural hearing loss cause?
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Cornea function?
Cornea function?
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Rods function?
Rods function?
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Fovea function?
Fovea function?
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Nasal retina fibers cross where?
Nasal retina fibers cross where?
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Lateral geniculate nucleus (LGN) location?
Lateral geniculate nucleus (LGN) location?
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Right optic tract lesion impact?
Right optic tract lesion impact?
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Unilateral spatial neglect cause?
Unilateral spatial neglect cause?
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Ventral processing stream function?
Ventral processing stream function?
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Optic disc characteristic?
Optic disc characteristic?
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Diabetic retinopathy impact?
Diabetic retinopathy impact?
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Primary visual cortex location?
Primary visual cortex location?
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Vestibulocochlear nerve (CN VIII) function?
Vestibulocochlear nerve (CN VIII) function?
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Ataxia definition?
Ataxia definition?
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Thalamus (LGN and MGN) function?
Thalamus (LGN and MGN) function?
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Dorsal column-medial lemniscus (DCML) pathway function?
Dorsal column-medial lemniscus (DCML) pathway function?
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Which cranial nerves help with speech?
Which cranial nerves help with speech?
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Study Notes
Cerebellum & Function
- The flocculonodular lobe relates to the pons and vestibular nuclei.
- Receives information from the vestibular nuclei and CN VIII.
- Important for balance and posture.
- The Purkinje cell is the only efferent output of the cerebellum.
- Spinocerebellar tracts carry proprioceptive information to the cerebellum.
- Cerebrocerebellum (lateral zone) is responsible for visually guided movement.
- Also responsible for the planning and timing of movements.
- The dentate nucleus is the largest of the deep cerebellar nuclei.
- Dentate Nucleus is responsible for planning, initiating, controlling, and correcting voluntary movements.
- The cerebrocerebellum (lateral zone) receives indirect information from all four cortical lobes via the deep pontine nuclei.
- Damage to the cerebellum results in deficits ipsilateral to the damage.
Vestibular System
- Semicircular canals detect angular motion of the head.
- Otoconia are located within the utricle and saccule.
- The utricle and saccule are responsible for detecting linear acceleration and head tilt.
- The vestibulo-ocular reflex (VOR) maintains stable visual fixation during head motion.
- VOR causes the eyes to move in the opposite direction of head movement during head motion.
- In the push-pull relationship, head rotation in one direction excites the vestibular organ on that side and inhibits the organ on the opposite side.
- BPPV is caused by otoconia displacing into one of the semicircular canals.
Auditory System
- The cochlea transmit the sounds heard to be interpreted.
- Sensorineural hearing loss is a disease of the cochlea or the neuronal pathway from the cochlea to the brain.
Visual System
- The cornea is the part of the eye responsible for refracting and focusing light into the orbit.
- Rods are highly sensitive structures in the retina that provide resolution in lower lit conditions.
- Rods are sensitive to monochromatic color.
- Fovea is critical for tasks that require high resolution with vision.
- At the optic chiasm, fibers from the nasal retina of each eye decussate (cross over) to the contralateral optic tract.
- Fibers from the temporal retina remain ipsilateral.
- LGN is a part of the thalamus, where the optic tracts synapse before projecting to the visual cortex via the optic radiations.
- A lesion of the right optic tract results in a loss of vision in the left visual field of both eyes, also known as left homonymous hemianopsia.
- Unilateral spatial neglect is commonly associated with a stroke or lesion in the right parietal lobe.
- Temporal (ventral) processing stream is involved in visual recognition, for identifying objects.
- The optic disc is the point where the axons of the retinal ganglion cells converge to form the optic nerve.
- Optic disc does not contain any photoreceptors.
- Diabetic retinopathy involves damage to the blood vessels within the eyes.
- Optic nerve ends in the primary visual cortex of the occipital lobe.
Combined Topics
- Damage to the vestibulocochlear nerve (CN VIII) affects the VOR.
- Ataxia is uncoordinated movement, and is a sign of cerebellar dysfunction.
- The thalamus serves as a relay station for sensory information.
- The lateral geniculate nucleus (LGN) in the thalamus relays visual information to the visual cortex.
- The medial geniculate nucleus (MGN) in the thalamus relays auditory information to the auditory cortex.
- The dorsal column-medial lemniscus (DCML) pathway carries light touch and proprioception, and its second-order neurons decussate in the medulla.
- Cerebellum contributes to speech articulation.
- Speech articulation motor control relies on cranial nerves V, VII, IX, X, and XII.
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