Podcast
Questions and Answers
What is the mechanism of action of cephalosporins?
What is the mechanism of action of cephalosporins?
Which of the following organisms are cephalosporins most effective against?
Which of the following organisms are cephalosporins most effective against?
How are first generation cephalosporins classified based on their spectrum of activity?
How are first generation cephalosporins classified based on their spectrum of activity?
Why are cefoxitin and cefotetan included with the cephalosporins despite being cephamycins?
Why are cefoxitin and cefotetan included with the cephalosporins despite being cephamycins?
Signup and view all the answers
What makes cephalosporins bactericidal?
What makes cephalosporins bactericidal?
Signup and view all the answers
How many generations is the cephalosporin class of drugs divided into based on the order of development?
How many generations is the cephalosporin class of drugs divided into based on the order of development?
Signup and view all the answers
What is the impact of renal function impairment on the half-life of most cephalosporins?
What is the impact of renal function impairment on the half-life of most cephalosporins?
Signup and view all the answers
When should dosage adjustments be considered for most oral cephalosporin agents?
When should dosage adjustments be considered for most oral cephalosporin agents?
Signup and view all the answers
In what scenario should cefotaxime be used instead of ceftriaxone in patients with severe hepatic impairment?
In what scenario should cefotaxime be used instead of ceftriaxone in patients with severe hepatic impairment?
Signup and view all the answers
What pregnancy category are cephalosporins classified as?
What pregnancy category are cephalosporins classified as?
Signup and view all the answers
Why should the use of cephalosporins during pregnancy be based on a risk/benefit determination?
Why should the use of cephalosporins during pregnancy be based on a risk/benefit determination?
Signup and view all the answers
What is the maternal to fetal serum ratio for cephalosporins?
What is the maternal to fetal serum ratio for cephalosporins?
Signup and view all the answers
Which of the following Enterobacteriaceae species are typically resistant to cephalosporins?
Which of the following Enterobacteriaceae species are typically resistant to cephalosporins?
Signup and view all the answers
What is a unique characteristic of cephamycins compared to other generations of cephalosporins?
What is a unique characteristic of cephamycins compared to other generations of cephalosporins?
Signup and view all the answers
Which of the following have increased activity against H. influenzae compared to first generation cephalosporins?
Which of the following have increased activity against H. influenzae compared to first generation cephalosporins?
Signup and view all the answers
What is a notable exception regarding the activity of ceftaroline among cephalosporins?
What is a notable exception regarding the activity of ceftaroline among cephalosporins?
Signup and view all the answers
Which of the following cephalosporins is active against both gram-positive and gram-negative organisms, including Pseudomonas?
Which of the following cephalosporins is active against both gram-positive and gram-negative organisms, including Pseudomonas?
Signup and view all the answers
What is the main concern associated with the use of third generation cephalosporins against uncommon gram-negative pathogens?
What is the main concern associated with the use of third generation cephalosporins against uncommon gram-negative pathogens?
Signup and view all the answers
What do second generation cephalosporins have increased activity against compared to first generation cephalosporins?
What do second generation cephalosporins have increased activity against compared to first generation cephalosporins?
Signup and view all the answers
Which generation of cephalosporins is known for having activity against Pseudomonas aeruginosa?
Which generation of cephalosporins is known for having activity against Pseudomonas aeruginosa?
Signup and view all the answers
Which characteristic is responsible for the resistance of MRSA, DRSP, Enterococcus faecalis, and Enterococcus faecium to cephalosporins?
Which characteristic is responsible for the resistance of MRSA, DRSP, Enterococcus faecalis, and Enterococcus faecium to cephalosporins?
Signup and view all the answers
Which cephalosporin is particularly active against most gram-positive and gram-negative pathogens, including resistant strains?
Which cephalosporin is particularly active against most gram-positive and gram-negative pathogens, including resistant strains?
Signup and view all the answers
Which cephalosporin is advised to be avoided in neonates at risk for hyperbilirubinemia, especially preterm infants, due to high albumin binding?
Which cephalosporin is advised to be avoided in neonates at risk for hyperbilirubinemia, especially preterm infants, due to high albumin binding?
Signup and view all the answers
Which generation of cephalosporins readily enter the CSF in the presence of meningeal inflammation?
Which generation of cephalosporins readily enter the CSF in the presence of meningeal inflammation?
Signup and view all the answers
What is the main route of excretion for most cephalosporins?
What is the main route of excretion for most cephalosporins?
Signup and view all the answers
Which drug combination is used in serious infections and single-dose therapy for sexually transmitted infections to increase cephalosporin plasma concentrations?
Which drug combination is used in serious infections and single-dose therapy for sexually transmitted infections to increase cephalosporin plasma concentrations?
Signup and view all the answers