Podcast
Questions and Answers
What is the primary mechanism of action of cephalosporins?
What is the primary mechanism of action of cephalosporins?
- Inhibition of RNA synthesis
- Inhibition of mucopeptide synthesis in the bacterial cell wall (correct)
- Inhibition of DNA synthesis
- Inhibition of protein synthesis
Why are cefoxitin and cefotetan usually included with the cephalosporins?
Why are cefoxitin and cefotetan usually included with the cephalosporins?
- For their antifungal capabilities
- Because of their chemical similarity to penicillins (correct)
- Due to their antiviral properties
- Because they inhibit RNA polymerase
Which classification system is used to divide cephalosporins into five generations?
Which classification system is used to divide cephalosporins into five generations?
- Chemical structure
- Clinical utility
- Spectrum of activity
- Order of development (correct)
What is the primary reason for grouping cephamycins and carbacephem with cephalosporins?
What is the primary reason for grouping cephamycins and carbacephem with cephalosporins?
When are cephalosporins most effective against bacteria?
When are cephalosporins most effective against bacteria?
What is the bactericidal effect of cephalosporins dependent on?
What is the bactericidal effect of cephalosporins dependent on?
What is the recommended timing for taking Ceftibuten to ensure proper absorption?
What is the recommended timing for taking Ceftibuten to ensure proper absorption?
Why should cefuroxime axetil tablets and suspension formulations not be used interchangeably?
Why should cefuroxime axetil tablets and suspension formulations not be used interchangeably?
What precaution should patients with phenylketonuria take regarding cefprozil?
What precaution should patients with phenylketonuria take regarding cefprozil?
Why must suspensions and antibiotic solutions be shaken before measurement?
Why must suspensions and antibiotic solutions be shaken before measurement?
What should a patient do if severe diarrhea occurs while taking antibiotics?
What should a patient do if severe diarrhea occurs while taking antibiotics?
How can diabetics taking cephalosporins avoid false positives on urine testing for glucose?
How can diabetics taking cephalosporins avoid false positives on urine testing for glucose?
Which cephalosporin should be avoided in neonates at risk for hyperbilirubinemia?
Which cephalosporin should be avoided in neonates at risk for hyperbilirubinemia?
What is the main route of excretion for most cephalosporins?
What is the main route of excretion for most cephalosporins?
Which generation of cephalosporins does not readily enter the CSF even with meningeal inflammation?
Which generation of cephalosporins does not readily enter the CSF even with meningeal inflammation?
What is a notable characteristic of ceftriaxone metabolism?
What is a notable characteristic of ceftriaxone metabolism?
Which cephalosporin is a prodrug metabolized to active metabolites?
Which cephalosporin is a prodrug metabolized to active metabolites?
Why is ceftriaxone contraindicated in neonates younger than 28 days with hyperbilirubinemia?
Why is ceftriaxone contraindicated in neonates younger than 28 days with hyperbilirubinemia?
Which cephalosporin has high concentrations found in bile?
Which cephalosporin has high concentrations found in bile?
What characteristic makes cefuroxime and cefpodoxime unique among cephalosporins?
What characteristic makes cefuroxime and cefpodoxime unique among cephalosporins?
What is unique about the bioavailability of suspension and tablet formulations of cefpodoxime proxetil and cefixime?
What is unique about the bioavailability of suspension and tablet formulations of cefpodoxime proxetil and cefixime?
Which statement about cephalosporins excretion is correct?
Which statement about cephalosporins excretion is correct?
Which patient population might experience serum sickness–like reactions when treated with cephalosporins?
Which patient population might experience serum sickness–like reactions when treated with cephalosporins?
What is a common delayed reaction seen with some cephalosporins, usually occurring following a second course of therapy?
What is a common delayed reaction seen with some cephalosporins, usually occurring following a second course of therapy?
Which of the following cephalosporins is not detected in breast milk?
Which of the following cephalosporins is not detected in breast milk?
Under what condition might seizure activity be induced by some parenteral cephalosporins?
Under what condition might seizure activity be induced by some parenteral cephalosporins?
Which age group has safety and efficacy not been established for when taking cefuroxime?
Which age group has safety and efficacy not been established for when taking cefuroxime?
Which condition is associated with an increased risk of coagulation abnormalities when administering certain cephalosporins?
Which condition is associated with an increased risk of coagulation abnormalities when administering certain cephalosporins?
Which adverse reaction is more likely to occur in patients who receive cefaclor?
Which adverse reaction is more likely to occur in patients who receive cefaclor?
What should be done if a patient develops anemia within 2 to 3 weeks of starting cephalosporin therapy?
What should be done if a patient develops anemia within 2 to 3 weeks of starting cephalosporin therapy?
Which oral cephalosporins are associated with a high incidence of non–C.difficile diarrhea?
Which oral cephalosporins are associated with a high incidence of non–C.difficile diarrhea?
What potential adverse reaction may occur with ceftriaxone use that clears upon discontinuation of the drug?
What potential adverse reaction may occur with ceftriaxone use that clears upon discontinuation of the drug?
Which group of bacteria is intrinsically resistant to cephalosporins?
Which group of bacteria is intrinsically resistant to cephalosporins?
Which of the following Enterobacteriaceae is commonly isolated in hospital settings and resistant to first generation cephalosporins?
Which of the following Enterobacteriaceae is commonly isolated in hospital settings and resistant to first generation cephalosporins?
Which second generation cephalosporin has limited activity against anaerobes like Bacteroides fragilis?
Which second generation cephalosporin has limited activity against anaerobes like Bacteroides fragilis?
Which bacteria are third generation cephalosporins generally active against?
Which bacteria are third generation cephalosporins generally active against?
Why is the use of third generation cephalosporins discouraged for certain uncommon gram-negative pathogens?
Why is the use of third generation cephalosporins discouraged for certain uncommon gram-negative pathogens?
Which of the following bacteria are fourth generation cephalosporins like cefepime resistant against?
Which of the following bacteria are fourth generation cephalosporins like cefepime resistant against?
What is the notable feature of ceftaroline, a fifth generation cephalosporin, compared to third generation cephalosporins?
What is the notable feature of ceftaroline, a fifth generation cephalosporin, compared to third generation cephalosporins?
Which mechanism of resistance is common among bacteria against cephalosporins?
Which mechanism of resistance is common among bacteria against cephalosporins?
Which drug can increase the risk for nephrotoxicity when interacting with cephalosporins?
Which drug can increase the risk for nephrotoxicity when interacting with cephalosporins?
Which cephalosporin is recommended as the treatment for gonorrhea because it is resistant to most other antibiotics?
Which cephalosporin is recommended as the treatment for gonorrhea because it is resistant to most other antibiotics?
What is the advantage of first generation cephalosporins for penicillin-allergic individuals?
What is the advantage of first generation cephalosporins for penicillin-allergic individuals?
Why are second generation oral cephalosporins preferred for skin and tissue infections over third generation?
Why are second generation oral cephalosporins preferred for skin and tissue infections over third generation?
Which second generation cephalosporin is not recommended for otitis media in current guidelines due to susceptibility to beta-lactamases?
Which second generation cephalosporin is not recommended for otitis media in current guidelines due to susceptibility to beta-lactamases?
What is a key consideration in selecting third generation cephalosporins for infections?
What is a key consideration in selecting third generation cephalosporins for infections?
Which cephalosporin can be dosed once daily for most infections due to its long half-life?
Which cephalosporin can be dosed once daily for most infections due to its long half-life?
What is a common side effect associated with some cephalosporins that must be distinguished from C.difficile infection?
What is a common side effect associated with some cephalosporins that must be distinguished from C.difficile infection?
Which oral cephalosporin has one of the lowest palatability ratings of all suspensions tested?
Which oral cephalosporin has one of the lowest palatability ratings of all suspensions tested?
Why should patients who are receiving protracted courses of cefotetan be monitored for prothrombin time (PT)?
Why should patients who are receiving protracted courses of cefotetan be monitored for prothrombin time (PT)?
What symptom may indicate the need for C.difficile testing in a patient on cephalosporins?
What symptom may indicate the need for C.difficile testing in a patient on cephalosporins?
For which type of infection are third generation parenteral cephalosporins like ceftriaxone and cefotaxime commonly used empirically?
For which type of infection are third generation parenteral cephalosporins like ceftriaxone and cefotaxime commonly used empirically?
What must be done if renal impairment is indicated in a patient on certain cephalosporins?
What must be done if renal impairment is indicated in a patient on certain cephalosporins?
Which parenteral cephalosporin may require administration of exogenous vitamin K if the prothrombin time (PT) is prolonged?
Which parenteral cephalosporin may require administration of exogenous vitamin K if the prothrombin time (PT) is prolonged?
Flashcards are hidden until you start studying
