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Questions and Answers
Which cells are involved in the principal mechanisms of central tolerance in T cells?
Which cells are involved in the principal mechanisms of central tolerance in T cells?
- Mature T cells
- CD8+ regulatory T cells
- CD4+ regulatory T cells (correct)
- Immature T cells
What happens to self-reactive lymphocytes that interact strongly with a self antigen in the thymus?
What happens to self-reactive lymphocytes that interact strongly with a self antigen in the thymus?
- They become functionally competent
- They enter peripheral tissues
- They receive signals that trigger apoptosis (correct)
- They develop into regulatory T cells
What determines whether a thymic CD4+ T cell that recognizes a self antigen will die or become a regulatory T cell?
What determines whether a thymic CD4+ T cell that recognizes a self antigen will die or become a regulatory T cell?
- The concentration of the antigen in the thymus
- The affinity of the lymphocytes' receptors for the antigen
- It is not established (correct)
- The presence of CD8+ T cells
Which protein is responsible for the thymic expression of tissue-restricted antigens?
Which protein is responsible for the thymic expression of tissue-restricted antigens?
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What is the cause of autoimmune polyendocrine syndrome?
What is the cause of autoimmune polyendocrine syndrome?
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Why do T cells specific for tissue-restricted antigens cause disease in autoimmune polyendocrine syndrome?
Why do T cells specific for tissue-restricted antigens cause disease in autoimmune polyendocrine syndrome?
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What is the main target of autoimmune attack in autoimmune polyendocrine syndrome?
What is the main target of autoimmune attack in autoimmune polyendocrine syndrome?
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