Podcast
Play an AI-generated podcast conversation about this lesson
Questions and Answers
Which cells are involved in the principal mechanisms of central tolerance in T cells?
Which cells are involved in the principal mechanisms of central tolerance in T cells?
- Mature T cells
- CD8+ regulatory T cells
- CD4+ regulatory T cells (correct)
- Immature T cells
What happens to self-reactive lymphocytes that interact strongly with a self antigen in the thymus?
What happens to self-reactive lymphocytes that interact strongly with a self antigen in the thymus?
- They become functionally competent
- They enter peripheral tissues
- They receive signals that trigger apoptosis (correct)
- They develop into regulatory T cells
What determines whether a thymic CD4+ T cell that recognizes a self antigen will die or become a regulatory T cell?
What determines whether a thymic CD4+ T cell that recognizes a self antigen will die or become a regulatory T cell?
- The concentration of the antigen in the thymus
- The affinity of the lymphocytes' receptors for the antigen
- It is not established (correct)
- The presence of CD8+ T cells
Which protein is responsible for the thymic expression of tissue-restricted antigens?
Which protein is responsible for the thymic expression of tissue-restricted antigens?
Signup and view all the answers
What is the cause of autoimmune polyendocrine syndrome?
What is the cause of autoimmune polyendocrine syndrome?
Signup and view all the answers
Why do T cells specific for tissue-restricted antigens cause disease in autoimmune polyendocrine syndrome?
Why do T cells specific for tissue-restricted antigens cause disease in autoimmune polyendocrine syndrome?
Signup and view all the answers
What is the main target of autoimmune attack in autoimmune polyendocrine syndrome?
What is the main target of autoimmune attack in autoimmune polyendocrine syndrome?
Signup and view all the answers
