Central Tolerance Mechanisms in T Cells
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Questions and Answers

Which cells are involved in the principal mechanisms of central tolerance in T cells?

  • Mature T cells
  • CD8+ regulatory T cells
  • CD4+ regulatory T cells (correct)
  • Immature T cells

    • What happens to self-reactive lymphocytes that interact strongly with a self antigen in the thymus?

  • They become functionally competent
  • They enter peripheral tissues
  • They receive signals that trigger apoptosis (correct)
  • They develop into regulatory T cells

    • What determines whether a thymic CD4+ T cell that recognizes a self antigen will die or become a regulatory T cell?

  • The concentration of the antigen in the thymus
  • The affinity of the lymphocytes' receptors for the antigen
  • It is not established (correct)
  • The presence of CD8+ T cells

    • Which protein is responsible for the thymic expression of tissue-restricted antigens?

    <p>AIRE (autoimmune regulator)</p> Signup and view all the answers

    What is the cause of autoimmune polyendocrine syndrome?

    <p>Mutations in the AIRE gene</p> Signup and view all the answers

    Why do T cells specific for tissue-restricted antigens cause disease in autoimmune polyendocrine syndrome?

    <p>They attack the appropriate peripheral tissues</p> Signup and view all the answers

    What is the main target of autoimmune attack in autoimmune polyendocrine syndrome?

    <p>Endocrine organs</p> Signup and view all the answers

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