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Cellular Transport Processes Quiz

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Questions and Answers

What is the role of dynamin in endocytosis?

Induce more PIP2 hydrolysis

Gather at the neck to create higher curvature and recruit phosphatase (correct)

Create higher membrane curvature

Transport and sort vesicles based on receptor type or membrane composition

How does clathrin assist in vesicle formation?

Directly associates with the membrane to form the vesicle

Acts as a scaffold protein that polymerizes and forms a cage around the vesicle (correct)

Binds with caveolin to drive membrane deformation

Is a tetrameric adaptor complex for coated vesicles

What initiates clathrin complex formation?

Dynamin-induced vesicle scission

Presence of adaptor protein and PIP2 accumulation (correct)

Dissociation of the coat after scission

Formation of coated vesicles by Ap2

What drives membrane deformation in caveolin-mediated endocytosis?

GTPase dynamin function Signup and view all the answers

What is the pH of early endosomes and how are they identified?

pH 6.0, identified by Rab5 Signup and view all the answers

Which of the following is NOT a key step in the trafficking of vesicles?

Fission Signup and view all the answers

Which type of endocytosis involves the capture and destruction of pathogens and some antigens as part of the immune response?

Phagocytosis Signup and view all the answers

Which of the following statements about the size of vesicles formed during different endocytic processes is correct?

Macropinosomes are larger than micropinocytic vesicles Signup and view all the answers

Which type of endocytosis involves the binding of substances to specific receptors on the cell surface?

Receptor-mediated endocytosis Signup and view all the answers

Which of the following is responsible for the rapid recruitment of dynamin to the neck of a forming vesicle during clathrin-mediated endocytosis?

Curvature of the membrane Signup and view all the answers

Which of the following is NOT a function of Rab GTPases in endocytosis?

Regulating the hydrolysis of ATP to ADP during vesicle scission Signup and view all the answers

What is the primary function of the phosphatase that is recruited to the endocytic site during clathrin-mediated endocytosis?

To protect the neck of the forming vesicle from collapse Signup and view all the answers

What is the primary function of the PIP2 phase segregation that occurs during clathrin-mediated endocytosis?

To create an interfacial force that squeezes the neck of the forming vesicle Signup and view all the answers

How do the Ap2 adaptor protein subunits contribute to clathrin-mediated endocytosis?

The μ2 and σ2 subunits bind to activated receptors, while the α and β2 subunits bind to clathrin Signup and view all the answers

Which of the following is a key difference between clathrin-mediated endocytosis and caveolin-mediated endocytosis?

Clathrin-mediated endocytosis requires the GTPase function of dynamin for vesicle scission, while caveolin-mediated endocytosis does not Signup and view all the answers