Cellular Respiration Quiz

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Questions and Answers

What is the net yield of ATP from glycolysis?

  • 2 ATP (correct)
  • 4 ATP
  • NADH does not produce ATP
  • 6 ATP

Where does pyruvate oxidation primarily take place in the cell?

  • Mitochondrial intermembrane space (correct)
  • Mitochondrial matrix
  • Cytoplasm
  • Nucleus

What molecule is produced in the Krebs cycle that is NOT produced in glycolysis?

  • ATP
  • FADH2 (correct)
  • NADH
  • Glucose

What is the total yield of NADH from one complete turn of the Krebs cycle?

<p>6 NADH (D)</p> Signup and view all the answers

Why is NADH important in cellular respiration?

<p>It donates electrons to the electron transport chain (C)</p> Signup and view all the answers

How many ATPs are produced via the electron transport chain from the NADH and FADH2 collected?

<p>Up to 34 ATP (C)</p> Signup and view all the answers

What is the primary role of the Krebs cycle in cellular respiration?

<p>To generate electron carriers (C)</p> Signup and view all the answers

Which of the following statements about cellular respiration is incorrect?

<p>Pyruvate yields FADH2 during its conversion (D)</p> Signup and view all the answers

Which of the following factors can directly impact metabolism?

<p>Age and hormone imbalance (A)</p> Signup and view all the answers

How can malnutrition typically affect metabolism?

<p>It results in decreased metabolic efficiency. (C)</p> Signup and view all the answers

What is a significant consequence of inherited metabolic diseases?

<p>Altered metabolism from birth (B)</p> Signup and view all the answers

Which of the following biomolecules can NOT be derived from basic dietary components?

<p>Hormones (C)</p> Signup and view all the answers

In terms of metabolic diseases, what is a critical clinical factor related to lactate generation?

<p>It signals abnormalities in glycolysis. (B)</p> Signup and view all the answers

Which type of food provides a primary fuel source in diets?

<p>Starch and glycogen (D)</p> Signup and view all the answers

What role do digestive enzymes play in metabolism?

<p>They catalyze metabolic reactions. (D)</p> Signup and view all the answers

What is the impact of cancer on cellular metabolism?

<p>It alters energy consumption patterns. (C)</p> Signup and view all the answers

Which of the following is NOT a basic dietary component of food?

<p>Metabolic enzymes (A)</p> Signup and view all the answers

What occurs when there are faults in metabolic enzymes?

<p>Overproduction of unwanted by-products (B)</p> Signup and view all the answers

What process involves the conversion of lactate to glucose in the liver?

<p>Gluconeogenesis (B)</p> Signup and view all the answers

During the Cori Cycle, what is the primary substance transported to the liver from muscles?

<p>Lactate (C)</p> Signup and view all the answers

What happens to glucose if it is not needed by the body?

<p>It is stored as glycogen (A)</p> Signup and view all the answers

Which two organs are primarily dependent on a constant fuel supply?

<p>Heart and Brain (C)</p> Signup and view all the answers

What is required for the conversion of lactate to glucose during the Cori Cycle?

<p>ATP (A)</p> Signup and view all the answers

What term describes the production of glucose from non-carbohydrate sources?

<p>Gluconeogenesis (D)</p> Signup and view all the answers

In which organ does gluconeogenesis predominantly occur?

<p>Liver (B)</p> Signup and view all the answers

What is the initial product of anaerobic glycolysis before it becomes lactate?

<p>Pyruvate (D)</p> Signup and view all the answers

What key consideration is important regarding fuel supply in metabolism?

<p>Different organs may have different fuel needs (A)</p> Signup and view all the answers

Which of the following is NOT a function of ATP in the body?

<p>Storage of glucose (D)</p> Signup and view all the answers

What is the primary purpose of glycolysis in cellular respiration?

<p>To convert glucose into pyruvate (C)</p> Signup and view all the answers

Which of the following best describes the location of glycolysis in a eukaryotic cell?

<p>In the cytoplasm (B)</p> Signup and view all the answers

Which chemical process immediately follows glycolysis during cellular respiration?

<p>Pyruvate processing (B)</p> Signup and view all the answers

Which of the following statements about the Citric Acid Cycle is false?

<p>It occurs in the nucleus of the cell. (A)</p> Signup and view all the answers

What regulates the series of reactions in glycolysis?

<p>Enzymes (A)</p> Signup and view all the answers

Which of the following is true regarding the final product of glycolysis?

<p>It is called pyruvate. (B)</p> Signup and view all the answers

Which of the following is not a characteristic of glycolysis?

<p>It generates oxygen as a byproduct. (D)</p> Signup and view all the answers

How many reactions are involved in the glycolytic pathway?

<p>10 (B)</p> Signup and view all the answers

What type of molecules are primarily formed during the Electron Transport Chain?

<p>Water and ATP (C)</p> Signup and view all the answers

Which of the following best describes the relationship between glycolysis and lactic acid fermentation?

<p>Pyruvate from glycolysis is the substrate for lactic acid fermentation. (B)</p> Signup and view all the answers

What are the end products of glycolysis?

<p>2 ATP and 2 pyruvate (A)</p> Signup and view all the answers

Where does glycolysis predominantly occur in the cell?

<p>Cytoplasm (D)</p> Signup and view all the answers

What is the role of NAD+ in glycolysis?

<p>Acts as an electron carrier (A)</p> Signup and view all the answers

What happens to lactose when a person is lactose intolerant?

<p>It remains undigested in the digestive system (D)</p> Signup and view all the answers

Which metabolic process involves the entry of glycogen and starch?

<p>Glycolysis (C)</p> Signup and view all the answers

During substrate-level phosphorylation in glycolysis, how many ATP molecules are net produced?

<p>2 (B)</p> Signup and view all the answers

What are the two main simple sugars produced from lactose digestion?

<p>Galactose and glucose (B)</p> Signup and view all the answers

What is produced by the reduction of NAD+ during glycolysis?

<p>NADH (A)</p> Signup and view all the answers

Which pathway directly feeds into ATP generation?

<p>Glycolysis (D)</p> Signup and view all the answers

What would be the consequence of a lactase deficiency?

<p>Lactose remaining undigested (A)</p> Signup and view all the answers

What is the primary consequence of lactose fermentation by gut bacteria?

<p>Gas production and bloating (D)</p> Signup and view all the answers

During anaerobic respiration, what product is formed from pyruvate in the absence of oxygen?

<p>Lactic acid (C)</p> Signup and view all the answers

Which enzyme catalyzes the conversion of NADH to NAD+ during lactic acid formation?

<p>Lactate dehydrogenase (B)</p> Signup and view all the answers

What occurs in the liver after lactic acid is produced during anaerobic respiration?

<p>Lactic acid is converted back into glucose via the cori cycle (D)</p> Signup and view all the answers

What is a possible serious consequence of extremely high levels of lactate in the body?

<p>It can cause muscle cramps and may be life-threatening (B)</p> Signup and view all the answers

How does NAD+ regeneration relate to the continuity of glycolysis?

<p>NADH must be converted back to NAD+ for glycolysis to continue (A)</p> Signup and view all the answers

In which environment does anaerobic respiration primarily occur?

<p>When oxygen is absent (B)</p> Signup and view all the answers

What stimulates an increase in the rate of glycolysis?

<p>Increased physical demand and exercise (B)</p> Signup and view all the answers

Which metabolic pathway is primarily used by yeast and bacteria during fermentation?

<p>Anaerobic respiration (B)</p> Signup and view all the answers

What is a common outcome of undigested lactose in the human gut?

<p>Gas and bloating due to bacterial fermentation (B)</p> Signup and view all the answers

Flashcards

Metabolism

The study of how the body uses food to create energy and build and repair tissues.

Catabolism

Processes that break down complex molecules into simpler ones, releasing energy.

Anabolism

Processes that build complex molecules from simpler ones, requiring energy.

Glucose

A simple sugar that serves as a primary energy source for the body.

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Glycogen

A complex carbohydrate that is stored in the liver and muscles for later use.

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Cellular Respiration

A chemical reaction that breaks down glucose to produce energy (ATP) and other products.

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Lipid Metabolism

The breakdown of fats for energy.

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Protein Metabolism

The breakdown of proteins for energy and building blocks.

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Metabolism (Summary)

The sum of all chemical reactions in the body.

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Glycolysis

The first stage of cellular respiration that breaks down glucose into pyruvate.

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Pyruvate

A three-carbon molecule produced by glycolysis. It is then processed further in cellular respiration.

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Glycolysis

A series of chemical reactions that occur in the cytoplasm, breaking down glucose into pyruvate. It does not require oxygen.

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Enzymes

Proteins that speed up chemical reactions in the body.

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Anaerobic Respiration

The process of generating energy (ATP) without oxygen. It happens when cells have limited oxygen.

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Lactic Acid Fermentation

A process that produces lactic acid as a byproduct of anaerobic respiration. It occurs when oxygen is limited.

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Pyruvate Processing

The next stage of cellular respiration after glycolysis, where pyruvate is converted into acetyl-CoA.

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Citric Acid Cycle

A series of chemical reactions that occur in the mitochondria, breaking down acetyl-CoA to produce energy (ATP).

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Electron Transport Chain

The final stage of cellular respiration, where electrons are passed from molecule to molecule, releasing energy to produce ATP.

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Lactose Fermentation

The process where bacteria break down lactose in the gut, producing gas, bloating, and potentially diarrhea.

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NAD+ Regeneration

The process of regenerating NAD+ from NADH, essential for glycolysis to continue.

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Anaerobic Respiration (Fermentation)

The process of energy production that occurs in the absence of oxygen, where an organic molecule acts as the final electron acceptor.

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Lactate Dehydrogenase (LDH)

An enzyme that converts pyruvate to lactate, key in anaerobic respiration.

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Cori Cycle

A metabolic pathway that converts lactate back to glucose in the liver.

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Alcoholic Fermentation

A type of fermentation where pyruvate is converted to ethanol and carbon dioxide.

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Lactic Acidosis

The build-up of lactate in the blood, which can lead to muscle cramps, pain, and even life-threatening conditions.

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ATP (Adenosine Triphosphate)

A high-energy molecule used by cells as their primary source of energy.

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NADH (Nicotinamide Adenine Dinucleotide)

A molecule involved in the transfer of electrons during cellular respiration, acting as an electron carrier.

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Substrate-Level Phosphorylation

A process that produces ATP by directly transferring a phosphate group from a substrate to ADP.

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Glycogenolysis

The process of breaking down glycogen, a stored form of glucose, into individual glucose molecules.

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Starch

A complex carbohydrate that is a major form of stored energy in plants.

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Monosaccharides

Simple sugars that are the building blocks of more complex carbohydrates.

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Lactose Intolerance

The inability to digest lactose, a sugar found in milk, due to a deficiency of the enzyme lactase.

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Lactase

An enzyme that breaks down lactose into simpler sugars, glucose and galactose, allowing their absorption.

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Pyruvate oxidation

A series of chemical reactions that occur in the mitochondrial matrix, where pyruvate is converted into acetyl-CoA, producing NADH and a small amount of ATP.

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Krebs cycle

A cycle of chemical reactions that occurs in the mitochondrial matrix and breaks down acetyl-CoA into CO2, producing ATP, NADH, and FADH2.

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NADH

A molecule that carries electrons, donating them to the electron transport chain, ultimately contributing to ATP synthesis.

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FADH2

A molecule that carries electrons, donating them to the electron transport chain, ultimately contributing to ATP synthesis.

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ATP

The energy currency of the cell, used for various cellular processes, produced primarily during cellular respiration.

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Phosphorylation

A process in which a phosphate group is added to a molecule, often a protein. This can activate or deactivate the molecule, leading to changes in its function.

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Lactate to glucose conversion

This refers to the process of converting lactate back to glucose in the liver. This requires energy (ATP) and it's a crucial way the body keeps up the fuel supply for muscles, especially during intense exercise.

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Gluconeogenesis

The body's way of creating glucose from non-carbohydrate sources, such as amino acids, lactate, and glycerol. It's a vital pathway for maintaining blood glucose levels when carbohydrate intake is low or during prolonged fasting.

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Pyruvate to glucose conversion

The process of converting pyruvate back into glucose. This is part of gluconeogenesis and helps to maintain blood glucose levels.

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Heart and brain reliance on glucose

The heart and brain are crucial organs that require a constant supply of glucose for their function. They cannot function properly without this energy source.

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The body's glucose supply

The body's natural way of making its own glucose supply when needed. This serves as a backup mechanism for maintaining blood glucose when dietary sources are limited or insufficient.

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Metabolically active organs

Metabolically active organs are those that have high energy demands and rely heavily on glucose metabolism for their function. These organs need a constant supply of glucose to maintain their activity.

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Anaerobic glycolysis

Anaerobic glycolysis is a metabolic process that occurs when there is a lack of oxygen. This process produces lactate, a byproduct that can be converted back to glucose through the Cori Cycle.

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Liver's role in glucose metabolism

The liver plays a critical role in maintaining blood glucose levels by converting lactate to glucose through the Cori Cycle. It also makes glucose from non-carbohydrate sources through gluconeogenesis.

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Study Notes

Cellular Respiration

  • Cellular respiration is a process that describes the energy production from glucose.
  • The lecture should cover glycolysis, Krebs cycle, and the difference between aerobic and anaerobic respiration.
  • Metabolism is clinically significant as it can reveal diseases such as diabetes, malnutrition, and metabolic diseases like glycogen disorders.
  • Metabolism also relates to age-related impacts on cellular metabolism.
  • The body obtains nutrition from food intake which is broken down into fats, carbohydrates, amino acids and vitamins/minerals.
  • The GI system will be discussed in detail in stage 2 of the curriculum.
  • Glucose is a major fuel source in the human diet.
  • Glucose is a sugar of life with storage and structural purposes.
  • Glucose breaks down to produce energy in the form of ATP.
  • The chemical formula for glucose is C6H12O6
  • Chemical processes occur in the conversion of glucose to ATP
  • The breakdown of glucose is via a series of redox reactions involving a transfer of electrons.
  • NAD+ and FAD act as electron carriers.
  • NAD+ is a coenzyme derived from Nicotinamide Adenine Dinucleotide.
  • NAD+ accepts H+ and electrons converted to NADH+H+
  • FAD is derived from Flavin Adenine Dinucleotide.
  • FAD accepts 2 electrons and 2H+ converted to FADHâ‚‚
  • NADH and FADHâ‚‚ carry high energy electrons
  • NADH produced in various parts of cellular respiration-useful for ATP production via the electron transport chain.
  • FAD proceeds to form FADH2 which is also used for ATP production.
  • ATP is the energy currency of biological systems
  • ATP is used in chemical, mechanical and transport work.
  • Hydrolysis of ATP to ADP is through a negative delta G -ATP is broken down to ADP and Pi
  • ATP can be formed into ADP and AMP
  • Glycolysis is the first stage of energy production
  • Glycolysis uses glucose from our diet as a starting material consisting of 10 steps, all controlled by enzymes.
  • Pyruvate is the end product of Glycolysis passed on to the next stage of respiration.
  • Glycolysis occurs in the cytoplasm
  • Glycolysis overview consists of two major stages
    • Stage 1- this stage needs energy to proceed and requires ATP
    • Stage 2- cyclic rings converted to smaller 3 carbon products
  • The next stage is the oxidation of pyruvate
  • Pyruvate moves into the mitochondria and is oxidised to acetyl coenzyme A (Acetyl CoA) via Pyruvate dehydrogenase (PDH)
  • The next step is the citric acid cycle
  • The citric acid cycle continues to produce high-energy electrons (NADH and FADHâ‚‚).
  • The net yield of glycolysis is 2 ATP and 2 NADH
  • The net yield of pyruvate oxidation is 2 NADH.
  • The net yield of the Krebs cycle is 2 ATP, 6 NADH, and 2 FADH2.
  • There are four 'proton pumps' (I, II, III, and IV) in the electron transport chain that use electrons harvested from NADH and FADH2.
  • The process generates a proton gradient
  • ATP synthase uses the proton gradient to produce a large amount of ATP.
  • Total ATP production from 1 molecule of glucose is 30-32.
  • In the absence of oxygen, pyruvate is reduced to form Lactic acid (or lactate).
  • The Cori Cycle allows for the recovery of lactate from muscle tissue to the liver to create glucose.
  • Gluconeogenesis is the process of making glucose from other molecules, which are then transported to the liver, or muscle.

Lactose Intolerance

  • Lactose is a sugar present in milk.
  • The enzyme Lactase converts lactose into glucose and galactose.
  • If there is a lack or low levels of lactase, lactose remains undigested
  • This causes gas, bloating, and diarrhea.

Other notes

  • There are various metabolic processes related to carbohydrate, lipid, amino acid and nucleotide metabolism in the human body
  • Information on other metabolic processes is in later stages of the program.

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