Podcast
Questions and Answers
Which factor causes an imbalance between the production and degradation of reactive oxygen species (ROS)?
Which factor causes an imbalance between the production and degradation of reactive oxygen species (ROS)?
- Mitochondrial aging (correct)
- Increased cellular loss
- Aberrant maintenance of telomeres
- Loss of WRN protein function
Which enzyme directly replaces damaged DNA and then resynthesizes a replacement stretch for the damaged strand?
Which enzyme directly replaces damaged DNA and then resynthesizes a replacement stretch for the damaged strand?
- Mn SOD
- Nucleotide excision repair (NER)
- Base excision repair (BER) (correct)
- Mismatch repair (MMR)
What is the main consequence of loss of WRN protein function?
What is the main consequence of loss of WRN protein function?
- Osteoporosis
- Type 2 diabetes
- Genomic instability (correct)
- Cataracts
Which process leads to an accumulation of somatic mutations in cells?
Which process leads to an accumulation of somatic mutations in cells?
Which enzyme plays a significant role in protecting against oxidative stress by degrading reactive oxygen species?
Which enzyme plays a significant role in protecting against oxidative stress by degrading reactive oxygen species?
What is the main cause of cellular senescence?
What is the main cause of cellular senescence?
What is the primary function of telomerase?
What is the primary function of telomerase?
Which factor contributes significantly to cellular aging?
Which factor contributes significantly to cellular aging?
What is a common consequence of bypassing replicative senescence?
What is a common consequence of bypassing replicative senescence?
Which molecule is a biomarker for senescent cells?
Which molecule is a biomarker for senescent cells?
What is one form of cellular senescence caused by excessive stress?
What is one form of cellular senescence caused by excessive stress?
What is the role of telomerase in stem cells and germ cells?
What is the role of telomerase in stem cells and germ cells?
Why do somatic cells have shorter telomeres compared to stem cells and germ cells?
Why do somatic cells have shorter telomeres compared to stem cells and germ cells?
What is the consequence of loss of telomeres in cells?
What is the consequence of loss of telomeres in cells?
In cancer cells, what allows for the maintenance of longer telomeres?
In cancer cells, what allows for the maintenance of longer telomeres?
What is the consequence of mutations in the WRN gene in Werner's Syndrome?
What is the consequence of mutations in the WRN gene in Werner's Syndrome?
