Podcast
Questions and Answers
Where do T-lymphocytes mature?
Where do T-lymphocytes mature?
Which lymphoid organ is known as the graveyard of RBCs?
Which lymphoid organ is known as the graveyard of RBCs?
What is the primary function of the lymph nodes?
What is the primary function of the lymph nodes?
What percentage of total lymphoid tissue does MALT constitute?
What percentage of total lymphoid tissue does MALT constitute?
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Which lymphoid organ contains lymphocytes and phagocytes and traps blood-borne microorganisms?
Which lymphoid organ contains lymphocytes and phagocytes and traps blood-borne microorganisms?
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Study Notes
Cells of Acquired Immunity
- Antigen-presenting cells (APCs) include macrophages, dendritic cells, and B-lymphocytes.
- T-lymphocytes consist of helper CD4 TCR, killer CD8 TCR, suppressor, and memory cells.
- B-lymphocytes include plasma cells and memory cells.
Lymphocyte Maturation
- Maturation of lymphocytes occurs in primary lymphoid organs: bone marrow for B-cells and thymus for T-cells.
- B-cell receptors (BCRs) are formed in bone marrow, resulting in mature B-cells.
- T-cell receptors (TCRs) are formed in the thymus, resulting in mature T-cells.
Secondary Lymphoid Organs
- Mature T-cells and B-cells move to secondary lymphoid organs, including the spleen, tonsils, appendix, Peyer's patches, and lymph nodes.
- Pathogen encounter in these organs leads to the formation of effector cells.
Thymus
- The thymus is the main lymphoid organ, formed during fetal life.
- It is located near the heart, beneath the breastbone, and decreases in size with age.
Lymphoid Organs
- T-lymphocytes originate in the bone marrow and mature in the thymus.
- B-lymphocytes originate and mature in the bone marrow.
- Primary lymphoid organs (PLOs) facilitate maturation and differentiation, while secondary lymphoid organs (SLOs) facilitate proliferation.
Spleen
- The spleen is a large, bean-shaped organ containing lymphocytes and phagocytes.
- It traps blood-borne microorganisms, filters the blood, and acts as a reservoir and graveyard for RBCs.
Lymph Node
- Lymph nodes are small, solid structures that trap and kill microbes in tissue fluid and lymph.
MALT
- Mucosal Associated Lymphoid Tissue (MALT) constitutes 50% of total lymphoid tissue.
- Examples of MALT include Gut Associated Lymphoid Tissue (GALT).
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Description
Explore the different types of cells involved in acquired immunity, including antigen-presenting cells, T-lymphocytes, and B-lymphocytes. Learn about their functions and interactions in the immune response.
