Cell Types: Permanent, Stable, Labile

What are cells that don't have the ability to multiply?

Stable cells cannot enter the cell cycle.

What is an example of permanent cells?

What can permanent cells only do?

What type of cells only multiply when receiving an external stimulus?

Stable cells are usually in the G0 resting phase.

Stable cells can divide and give rise to different cell types.

What must happen for stable cells to enter the G1 phase?

List examples of stable cells.

What type of cells can undergo hypertrophy and/or hyperplasia?

What type of cells multiply constantly throughout life?

Which type of cells is most affected by chemotherapy that inhibits M and S phases?

What do labile cells contain?

List examples of labile cells.

Why are labile cells affected by radiation and S phase chemotherapy drugs?

Permanent Cells

Defined as cells that don't have the ability to multiply.
Cannot enter the cell cycle and are permanently differentiated.
Key examples include neurons and striated skeletal or cardiac muscle cells.
Permanent cells can only undergo hypertrophy (increase in cell size) or atrophy (decrease in cell size).

Stable Cells

These cells multiply only when stimulated by external factors.
Usually found in the G0 resting phase of the cell cycle.
Can divide, producing daughter cells of the same lineage.
Require stimulation by hormones and growth factors to transition into the G1 phase.
Examples include progenitor blood cells, skin cells, liver cells, and smooth muscle.
Capable of undergoing hypertrophy and/or hyperplasia (increase in the number of cells).

Labile Cells

Characterized by constant multiplication throughout life.
Most affected by chemotherapy targeting M (mitosis) and S (synthesis) phases due to their high mitotic activity.
Contain stem cells, which are essential for regeneration and repair.
Examples include bone marrow stem cells, skin cells, and intestinal cells.
Vulnerable to damage from radiation and S-phase chemotherapy drugs due to their rapid division rates.

Explore the differences between permanent, stable, and labile cells in this quiz. Understand their characteristics, functions, and examples. Test your knowledge on how these cell types respond to various physiological stimuli and their roles in the human body.