Cell Transport Mechanisms Quiz
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Questions and Answers

Which of the following types of transport requires a transmembrane protein?

  • Simple diffusion
  • Both B and C (correct)
  • Active transport
  • Facilitated diffusion
  • Facilitated diffusion requires the cell to expend energy.

    False (B)

    What is the term for the maximum transport rate of a substance that requires a carrier protein?

    Tmax

    The movement of ions across the plasma membrane through ion channels is an example of ______.

    <p>Facilitated diffusion</p> Signup and view all the answers

    Match the following types of transport with their characteristics:

    <p>Simple diffusion = Does not require a transmembrane protein Facilitated diffusion = Requires a transmembrane protein but does not require energy Active transport = Requires a transmembrane protein and energy Osmosis = Diffusion of water across a semipermeable membrane</p> Signup and view all the answers

    Diffusion is an active process that requires energy input.

    <p>False (B)</p> Signup and view all the answers

    The kinetic energy of molecules is directly related to their ______.

    <p>temperature</p> Signup and view all the answers

    Explain the concept of net diffusion.

    <p>Net diffusion is the overall movement of molecules from an area of high concentration to an area of low concentration. It is the difference between the movement of molecules in both directions, resulting in a net movement towards the area of lower concentration.</p> Signup and view all the answers

    Action potential propagation is a two-way process, meaning it can travel both forward and backward along the axon.

    <p>False (B)</p> Signup and view all the answers

    Match the following factors with their effect on the rate of diffusion:

    <p>Temperature = Higher temperature leads to faster diffusion Molecular weight = Heavier molecules diffuse slower Concentration gradient = Larger difference in concentration results in faster diffusion Distance = Diffusion is rapid over short distances, slower over longer distances</p> Signup and view all the answers

    Which of the following is TRUE about action potential propagation in myelinated neurons?

    <p>Myelin increases membrane resistance, leading to faster propagation. (A)</p> Signup and view all the answers

    Why is diffusion an essential process for the human body?

    <p>It allows for the transport of nutrients to every cell in the body. (A), It enables the removal of waste products from cells. (B), It facilitates communication between different cells in the body. (C), All of the above (D)</p> Signup and view all the answers

    The ______ is the region of the neuron with the highest density of voltage-gated Na+ channels.

    <p>axon hillock</p> Signup and view all the answers

    What are two factors that contribute to increased conduction velocity of action potentials?

    <p>Axon diameter and myelination</p> Signup and view all the answers

    Match the following terms with their appropriate descriptions:

    <p>Node of Ranvier = Gaps in the myelin sheath where voltage-gated Na+ channels are concentrated Saltatory Conduction = Action potentials 'jump' from one Node of Ranvier to the next Schwann Cells = Myelin-producing cells in the peripheral nervous system Oligodendrocytes = Myelin-producing cells in the central nervous system</p> Signup and view all the answers

    Which of the following describes the type of conduction in unmyelinated axons?

    <p>Continuous conduction (A)</p> Signup and view all the answers

    What is the main reason why action potentials typically move in one direction along the axon?

    <p>The refractory period</p> Signup and view all the answers

    Which structure is responsible for transmitting signals across the synapse?

    <p>Synaptic vesicle (B)</p> Signup and view all the answers

    Which of the following is NOT a type of ion channel involved in electrical signaling?

    <p>Sodium-potassium channels (A)</p> Signup and view all the answers

    Action potentials are generated by the opening and closing of ligand-gated ion channels.

    <p>False (B)</p> Signup and view all the answers

    What is the name of the electrical signal that is generated by neurons to communicate with each other?

    <p>Action potential</p> Signup and view all the answers

    The resting membrane potential of a neuron is typically around ______ mV.

    <p>-70</p> Signup and view all the answers

    Match the following types of ion channels with their corresponding stimuli:

    <p>Leak channels = Always open Ligand-gated channels = Chemicals Voltage-gated channels = Voltage changes Mechanically-gated channels = Changes in shape (e.g. baroreceptors)</p> Signup and view all the answers

    Which of the following statements about graded potentials is TRUE?

    <p>They can summate. (C)</p> Signup and view all the answers

    During the rising phase of an action potential, sodium ions flow into the neuron.

    <p>True (A)</p> Signup and view all the answers

    What is the name of the period during which a neuron cannot generate another action potential, even if stimulated?

    <p>Refractory period</p> Signup and view all the answers

    Which of the following statements correctly describes the potential difference across the plasma membrane?

    <p>It can be either positive or negative, depending on the specific cell type and its activity. (A)</p> Signup and view all the answers

    The electrochemical gradient takes into account both the concentration gradient and the electrical gradient.

    <p>True (A)</p> Signup and view all the answers

    What is the typical resting membrane potential of a neuron?

    <p>-70 mV</p> Signup and view all the answers

    The movement of ions across the plasma membrane is influenced by both the ______ gradient and the ______ gradient.

    <p>concentration, electrical</p> Signup and view all the answers

    Which of the following is NOT a major mode of signal transmission?

    <p>Synaptic (B)</p> Signup and view all the answers

    Match the following signal transmission modes with their descriptions:

    <p>Autocrine = A cell releases a signal that acts on itself. Paracrine = A cell releases a signal that acts on nearby cells. Endocrine = A cell releases a signal that travels through the bloodstream to act on distant cells. Neurotransmitters = Chemical messengers released by neurons that act on nearby target cells. Neurohormones = Hormonal signals released by neurons that travel through the bloodstream to act on distant cells.</p> Signup and view all the answers

    What is the role of second messengers in signal transduction?

    <p>To relay the signal from the primary messenger to intracellular targets and amplify the signal.</p> Signup and view all the answers

    Hydrophilic molecules can easily cross the plasma membrane.

    <p>False (B)</p> Signup and view all the answers

    Primary Active Transport utilizes energy directly, while secondary active transport indirectly utilizes energy

    <p>True (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of primary active transport?

    <p>Utilizes the energy gradient of another molecule (D)</p> Signup and view all the answers

    The Na+/K+-ATPase pump pumps ______ sodium ions out of the cell and ______ potassium ions into the cell.

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    Which statement correctly describes primary active transport?

    <p>It directly uses ATP to pump substances against their gradient. (B)</p> Signup and view all the answers

    The sodium-dependent glucose cotransporter operates independently from sodium's concentration gradient.

    <p>False (B)</p> Signup and view all the answers

    What is an example of primary active transport?

    <p>Na+/K+-ATPase Pump</p> Signup and view all the answers

    The process of __________ involves pumping molecules against their concentration gradients using energy from primary active transport.

    <p>secondary active transport</p> Signup and view all the answers

    Match the following transport types with their descriptions:

    <p>Cotransport = Molecules move in the same direction across the membrane Countertransport = Molecules move in opposite directions across the membrane</p> Signup and view all the answers

    What is the role of the Na+/K+-ATPase pump?

    <p>It pumps 3 Na+ out and 2 K+ into the cell. (D)</p> Signup and view all the answers

    Secondary active transport is energy independent.

    <p>False (B)</p> Signup and view all the answers

    Name one example of secondary active transport.

    <p>Sodium-dependent glucose cotransporters (SGLT1 and SGLT2)</p> Signup and view all the answers

    Flashcards

    Membrane Potential

    The potential difference across a cell's plasma membrane, measured in millivolts.

    Resting Membrane Potential

    The membrane potential of a cell at rest, typically around -70 mV in neurons.

    Electrochemical Gradient

    A combination of the concentration gradient and electrical gradient affecting ion movement.

    Chemical Driving Force

    Movement of substances down their concentration gradient.

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    Electrical Driving Force

    Movement of ions due to attraction and repulsion of charges.

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    Driving Forces of Ion Movement

    Forces that determine how ions cross the plasma membrane: chemical and electrical.

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    Concentration Gradient

    The difference in concentration of a substance across a space.

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    Membrane Charge (Vm)

    Another term for membrane potential, indicating voltage across the membrane.

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    Facilitated Diffusion

    A process that allows substances to cross membranes with the help of transmembrane proteins without using energy.

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    Ion Channels

    Proteins that allow charged ions to pass through the plasma membrane following their electrochemical gradient.

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    Active Transport

    Movement of substances against their concentration gradient using energy (ATP).

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    Osmosis

    The diffusion of water across a selectively permeable membrane from high to low concentration.

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    Carrier-mediated Transport

    Transport that requires carriers or channels, which can saturate and reach a maximum rate.

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    Action Potential Propagation

    The process of an action potential traveling from the axon hillock to the axon terminal.

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    Kinetic Energy

    The energy of motion of molecules that influences their movement and collisions.

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    Net Diffusion

    The overall movement of molecules from high to low concentration until equilibrium is reached.

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    Axon Hillock

    The part of a neuron where action potentials are initiated due to high density of Na+ channels.

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    Factors affecting Diffusion Rate

    Temperature, molecular weight, and concentration gradients influence how fast diffusion occurs.

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    Unmyelinated Axons

    A type of axon where action potentials propagate slowly from the trigger zone to the axon terminal.

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    Myelinated Neurons

    Neurons that have myelin, allowing faster action potential propagation via saltatory conduction.

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    Diffusion Importance

    Diffusion allows for efficient material exchange at short distances in the body.

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    Saltatory Conduction

    The jumping of action potentials between Nodes of Ranvier in myelinated axons, increasing speed.

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    Node of Ranvier

    A break in the myelin sheath where voltage-gated Na+ channels are concentrated.

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    Refractory Period

    The time after an action potential during which a neuron cannot fire again, ensuring one-way propagation.

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    Post-Synaptic Potentials (PSPs)

    Changes in the post-synaptic membrane potential due to neurotransmitter action; can be excitatory (EPSP) or inhibitory (IPSP).

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    Electrical Signals

    Changes in membrane potential used by neurons to communicate.

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    Leak Channels

    Ion channels that are always open, allowing ions to flow freely.

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    Ligand-gated Channels

    Ion channels that open in response to specific chemical signals.

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    Voltage-gated Channels

    Ion channels that open or close in response to voltage changes.

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    Action Potentials

    Rapid changes in membrane potential that propagate signals along neurons.

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    Graded Potentials

    Small changes in membrane potential that can summate to trigger action potentials.

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    Primary Active Transport

    Transport across the plasma membrane that requires energy, usually from ATP.

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    Pumps

    Transmembrane proteins that transport substances against their concentration gradient.

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    Na+/K+-ATPase Pump

    A specific pump that moves 3 Na+ out and 2 K+ into the cell, using ATP.

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    Secondary Active Transport

    Transport that uses the gradient created by primary active transport, not ATP directly.

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    Cotransport (Symport)

    A type of secondary active transport where two molecules move in the same direction across the membrane.

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    Countertransport (Antiport)

    Secondary active transport where two molecules move in opposite directions across the membrane.

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    Sodium-dependent glucose cotransporter (SGLT)

    Transporters that use Na+ gradient to transport glucose into cells.

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    Study Notes

    Action Potential Propagation and Transmission

    • Action potentials propagate from the axon hillock to the axon terminal.
    • The propagation is one-way due to the absolute refractory period following the action potential.
    • The axon hillock has the highest density of voltage-gated Na+ channels.
    • Conduction velocity differs in myelinated and unmyelinated neurons.

    Session Learning Objectives (February 7th, 2025)

    • Students will be able to describe the process of action potential propagation in unmyelinated and myelinated neurons.
    • They will differentiate the conduction velocity difference between these neuron types and
    • recall, and draw the events of synaptic transmission in the presynaptic cell,
    • describe the types of synapses (electrical and chemical),
    • recall post-synaptic potentials (PSPs) and the ions responsible for depolarization (excitatory) and hyperpolarization (inhibitory),
    • including excitatory post-synaptic potentials (EPSP) and
    • inhibitory post-synaptic potentials (IPSP).

    Action Potential Propagation

    • Action potential propagation from the axon hillock to the axon terminal is typically one-way.
    • This is because the absolute refractory period follows along the "wake" of the moving action potential.
    • The axon hillock has the highest density of voltage-gated Na+ channels.

    Action Potential Propagation: Unmyelinated Axons

    • Action potentials begin at the "trigger zone" (axon hillock) and propagate to the axon terminal.
    • Propagation is slow.
    • Depolarization at one site triggers depolarization of the adjacent site in a wave-like manner (initiation and propagation).
    • Conduction is relatively slow in unmyelinated axons.

    Action Potential Propagation in Myelinated Neurons

    • Myelin is created by oligodendrocytes in the CNS and Schwann cells in the PNS.
    • Myelin increases membrane resistance to current flow, so ions flow along the axon interior instead of against the high resistance membrane.
    • Propagation is much faster, and occurs via saltatory conduction.
    • Saltatory conduction is where action potentials jump from Node of Ranvier to Node of Ranvier.
    • Large diameter axons have faster conduction velocity due to a higher density of voltage-gated channels.
    • Myelin further increases conduction velocity.

    AP Propagation

    • One-way propagation (from axon hillock to axon terminal) starts at the axon hillock and moves toward the axon terminal.
    • The refractory period prevents it from moving in the retrograde direction after initiation.
    • Velocity increases with axon diameter and myelination (saltatory conduction).
    • Relevant pathologies include multiple sclerosis and diabetes mellitus.

    Synapses

    • Neurons are functionally associated with other neurons, and effector organs (muscles or glands).
    • Two types of synapses exist:
    • Electrical synapses.
    • Chemical synapses.

    Synaptic Transmission: Electrical

    • Two (or more) excitable cells are linked together by gap junctions.
    • Transmission is very rapid.
    • Multiple cells in a tissue/organ can "behave as one".

    Synaptic Transmission: Chemical

    • Slower than electrical synapses.
    • More complex and modifiable.
    • Communication from one neuron to other neurons, to muscle cells, gland cells, and other cells is via chemical synapses.

    Chemical Synaptic Transmission: Presynaptic Events

    • AP propagates to axon terminal.
    • Voltage-gated Ca2+ channels open.
    • Rapid influx of Ca2+ activates vesicle exocytosis, allowing vesicles to fuse with plasma membrane.
    • Neurotransmitter diffuses across synaptic cleft (15 nm) onto postsynaptic cell.

    Postsynaptic Events at Excitatory Synapse

    • Neurotransmitter (NT) binds to a post-synaptic receptor, opening ligand-gated channels.
    • Cations (mainly Na+ or Ca2+) flow into the cell.
    • The net effect is depolarization (EPSP).

    Postsynaptic Events at Inhibitory Synapse

    • NT binds to a post-synaptic receptor, opening ligand-gated channels.
    • Either K+ flows out or Cl- flows into the cell.
    • The net effect is hyperpolarization (IPSP).

    Chemical Synaptic Transmission

    • Postsynaptic potentials are brief because neurotransmitters (NT) rapidly bind and unbind to receptors.

    Chemical Signals: Neurotransmitters

    • There are many different types of neurotransmitters.
    • The receptor determines whether an IPSP or EPSP develops.

    Chemical Synaptic Transmission: Summary

    • AP propagates to axon terminal.
    • Voltage-gated Ca2+ channels open.
    • Ca2+ initiates vesicle exocytosis.
    • Neurotransmitter crosses across the synapse.
    • NT binds to a receptor.
    • Ligand-gated channels open.
    • Ions flow.
    • A graded potential (EPSP or IPSP) occurs.

    Postsynaptic Potential

    • Net effect could be depolarization (EPSP) or hyperpolarization (IPSP) .

    Membrane, graded, and action potentials

    • Key difference between a graded potential and an action potential
    • Types of channels used
    • Phases of an action potential

    In-class Activity

    • Predicting net flux of Cl- at various membrane potentials.

    Ionic Basis of Action Potentials

    • Action Potentials (AP) occur in response to graded potentials, summing up to reach threshold.
    • APs are initiated at the trigger zone.
    • An AP typically consists of three phases.
    • Understanding the changing permeability of Na+ and K+ is essential to understanding APs.

    Phase 1: Rapid Depolarization

    • Voltage-gated Na+ channels open, rapidly depolarizing the membrane as sodium enters.
    • Voltage-gated K+ channels remain closed.

    Voltage-Gated Na+ Gating Properties

    • Fast to open, fast to inactive/close

    Phase 2: Repolarization

    • The decrease in Na+ permeability (sodium channels inactivate) causes a rapid decrease in the positive charge entering the cell.
    • Lots of positive charge (K+) leaves the cell.

    Voltage-Gated K+ Gating Properties

    • Slow to open, slow to close

    Phase 3: Afterhyperpolarization

    • Voltage-gated Na+ channels are inactivated, preventing further Na+ entry into the cell.
    • Voltage-gated K+ channels are slow to close, allowing further K+ outflow, hyperpolarizing the membrane to a potential more negative than the RMP.
    • Eventually, the voltage-gated K+ channels close, and the NA+/K+-ATPase pumps and leak channels bring the cell back to RMP.

    Flow Chart of Channel Events

    • Graded potentials depolarize the membrane, reaching threshold.
    • Voltage-gated Na+ channels open and membrane rapidly depolarizes.
    • Voltage-gated Na+ channels inactivate while Voltage-gated K+ channels open, resulting in membrane repolarization.

    Testing Your Understanding

    • Comparing changes in ion channel permeability to the change in membrane potential.

    Refractory Periods

    • During and immediately after an action potential, the membrane is less excitable than at rest.
    • Absolute refractory period: it's impossible for a cell to generate a second action potential regardless of stimulus size.
    • Voltage-gated Na+ channels are not available to open during this time.
    • Relative refractory period: possible to generate a second AP only with a larger than normal stimulus.
    • Some voltage-gated Na+ channels have reentered the "closed" state and are available to open.

    Action Potentials

    • All-or-none: Once the membrane is depolarized to threshold, the amplitude is independent of the stimulus size.
    • Not graded by stimulus size: ECF conditions such as higher ECF Na+ concentration can influence AP properties.
    • No summation due to refractory period: Absolute and relative refractory periods prevent summation.
    • Do not decrease with distance: Propagate over long distances.

    Equilibrium Potential (Nernst Potential)

    • For any given concentration gradient of a single ion, the membrane potential that exactly opposes the concentration gradient is known as the equilibrium potential.
    • At the equilibrium potential, the movement of an ion across the membrane due to its concentration gradient is opposed by the movement of the ion in the opposite direction due to its electrical gradient.
    • This is not the resting membrane potential.

    Ion Concentrations

    • Intracellular and Extracellular fluid concentration of different ions

    In-Class Question

    • Equilibrium potential of K+.
    • Net flux of K+ in a resting cell

    Membrane Potential

    • When a cell is permeable to more than one ion (e.g., K+ and Na+), both affect the resting membrane potential in proportion to their relative permeabilities and conductances.
    • Vm is a weighted average of each ion's flux.
    • Relative permeability determines which ion (K+ is the primary determinant) dominates in determining RMP.

    Signaling through Dynamic Changes in Membrane Potential

    • Changes in membrane potential are the basis of cellular communication, allowing cells to receive and send information.

    Electrical Signals

    • Neurons communicate via electrical signals—changes in membrane potential.
    • Ion channels open and close to change membrane potential.

    Types of Ion Channels

    • Leak channels
    • Ligand-gated channels
    • Voltage-gated channels
    • Mechanically-gated channels

    Two Types of Electrical Signals

    • Graded potentials are small and short distance; action potentials are large and long distance.
    • Graded potentials amplitude varies with stimulus intensity and may be depolarizing or hyperpolarizing. Their amplitude decreases with distance. Summation is possible.
    • Action potentials are all-or-none, have similar amplitude, are initiated by depolarization, and do not summate.

    Graded Potentials

    • Are proportional to the size of the stimulus.
    • Decrease with distance from the stimulus site.
    • Are short-distance signals.
    • Can be depolarizations or hyperpolarizations.
    • Summate with each other. AKA sensory receptor potentials or generator potentials.

    Osmolarity

    • Total solute concentration of a solution per unit volume.
    • Normal osmolarity of ECF and ICF in most physiological solutions is approximately 300 mOsm.
    • Tonicity describes the relative concentration of nonpenetrating solutes between two solutions, either (hypertonic, hypotonic, or isotonic).

    Ion Channels, Active Transport, and Vesicular Transport

    • Leak channels
    • Ligand-gated channels
    • Voltage-gated channels
    • Primary active transport
    • Secondary active transport
    • Vesicular transport or transport through vesicles

    Transport Rate Across the Membrane

    • Simple diffusion: rate increases with concentration.
    • Carrier-mediated transport: rate reaches a maximum (Vmax) before saturation.

    Primary Active Transport

    • Requires energy (usually ATP) to transport substances directly across the cell membrane.
    • Uses transmembrane proteins (pumps).
    • Pumps against concentration gradient.

    Secondary Active Transport

    • Uses energy from another molecule's concentration gradient to transport substances against their concentration gradient.
    • Uses transmembrane proteins.
    • Two main types: cotransport (symport), and countertransport (antiport).

    Vesicular Transport: Endocytosis and Exocytosis

    • Endocytosis: Molecules from the ECF enter the cell via vesicles formed from the plasma membrane.
    • Exocytosis: Intracellular vesicles fuse with plasma membrane, releasing contents into the ECF.

    Proteins in the Phospholipid Bilayer

    • Allow the cell to be selectively permeable.

    The Cell Membrane

    • Dynamic: many membrane processes are always occurring., such as cardiac muscle.

    Physiology 3051

    • Basics of physiology, homeostasis, and various body functions.

    In-Class Activity (Various)

    • In-class activities were presented to students to apply their knowledge of diffusion, chemical driving forces, and membrane potentials.

    Neurophysiology

    • Specific aspects of neurophysiology (related to nerve cells, action potentials, and related mechanisms, and processes).

    Penetrating and Non-penetrating Substances

    • Classification of substances based on their ability (or inability) to cross cell membranes.

    Learning Objectives(various)

    • Overview of different physiologically relevant topics and learning objectives.

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    Quiz Team

    Description

    Test your knowledge on the mechanisms of cell transport, including facilitated diffusion, active transport, and ion channels. Explore concepts like net diffusion and the action potential in neurons. This quiz covers essential processes vital for the human body.

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