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What is a characteristic feature of exocytosis?
What is a characteristic feature of exocytosis?
Which of the following best describes endocytosis?
Which of the following best describes endocytosis?
What process describes the movement of water across a semi-permeable membrane?
What process describes the movement of water across a semi-permeable membrane?
In osmosis, water moves from areas of ____ water concentration to areas of ____ water concentration.
In osmosis, water moves from areas of ____ water concentration to areas of ____ water concentration.
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When conducting an osmosis experiment with potato pieces, which solution will most likely cause the potato to lose the most water?
When conducting an osmosis experiment with potato pieces, which solution will most likely cause the potato to lose the most water?
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Which transport mechanism uses energy to move substances across the cell membrane?
Which transport mechanism uses energy to move substances across the cell membrane?
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Which of the following statements correctly describes simple diffusion?
Which of the following statements correctly describes simple diffusion?
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According to Fick's law of diffusion, which factor does NOT affect the diffusion rate?
According to Fick's law of diffusion, which factor does NOT affect the diffusion rate?
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What is the primary difference between primary and secondary active transport?
What is the primary difference between primary and secondary active transport?
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Which type of transport involves the movement of macromolecules across the cell membrane?
Which type of transport involves the movement of macromolecules across the cell membrane?
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What term describes the pressure required to prevent the flow of water across a semipermeable membrane?
What term describes the pressure required to prevent the flow of water across a semipermeable membrane?
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In which type of transport do particles move according to their concentration gradient?
In which type of transport do particles move according to their concentration gradient?
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What must be true for a substance to passively diffuse through the cell membrane?
What must be true for a substance to passively diffuse through the cell membrane?
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What role do hormones play in glucose transport in the body?
What role do hormones play in glucose transport in the body?
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Which type of transport requires energy?
Which type of transport requires energy?
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In facilitated diffusion, what is used to help transport particles across the membrane?
In facilitated diffusion, what is used to help transport particles across the membrane?
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What describes the sodium-potassium pump?
What describes the sodium-potassium pump?
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Which of the following correctly defines secondary active transport?
Which of the following correctly defines secondary active transport?
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What characterizes primary active transport?
What characterizes primary active transport?
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Which of the following best describes simple diffusion?
Which of the following best describes simple diffusion?
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How does diabetes mellitus affect glucose transport?
How does diabetes mellitus affect glucose transport?
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Which of the following statements about energy in transport processes is incorrect?
Which of the following statements about energy in transport processes is incorrect?
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Which factor primarily influences the number of carriers present for glucose transport?
Which factor primarily influences the number of carriers present for glucose transport?
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What is the relationship between temperature and the rate of diffusion as described in the content?
What is the relationship between temperature and the rate of diffusion as described in the content?
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Which statement best describes why charged molecules have low diffusion rates through cell membranes?
Which statement best describes why charged molecules have low diffusion rates through cell membranes?
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What distinguishes ligand-gated channels from leakage channels?
What distinguishes ligand-gated channels from leakage channels?
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What is the function of the ion channels mentioned in the content?
What is the function of the ion channels mentioned in the content?
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How does the surface area of a membrane influence diffusion according to the provided equation?
How does the surface area of a membrane influence diffusion according to the provided equation?
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What characteristic distinguishes leakage channels from other types of ion channels?
What characteristic distinguishes leakage channels from other types of ion channels?
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What is the primary role of sodium in the extracellular fluid (ECF)?
What is the primary role of sodium in the extracellular fluid (ECF)?
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What role does molecular weight play in the rate of diffusion?
What role does molecular weight play in the rate of diffusion?
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What type of gated channel responds to chemical signals like neurotransmitters?
What type of gated channel responds to chemical signals like neurotransmitters?
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How do local anesthetics affect sodium channels?
How do local anesthetics affect sodium channels?
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In the context of diffusion through membranes, what is the effect of hydrated ions?
In the context of diffusion through membranes, what is the effect of hydrated ions?
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Which channel type is specifically mentioned as a way for ions to diffuse across a membrane?
Which channel type is specifically mentioned as a way for ions to diffuse across a membrane?
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What is facilitated diffusion primarily dependent on?
What is facilitated diffusion primarily dependent on?
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What does the abbreviation 'ECF' stand for in the context of ion leakage channels?
What does the abbreviation 'ECF' stand for in the context of ion leakage channels?
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What is meant by the transport maximum in cellular transport?
What is meant by the transport maximum in cellular transport?
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What characterizes voltage-gated channels?
What characterizes voltage-gated channels?
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Which ion is primarily maintained as the chief intracellular cation?
Which ion is primarily maintained as the chief intracellular cation?
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What is the main reason sodium enters a cell during depolarization?
What is the main reason sodium enters a cell during depolarization?
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What is the effect of facilitated diffusion on glucose transport?
What is the effect of facilitated diffusion on glucose transport?
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Which type of channel is affected by changes in membrane potential?
Which type of channel is affected by changes in membrane potential?
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Study Notes
Module Information
- Module: HUMAN BODY FUNCTION (HBF-102)
- Academic Year: 2024/2025
- Year: 1
- Semester: 1
Transport Across the Cell Membrane
- The transport across cell membranes can be passive or active.
- Passive transport doesn't require energy, while active transport does.
- Passive transport includes simple diffusion and facilitated diffusion.
- Active transport can be primary or secondary.
Objectives
- Differentiate between the types of transport across cell membranes
- List different types of channels
- Identify different types of carriers
- Explain how macromolecules cross cell membranes
- Define osmosis and osmotic pressure
Active vs Passive Transport
- Active transport moves molecules against the concentration gradient. It requires energy.
- Passive transport moves molecules with the concentration gradient. It doesn't require energy.
Simple Diffusion
- Simple diffusion is a passive transport.
- It doesn't require energy or carriers.
- Molecules move from an area of high concentration to an area of low concentration.
- It's affected by Fick's law of diffusion.
Fick's Law of Diffusion
- Diffusion rate is directly proportional to the permeability coefficient, concentration gradient, and surface area.
- Diffusion rate is inversely proportional to the thickness of the membrane.
- Increasing temperature increases the rate of diffusion.
Demonstration of Diffusion in Fluids
- Place methylene blue crystals in beakers with different temperatures (cold, room temperature, hot) of water.
- Observe and record the time it takes for the dye to disperse evenly in each beaker.
Charged Molecules and Cell Membranes
- Charged molecules diffuse across cell membranes at an extremely low rate.
- This is due to the formation of large hydrated ions with water, and the interaction between charges on the molecules and membrane.
Ion Channels
- Ion channels are important for ion diffusion.
- Ions move through these channels by simple diffusion, following their electrochemical gradient.
- Types include leakage, voltage-gated, and ligand-gated channels.
Leakage Channels
- Leakage channels are water pathways through integral proteins in the cell membrane.
- They are tubular and extend from the extracellular fluid (ECF) to the intracellular fluid (ICF).
- These channels are highly selective.
- Examples include Na+ and K+ leakage channels.
Gated Channels
- Gated channels have gates that open or close in response to specific signals.
- Ligand-gated channels open or close when a specific molecule (ligand) binds to them, like neurotransmitters.
- Voltage-gated channels open or close in response to changes in membrane potential.
- Examples of voltage-gated channels include Na+ and K+ voltage-gated channels.
Role of Sodium Channels in Local Anesthesia
- Local anesthetics bind to voltage-gated sodium channels.
- Binding blocks sodium entry into the cell.
- This prevents the generation and conduction of action potentials (no pain sensation).
Facilitated Diffusion
- Facilitated diffusion is a passive transport that requires a carrier protein.
- Molecules move from high to low concentration.
- It has a transport maximum.
- An example is the transport of glucose.
Transport Maximum
- Transport maximum is the maximal rate at which a substance can be transported by facilitated diffusion.
- It depends on the number of carriers in the membrane.
- Affected by hormones (e.g., insulin). An increase in Insulin increases the rate of glucose carrier.
Active Transport
- Active transport is uphill/against the concentration gradient, and thus requires energy from ATP.
- It involves carrier proteins.
- Types are primary active transport and secondary active transport
Primary Active Transport
- Carriers have ATPase activity.
- This type of transport moves molecules 'uphill' against their concentration gradient.
- Includes Na+-K+ pump, Ca2+ pump, and H+-K+ pump.
Secondary Active Transport
- This type of transport depends on the sodium gradient created by the sodium-potassium pump.
- It is either cotransport (symport) or countertransport (antiport).
Exocytosis
- Transports material to outside the cell.
- An active transport process that requires energy.
- Example: Transport of acetylcholine at the motor end plate.
Endocytosis
- Transport of materials into the cell.
- Active process that requires energy.
- Example: Phagocytosis of bacteria and dead tissue.
Osmosis
- Passive transport of water across a semi-permeable membrane.
- Water moves from an area of high water concentration (low solute concentration) to an area of low water concentration (high solute concentration).
Osmotic Pressure
- Pressure required to prevent osmosis.
Isotonic, Hypotonic, Hypertonic Solutions
- Isotonic: Solute concentration inside the cell equals the solution outside the cell.
- Hypotonic: Solute concentration inside the cell is higher than outside. Water moves into the cell.
- Hypertonic: Solute concentration inside the cell is lower than outside. Water moves out of the cell.
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Description
This quiz tests your understanding of various cell transport mechanisms, including exocytosis, endocytosis, osmosis, and diffusion. Explore the processes that govern the movement of substances across cell membranes and their implications. Perfect for biology students looking to reinforce their knowledge in cell biology.