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Questions and Answers
What is the first stage of cell signaling?
What is the first stage of cell signaling?
- Activation
- Transduction
- Response
- Reception (correct)
What role does a ligand play in signal transduction?
What role does a ligand play in signal transduction?
- It changes the receptor protein's shape permanently.
- It acts as the actual 'signal' being transduced. (correct)
- It amplifies the signal inside the cell.
- It inhibits protein kinases from functioning.
Which of the following best describes transduction in a signal transduction pathway?
Which of the following best describes transduction in a signal transduction pathway?
- The final response of the cell to the signal.
- The initial binding of a ligand to a receptor.
- The alteration of cell membrane permeability.
- The process of relay and amplification of the signal within the cell. (correct)
What potential consequence can arise from mutations to receptor proteins in signaling pathways?
What potential consequence can arise from mutations to receptor proteins in signaling pathways?
Defective protein phosphatases are implicated in diseases such as cancer and diabetes. What impact would such defects have on signal transduction pathways?
Defective protein phosphatases are implicated in diseases such as cancer and diabetes. What impact would such defects have on signal transduction pathways?
What type of signaling involves direct contact between cells?
What type of signaling involves direct contact between cells?
Which type of signaling is primarily responsible for communication during embryonic development?
Which type of signaling is primarily responsible for communication during embryonic development?
In which type of local signaling do cells release neurotransmitters?
In which type of local signaling do cells release neurotransmitters?
What is an example of a long-distance signaling molecule in animals?
What is an example of a long-distance signaling molecule in animals?
How do hormones travel to their target cells in animals?
How do hormones travel to their target cells in animals?
What characterizes paracrine signaling?
What characterizes paracrine signaling?
Which cellular structure allows passage of signaling substances between adjacent cells in plants?
Which cellular structure allows passage of signaling substances between adjacent cells in plants?
Which of the following does NOT describe local signaling?
Which of the following does NOT describe local signaling?
Which type of signaling is essential for maintaining adult stem cell populations?
Which type of signaling is essential for maintaining adult stem cell populations?
What type of signal do immune cells use to communicate with T cells?
What type of signal do immune cells use to communicate with T cells?
What type of signaling involves a cell secreting a substance to an adjacent target cell?
What type of signaling involves a cell secreting a substance to an adjacent target cell?
Which structures allow plant cells in direct contact to diffuse substances for communication?
Which structures allow plant cells in direct contact to diffuse substances for communication?
Which of the following is the correct order of the stages of cell signaling?
Which of the following is the correct order of the stages of cell signaling?
What happens during the transduction stage of cell signaling?
What happens during the transduction stage of cell signaling?
Which molecule typically initiates the reception process in cell signaling?
Which molecule typically initiates the reception process in cell signaling?
In which stage of cell signaling does a cell process get altered?
In which stage of cell signaling does a cell process get altered?
What is the role of receptor proteins in the reception phase of cell signaling?
What is the role of receptor proteins in the reception phase of cell signaling?
Who conducted significant research on how hormones act on cells?
Who conducted significant research on how hormones act on cells?
What triggers the activation of G protein coupled receptors (GPCRs)?
What triggers the activation of G protein coupled receptors (GPCRs)?
Which molecule is produced when GDP is exchanged for GTP in GPCR activation?
Which molecule is produced when GDP is exchanged for GTP in GPCR activation?
What is the role of ion channels in cellular signaling?
What is the role of ion channels in cellular signaling?
Which statement best describes the relationship between GPCRs and G proteins?
Which statement best describes the relationship between GPCRs and G proteins?
What occurs at the cytoplasmic side of a GPCR upon ligand binding?
What occurs at the cytoplasmic side of a GPCR upon ligand binding?
Which ions are commonly allowed to pass through ligand-gated ion channels?
Which ions are commonly allowed to pass through ligand-gated ion channels?
What role does the enzyme play after being activated by the G protein?
What role does the enzyme play after being activated by the G protein?
In which system are ligand-gated ion channels primarily important?
In which system are ligand-gated ion channels primarily important?
What triggers the activation of a receptor upon ligand binding?
What triggers the activation of a receptor upon ligand binding?
Which type of receptors primarily bind large, polar, and water-soluble ligands?
Which type of receptors primarily bind large, polar, and water-soluble ligands?
What is the primary role of second messengers in signal transduction?
What is the primary role of second messengers in signal transduction?
Which hormone type is most likely to use intracellular receptors?
Which hormone type is most likely to use intracellular receptors?
What process is responsible for turning on or off specific genes in response to hormone activation?
What process is responsible for turning on or off specific genes in response to hormone activation?
How does phosphorylation affect protein activity in signal transduction?
How does phosphorylation affect protein activity in signal transduction?
During transduction, a change in the receptor's shape typically leads to what?
During transduction, a change in the receptor's shape typically leads to what?
Which statement accurately describes the role of ligands in cellular signaling?
Which statement accurately describes the role of ligands in cellular signaling?
Which statement is true regarding the nature of receptors?
Which statement is true regarding the nature of receptors?
What is the consequence of dephosphorylation in a signal transduction pathway?
What is the consequence of dephosphorylation in a signal transduction pathway?
Flashcards
Why is cell communication important?
Why is cell communication important?
Communication between cells is essential for the survival and functioning of all organisms. It's the basis of growth and development for multicellular organisms.
How do cells communicate?
How do cells communicate?
Cells can communicate in three main ways: direct contact, local signaling, and long-distance signaling.
What is direct contact communication?
What is direct contact communication?
In direct contact communication, cells physically touch and share information through cell junctions.
How do cells connect in direct contact communication?
How do cells connect in direct contact communication?
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What is local signaling?
What is local signaling?
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What is paracrine signaling?
What is paracrine signaling?
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What is synaptic signaling?
What is synaptic signaling?
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What are hormones and what do they do?
What are hormones and what do they do?
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How does hormonal (endocrine) signaling work?
How does hormonal (endocrine) signaling work?
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What determines a cell's response to a signal?
What determines a cell's response to a signal?
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Paracrine signaling
Paracrine signaling
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Plasmodesmata
Plasmodesmata
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Reception
Reception
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Transduction
Transduction
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Response
Response
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Ligand
Ligand
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Receptor protein
Receptor protein
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Signal transduction pathway
Signal transduction pathway
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Protein kinase
Protein kinase
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Protein phosphatase
Protein phosphatase
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Second messenger
Second messenger
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Intracellular Receptors
Intracellular Receptors
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Cell communication
Cell communication
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Mutations in signal transduction pathways
Mutations in signal transduction pathways
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Defective protein phosphatases
Defective protein phosphatases
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What are G protein coupled receptors (GPCRs)?
What are G protein coupled receptors (GPCRs)?
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How are GPCRs activated?
How are GPCRs activated?
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What are ligand-gated ion channels?
What are ligand-gated ion channels?
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What does a GPCR bind to?
What does a GPCR bind to?
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How does ligand binding activate a GPCR?
How does ligand binding activate a GPCR?
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What happens after the GPCR and G protein are activated?
What happens after the GPCR and G protein are activated?
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Why are ligand-gated ion channels important?
Why are ligand-gated ion channels important?
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What happens when a ligand binds to a ligand-gated ion channel?
What happens when a ligand binds to a ligand-gated ion channel?
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Study Notes
Cell Communication and Signal Transduction
- Cell-to-cell communication is vital for cell function and survival.
- This process drives the growth and development of multicellular organisms.
- Cells communicate via three general methods: direct contact, local signaling, and long-distance signaling.
Direct Contact
- Cells communicate directly through cell junctions, particularly gap junctions in animal cells and plasmodesmata in plant cells.
- Substances dissolved in the cytoplasm readily pass between connected cells.
- An example of this is between antigen-presenting cells (APCs) and T cells.
Local Signaling
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Local regulators, also known as ligands, are used for short-distance signaling.
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These molecules travel through extracellular fluid to stimulate a response in a target cell.
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Examples include:
- Paracrine signaling: local regulators diffuse to nearby cells. Growth factors are examples.
- Synaptic signaling: neurotransmitters are released into the synaptic cleft to quickly affect adjacent target cells.
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In the animal nervous system this occurs when a neurotransmitter is released in response to an electric signal. Drugs for depression, anxiety and PT stress disorder affect the signaling process.
Long-Distance Signaling
- Hormones are employed for long-distance signaling in animals and plants.
- Plant hormones travel in vascular tissue (xylem and phloem) or even via the air.
- In animals, specialized cells release hormones into the circulatory system to reach target cells. An example is insulin released by the pancreas into the blood.
Stages of Cell Signaling
- Cell-to-cell communication happens in three stages:
- Reception: a signaling molecule (ligand) binds to a receptor protein on the target cell surface.
- Transduction: the binding event causes a conformational change on the receptor, initiating a signal transduction pathway. Often this sequence of events involves multiple steps.
- Response: the signal transduction pathway triggers a specific cellular response.
Receptors
- Receptors are macromolecules that bind to ligands (signaling molecules).
- Receptor binding is highly specific.
- Receptors can be:
- Plasma membrane receptors: these bind to large, polar ligands.
- Often involve G protein-coupled receptors (GPCRs) or ligand-gated ion channels.
- Intracellular receptors: ligands are small and hydrophobic so can cross the plasma membrane, these receptors are often found in the cytoplasm or nucleus.
- Ligands for intracellular receptors include steroid and thyroid hormones as well as nitric oxide gas.
- Plasma membrane receptors: these bind to large, polar ligands.
Transduction: The Process
- Signal transduction pathways often involve protein kinases that transfer phosphate groups leading to increased activity of the protein.
- The pathway can be shut off (or stopped) through dephosphorylation which is the removal of the phosphate group.
- Small molecules (second messengers) can amplify and relay the signal. Cyclic AMP (cAMP) is a common second messenger
Final Response
- The final molecule in the signaling pathway triggers a cellular response, ranging from altering membrane permeability to changing enzyme activity or even altering the expression of specific genes.
Changes in Signaling
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Mutations in signaling pathways can affect the transduction of signals.
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Defects like those seen in protein phosphatases can potentially cause issues with normal transduction pathways, which can result in diseases like cancer or diabetes.
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Different types of cells and organisms may have different ways of signaling and responding.
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