Cell Signaling Process Quiz

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Questions and Answers

What initiates the process of transduction in the signaling pathway?

  • The release of epinephrine into the bloodstream
  • The binding of the signaling molecule to a receptor protein (correct)
  • The cellular response triggered by the signal
  • The change of shape in the receptor protein

What is the primary role of cell-surface receptor proteins in signaling?

  • To block unwanted signaling molecules
  • To absorb signaling molecules from the environment
  • To catalyze cellular responses directly
  • To transmit information from outside the cell to the inside (correct)

Which stage follows reception in the signaling process?

  • Translation
  • Translocation
  • Transduction (correct)
  • Transcription

Which of the following is a type of receptor protein mentioned?

<p>G protein-coupled receptors (D)</p> Signup and view all the answers

What happens to the receptor protein upon binding of a signaling molecule?

<p>It changes shape (A)</p> Signup and view all the answers

What is the final stage of the signaling process?

<p>Response (D)</p> Signup and view all the answers

What commonly results from malfunctions of receptor proteins?

<p>Development of diseases (C)</p> Signup and view all the answers

How do water-soluble signaling molecules generally interact with cells?

<p>They bind to transmembrane receptor proteins (A)</p> Signup and view all the answers

What is the initial step in the process of cell signaling?

<p>Cells identify their mates using signaling molecules (A)</p> Signup and view all the answers

What occurs after the binding of signaling molecules to cell receptors?

<p>Changes in the target cell lead to a coordinated response (D)</p> Signup and view all the answers

What are the two mating types of yeast cells known as?

<p>a and α (B)</p> Signup and view all the answers

What specific process do Myxobacteria use to coordinate behavior when nutrients are scarce?

<p>Quorum sensing (D)</p> Signup and view all the answers

What is the fused cell from mating yeast cells called?

<p>a/α cell (D)</p> Signup and view all the answers

What do the signaling molecules secreted by yeast cells do?

<p>Bind to receptors on opposite type cells (D)</p> Signup and view all the answers

What structure do Myxobacteria form in response to nutrient scarcity?

<p>Fruiting body (B)</p> Signup and view all the answers

What is the significance of quorum sensing in bacterial populations?

<p>It allows coordination of behavior among a group of cells (A)</p> Signup and view all the answers

What occurs when a ligand binds to a ligand-gated ion channel?

<p>The receptor changes shape and opens the gate. (B)</p> Signup and view all the answers

What is the primary function of ligand-gated ion channels in the nervous system?

<p>To trigger electrical signals by allowing ion flow. (B)</p> Signup and view all the answers

Where are intracellular receptor proteins primarily located?

<p>In the cytoplasm or nucleus of target cells. (C)</p> Signup and view all the answers

What type of molecules can typically bind to intracellular receptors?

<p>Hydrophobic or small signaling molecules. (B)</p> Signup and view all the answers

What happens to the receptor protein after a hormone binds to an intracellular receptor?

<p>It forms a hormone-receptor complex that can trigger a response. (B)</p> Signup and view all the answers

How does the process of ligand binding affect the concentration of ions inside a cell?

<p>It allows specific ions to flow in and out, rapidly changing their concentration. (A)</p> Signup and view all the answers

What role do voltage-gated ion channels play in the nervous system?

<p>They are activated by changes in membrane potential. (B)</p> Signup and view all the answers

What is required for a ligand-gated ion channel to open?

<p>Binding of a signaling molecule to the receptor. (B)</p> Signup and view all the answers

What is the primary role of calcium ions in cellular function?

<p>They serve as critical intracellular messengers. (B)</p> Signup and view all the answers

Which molecule is generated by phospholipase C during calcium signaling?

<p>DAG (B)</p> Signup and view all the answers

How does IP₃ contribute to calcium signaling pathways?

<p>By diffusing through the cytosol to bind to calcium channels in the ER. (B)</p> Signup and view all the answers

What happens to calcium ions when they flow out of the ER?

<p>They activate specific proteins, triggering cellular responses. (B)</p> Signup and view all the answers

What two second messengers are involved in calcium signaling pathways?

<p>DAG and IP₃ (D)</p> Signup and view all the answers

Where does the signaling molecule bind to initiate the calcium signaling pathway?

<p>To the G protein-coupled receptor. (D)</p> Signup and view all the answers

What initiates the activation of phospholipase C in the calcium signaling pathway?

<p>The binding of a signaling molecule to a receptor. (C)</p> Signup and view all the answers

What is the primary role of glycogen phosphorylase in the signaling pathway initiated by epinephrine?

<p>It releases glucose monomers from glycogen. (D)</p> Signup and view all the answers

What is the result of a small change in cytosolic calcium ion concentration?

<p>It represents a significant percentage change. (D)</p> Signup and view all the answers

How does the cell amplify the signal received from epinephrine?

<p>Through a cascade of relay molecules. (D)</p> Signup and view all the answers

What determines the different responses of cells to the same signaling molecule?

<p>The collection of proteins present in the cell. (A)</p> Signup and view all the answers

What is one potential outcome of activating multiple molecules of G protein by a single receptor protein?

<p>Enhanced signal amplification in the pathway. (C)</p> Signup and view all the answers

Which of the following best describes the relationship between different proteins and cellular response?

<p>Different proteins lead to varying cellular responses to a common signal. (A)</p> Signup and view all the answers

What is a primary mechanism by which signaling pathways affect cellular functions?

<p>By regulating gene expression (B)</p> Signup and view all the answers

What is the role of transcription factors in signaling pathways?

<p>They activate specific genes (B)</p> Signup and view all the answers

Which process allows for amplification of the initial signal in a signaling pathway?

<p>Control points (B)</p> Signup and view all the answers

How do some signaling pathways regulate protein activity without changing gene expression?

<p>By altering protein structures directly (C)</p> Signup and view all the answers

What contributes to the specificity of signaling responses among different pathways?

<p>Scaffolding proteins (D)</p> Signup and view all the answers

What is an important aspect of the regulation of signaling pathways?

<p>Signal termination (D)</p> Signup and view all the answers

What is a consequence of improper functioning of signaling pathways?

<p>Development of cancer (B)</p> Signup and view all the answers

What cellular response can be influenced by signals like epinephrine?

<p>Breakdown of glycogen (B)</p> Signup and view all the answers

What role do scaffolding proteins play in cell signaling?

<p>They hold multiple relay proteins together. (A)</p> Signup and view all the answers

How do different cells respond to the same signaling molecules?

<p>Their responses vary due to differences in their protein sets. (B)</p> Signup and view all the answers

What is the significance of branching pathways in cell signaling?

<p>They economize on producing different proteins. (C)</p> Signup and view all the answers

What is the effect of scaffolding proteins in mouse brain cells?

<p>They organize several kinases at an activated receptor. (A)</p> Signup and view all the answers

What role does cross-talk between signaling pathways play in cellular responses?

<p>It can modulate a single response from different signals. (C)</p> Signup and view all the answers

What is a primary function of cascades of molecular interactions in cell signaling?

<p>To relay signals from receptors to target molecules (D)</p> Signup and view all the answers

What benefit do multistep signal transduction pathways provide?

<p>The possibility of amplifying the signal (D)</p> Signup and view all the answers

What happens when a signaling molecule binds to its receptor?

<p>It triggers the first step in a signal transduction pathway (A)</p> Signup and view all the answers

How do relay molecules function in signal transduction?

<p>They relay signals and are often proteins (A)</p> Signup and view all the answers

What occurs after the steroid hormone binds to its receptor protein?

<p>The hormone-receptor complex enters the nucleus (B)</p> Signup and view all the answers

Why is a cell-surface receptor protein not needed for steroid hormones?

<p>They can pass through the plasma membrane (A)</p> Signup and view all the answers

What role does the protein act as after the binding of aldosterone in the nucleus?

<p>A transcription factor (A)</p> Signup and view all the answers

What is the outcome of mRNA that is transcribed from the gene activated by aldosterone?

<p>It is translated into a specific protein (D)</p> Signup and view all the answers

What is the primary role of protein kinases in phosphorylation?

<p>To transfer phosphate groups from ATP to proteins (C)</p> Signup and view all the answers

What happens to a protein after it is phosphorylated?

<p>It changes shape and may become active (C)</p> Signup and view all the answers

Which amino acids are primarily targeted by serine/threonine kinases?

<p>Serines and Threonines (D)</p> Signup and view all the answers

What is the function of protein phosphatases?

<p>To remove phosphate groups from proteins (B)</p> Signup and view all the answers

In a phosphorylation cascade, what typically happens after one protein activates another?

<p>The activated protein phosphorylates the next protein (B)</p> Signup and view all the answers

What would be a direct consequence of a mutation in protein kinase 3 that prevents its phosphorylation?

<p>The entire phosphorylation cascade would be halted (C)</p> Signup and view all the answers

What results from the action of both phosphorylation and dephosphorylation on proteins?

<p>Regulation of protein activity and availability (B)</p> Signup and view all the answers

How do phosphorylation cascades benefit cellular signaling?

<p>They allow for a rapid and amplified signaling response (A)</p> Signup and view all the answers

What is the chief caspase in nematodes like C. elegans?

<p>Ced-3 (A)</p> Signup and view all the answers

Which protein acts as a brake in the apoptosis process of C. elegans?

<p>Ced-9 (B)</p> Signup and view all the answers

How is apoptosis regulated in C. elegans?

<p>At the protein activity level (D)</p> Signup and view all the answers

What happens when a death signal is received by C. elegans?

<p>Ced-9 is deactivated (D)</p> Signup and view all the answers

What key proteins are essential for the apoptosis process in C. elegans?

<p>Ced-3 and Ced-4 (D)</p> Signup and view all the answers

How many types of caspases do humans have in their apoptosis pathways?

<p>15 (C)</p> Signup and view all the answers

What function do caspases serve in the process of apoptosis?

<p>They fragment cell components (A)</p> Signup and view all the answers

What distinguishes the apoptotic process of C. elegans from that of mammals?

<p>The complexity of the pathways (D)</p> Signup and view all the answers

Flashcards

Cell Signaling

The process of communication between cells using chemical signals.

Signaling Molecules

Chemical messengers used by cells to communicate.

Mating Factors

Signaling molecules yeast cells use to identify mates.

Quorum Sensing

A way bacteria coordinate behavior based on cell number.

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Yeast Mating Types

Two types of yeast cells ('a' and 'α') that identify and fuse with the opposite type.

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Fruiting Body

Structure formed by bacteria to protect spores during scarcity.

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Receptor

A protein that responds to a specific signal molecule.

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Myxobacteria

Bacteria that use quorum sensing for spore formation.

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Receptor Protein

A protein that binds to a signaling molecule and initiates a cellular response.

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Transduction

The second stage of cell signaling, where the receptor protein's shape change initiates a series of reactions that convert the signal.

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Cellular Response

The final stage of cell signaling, where the signal triggers a specific action in the target cell.

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Target Cell

A cell that has receptors specific to a signaling molecule.

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G protein-coupled receptors (GPCRs)

A type of transmembrane receptor protein involved in signal transduction.

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Cell-surface receptor protein

A protein found on the surface of a cell membrane that binds to signaling molecules and triggers intracellular responses.

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Ligand-gated Ion Channel

A type of transmembrane receptor that opens a gate to allow ions to pass through when a signaling molecule (ligand) binds to it.

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How do Ligand-gated Ion Channels work?

When a signaling molecule binds, the receptor changes shape, opening the gate for specific ions to enter the cell, altering the cell's internal ion concentration. This change can directly affect the cell's activity.

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What happens when the ligand detaches?

Once the ligand detaches from the receptor, the gate closes, preventing further ion flow into the cell.

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Ion Channels in the Nervous System

Neurotransmitters released at a synapse bind to ligand-gated ion channels on the receiving nerve cell, triggering an electrical signal.

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Intracellular Receptor

A receptor protein located within the cytoplasm or nucleus of a cell that binds to signaling molecules that can cross the cell membrane.

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Types of Intracellular Signaling Molecules

Steroid hormones, thyroid hormones, and nitric oxide (NO) are examples of signaling molecules that can pass through the cell membrane.

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How do Intracellular Receptors work?

Once inside the cell, the signaling molecule binds to the receptor, forming a complex that triggers a response, often turning genes on or off.

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Specificity of Intracellular Receptors

Only cells with the specific receptor for a given signaling molecule will respond to it, ensuring targeted action.

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Signal Transduction

The process of converting a signal from outside the cell to a specific response inside the cell.

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Relay Molecules

Proteins that pass a signal along a signaling pathway. They are often activated by adding or removing a phosphate group.

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Signal Amplification

A mechanism where a small signal is amplified by multiple steps in a signaling pathway, resulting in a stronger response.

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Steroid Hormone

A lipid-based signaling molecule that can pass through the plasma membrane and bind to receptors inside the cell.

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Transcription Factor

A protein that binds to DNA and regulates gene expression by controlling the transcription of genes into mRNA.

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Why doesn't a steroid hormone need a cell-surface receptor?

Steroid hormones are lipid-soluble, meaning they can pass directly through the phospholipid bilayer of the plasma membrane and enter the cell.

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How does the hormone-receptor complex activate gene transcription?

The complex binds to specific DNA sequences called promoters, which are located near the start of genes. This binding promotes the recruitment of RNA polymerase, which then initiates transcription of the gene into mRNA.

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Protein Phosphorylation

The process of adding a phosphate group to a protein, often changing its shape and activity.

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Protein Kinase

An enzyme that transfers a phosphate group from ATP to a protein, often activating it.

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What type of amino acids are phosphorylated by serine/threonine kinases?

Serine and threonine amino acids.

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Protein Phosphorylation Cascade

A series of protein kinases where one activates another, with each activating a different protein.

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Dephosphorylation

The process of removing a phosphate group from a protein, often deactivating it.

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Protein Phosphatase

An enzyme that removes phosphate groups from proteins, often deactivating them.

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What happens to a protein after dephosphorylation?

It becomes inactive and available to be reused.

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Why is a phosphorylation cascade important?

It amplifies a signal, allowing a small initial signal to have a large effect on the cell.

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Nuclear Responses

Cellular responses to signals that involve changes inside the nucleus, often affecting gene expression.

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Cytoplasmic Responses

Cellular responses to signals that occur outside the nucleus, directly affecting proteins and processes in the cytoplasm.

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Control Points

Key steps in a signaling pathway where the response can be adjusted or regulated.

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Scaffolding Proteins

Proteins that organize and bring together signaling molecules, increasing signaling efficiency.

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Signal Termination

The process of shutting down a signal after its job is done.

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Why is signal termination important?

Signal termination ensures appropriate cellular responses and prevents uncontrolled reactions, contributing to cell homeostasis.

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Specificity in Cell Signaling

Different cells respond uniquely to the same signal due to variations in their protein composition. This allows for tailored responses based on cell type and function.

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How do cells respond differently to the same signal?

Cells have different sets of proteins, including receptors, relay proteins, and effector proteins, which determine their unique responses to a signal.

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What is the role of glycogen phosphorylase?

An enzyme activated during signaling that breaks down glycogen into glucose 1-phosphate, a precursor for energy production.

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How many glucose molecules are released per signaling molecule?

This is unanswerable without the details presented in Figure 11.16. The number of released glucose molecules is amplified through a cascade of reactions.

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Branched Signaling Pathways

A single signaling molecule can trigger multiple relay proteins and second messengers, leading to a complex network of responses. Different pathways can converge to regulate a single response.

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Signaling Efficiency: Scaffolding Proteins

Large relay proteins that organize and bring together multiple proteins involved in a signaling pathway, enhancing the speed and accuracy of signal transfer.

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Cross-Talk between Pathways

Interaction between different signaling pathways, allowing for a coordinated and integrated cellular response.

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How do cells economize on protein production?

Cells utilize a limited number of proteins in different combinations to participate in multiple signaling pathways, reducing the need for a large number of unique proteins.

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Apoptosis

Programmed cell death, a controlled process where cells self-destruct in a controlled manner.

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Ced-3 and Ced-4

Two key proteins essential for apoptosis in C. elegans, they are inactive until a death signal is received.

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Ced-9

A regulatory protein that inhibits Ced-3 and Ced-4, preventing apoptosis.

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Apoptotic Pathway

A sequence of events initiated by a death signal, leading to activation of caspases and cell death.

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Caspases

Proteases and nucleases that fragment cell components during apoptosis.

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Ced-3 in Nematodes

The main caspase in C. elegans, responsible for carrying out the cell death program.

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Mammalian Apoptosis

More complex than in C. elegans, involving multiple caspases and various pathways depending on cell type and signal.

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Comparison to Mammals

The basic process of apoptosis is similar in C. elegans and mammals, but mammals have more intricate pathways.

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What is the role of calcium ions in cell signaling?

Calcium ions (Ca²⁺) act as a crucial intracellular messenger. Their concentration changes in response to signals, triggering various cellular responses.

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What are second messengers?

Small molecules that relay signals within a cell, amplifying and spreading the signal from the receptor to target proteins.

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What is IP₃?

Inositol trisphosphate (IP₃) is a second messenger that triggers the release of calcium ions from the endoplasmic reticulum (ER).

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What is DAG?

Diacylglycerol (DAG) is a second messenger involved in activating protein kinase C, another important signaling pathway.

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How does IP₃ initiate calcium release?

IP₃ binds to IP₃-gated calcium channels on the ER membrane, opening the channels and allowing calcium ions to flow out into the cytosol.

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What are the main steps of calcium signaling pathways initiated by G protein-coupled receptors?

  1. Signaling molecule binds to the receptor. 2. Receptor activates phospholipase C. 3. Phospholipase C cleaves PIP₂ into DAG and IP₃. 4. IP₃ diffuses and binds to ER channels. 5. Calcium ions flow out of the ER. 6. Calcium activates proteins, triggering responses.
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How does calcium signaling illustrate signal transduction?

Signal transduction involves converting a signal from outside the cell into a cellular response. In calcium signaling, a signal from a receptor is amplified and relayed within the cell.

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What other types of receptors can initiate calcium signaling?

Receptor tyrosine kinases can also activate this pathway, demonstrating its versatility in different signaling situations.

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