Podcast
Questions and Answers
What initiates the process of transduction in the signaling pathway?
What initiates the process of transduction in the signaling pathway?
- The release of epinephrine into the bloodstream
- The binding of the signaling molecule to a receptor protein (correct)
- The cellular response triggered by the signal
- The change of shape in the receptor protein
What is the primary role of cell-surface receptor proteins in signaling?
What is the primary role of cell-surface receptor proteins in signaling?
- To block unwanted signaling molecules
- To absorb signaling molecules from the environment
- To catalyze cellular responses directly
- To transmit information from outside the cell to the inside (correct)
Which stage follows reception in the signaling process?
Which stage follows reception in the signaling process?
- Translation
- Translocation
- Transduction (correct)
- Transcription
Which of the following is a type of receptor protein mentioned?
Which of the following is a type of receptor protein mentioned?
What happens to the receptor protein upon binding of a signaling molecule?
What happens to the receptor protein upon binding of a signaling molecule?
What is the final stage of the signaling process?
What is the final stage of the signaling process?
What commonly results from malfunctions of receptor proteins?
What commonly results from malfunctions of receptor proteins?
How do water-soluble signaling molecules generally interact with cells?
How do water-soluble signaling molecules generally interact with cells?
What is the initial step in the process of cell signaling?
What is the initial step in the process of cell signaling?
What occurs after the binding of signaling molecules to cell receptors?
What occurs after the binding of signaling molecules to cell receptors?
What are the two mating types of yeast cells known as?
What are the two mating types of yeast cells known as?
What specific process do Myxobacteria use to coordinate behavior when nutrients are scarce?
What specific process do Myxobacteria use to coordinate behavior when nutrients are scarce?
What is the fused cell from mating yeast cells called?
What is the fused cell from mating yeast cells called?
What do the signaling molecules secreted by yeast cells do?
What do the signaling molecules secreted by yeast cells do?
What structure do Myxobacteria form in response to nutrient scarcity?
What structure do Myxobacteria form in response to nutrient scarcity?
What is the significance of quorum sensing in bacterial populations?
What is the significance of quorum sensing in bacterial populations?
What occurs when a ligand binds to a ligand-gated ion channel?
What occurs when a ligand binds to a ligand-gated ion channel?
What is the primary function of ligand-gated ion channels in the nervous system?
What is the primary function of ligand-gated ion channels in the nervous system?
Where are intracellular receptor proteins primarily located?
Where are intracellular receptor proteins primarily located?
What type of molecules can typically bind to intracellular receptors?
What type of molecules can typically bind to intracellular receptors?
What happens to the receptor protein after a hormone binds to an intracellular receptor?
What happens to the receptor protein after a hormone binds to an intracellular receptor?
How does the process of ligand binding affect the concentration of ions inside a cell?
How does the process of ligand binding affect the concentration of ions inside a cell?
What role do voltage-gated ion channels play in the nervous system?
What role do voltage-gated ion channels play in the nervous system?
What is required for a ligand-gated ion channel to open?
What is required for a ligand-gated ion channel to open?
What is the primary role of calcium ions in cellular function?
What is the primary role of calcium ions in cellular function?
Which molecule is generated by phospholipase C during calcium signaling?
Which molecule is generated by phospholipase C during calcium signaling?
How does IP₃ contribute to calcium signaling pathways?
How does IP₃ contribute to calcium signaling pathways?
What happens to calcium ions when they flow out of the ER?
What happens to calcium ions when they flow out of the ER?
What two second messengers are involved in calcium signaling pathways?
What two second messengers are involved in calcium signaling pathways?
Where does the signaling molecule bind to initiate the calcium signaling pathway?
Where does the signaling molecule bind to initiate the calcium signaling pathway?
What initiates the activation of phospholipase C in the calcium signaling pathway?
What initiates the activation of phospholipase C in the calcium signaling pathway?
What is the primary role of glycogen phosphorylase in the signaling pathway initiated by epinephrine?
What is the primary role of glycogen phosphorylase in the signaling pathway initiated by epinephrine?
What is the result of a small change in cytosolic calcium ion concentration?
What is the result of a small change in cytosolic calcium ion concentration?
How does the cell amplify the signal received from epinephrine?
How does the cell amplify the signal received from epinephrine?
What determines the different responses of cells to the same signaling molecule?
What determines the different responses of cells to the same signaling molecule?
What is one potential outcome of activating multiple molecules of G protein by a single receptor protein?
What is one potential outcome of activating multiple molecules of G protein by a single receptor protein?
Which of the following best describes the relationship between different proteins and cellular response?
Which of the following best describes the relationship between different proteins and cellular response?
What is a primary mechanism by which signaling pathways affect cellular functions?
What is a primary mechanism by which signaling pathways affect cellular functions?
What is the role of transcription factors in signaling pathways?
What is the role of transcription factors in signaling pathways?
Which process allows for amplification of the initial signal in a signaling pathway?
Which process allows for amplification of the initial signal in a signaling pathway?
How do some signaling pathways regulate protein activity without changing gene expression?
How do some signaling pathways regulate protein activity without changing gene expression?
What contributes to the specificity of signaling responses among different pathways?
What contributes to the specificity of signaling responses among different pathways?
What is an important aspect of the regulation of signaling pathways?
What is an important aspect of the regulation of signaling pathways?
What is a consequence of improper functioning of signaling pathways?
What is a consequence of improper functioning of signaling pathways?
What cellular response can be influenced by signals like epinephrine?
What cellular response can be influenced by signals like epinephrine?
What role do scaffolding proteins play in cell signaling?
What role do scaffolding proteins play in cell signaling?
How do different cells respond to the same signaling molecules?
How do different cells respond to the same signaling molecules?
What is the significance of branching pathways in cell signaling?
What is the significance of branching pathways in cell signaling?
What is the effect of scaffolding proteins in mouse brain cells?
What is the effect of scaffolding proteins in mouse brain cells?
What role does cross-talk between signaling pathways play in cellular responses?
What role does cross-talk between signaling pathways play in cellular responses?
What is a primary function of cascades of molecular interactions in cell signaling?
What is a primary function of cascades of molecular interactions in cell signaling?
What benefit do multistep signal transduction pathways provide?
What benefit do multistep signal transduction pathways provide?
What happens when a signaling molecule binds to its receptor?
What happens when a signaling molecule binds to its receptor?
How do relay molecules function in signal transduction?
How do relay molecules function in signal transduction?
What occurs after the steroid hormone binds to its receptor protein?
What occurs after the steroid hormone binds to its receptor protein?
Why is a cell-surface receptor protein not needed for steroid hormones?
Why is a cell-surface receptor protein not needed for steroid hormones?
What role does the protein act as after the binding of aldosterone in the nucleus?
What role does the protein act as after the binding of aldosterone in the nucleus?
What is the outcome of mRNA that is transcribed from the gene activated by aldosterone?
What is the outcome of mRNA that is transcribed from the gene activated by aldosterone?
What is the primary role of protein kinases in phosphorylation?
What is the primary role of protein kinases in phosphorylation?
What happens to a protein after it is phosphorylated?
What happens to a protein after it is phosphorylated?
Which amino acids are primarily targeted by serine/threonine kinases?
Which amino acids are primarily targeted by serine/threonine kinases?
What is the function of protein phosphatases?
What is the function of protein phosphatases?
In a phosphorylation cascade, what typically happens after one protein activates another?
In a phosphorylation cascade, what typically happens after one protein activates another?
What would be a direct consequence of a mutation in protein kinase 3 that prevents its phosphorylation?
What would be a direct consequence of a mutation in protein kinase 3 that prevents its phosphorylation?
What results from the action of both phosphorylation and dephosphorylation on proteins?
What results from the action of both phosphorylation and dephosphorylation on proteins?
How do phosphorylation cascades benefit cellular signaling?
How do phosphorylation cascades benefit cellular signaling?
What is the chief caspase in nematodes like C. elegans?
What is the chief caspase in nematodes like C. elegans?
Which protein acts as a brake in the apoptosis process of C. elegans?
Which protein acts as a brake in the apoptosis process of C. elegans?
How is apoptosis regulated in C. elegans?
How is apoptosis regulated in C. elegans?
What happens when a death signal is received by C. elegans?
What happens when a death signal is received by C. elegans?
What key proteins are essential for the apoptosis process in C. elegans?
What key proteins are essential for the apoptosis process in C. elegans?
How many types of caspases do humans have in their apoptosis pathways?
How many types of caspases do humans have in their apoptosis pathways?
What function do caspases serve in the process of apoptosis?
What function do caspases serve in the process of apoptosis?
What distinguishes the apoptotic process of C. elegans from that of mammals?
What distinguishes the apoptotic process of C. elegans from that of mammals?
Flashcards
Cell Signaling
Cell Signaling
The process of communication between cells using chemical signals.
Signaling Molecules
Signaling Molecules
Chemical messengers used by cells to communicate.
Mating Factors
Mating Factors
Signaling molecules yeast cells use to identify mates.
Quorum Sensing
Quorum Sensing
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Yeast Mating Types
Yeast Mating Types
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Fruiting Body
Fruiting Body
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Receptor
Receptor
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Myxobacteria
Myxobacteria
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Receptor Protein
Receptor Protein
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Transduction
Transduction
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Cellular Response
Cellular Response
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Target Cell
Target Cell
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G protein-coupled receptors (GPCRs)
G protein-coupled receptors (GPCRs)
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Cell-surface receptor protein
Cell-surface receptor protein
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Ligand-gated Ion Channel
Ligand-gated Ion Channel
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How do Ligand-gated Ion Channels work?
How do Ligand-gated Ion Channels work?
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What happens when the ligand detaches?
What happens when the ligand detaches?
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Ion Channels in the Nervous System
Ion Channels in the Nervous System
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Intracellular Receptor
Intracellular Receptor
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Types of Intracellular Signaling Molecules
Types of Intracellular Signaling Molecules
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How do Intracellular Receptors work?
How do Intracellular Receptors work?
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Specificity of Intracellular Receptors
Specificity of Intracellular Receptors
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Signal Transduction
Signal Transduction
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Relay Molecules
Relay Molecules
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Signal Amplification
Signal Amplification
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Steroid Hormone
Steroid Hormone
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Transcription Factor
Transcription Factor
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Why doesn't a steroid hormone need a cell-surface receptor?
Why doesn't a steroid hormone need a cell-surface receptor?
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How does the hormone-receptor complex activate gene transcription?
How does the hormone-receptor complex activate gene transcription?
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Protein Phosphorylation
Protein Phosphorylation
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Protein Kinase
Protein Kinase
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What type of amino acids are phosphorylated by serine/threonine kinases?
What type of amino acids are phosphorylated by serine/threonine kinases?
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Protein Phosphorylation Cascade
Protein Phosphorylation Cascade
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Dephosphorylation
Dephosphorylation
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Protein Phosphatase
Protein Phosphatase
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What happens to a protein after dephosphorylation?
What happens to a protein after dephosphorylation?
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Why is a phosphorylation cascade important?
Why is a phosphorylation cascade important?
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Nuclear Responses
Nuclear Responses
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Cytoplasmic Responses
Cytoplasmic Responses
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Control Points
Control Points
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Scaffolding Proteins
Scaffolding Proteins
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Signal Termination
Signal Termination
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Why is signal termination important?
Why is signal termination important?
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Specificity in Cell Signaling
Specificity in Cell Signaling
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How do cells respond differently to the same signal?
How do cells respond differently to the same signal?
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What is the role of glycogen phosphorylase?
What is the role of glycogen phosphorylase?
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How many glucose molecules are released per signaling molecule?
How many glucose molecules are released per signaling molecule?
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Branched Signaling Pathways
Branched Signaling Pathways
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Signaling Efficiency: Scaffolding Proteins
Signaling Efficiency: Scaffolding Proteins
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Cross-Talk between Pathways
Cross-Talk between Pathways
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How do cells economize on protein production?
How do cells economize on protein production?
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Apoptosis
Apoptosis
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Ced-3 and Ced-4
Ced-3 and Ced-4
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Ced-9
Ced-9
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Apoptotic Pathway
Apoptotic Pathway
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Caspases
Caspases
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Ced-3 in Nematodes
Ced-3 in Nematodes
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Mammalian Apoptosis
Mammalian Apoptosis
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Comparison to Mammals
Comparison to Mammals
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What is the role of calcium ions in cell signaling?
What is the role of calcium ions in cell signaling?
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What are second messengers?
What are second messengers?
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What is IP₃?
What is IP₃?
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What is DAG?
What is DAG?
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How does IP₃ initiate calcium release?
How does IP₃ initiate calcium release?
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What are the main steps of calcium signaling pathways initiated by G protein-coupled receptors?
What are the main steps of calcium signaling pathways initiated by G protein-coupled receptors?
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How does calcium signaling illustrate signal transduction?
How does calcium signaling illustrate signal transduction?
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What other types of receptors can initiate calcium signaling?
What other types of receptors can initiate calcium signaling?
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