term 1- week 8
10 Questions
2 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

  1. Which of the following results would you predict to occur with a mutation that changes the phosphorylatable Tyr of the Insulin Receptor (cannot be phosphorylated)?

  • constant uptake of glucose from the bloodstream
  • upregulated protein synthesis, causing upregulated cell growth and division
  • inability to take up glucose from the bloodstream (correct)
  • B and C
  • ) Which of the following proteins is required for the GLUT4 transporter to be localized on the plasma membrane for glucose uptake

  • . PI-3K (correct)
  • Glycogen Synthase
  • PI-PLC
  • . GSK3
  • . When insulin binds to its receptor, all of the following happen EXCEPT:

  • There is autophosphorylation of the tyrosine residues on the beta subunit
  • IRS1 becomes phosphorylated by the insulin receptor
  • Ras releases GTP and binds to GDP (correct)
  • PKB phosphorylates GSK3/Inactive GSK3 promotes glycogen synthesis
  • Which second messenger signals the release of Ca++ from the endoplasmic reticulum?

    <p>. Inositol triphosphate (IP3)</p> Signup and view all the answers

    1. The diagram shows some biochemical pathways in a liver cell, some of which are reversible. Five reactions whose rate in a certain direction can be changed by the presence of a hormone are labelled 1 – 5. Each number relates to the direction of the arrow nearest to the number. Which numbered reactions have their rate increased in the presence of insulin?

    <p>1,2 and 5</p> Signup and view all the answers

    When epinephrine or glucagon bind to their receptor on the membrane and activate the cAMP cascade, all of the following happen EXCEPT

    <p>G-protein is freed from its tether and diffuses away from the cell membrane</p> Signup and view all the answers

    What type of protein is Ras?

    <p>A small monomeric GTPase switch protein</p> Signup and view all the answers

    ) Concerning the insulin receptor and the IRS protein:

    <p>d)The IRS binds to the phosphorylated beta-chains of the insulin receptor</p> Signup and view all the answers

    ) Which of the following enzymes is activated by cyclic AMP, passing on the hormonal signal?

    <p>Protein kinase A</p> Signup and view all the answers

    Which pathway for glycogen breakdown in the liver would prevent the cell from breaking down glycogen in response to epinephrine

    <p>C. One that prevents it from binding GTP</p> Signup and view all the answers

    Study Notes

    Insulin Receptor and Signaling

    • A mutation that changes the phosphorylatable Tyr of the Insulin Receptor prevents phosphorylation.
    • Insulin binding to its receptor triggers all events except one (to be specified).

    GLUT4 Transporter and Glucose Uptake

    • The presence of a specific protein is required for GLUT4 transporter localization on the plasma membrane for glucose uptake.

    Second Messenger Signaling

    • A specific second messenger signals the release of Ca++ from the endoplasmic reticulum.

    Hormone Regulation of Biochemical Pathways

    • In a liver cell, certain reactions (1-5) have their rate changed by the presence of a hormone.
    • Insulin increases the rate of specific reactions (to be specified).

    Epinephrine and Glucagon Signaling

    • When epinephrine or glucagon bind to their receptor, all events occur except one (to be specified).
    • The cAMP cascade is activated by epinephrine or glucagon binding.

    Ras Protein and Signaling

    • Ras is a type of protein involved in signaling pathways.

    cAMP-activated Enzymes

    • A specific enzyme is activated by cyclic AMP, passing on the hormonal signal.

    Glycogen Breakdown Regulation

    • A specific pathway for glycogen breakdown in the liver prevents the cell from breaking down glycogen in response to epinephrine.
    • Insulin and IRS protein interactions play a crucial role in glycogen metabolism regulation.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Test your knowledge on cell signaling pathways with this quiz! Identify the different types of signaling proteins including tyrosine kinase, monomeric GTPase switch protein, serine-threonine kinase, and G protein coupled receptor. Sharpen your understanding of how these proteins function in cellular communication and their roles in various signaling pathways.

    More Like This

    Insulin Signaling
    35 questions

    Insulin Signaling

    SharpChalcedony avatar
    SharpChalcedony
    IRS-1 Signaling Pathway
    10 questions

    IRS-1 Signaling Pathway

    SportyDramaticIrony9404 avatar
    SportyDramaticIrony9404
    Use Quizgecko on...
    Browser
    Browser