Cell Plasma Membrane Structure and Function

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Questions and Answers

What is the primary function of the Na+/K+ pump in active transport?

  • To maintain the electrochemical gradients by pumping Na+ and K+ ions. (correct)
  • To hydrolyze ATP for energy in passive transport mechanisms.
  • To facilitate passive diffusion of ions across the membrane.
  • To transport glucose and amino acids into the cell.

Which of the following best describes secondary active transport?

  • The regulation of ion concentration solely through the Na+/K+ pump.
  • Passive transport utilizing ion channels without energy input.
  • Movement of substances against their concentration gradient coupled with Na+ flow. (correct)
  • Transport of substances against their concentration gradient using direct ATP hydrolysis.

In the context of active transport, which mechanism requires ATP hydrolysis directly?

  • Antiport transport mechanisms.
  • Primary active transport mechanisms. (correct)
  • Symport transport mechanisms.
  • Secondary active transport mechanisms.

What is the outcome of the action of the Na+/K+ pump on ion distribution across the cell membrane?

<p>Establishes a steep Na+ concentration gradient favoring its exit from the cell. (D)</p> Signup and view all the answers

Which scenario exemplifies an antiport mechanism in secondary active transport?

<p>Na+ ions moving into the cell while H+ ions move out. (C)</p> Signup and view all the answers

What feature of phospholipids makes them suitable for forming a bilayer in the plasma membrane?

<p>They are amphipathic with both hydrophilic and hydrophobic components. (A)</p> Signup and view all the answers

Which function of the cell membrane involves the use of glycoproteins and glycolipids?

<p>Cell recognition (D)</p> Signup and view all the answers

What is true about the fatty acid tails of phospholipids in the membrane?

<p>They can vary in length between 12-20 carbons. (D)</p> Signup and view all the answers

Which of the following is NOT a function of the plasma membrane?

<p>Formation of energy in the mitochondria (D)</p> Signup and view all the answers

What effect does the aqueous environment have on the formation of the phospholipid bilayer?

<p>It makes bilayer formation more energetically favorable. (D)</p> Signup and view all the answers

Which of the following phospholipids is known to be the most abundant in cell membranes?

<p>Phosphatidylcholine (B)</p> Signup and view all the answers

Which term describes the selective barrier property of the cell plasma membrane?

<p>Selectively permeable (A)</p> Signup and view all the answers

Which function of the cell membrane is primarily facilitated by proteins embedded within the bilayer?

<p>Transport (A)</p> Signup and view all the answers

Which factor contributes to increased membrane fluidity?

<p>Short fatty acid chains (C)</p> Signup and view all the answers

What is the function of cholesterols in the plasma membrane?

<p>Reducing membrane fluidity (C)</p> Signup and view all the answers

Which lipid is primarily found on the cytosolic side and is crucial for activating protein kinase C?

<p>Phosphatidylserine (C)</p> Signup and view all the answers

What characteristic differentiates integral membrane proteins from peripheral membrane proteins?

<p>Integral proteins can span the bilayer (A)</p> Signup and view all the answers

Which function do receptors on transmembrane proteins serve?

<p>Binding ligands for signal transduction (D)</p> Signup and view all the answers

How does facilitated diffusion differ from active transport?

<p>Facilitated diffusion requires membrane proteins (D)</p> Signup and view all the answers

What is a characteristic of membrane asymmetry?

<p>Different lipid compositions exist on each side of the membrane (C)</p> Signup and view all the answers

Which type of protein is involved in transport across membranes?

<p>Transporters like channel proteins (D)</p> Signup and view all the answers

What is the role of glycoproteins in the membrane?

<p>Cell-cell recognition (B)</p> Signup and view all the answers

Which of the following statements incorrectly describes peripheral membrane proteins?

<p>Can span the entire membrane (A)</p> Signup and view all the answers

What happens during apoptosis related to phosphatidylserine?

<p>It is released into the extracellular space (B)</p> Signup and view all the answers

Which of the following correctly describes facilitated diffusion?

<p>Occurs through channel or carrier proteins (A)</p> Signup and view all the answers

What is the impact of fatty acid saturation on membrane fluidity?

<p>Unsaturated fatty acids facilitate looser packing (D)</p> Signup and view all the answers

What is the primary role of transport proteins in the plasma membrane?

<p>Facilitating movement of substances (D)</p> Signup and view all the answers

Flashcards

Primary Active Transport

A type of active transport that uses energy directly from ATP hydrolysis to move substances against their concentration gradient.

Na+/K+ pump

A key example of primary active transport. It pumps 3 Na+ ions out of the cell and 2 K+ ions into the cell.

Secondary Active Transport

A type of active transport that indirectly uses energy from ATP hydrolysis. It couples the movement of one substance down its concentration gradient with the movement of another substance against its concentration gradient.

Symport

A type of secondary active transport where two substances move in the same direction across the membrane.

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Antiport

A type of secondary active transport where two substances move in opposite directions across the membrane.

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What is the cell membrane?

The cell membrane is a selectively permeable barrier that controls what enters and leaves the cell. It's made up of a mix of lipids (like phospholipids) and proteins.

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What is a phospholipid?

Phospholipids are the most abundant type of lipid in cell membranes. They have a hydrophilic head (attracted to water) and two hydrophobic tails (repelled by water).

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How do phospholipids form a membrane?

Phospholipids arrange themselves into a bilayer in water. The hydrophilic heads face outwards (towards water), and the hydrophobic tails face inwards (away from water).

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What does 'selectively permeable' mean?

The cell membrane is selectively permeable, meaning some substances can pass through easily, while others are blocked. This controls the environment inside the cell.

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Why is cell recognition important?

The cell membrane is also involved in cell recognition. This is how the immune system tells its own cells from foreign invaders.

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What is the role of membrane potential?

The arrangement of molecules in the cell membrane creates a charge difference across the membrane (called the membrane potential). This is crucial for many cell processes.

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How do enzymes function in the cell membrane?

Enzymes are proteins that help speed up chemical reactions. Some enzymes sit within the cell membrane and assist with important processes.

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What is the role of the cell membrane in communication?

The cell membrane plays a critical role in communication between cells. It receives signals, interprets them, and then triggers responses within the cell.

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Membrane Fluidity

The plasma membrane is a dynamic structure where components like lipids and proteins move laterally across the membrane.

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Facilitated Diffusion

The movement of molecules or ions across a membrane from a region of high concentration to a region of low concentration, facilitated by membrane transport proteins. It does not require energy from ATP.

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Active Transport

The movement of substances across a membrane against their concentration gradient, requiring energy from ATP hydrolysis.

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Transmembrane Protein

A type of membrane protein that spans the entire lipid bilayer, connecting the extracellular side to the intracellular side.

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Single-pass Transmembrane Protein

Integral membrane proteins that extend across the membrane only once. Often form a-helical structures.

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Multi-pass Transmembrane Protein

Integral membrane proteins that traverse the membrane multiple times, forming multiple a-helical segments.

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B-barrel Protein

A type of transmembrane protein that forms a barrel-like structure in the membrane, allowing molecules to pass through.

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Lipid-linked Proteins

Integral membrane proteins that are attached to the membrane via lipid molecules.

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Peripheral Membrane Proteins

Proteins that associate with the membrane through non-covalent interactions, and can be easily removed.

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Receptor Function

Cellular communication involves signalling molecules binding to specific receptor proteins located on the membrane.

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Membrane Asymmetry

The arrangement of phospholipid molecules in a membrane is not symmetrical, with different lipid compositions on the cytosolic and extracellular sides.

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Phosphatidylserine

A phospholipid found primarily on the cytosolic side of the membrane, plays roles in protein kinase C activation and signaling during apoptosis.

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Phosphatidylinositol

A type of phospholipid found predominantly on the cytosolic side, involved in signaling pathways and protein binding.

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Glycolipids

Lipids with carbohydrate groups attached, found exclusively on the extracellular side of the membrane. They play significant roles in cell recognition and signaling.

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Anchoring Proteins

A type of protein that links the extracellular matrix to the cytoskeleton, allowing for cell mobility.

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Study Notes

Cell Plasma Membrane Structure and Function

  • The cell plasma membrane is a selectively permeable barrier, protecting the cell's interior.
  • Composed of a lipid bilayer with embedded proteins.
  • Each lipid molecule has a hydrophobic tail and a hydrophilic head.
  • The bilayer's formation is energetically favorable in aqueous environments. The closed, round shape minimizes exposure of hydrophobic tails to water.

Cell Membrane Functions

  • Cell recognition: Glycolipids and glycoproteins identify cells to the immune system.
  • Intracellular environment: Maintains membrane potential.
  • Protection: Acts as a barrier.
  • Transport: Proteins facilitate ion movement.
  • Catalytic function: Enzymes embedded within the bilayer catalyze reactions.
  • Cellular communication: Signal transduction occurs through the membrane.

Phospholipids

  • The most abundant lipids in cell membranes.
  • Examples include phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol, and sphingomyelin.
  • Amphipathic: Possess both hydrophobic (fatty acid tails) and hydrophilic (phosphate head) regions.
  • Fatty acid chains vary in length (12-20 carbons). Often one saturated, one unsaturated.

Membrane Fluidity

  • The membrane is fluid, allowing for lateral diffusion of lipids and proteins.
  • Crucial for cell signaling, cell division, and membrane fusion.
  • Factors affecting fluidity:
    • Shorter fatty acid chains increase fluidity.
    • More unsaturated fatty acid chains enhance fluidity
    • Cholesterol decreases fluidity by restricting movement of other molecules. Cholesterol's structure consists of four hydrophobic rings and a small polar region.

Membrane Asymmetry

  • Lipid composition on the intracellular and extracellular faces differs.
  • More phosphatidylserine on the cytosolic side. Phosphatidylserine's movement to the extracellular side signals apoptosis.
  • Phosphatidylinositol and other signaling lipids are on the cytosolic side.
  • Glycolipids are exclusively on the extracellular side.

Membrane Proteins

  • Integral proteins: Permanently embedded in the bilayer, often transmembrane proteins.
    • Transmembrane proteins can be single-pass alpha-helices, multiple-pass alpha-helices, or beta-barrels.
    • Or lipid-linked.
  • Peripheral proteins: Non-covalently bound to the membrane, easily removed.

Membrane Protein Functions

  • Transporters: Channels and carrier proteins facilitate movement across the membrane.
  • Anchors: Integrins link ECM to the cytoskeleton, aiding motility.
  • Receptors: Bind ligands, transmitting signals.
  • Glycoproteins: Cell-cell recognition.
  • Enzymes: Catalyze reactions.
  • Intracellular joining: Joins cells together (e.g., gap junctions).
  • Signal transduction molecules: Amplify and pass on signals.

Transport Across Membranes

  • Facilitated diffusion: Passive movement down a concentration gradient using proteins (channels or uniporters). Large or polar molecules needing assistance.
  • Active transport: Movement against a concentration gradient, requiring ATP.
    • Primary active transport: Directly uses ATP hydrolysis. Example: Na+/K+ pump.
    • Secondary active transport: Uses the gradient established by primary active transport (e.g., Na+ gradient). Can be symport (same direction) or antiport (opposite direction).

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