Cell Membrane Transport Mechanisms Quiz
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Questions and Answers

What characterizes diffusion across a cell membrane?

  • It requires energy input.
  • It forms vesicles within the cell.
  • It is driven by random molecular motion. (correct)
  • It involves transport proteins.
  • Which transport mechanism allows for the ingestion of large particles like bacteria?

  • Diffusion
  • Facilitated transport
  • Phagocytosis (correct)
  • Pinocytosis
  • What is an example of a substance that combines with intrinsic factor to enter cells via endocytosis?

  • Vitamin D
  • Calcium
  • Vitamin B12 (correct)
  • Iron
  • Which of the following best describes pinocytosis?

    <p>It involves the rapid ingestion of extracellular fluid. (C)</p> Signup and view all the answers

    In which type of cells is pinocytosis particularly rapid?

    <p>Macrophages (D)</p> Signup and view all the answers

    What initiates phagocytosis in immune cells?

    <p>The interaction of antibodies with receptors (B)</p> Signup and view all the answers

    Which of the following substances is not typically internalized via endocytosis?

    <p>Small gas molecules (D)</p> Signup and view all the answers

    How does the mechanism of active transport differ from diffusion?

    <p>Active transport requires energy and involves protein carriers. (C)</p> Signup and view all the answers

    Which process facilitates the transport of glucose into cells?

    <p>Carrier-mediated diffusion (D)</p> Signup and view all the answers

    What is a key characteristic of carrier-mediated diffusion?

    <p>It is a saturable process (B)</p> Signup and view all the answers

    How is the rate of molecular movement across a barrier calculated in passive diffusion?

    <p>Rate = (C1 - C2) x Permeability coefficient x Area / Thickness (D)</p> Signup and view all the answers

    What is the primary mechanism of water transport across a semi-permeable membrane?

    <p>Osmosis (A)</p> Signup and view all the answers

    Which of the following statements about active transport is accurate?

    <p>It is a process that can be inhibited by specific inhibitors. (D)</p> Signup and view all the answers

    Which of the following mechanisms is NOT governed by Fick's law?

    <p>Carrier-mediated diffusion (A)</p> Signup and view all the answers

    Probenecid is used clinically to affect the transport of which substance?

    <p>Uric acid (B)</p> Signup and view all the answers

    What distinguishes endocytosis from other transport mechanisms?

    <p>It is an energy-dependent process. (A)</p> Signup and view all the answers

    What is the main characteristic of a lipid bilayer in relation to water molecules?

    <p>It acts as a barrier against water movement. (A)</p> Signup and view all the answers

    How does active transport differ from diffusion?

    <p>Active transport can move substances against an energy gradient. (B)</p> Signup and view all the answers

    What defines simple diffusion through a cell membrane?

    <p>It involves random movement without interaction with proteins. (C)</p> Signup and view all the answers

    What is facilitated diffusion?

    <p>Diffusion that requires a chemical binding with carrier proteins. (B)</p> Signup and view all the answers

    Which of the following substances is most likely to diffuse through the lipid bilayer easily?

    <p>Carbon dioxide (C)</p> Signup and view all the answers

    What role do small water-filled pores in capillary membranes play?

    <p>They allow passive movement of small molecules only. (B)</p> Signup and view all the answers

    Which process is governed by Fick's law?

    <p>Diffusion through watery extracellular spaces. (D)</p> Signup and view all the answers

    Which of the following describes lipid diffusion?

    <p>It allows molecules to dissolve directly in lipid structures. (B)</p> Signup and view all the answers

    What process describes the attachment of cell membrane receptors to surface ligands of a particle?

    <p>Phagocytosis (B)</p> Signup and view all the answers

    What is the function of lysosomes in phagocytosis?

    <p>To break down the phagocytized material (D)</p> Signup and view all the answers

    Which agent is NOT found in lysosomes to combat phagocytized bacteria?

    <p>Lactoferrin (C)</p> Signup and view all the answers

    What occurs immediately after a phagocytic vesicle forms within a cell?

    <p>Lysosomes attach and empty their enzymes (C)</p> Signup and view all the answers

    What happens to indigestible substances post-digestion in a phagocytic vesicle?

    <p>They are excreted through exocytosis (D)</p> Signup and view all the answers

    What do foodstuffs react with inside the cell to release energy?

    <p>Enzymes and oxygen (D)</p> Signup and view all the answers

    Which component is essential for the activation of lysosomal hydrolases?

    <p>Acidic pH of about 5.0 (A)</p> Signup and view all the answers

    What mechanism helps push the phagocytic vesicle into the cell?

    <p>Contractile proteins surrounding the vesicle (B)</p> Signup and view all the answers

    Flashcards

    Diffusion

    The movement of substances across a membrane from a high concentration area to a low concentration area, driven by random molecular motion.

    Simple Diffusion

    A type of diffusion where substances move across the membrane without the help of carrier proteins. It relies on kinetic energy and concentration gradients.

    Facilitated Diffusion

    A type of diffusion where substances require the assistance of carrier proteins to cross the membrane. The carrier protein binds to the substance and facilitates its movement.

    Active Transport

    The movement of substances across a membrane against their concentration gradient, requiring energy from the cell.

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    Aqueous Diffusion

    The movement of molecules through the watery spaces between cells or across the membrane, often through small pores.

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    Lipid Diffusion

    The movement of molecules through membranes or lipid structures, dissolving directly into the lipid bilayer.

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    Cell Membrane as a Barrier

    The cell membrane is composed of a phospholipid bilayer, which is not miscible with either the extracellular or intracellular fluid. This creates a barrier to movement of water and water-soluble substances between the two compartments.

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    Concentration Gradient

    The relative concentration of a substance inside the cell versus outside the cell. It drives simple and facilitated diffusion, but can be countered by active transport.

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    Passive Transport

    The movement of a substance through a membrane without requiring the cell to expend energy. It relies on random molecular motion and concentration gradients.

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    Phagocytosis

    The process by which cells engulf large particles, such as bacteria or cellular debris, by wrapping their membrane around them.

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    Pinocytosis

    The process by which cells engulf small particles or fluids by forming tiny vesicles through a folding of the cell membrane.

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    Endocytosis

    Large particles or substances that cannot easily cross the cell membrane are internalized through this process, which involves wrapping the membrane around the substance and forming a vesicle.

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    Receptor-mediated endocytosis

    A type of endocytosis where specific molecules bind to receptors on the cell membrane, triggering the formation of a vesicle and internalization.

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    Membrane Transport Protein

    A protein structure that spans the cell membrane, providing a pathway for specific substances to enter or exit the cell. These may be involved in active transport or facilitated diffusion.

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    Fick's Law of Diffusion

    The rate of molecule movement across a membrane is predicted by Fick's law, which considers factors like concentration gradient, permeability, area, and thickness of the barrier.

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    Carrier-mediated Diffusion

    This is a passive process where molecules move across a membrane with the help of a carrier molecule. An example is glucose uptake by cells.

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    Osmosis

    Water moves across a semi-permeable membrane from an area of high water concentration to an area of low water concentration.

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    Selective Inhibitors for Carriers

    Inhibitors of specific carriers, like probenecid, might have clinical value by affecting the transport of certain substances. For example, probenecid can increase uric acid elimination, benefiting gout patients.

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    Opsonization

    The process of attaching antibodies to the surface of a pathogen, making it easier for phagocytes to engulf and destroy it.

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    Lysosome

    A small organelle inside cells containing enzymes that digest waste products, break down pathogens, and recycle cellular components.

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    Hydrolysis

    The process of breaking down large molecules into smaller ones, such as proteins into amino acids, by enzymes.

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    Vesicle

    A membrane-bound sac inside a cell formed by the engulfment of extracellular fluid or particles.

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    Lysozyme

    An enzyme found in lysosomes that breaks down bacterial cell walls.

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    Study Notes

    Functional Systems of the Cell: Transport of Substances

    • The lipid bilayer of the cell membrane acts as a barrier, preventing the movement of water and water-soluble substances between the extracellular and intracellular fluid compartments. It is not miscible with either fluid.

    Cellular Transport

    • Passive Transport (Small Molecules):
      • Simple Diffusion: Random movement of molecules through intermolecular spaces or with carrier proteins in the membrane, driven by concentration gradient.
      • Facilitated Diffusion: Movement of molecules across a membrane with the assistance of a carrier protein, utilizing a concentration gradient. This can be through channels (nonspecific transport) or carriers (specific).
    • Active Transport (Small Molecules):
      • Movement of ions or substances against a concentration gradient, requiring energy in addition to kinetic energy (usually ATP). This involves carrier proteins.
    • Large Molecules:
      • Exocytosis: Outbound transport of large molecules using vesicles.
      • Endocytosis: Inbound transport of large molecules using vesicles. Includes phagocytosis (ingestion of large particles like bacteria or tissue debris), and pinocytosis (ingestion of minute particles and fluids).

    Diffusion

    • Diffusion is the random movement of molecules.
    • Types of diffusion through the cell membrane:
      • Simple Diffusion: Molecules move through the membrane without the help of carrier proteins.
      • Facilitated Diffusion: Molecules move through the membrane with the assistance/interaction of carrier proteins, which bind chemically to them.

    Aqueous Diffusion

    • Movement of molecules through the watery extracellular and intracellular spaces.
    • Most capillaries have small water-filled pores that allow molecules up to the size of small proteins to diffuse between blood and the extravascular space.
    • Governed by Fick's law.

    Lipid Diffusion

    • Movement of molecules through membranes and other lipid structures, occurring directly in the lipid bilayer if the molecule is lipid-soluble.
    • Examples include oxygen, nitrogen, carbon dioxide, and alcohols.
    • Governed by Fick's law.

    Fick's Law of Diffusion

    • Predicts the rate of movement of molecules across a barrier.
    • Factors for calculating rate:
      • Concentration gradient (C1 - C2).
      • Permeability coefficient
      • Area
      • Thickness

    Carrier-Mediated Diffusion

    • Movement across the membrane facilitated by a macromolecule (carrier protein).
    • Specific for certain chemical structures.
    • Saturable process.
    • Does not move against a concentration gradient (a type of passive transport).
    • Example: Glucose uptake by cells.

    Transport by Special Carriers

    • Drugs may be transported by mechanisms that carry similar endogenous substances (e.g., amino acid carriers in the blood-brain barrier).
    • Not governed by Fick's law.
    • Capacity-limited.
    • Probenecid: Selective inhibitor for uric acid transport, increasing its excretion (used in gout). Sometimes used with penicillin antibiotics to increase antibiotic blood levels and enhance their effectiveness to fight infections.

    Endocytosis

    • Involves the movement of large molecules into the cell.
    • Pinocytosis: Ingestion of minute particles and fluids.
    • Phagocytosis: Ingestion of large particles (bacteria, whole cells, or tissue debris).

    Steps of Phagocytosis

    • Attachment: Cell membrane receptors attach to surface ligands on particles.
    • Evagination: Membrane surrounds the particle.
    • Vesicle Formation: A phagocytic vesicle is formed.
    • Contraction & Separation: Cytoplasmic fibrils contract, pinching off the vesicle from the membrane.
    • The vesicle is now inside the cytoplasm

    Lysosomes

    • Digestive vesicles formed inside cells.
    • Contain acid hydrolases that digest proteins, carbohydrates, and lipids.
    • Breakdown products are released into the cytoplasm.
    • Contain bactericidal agents (lysozyme, lysoferrin, and low pH) to destroy phagocytized bacteria..
    • The remaining indigestible material forms a residual body that is eventually expelled from the cell via exocytosis

    Mitochondria

    • Site of cellular respiration.
    • Breakdown of glucose, fatty acids, and amino acids with oxygen to produce ATP (adenosine triphosphate), a high-energy compound.
    • Vital for supplying energy for cellular functions.

    Uses of ATP for Cellular Function

    • Transport: Active transport of substances through membranes.
    • Synthesis: Chemical compound synthesis throughout the cell, such as protein synthesis.
    • Mechanical work: Energy for muscle contraction.

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    Cell Membrane Transport PDF

    Description

    Test your understanding of the various mechanisms that regulate transport across cell membranes, including diffusion, endocytosis, and active transport. This quiz covers key concepts essential for studying cellular physiology and the functions of immune cells. Challenge yourself to identify the processes by which substances move in and out of cells.

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