Cell Membrane Structure and Functions
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Questions and Answers

Which statements correctly describe the functions of the cell membrane?

  • It protects the cell from toxic substances. (correct)
  • It maintains different compositions in intracellular and extracellular fluids. (correct)
  • It acts solely as a storage site for substances.
  • It allows all substances to pass through freely.
  • Which transport mechanism does not require energy input?

  • Primary active transport
  • Facilitated diffusion (correct)
  • Secondary active transport
  • Endocytosis
  • What characteristic of solutes does NOT influence their transport across the cell membrane?

  • Size of the solute
  • Concentration of the solute
  • Color of the solute (correct)
  • Charge of the solute
  • What role do integral proteins play in the cell membrane?

    <p>Facilitate the movement of solutes across the membrane. (C)</p> Signup and view all the answers

    Which type of active transport mechanism utilizes primary energy input?

    <p>Primary active transport (C)</p> Signup and view all the answers

    Which of the following accurately describes a characteristic of passive transport?

    <p>Occurs until equilibrium is reached. (A)</p> Signup and view all the answers

    What distinguishes secondary active transport from primary active transport?

    <p>It does not require ATP directly. (A)</p> Signup and view all the answers

    What is the primary composition of the cell membrane?

    <p>Phospholipid bilayer with embedded proteins. (A)</p> Signup and view all the answers

    What is the primary driving force behind the movement of particles during simple diffusion?

    <p>Equilibrium of particle distribution (B)</p> Signup and view all the answers

    Which of the following particles would most likely diffuse through the lipid bilayer without assistance?

    <p>Oxygen (O2) (A)</p> Signup and view all the answers

    Which factor does NOT influence the rate of diffusion as outlined in Fick's Law?

    <p>Color of substance (B)</p> Signup and view all the answers

    What type of channel needs a specific condition to open during facilitated diffusion?

    <p>Gated channel (D)</p> Signup and view all the answers

    How does an increase in temperature affect the rate of diffusion?

    <p>Increases the kinetic energy of particles (D)</p> Signup and view all the answers

    In cases of mutations affecting ionic channels, what physiological effects could result?

    <p>Convulsions or paralysis (A)</p> Signup and view all the answers

    According to Fick's law, what happens to the net rate of diffusion if the thickness of the membrane increases (ΔX)?

    <p>It decreases (A)</p> Signup and view all the answers

    What role do hydrated forms of ions play in diffusion through membranes?

    <p>They hinder diffusion due to their larger size (D)</p> Signup and view all the answers

    What is the main limitation in the rate of carrier mediated transport as it approaches Vmax?

    <p>Number of available carriers and rate of conformational change (B)</p> Signup and view all the answers

    In which type of solution do red blood cells not experience any change in shape?

    <p>Isotonic solution (C)</p> Signup and view all the answers

    What is the principle behind osmotic pressure?

    <p>Pressure required to prevent water from moving towards the solution with higher concentration (B)</p> Signup and view all the answers

    Which of the following correctly describes osmolality?

    <p>Concentration of all particles regardless of diffusibility (B)</p> Signup and view all the answers

    What effect occurs in red blood cells when placed in a hypotonic solution?

    <p>Cells swell and may undergo hemolysis (B)</p> Signup and view all the answers

    Which factor does NOT influence the specifics of carrier mediated transport?

    <p>Presence of temperature fluctuations (B)</p> Signup and view all the answers

    According to the Gibbs-Donnan equilibrium, what determines the concentration difference of diffusible ions across a semipermeable membrane?

    <p>Presence of non-diffusible solutes in one compartment (B)</p> Signup and view all the answers

    Which of the following describes competitive inhibition in carrier mediated transport?

    <p>Inhibition by competing for the same binding site (C)</p> Signup and view all the answers

    What primary role do pseudopodia serve in amoeba and white blood cells?

    <p>Locomotion and feeding (C)</p> Signup and view all the answers

    Which statement is true regarding passive transport mechanisms?

    <p>They operate along concentration and electrical gradients. (C)</p> Signup and view all the answers

    Which characteristic is essential for facilitated diffusion compared to simple diffusion?

    <p>It requires a carrier mediated by specific proteins. (A)</p> Signup and view all the answers

    During phagocytosis, which sequence of events occurs when a bacterium is internalized?

    <p>Pseudopodia formation, digestion, absorption, residual body formation (C)</p> Signup and view all the answers

    What primarily differentiates active transport from passive transport?

    <p>Active transport does not depend on the concentration gradient. (D)</p> Signup and view all the answers

    Which statement accurately describes the nature of electrical gradients across compartments?

    <p>All solutions are electrically neutral with equal numbers of anions and cations. (C)</p> Signup and view all the answers

    What is a primary characteristic of active transport?

    <p>Transport is mediated by carrier proteins with specificity. (B)</p> Signup and view all the answers

    In what way does the Na+ - K+ pump contribute to cellular functions?

    <p>It generates a high K+ concentration inside the cell, which aids cell volume maintenance. (A)</p> Signup and view all the answers

    What defines primary active transport mechanisms?

    <p>They involve ATP hydrolysis directly for ion transport. (A)</p> Signup and view all the answers

    Which substance is NOT typically transported by active transport mechanisms?

    <p>Oxygen (D)</p> Signup and view all the answers

    Filtration in biological systems primarily relies on which of the following?

    <p>Pressure differences across membranes. (B)</p> Signup and view all the answers

    What role do non-diffusible particles like Pr- and PO4- play in the intracellular fluid (ICF)?

    <p>They raise the levels of diffusible K+ ions. (A)</p> Signup and view all the answers

    Which process is used to effectively eliminate waste products in blood during renal failure?

    <p>Dialysis (A)</p> Signup and view all the answers

    Which statement accurately describes the effect of aldosterone on pump activity?

    <p>Aldosterone increases the activity of pumps. (A)</p> Signup and view all the answers

    What role does insulin play in pump activity according to the content?

    <p>Insulin increases pump activity. (A)</p> Signup and view all the answers

    Which process involves the uptake of large multimolecular particles through specialized cells?

    <p>Phagocytosis (D)</p> Signup and view all the answers

    Which transporter is specifically involved in the active transport of glucose along with sodium?

    <p>SGLT-1 (B)</p> Signup and view all the answers

    What is the primary mechanism through which receptor-mediated endocytosis selectively imports large molecules?

    <p>Utilization of energy and microfilaments. (C)</p> Signup and view all the answers

    What distinguishes synport transport mechanisms from antiport ones?

    <p>Synports simultaneously move two different substances in the same direction. (A)</p> Signup and view all the answers

    What is the primary consequence of oubain or digitalis on cardiac muscle cells?

    <p>Maintenance of calcium ion concentration in the ICF. (B)</p> Signup and view all the answers

    What occurs during pinocytosis?

    <p>Formation of vesicles to engulf extracellular fluid. (C)</p> Signup and view all the answers

    Flashcards

    Cell Membrane

    The outer layer of a cell, and its organelles, made of a phospholipid bilayer and proteins that controls what enters and exits.

    Passive Transport

    Movement of molecules across the cell membrane without energy input.

    Active Transport

    Movement of molecules across the cell membrane that requires energy input.

    Simple Diffusion

    Passive transport where molecules move from high to low concentration.

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    Facilitated Diffusion

    Passive transport where molecules move through protein channels.

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    Osmosis

    Passive transport of water across a semipermeable membrane.

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    Primary Active Transport

    Active transport where energy directly powers the movement of molecules against the concentration gradient.

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    Membrane Transport

    Movement of materials across cell membranes, vital for cell function.

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    Factors affecting diffusion rate

    Lipid solubility, molecular size/weight, temperature, membrane thickness, surface area, and concentration gradient influence the speed of diffusion.

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    Diffusion through lipid bilayer

    Lipid-soluble substances (O2, CO2) pass easily, while water-soluble substances (water, urea) have more difficulty.

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    Protein channels

    Proteins embedded in the membrane that regulate the passage of specific ions or molecules.

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    Concentration gradient

    Difference in the concentration of a substance across a membrane. Higher concentration to lower concentration.

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    Fick's Law

    Equation describing the rate of diffusion, considering factors like concentration gradient, permeability, surface area, molecular weight, and membrane thickness.

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    Channelopathies

    Conditions resulting from mutations in ion channel genes, affecting muscle and brain function.

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    Carrier-mediated transport

    Movement of molecules across the membrane facilitated by carrier proteins. These proteins bind to specific molecules and transport them across the membrane.

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    Vmax

    The maximum rate of transport in carrier-mediated transport. It's reached when all carrier proteins are saturated with molecules, limiting further transport.

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    Specificity in transport

    Carrier proteins bind to specific molecules, meaning they only transport certain types of molecules. This makes transport selective.

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    Competitive inhibition

    A molecule that resembles the transported molecule competes for the same binding site on the carrier protein, reducing transport efficiency.

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    Noncompetitive inhibition

    A molecule binds to a different site on the carrier protein, changing its shape and hindering transport.

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    Osmotic Pressure

    The pressure required to prevent the movement of water across a semipermeable membrane. It is proportional to the concentration of solutes in the solution.

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    Isotonic Solution

    A solution with the same osmolarity as the surrounding environment (e.g., plasma). Cells in this solution neither shrink nor swell.

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    Pseudopodia

    Temporary extensions of the cell membrane used by amoeba and white blood cells for movement and engulfing food.

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    Phagocytosis

    The process by which cells engulf large particles, such as bacteria, by surrounding them with their cell membrane.

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    Electrical Gradient

    The difference in electrical charge across a membrane, influencing the movement of ions.

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    What determines membrane permeability?

    Factors like lipid solubility, molecular size, temperature, and membrane thickness influence how easily substances cross a membrane.

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    Na+-K+ Pump

    A primary active transport system that pumps 3 sodium ions out of the cell and 2 potassium ions into the cell, maintaining cell volume and electrical gradient.

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    Saturation in Transport

    When all carrier proteins are bound to molecules, further transport is limited even if more molecules are available.

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    What increases Na-K ATPase activity?

    Thyroid hormones stimulate the activity of the Na-K ATPase pump, increasing its activity and impacting membrane potential.

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    What else increases the Na-K pump?

    Aldosterone, a hormone involved in electrolyte balance, also increases the activity of the Na-K ATPase pump, contributing to fluid and electrolyte regulation.

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    Dopamine's effect on the pump

    Dopamine, a neurotransmitter, inhibits the activity of the Na-K ATPase pump, having a contrasting effect compared to thyroid hormones and aldosterone.

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    Insulin's role in the pump

    Insulin, a hormone involved in glucose regulation, increases the activity of the Na-K ATPase pump, facilitating glucose uptake into cells.

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    Oubain/Digitalis's effect

    Oubain and Digitalis inhibit the activity of the Na-K ATPase pump, specifically in cardiac muscle, helping maintain calcium levels for muscle contraction.

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    Secondary active transport

    A process where the movement of a substance against its concentration gradient is coupled to the movement of another substance down its concentration gradient.

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    Sodium-glucose cotransporter (SGLT-1)

    A carrier protein located in the apical membrane of intestinal cells that transports glucose and sodium ions into the cell, driven by the sodium gradient.

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    Facilitated diffusion for glucose

    Glucose moves across the basal membrane of intestinal cells via facilitated diffusion through the GLUT-2 transporter protein.

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    Study Notes

    Cell Membrane Structure

    • The cell membrane surrounds the entire cell and its organelles.
    • It's a fluid structure, allowing molecule movement.
    • The phospholipid bilayer forms the base, with polar/hydrophilic heads and nonpolar/hydrophobic tails.
    • Integral proteins act as carriers and channels; peripheral proteins as receptors and antigens.

    Functions of the Cell Membrane

    • Acts as a semi-permeable barrier (selective).
    • Maintains differences in composition between ICF and ECF, and organelle fluids.
    • Protects the cell from harmful substances.
    • Facilitates the excretion of waste products.
    • Transports nutrients.
    • Receives chemical and electrical signals from the environment.
    • Provides a site for attachment to neighboring cells.

    Transport Across the Cell Membrane

    • Membrane transport is essential for cellular life and function throughout the cell cycle.
    • It encompasses the incorporation of molecules and discharge of waste products needed for cellular function.
    • Transport depends on membrane permeability, solute concentration, and solute size/charge.
    • Three mechanisms for substance movement across membranes are passive, facilitated, and active transport.
    • Some mechanisms require energy and a transmembrane protein; others don't.

    Transport Mechanisms

    • Passive Transport: Includes simple diffusion, facilitated diffusion, filtration, osmosis, and dialysis.
    • Active Transport: Includes primary active transport, secondary active transport, endocytosis (pinocytosis, receptor-mediated endocytosis, phagocytosis), and exocytosis.

    Passive Transport

    • Simple Diffusion: Movement of molecules from a higher concentration to a lower concentration until equilibrium is reached. Substances can move through the lipid bilayer or through protein channels (leaky channels; gated channels (voltage gated; ligand gated)). -Examples of Substances that can move through the Lipid bilayer: O2, CO2, alcohols and steroids -Examples of Substances that are not able to pass directly through the lipid bilayer include: water, urea, sugar, and electrolytes.
    • Facilitated Diffusion: Uses carrier proteins in the membrane to move substances from high to low concentration; the carrier can become saturated. The rate is proportional to the concentration gradient, up to the maximum transport rate Vmax. Examples: glucose and amino acids.
    • Filtration: Movement of fluid and small solutes through a membrane due to pressure differences.
    • Osmosis: Movement of water across a semi-permeable membrane from a low solute concentration to a high solute concentration to balance concentrations.
    • Dialysis: Separation of dissolved particles of different sizes through a membrane.

    Factors Affecting Diffusion Rate

    • Lipid solubility
    • Molecular size/weight
    • Temperature
    • Membrane thickness
    • Surface area
    • Concentration gradient
    • Pressure gradient
    • Electrical gradient

    Gibbs-Donnan Equilibrium

    • Describes the differences in concentration of diffusible ions in compartments separated by a semi-permeable membrane when one compartment has non-diffusible ions. -Proteins are non-diffusible and affect the equilibrium.

    Osmosis and Osmotic Pressure

    • Water moves from a lower concentration of solute to a higher concentration across a semi-permeable membrane.
    • Osmotic pressure is the minimal pressure needed to prevent water movement.
    • Osmolarity (mOsmols) is the concentration of osmotically active particles.

    Applied Aspects of Osmosis

    • Isotonic solutions have the same osmolarity as plasma (290 mOsmol/L). Red blood cells neither shrink nor swell in isotonic solutions.
    • Hypotonic solutions have lower osmolarity than plasma, causing red blood cells to swell and potentially burst.
    • Hypertonic solutions have higher osmolarity than plasma, causing red blood cells to shrink.

    Filtration in Capillaries

    • Filtration is the movement of fluid and small solutes through a membrane under pressure.
    • At the arterial end of capillaries, hydrostatic pressure forces fluid out.
    • At the venous end, osmotic pressure draws fluid in.

    Active Transport

    • Primary Active Transport: Uses energy directly from ATP to move substances against the concentration gradient. Examples include the Na+/K+ pump, Ca2+ pump, and H+/K+ pump.
    • Secondary Active Transport: Employs an electrochemical gradient (established by primary active transport) to move another substance against its gradient. Examples include glucose uptake and amino acid absorption.

    Endocytosis

    • Pinocytosis: (Ingestion of fluid and small molecules, used by all cells)
    • Receptor-Mediated Endocytosis: (Selective uptake of specific molecules).
    • Phagocytosis: (Ingestion of large particles and tissues, specialized cells, like white blood cells)

    Dialysis

    • Dialysis is used to separate waste products from blood in cases of kidney failure. Dialysis membranes only allow the passage of certain-sized particles .

    Transport Classifications

    • Differentiate transport categories: uniporter, symporter, and antiporter.

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    Description

    Explore the intricate structure and vital functions of the cell membrane in this quiz. Dive into details about its fluid nature, the role of phospholipids, proteins, and the mechanisms of transport essential for cellular life. Test your knowledge on how the cell membrane contributes to maintaining homeostasis and communication.

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