Cell Membrane Structure and Composition
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Questions and Answers

What is the main function of linker proteins?

  • Assist in cell division
  • Facilitate cell signaling
  • Transport ions across the membrane
  • Attach cells to the extracellular matrix (correct)
  • Which type of membrane transport does not require energy?

  • Exocytosis
  • Facilitated diffusion (correct)
  • Active transport
  • Endocytosis
  • Which process is characterized by the transport of two different molecules in the same direction?

  • Simple diffusion
  • Facilitated diffusion
  • Antiport
  • Symport (correct)
  • What type of ion channels opens in response to a change in membrane potential?

    <p>Voltage-gated channels (B)</p> Signup and view all the answers

    What distinguishes facilitated diffusion from simple diffusion?

    <p>Facilitated diffusion requires ion channels or carrier proteins. (D)</p> Signup and view all the answers

    Which of the following conditions is caused by abnormal carrier proteins leading to kidney stones?

    <p>Cystinuria (D)</p> Signup and view all the answers

    Aquaporins are specialized channels for the transport of which substance?

    <p>Water (B)</p> Signup and view all the answers

    What is the primary consequence of cystic fibrosis related to NaCl transport?

    <p>Increased secretion of mucin (C)</p> Signup and view all the answers

    What primarily drives active transport in cells?

    <p>Energy from ATP. (A)</p> Signup and view all the answers

    What happens to a red blood cell when placed in a hypotonic solution?

    <p>It ruptures. (B)</p> Signup and view all the answers

    Which process involves the engulfment of solid particles by a cell?

    <p>Phagocytosis. (D)</p> Signup and view all the answers

    What is the role of ATP-binding cassette (ABC) transporters in eukaryotic cells?

    <p>To export toxins and drugs. (C)</p> Signup and view all the answers

    Which type of secretion involves a response to an extracellular signal?

    <p>Regulated secretion. (B)</p> Signup and view all the answers

    What is the main consequence of placing plant cells in a hypertonic solution?

    <p>They undergo plasmolysis. (D)</p> Signup and view all the answers

    Which active transport mechanism involves the simultaneous transport of glucose and Na+ in the same direction?

    <p>Secondary active transport. (B)</p> Signup and view all the answers

    What defines receptor-mediated endocytosis?

    <p>Engulfment of liquid and particles with receptor help. (D)</p> Signup and view all the answers

    Which statement accurately describes transmembrane proteins?

    <p>They can include single pass and multipass proteins. (D)</p> Signup and view all the answers

    What is the primary role of glycocalyx?

    <p>Facilitate cell-cell recognition and attachment. (A)</p> Signup and view all the answers

    Which type of protein primarily uses energy for transport?

    <p>Pump proteins (B)</p> Signup and view all the answers

    Which statement is true about the protein to lipid ratio in cell membranes?

    <p>Most cells have a ratio of 1:1, whereas myelin cells have 1:4. (B)</p> Signup and view all the answers

    What is the function of channel proteins in the membrane?

    <p>They facilitate passive diffusion of ions and small molecules. (D)</p> Signup and view all the answers

    Which type of integral protein spans the lipid bilayer and might loop several times?

    <p>Multipass transmembrane protein (B)</p> Signup and view all the answers

    What distinguishes non-transmembrane proteins from transmembrane proteins?

    <p>Non-transmembrane proteins do not span the lipid bilayer. (D)</p> Signup and view all the answers

    What role do Siglecs play in relation to immune cells?

    <p>They allow cancer cells to evade detection by the immune system. (A)</p> Signup and view all the answers

    What is the primary reason the plasma membrane is considered 'fluid'?

    <p>It contains elastic fluid lipid molecules. (A)</p> Signup and view all the answers

    Which component of the plasma membrane is primarily responsible for its structural integrity?

    <p>Phospholipids (C)</p> Signup and view all the answers

    In the fluid mosaic model, what role do integral proteins play?

    <p>They are involved in signal transduction. (D)</p> Signup and view all the answers

    What is the characteristic of the hydrophilic head of phospholipids?

    <p>It contains glycerol and phosphate groups. (C)</p> Signup and view all the answers

    How does temperature affect the fluidity of the plasma membrane?

    <p>Fluidity increases with increased temperature. (B)</p> Signup and view all the answers

    Which type of protein is found on the outer or inner surfaces of the plasma membrane?

    <p>Peripheral proteins (D)</p> Signup and view all the answers

    What is the main function of cholesterol in the plasma membrane?

    <p>To enhance fluidity and stabilize membrane structure. (D)</p> Signup and view all the answers

    What distinguishes glycolipids in the plasma membrane?

    <p>They consist of a lipid and a carbohydrate. (A)</p> Signup and view all the answers

    Flashcards

    Integral Proteins

    Proteins embedded within the phospholipid bilayer, interacting with the hydrophobic part. Their ratio to lipids varies between cells, with myelin cells having a lower protein-to-lipid ratio.

    Non-Transmembrane Proteins

    Integral proteins that do not span the entire lipid bilayer, remaining within one side.

    Transmembrane Proteins

    Integral proteins that completely cross the lipid bilayer, providing a pathway for molecules.

    Single Pass Transmembrane Proteins

    Transmembrane proteins that pass through the lipid bilayer only once.

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    Multipass Transmembrane Proteins

    Transmembrane proteins that cross the lipid bilayer multiple times, forming loops and channels.

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    Siglecs

    Transmembrane proteins found on normal cells, recognized by immune cells as 'self'. Cancer cells can mimic this to evade the immune system.

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    Glycocalyx

    A layer of sugar molecules attached to the outer surface of the plasma membrane.

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    Functions of the Glycocalyx

    The functions of glycocalyx include attachment to the extracellular matrix, binding antigens and enzymes, cell recognition and communication, protection, and activation of immune cells.

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    Linker proteins

    Proteins that connect cells to the extracellular matrix, providing structural support and anchoring.

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    Structural proteins

    Proteins that connect adjacent cells to one another, maintaining tissue integrity and facilitating communication.

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    Simple diffusion

    A type of passive transport where molecules move from an area of high concentration to low concentration, requiring no energy.

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    Facilitated diffusion

    A type of passive transport that uses carrier proteins or ion channels to facilitate the movement of molecules across cell membranes.

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    Ion channel proteins

    Proteins that span cell membranes, enabling the transport of specific ions across the membrane, often in response to specific stimuli.

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    Aquaporins

    Channel proteins specifically designed for the rapid transport of water molecules, ensuring proper hydration.

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    Carrier proteins

    Proteins that bind to specific molecules and transport them across the cell membrane, undergoing conformational changes to facilitate transport.

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    Cystinuria

    A hereditary condition where defective carrier proteins lead to the inability to remove cysteine from the urine, resulting in kidney stones.

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    Osmosis

    Movement of water from an area with low solute concentration (hypotonic) to an area with high solute concentration (hypertonic).

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    Active Transport

    A form of active transport that requires energy (ATP) to move molecules against their concentration gradient.

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    Symport

    A type of active transport where the energy for moving one molecule is obtained from the movement of another molecule in the same direction.

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    Antiport

    A type of active transport where the energy for moving one molecule is obtained from the movement of another molecule in the opposite direction.

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    Primary Active Transport

    A type of active transport where energy is directly provided by ATP to move molecules against their concentration gradient.

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    Secondary Active Transport

    A type of active transport where energy is indirectly provided by ATP, often using the concentration gradient of another molecule.

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    Endocytosis

    Cellular uptake of large materials by forming vesicles from the plasma membrane.

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    Exocytosis

    Cellular release of large materials from the cell by the fusion of vesicles with the plasma membrane.

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    Fluid mosaic model

    Describes the cell membrane as a fluid, constantly moving structure with diverse components like lipids, proteins, and carbohydrates.

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    E-face

    The outer layer of the cell membrane, facing the extracellular environment.

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    P-face

    The inner layer of the cell membrane, facing the intracellular environment.

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    Phospholipid bilayer

    The main component of the cell membrane, made of two layers of phospholipids.

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    Peripheral proteins

    Proteins attached to the surface of the cell membrane, either the inner (P-face) or outer (E-face).

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    Semipermeability

    The ability of the cell membrane to let some molecules pass through while blocking others.

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    Passive transport

    A process where molecules move across the membrane from a high concentration to a low concentration without using energy.

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    Study Notes

    Cell Membrane Structure

    • The cell membrane (also called the plasma membrane or plasma lemma) is approximately 7.5 nm thick.
    • It's a phospholipid bilayer with integral (intrinsic) and peripheral (extrinsic) proteins embedded within.
    • Lipids and proteins may be attached to carbohydrates.
    • The inner leaflet faces the cytoplasm (P-face), and the outer leaflet faces the extracellular matrix (E-face).
    • Under electron microscopy, the membrane appears trilaminar.

    Cell Membrane Composition

    • The membrane is primarily composed of phospholipids (lipid + phosphate group).
    • It also contains glycolipids (lipid + carbohydrate) and cholesterol, a sterol.
    •  Phospholipids are amphipathic, with a polar (hydrophilic) head and two nonpolar (hydrophobic) fatty acid tails.
    • Cholesterol is present in both leaflets, comprising only 2% of plasma membrane lipids.
    •  The membrane is more fluid when temperature is high and fatty acid tails are unsaturated.
    • Fluidity decreases with higher cholesterol content.

    Cell Membrane Proteins

    • Membrane proteins are categorized into peripheral (extrinsic) and integral (intrinsic) types.
    • Peripheral proteins are located on the external or internal surfaces and associate with the hydrophilic head of the lipid bilayer.
    • Integral proteins are embedded within the phospholipid bilayer, interacting with hydrophobic tails.
    • The protein-to-lipid ratio typically is 1:1, but can be 1:4 in myelin cells.
    • Many integral proteins are transmembrane, spanning the entire bilayer.
    • Transmembrane proteins can be single-pass or multi-pass.
    •  Single-pass proteins pass once, while multi-pass proteins pass multiple times through the lipid bilayer.

    Cell Membrane Functions

    • Maintain cell integrity.
    • Act as a semipermeable barrier.
    • Enables molecule recognition and transport.
    • Facilitate signal transduction.
    • Allow cell-to-cell contact and communication.
    • Maintain potential difference in nervous tissue.
    • Attach to the cytoskeleton and extracellular matrix.

    Cell Membrane Transport

    • Membrane transport moves substances across the cell membrane.
      • There are passive (no energy required) and active (energy required) processes.
    • Passive transport occurs down the concentration or electrochemical gradient.
      • Simple diffusion is a nonspecific process through the phospholipid bilayer, with little specificity.
        • Small, nonpolar (e.g., O2, N2) and small, uncharged, polar (e.g., H₂O, CO2, glycerol) molecules are able to move through the membrane by simple diffusion.
      • Facilitated diffusion is a specific process through protein channels or carriers.
        • Ion channels (e.g., K⁺ leak channels, voltage-gated channels, mechanically gated channels, and ligand-gated channels) and aquaporins (water channels) increase the rate of transport across the membrane. - Carrier proteins (e.g., glucose transporters) undergo conformational changes to transport specific molecules.
    • Active transport moves substances against their concentration or electrochemical gradient, requiring energy (ATP).
      • Primary active transport (e.g., Na⁺-K⁺ pump) directly utilizes ATP to move molecules.
      • Secondary active transport (e.g., glucose transport) couples the movement of one molecule down its gradient to the movement of another molecule against its gradient.
      • ATP-binding cassette (ABC) transporters use ATP to move substances across the cell membrane.

    Glycocalyx

    • The glycocalyx is a carbohydrate-rich layer on the outer surface of the plasma membrane.
    • It's composed of oligosaccharides covalently connected to proteins (glycoproteins) and lipids (glycolipids).
    • Functions include cell-cell recognition, communication, binding to extracellular matrix molecules, and protection.

    Examples of Ion Channels & Diseases

    • Ion channels are integral membrane proteins that regulate the movement of ions across the cell membrane.
    • Types include K⁺ leak channels, voltage-gated channels, mechanically gated channels, and ligand-gated channels.
    • Examples of diseases involving ion channel malfunction include cystic fibrosis (malfunctioning chloride channel proteins) and cystinuria (abnormal carrier proteins).

    Endocytosis and Exocytosis

    • Endocytosis is the process of taking substances into the cell. It involves a portion of the plasma membrane engulfing the substances.
      • Types of endocytosis include phagocytosis, pinocytosis, and receptor-mediated endocytosis
    • Exocytosis is the process of releasing substances out of the cell. It involves secretory granules fusing with the plasma membrane.
      • Types of exocytosis include regulated secretion and constitutive secretion

    Other important concepts

    • In the case of poisonous snake bites, the venom often targets acetylcholine receptors, leading to muscle paralysis.
    • Graves' disease is an autoimmune disease in which antibodies stimulate thyroid-stimulating hormone receptors, resulting in hyperthyroidism.

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    Description

    Explore the intricate details of cell membrane structure and composition. This quiz covers the phospholipid bilayer, the types of proteins involved, and the role of cholesterol in membrane fluidity. Test your understanding of important concepts regarding the cellular barrier that protects and organizes cellular contents.

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