Cell Junctions and Cell Adhesion Molecules Quiz
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Questions and Answers

Which type of cell junctions specifically prevent small molecules from leaking across the cell sheet?

  • Desmosomes
  • Tight junctions (correct)
  • Hemidesmosomes
  • Anchoring junctions

Which of the following proteins is essential for the formation and function of tight junctions?

  • Claudins (correct)
  • Occludin
  • Tricellulin
  • Vinculin

How do hemidesmosomes differ from desmosomes in terms of function?

  • Hemidesmosomes connect cells through a dense cytoplasmic plaque, while desmosomes connect cells via integrins.
  • Hemidesmosomes connect adjacent epithelial cells, while desmosomes connect cells to the extracellular matrix. (correct)
  • Hemidesmosomes prevent transepithelial leakage, while desmosomes are essential for cell-cell adhesion.
  • Hemidesmosomes are found in heart muscle, while desmosomes are found in skin epithelium.

In the context of epithelial sheets, where are adherens junctions typically located?

<p>Near the apex of each cell just below the tight junction (B)</p> Signup and view all the answers

Why are desmosomes crucial in holding cells together, as illustrated by certain skin diseases?

<p>They physically connect cells and disruption leads to severe blistering. (D)</p> Signup and view all the answers

Which proteins are key components of type I hemidesmosomes?

<p>Integrin subunits α6 and β4 (D)</p> Signup and view all the answers

What is the main function of integrins in cancer progression?

<p>Supporting oncogenic growth factor receptor signaling (D)</p> Signup and view all the answers

How do gap junctions differ from tight junctions in terms of cell membrane contact?

<p>Gap junctions hold interacting membranes at a fixed distance (D)</p> Signup and view all the answers

What size molecules can pass through gap junction channels?

<p>Molecules up to about 1000 daltons (C)</p> Signup and view all the answers

How do connexin Cx43 and Cx40 contribute to cell coupling in different tissues?

<p>They insulate different cell types electrically (D)</p> Signup and view all the answers

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