10 Questions
Which type of cell junctions specifically prevent small molecules from leaking across the cell sheet?
Tight junctions
Which of the following proteins is essential for the formation and function of tight junctions?
Claudins
How do hemidesmosomes differ from desmosomes in terms of function?
Hemidesmosomes connect adjacent epithelial cells, while desmosomes connect cells to the extracellular matrix.
In the context of epithelial sheets, where are adherens junctions typically located?
Near the apex of each cell just below the tight junction
Why are desmosomes crucial in holding cells together, as illustrated by certain skin diseases?
They physically connect cells and disruption leads to severe blistering.
Which proteins are key components of type I hemidesmosomes?
Integrin subunits α6 and β4
What is the main function of integrins in cancer progression?
Supporting oncogenic growth factor receptor signaling
How do gap junctions differ from tight junctions in terms of cell membrane contact?
Gap junctions hold interacting membranes at a fixed distance
What size molecules can pass through gap junction channels?
Molecules up to about 1000 daltons
How do connexin Cx43 and Cx40 contribute to cell coupling in different tissues?
They insulate different cell types electrically
Test your knowledge on cell specialized junctions and adhesion molecules that play a crucial role in cell-cell and cell-matrix interactions, especially in epithelial tissues. Learn how these structures can be visualized through different microscopy techniques.
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