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Questions and Answers
What role do cyclins play in the cell cycle?
What role do cyclins play in the cell cycle?
- They chaperone proteins that regulate the cell cycle.
- They form complexes with cyclin-dependent kinases to regulate kinase activity. (correct)
- They act as inhibitors for cell cycle progression.
- They are responsible for inducing apoptosis.
How does the kinase activity of CDKs become activated?
How does the kinase activity of CDKs become activated?
- By being synthesized in the presence of GTP.
- By degradation of the corresponding cyclin.
- Through formation of complexes with cyclins. (correct)
- By direct phosphorylation of the CDK molecule.
What defines the nature of cyclins in the cell cycle?
What defines the nature of cyclins in the cell cycle?
- They are constantly present and do not change during the cycle.
- They are always phosphorylated and active.
- They exhibit cyclic patterns of synthesis and degradation. (correct)
- They inhibit the activity of CDKs consistently.
What happens when there is a transient increase in a cyclin's synthesis?
What happens when there is a transient increase in a cyclin's synthesis?
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What is the primary function of cyclin-dependent kinases (CDKs) in the cell cycle?
What is the primary function of cyclin-dependent kinases (CDKs) in the cell cycle?
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Study Notes
Cell Cycle Regulation
- The cell cycle is controlled by specific activators (promote progression) and inhibitors (suppress progression).
- Proteins called cyclins play a crucial role in coordinating the different phases of the cell cycle.
Cyclins and CDKs
- Cyclins are named for their cyclic production and degradation throughout the cell cycle.
- Cyclin-dependent kinases (CDKs) are enzymes that are associated with cyclins and are essential for cell cycle advancement.
- CDKs are synthesized continuously but require cyclins to become enzymatically active.
Mechanism of Action
- CDKs gain kinase activity by forming complexes with their corresponding cyclins.
- Increased synthesis of a specific cyclin leads to higher kinase activity of its associated CDK, allowing for proper cell cycle progression.
- The interaction between cyclins and CDKs ensures precise timing and regulation of cell cycle events.
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