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Cell Cycle Regulation and Retinoblastoma
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Cell Cycle Regulation and Retinoblastoma

Created by
@FerventPrudence

Questions and Answers

What is the consequence of mutations leading to unregulated expression of cyclin D1?

  • Cell cycle arrest
  • Differentiation of cells
  • Induction of apoptosis
  • Development of human cancers (correct)

    • What is the primary role of Cdk4,6/cyclin D1 complexes in the cell cycle?

  • Inhibition of cell growth
  • Initiation of DNA replication
  • Induction of apoptosis
  • Progression through the restriction point (correct)

    • What is the primary substrate protein of Cdk4,6/cyclin D1 complexes?

  • p27
  • E2F
  • Rb protein (correct)
  • Cyclin E

    • What is the role of E2F in the cell cycle?

    <p>Stimulation of cyclin E synthesis</p> Signup and view all the answers

    What is the mechanism of inhibition of Cdk2 activity in G0 or early G1?

    <p>Inhibition by p27</p> Signup and view all the answers

    What is the consequence of growth factor signaling on p27 levels?

    <p>Reduced transcription and translation of p27</p> Signup and view all the answers

    What is the role of the Rb-E2F pathway in the cell cycle?

    <p>Regulation of cell growth and division</p> Signup and view all the answers

    What is the consequence of phosphorylation of Rb?

    <p>Stimulation of cyclin E synthesis</p> Signup and view all the answers

    What is the role of cyclin E in the cell cycle?

    <p>Mediation of entry into S phase</p> Signup and view all the answers

    What is the primary mechanism of cyclin D1 degradation?

    <p>Rapid degradation by unknown mechanisms</p> Signup and view all the answers

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