Podcast
Play an AI-generated podcast conversation about this lesson
Questions and Answers
What is the consequence of mutations leading to unregulated expression of cyclin D1?
What is the consequence of mutations leading to unregulated expression of cyclin D1?
- Cell cycle arrest
- Differentiation of cells
- Induction of apoptosis
- Development of human cancers (correct)
What is the primary role of Cdk4,6/cyclin D1 complexes in the cell cycle?
What is the primary role of Cdk4,6/cyclin D1 complexes in the cell cycle?
- Inhibition of cell growth
- Initiation of DNA replication
- Induction of apoptosis
- Progression through the restriction point (correct)
What is the primary substrate protein of Cdk4,6/cyclin D1 complexes?
What is the primary substrate protein of Cdk4,6/cyclin D1 complexes?
- p27
- E2F
- Rb protein (correct)
- Cyclin E
What is the role of E2F in the cell cycle?
What is the role of E2F in the cell cycle?
Signup and view all the answers
What is the mechanism of inhibition of Cdk2 activity in G0 or early G1?
What is the mechanism of inhibition of Cdk2 activity in G0 or early G1?
Signup and view all the answers
What is the consequence of growth factor signaling on p27 levels?
What is the consequence of growth factor signaling on p27 levels?
Signup and view all the answers
What is the role of the Rb-E2F pathway in the cell cycle?
What is the role of the Rb-E2F pathway in the cell cycle?
Signup and view all the answers
What is the consequence of phosphorylation of Rb?
What is the consequence of phosphorylation of Rb?
Signup and view all the answers
What is the role of cyclin E in the cell cycle?
What is the role of cyclin E in the cell cycle?
Signup and view all the answers
What is the primary mechanism of cyclin D1 degradation?
What is the primary mechanism of cyclin D1 degradation?
Signup and view all the answers
