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Cell Cycle Regulation and Retinoblastoma

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Cell Cycle Regulation and Retinoblastoma

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Questions and Answers

What is the consequence of mutations leading to unregulated expression of cyclin D1?

Cell cycle arrest

Differentiation of cells

Induction of apoptosis

Development of human cancers (correct)

What is the primary role of Cdk4,6/cyclin D1 complexes in the cell cycle?

Inhibition of cell growth

Initiation of DNA replication

Induction of apoptosis

Progression through the restriction point (correct)

What is the primary substrate protein of Cdk4,6/cyclin D1 complexes?

p27

E2F

Rb protein (correct)

Cyclin E

What is the role of E2F in the cell cycle?

Stimulation of cyclin E synthesis Signup and view all the answers

What is the mechanism of inhibition of Cdk2 activity in G0 or early G1?

Inhibition by p27 Signup and view all the answers

What is the consequence of growth factor signaling on p27 levels?

Reduced transcription and translation of p27 Signup and view all the answers

What is the role of the Rb-E2F pathway in the cell cycle?

Regulation of cell growth and division Signup and view all the answers

What is the consequence of phosphorylation of Rb?

Stimulation of cyclin E synthesis Signup and view all the answers

What is the role of cyclin E in the cell cycle?

Mediation of entry into S phase Signup and view all the answers

What is the primary mechanism of cyclin D1 degradation?

Rapid degradation by unknown mechanisms Signup and view all the answers