10 Questions
What is the consequence of mutations leading to unregulated expression of cyclin D1?
Development of human cancers
What is the primary role of Cdk4,6/cyclin D1 complexes in the cell cycle?
Progression through the restriction point
What is the primary substrate protein of Cdk4,6/cyclin D1 complexes?
Rb protein
What is the role of E2F in the cell cycle?
Stimulation of cyclin E synthesis
What is the mechanism of inhibition of Cdk2 activity in G0 or early G1?
Inhibition by p27
What is the consequence of growth factor signaling on p27 levels?
Reduced transcription and translation of p27
What is the role of the Rb-E2F pathway in the cell cycle?
Regulation of cell growth and division
What is the consequence of phosphorylation of Rb?
Stimulation of cyclin E synthesis
What is the role of cyclin E in the cell cycle?
Mediation of entry into S phase
What is the primary mechanism of cyclin D1 degradation?
Rapid degradation by unknown mechanisms
Test your knowledge on the role of Cip/Kip proteins, Cdk2, and cyclin A/E in regulating cell cycle progression through G1 and S phases. Also, explore the connection between the Rb gene and retinoblastoma, a childhood eye tumor.
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