Neoplasia
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Questions and Answers

Which process leads to the tumour outgrowing its blood supply?

  • Apoptosis resistance
  • Immune evasion
  • Altered metabolism
  • Sustained angiogenesis (correct)
  • What is the hypothesis called where one genetic change is inherited, and the second mutation occurs in a retinal cell?

  • Wahlberg effect
  • Knudson's Two Hit Hypothesis (correct)
  • Li-Fraumeni hypothesis
  • APC/Beta-catenin pathway
  • In viral carcinogenesis, what does insensitivity to growth inhibition lead to?

  • Apoptosis evasion (correct)
  • Tumour growth promotion
  • Immune system activation
  • Altered metabolism
  • Which protein enables DNA damage repair and is rendered ineffective by a BRCA mutation?

    <p>Rad51</p> Signup and view all the answers

    What is the most common cancer associated with Li-Fraumeni syndrome?

    <p><strong>Osteosarcoma (bone cancer)</strong></p> Signup and view all the answers

    What neoplasm is associated with APC/Beta-catenin gene mutation?

    <p><strong>Familial adenomatous polyposis (FAP)</strong></p> Signup and view all the answers

    Which tumour suppressor gene is widely disregulated in cancer?

    <p><strong>p53</strong></p> Signup and view all the answers

    What causes a mutant cell to arise due to DNA remaining damaged?

    <p><strong>Failure of p53 activation</strong></p> Signup and view all the answers

    What is the main function of Nivolumab in immunotherapy for head and neck cancer?

    <p><strong>Blocking immune system suppression</strong></p> Signup and view all the answers

    Which process is responsible for making cancer cells evade detection by cytotoxic T cells?

    <p><strong>Immune evasion</strong></p> Signup and view all the answers

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