18 Questions
During which phase of the cell cycle is DNA replication identified by labeling cells with radioactive thymidine?
S
What is the main function of the DNA damage checkpoint in late G2?
To verify DNA replication and detect any damage
What is responsible for the ubiquitination of cyclins and structural proteins?
APC/C complex
Which of the following is a key biochemical principle of the cell cycle regulation?
Ubiquitin-dependent proteolysis
What is the role of the restriction point in the G1 phase?
To look for growth signals
What is the name of the complex responsible for the degradation of cyclins and structural proteins?
APC/C complex
What is the primary target of the APC/C complex during prometaphase?
Cyclin A
What is the primary event that occurs during the G1/S transition?
D-type cyclins activate CDK4/6
What happens to chromosomes during early G1 phase?
They decondense
What is the function of the retinoblastoma protein (Rb) during the G1 phase?
To block E2F transcriptional activity
What is the outcome of a cell entering the G0 phase?
The cell stops cycling but remains active
What is the primary function of the APC/C complex during late mitosis?
To target cyclin B for destruction
What happens to p53 when it gets phosphorylated?
Mdm2 can't bind to it
What is the function of Cdk1 in the cell cycle?
To phosphorylate lamins and break down the nuclear envelope
What is the role of cyclin B in the cell cycle?
To activate Cdk1 activity
What happens to Cdk1 activity during late G2 phase?
It becomes fully active after dephosphorylation by Cdc25
What is the effect of Wee1 on Cdk1 activity?
It inhibits Cdk1 by phosphorylating T-14 and Y-15
What is the outcome of Cdk1/cyclin B kinase activity in the nucleus?
Entry into mitosis
Test your knowledge of the cell cycle, including the phases of G1, S, G2, and M, as well as the four checkpoints that ensure proper DNA replication and cell division. Learn about the restriction point, DNA damage checkpoints, and more.
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