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Cell Cycle Phases and Checkpoints

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Questions and Answers

During which phase of the cell cycle is DNA replication identified by labeling cells with radioactive thymidine?

S (correct)

What is the main function of the DNA damage checkpoint in late G2?

To ensure proper chromosome condensation

To promote spindle formation

To verify DNA replication and detect any damage (correct)

To regulate cyclin-dependent kinases

What is responsible for the ubiquitination of cyclins and structural proteins?

Cyclin-dependent kinases

Ubiquitin-dependent proteolysis

Mdm2

APC/C complex (correct)

Which of the following is a key biochemical principle of the cell cycle regulation?

Ubiquitin-dependent proteolysis Signup and view all the answers

What is the role of the restriction point in the G1 phase?

To look for growth signals Signup and view all the answers

What is the name of the complex responsible for the degradation of cyclins and structural proteins?

APC/C complex Signup and view all the answers

What is the primary target of the APC/C complex during prometaphase?

Cyclin A Signup and view all the answers

What is the primary event that occurs during the G1/S transition?

D-type cyclins activate CDK4/6 Signup and view all the answers

What happens to chromosomes during early G1 phase?

They decondense Signup and view all the answers

What is the function of the retinoblastoma protein (Rb) during the G1 phase?

To block E2F transcriptional activity Signup and view all the answers

What is the outcome of a cell entering the G0 phase?

The cell stops cycling but remains active Signup and view all the answers

What is the primary function of the APC/C complex during late mitosis?

To target cyclin B for destruction Signup and view all the answers

What happens to p53 when it gets phosphorylated?

Mdm2 can't bind to it Signup and view all the answers

What is the function of Cdk1 in the cell cycle?

To phosphorylate lamins and break down the nuclear envelope Signup and view all the answers

What is the role of cyclin B in the cell cycle?

To activate Cdk1 activity Signup and view all the answers

What happens to Cdk1 activity during late G2 phase?

It becomes fully active after dephosphorylation by Cdc25 Signup and view all the answers

What is the effect of Wee1 on Cdk1 activity?

It inhibits Cdk1 by phosphorylating T-14 and Y-15 Signup and view all the answers

What is the outcome of Cdk1/cyclin B kinase activity in the nucleus?

Entry into mitosis Signup and view all the answers