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Questions and Answers
What is the primary structure specified by a gene according to the 'one gene-one protein' definition?
What is the primary structure specified by a gene according to the 'one gene-one protein' definition?
What are chromosomes composed of?
What are chromosomes composed of?
What is the total hereditary endowment of DNA called?
What is the total hereditary endowment of DNA called?
What serves to carry the genomic information from cell to cell?
What serves to carry the genomic information from cell to cell?
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What creates the appearance of 'beads on a string' in chromatin structure?
What creates the appearance of 'beads on a string' in chromatin structure?
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What is the characteristic feature of chromosome number within a species?
What is the characteristic feature of chromosome number within a species?
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What is the estimated number of crossovers per homologous pair in Baker’s yeast during meiosis?
What is the estimated number of crossovers per homologous pair in Baker’s yeast during meiosis?
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How many unique (haploid) gametes are produced as the end result of meiosis in Baker’s yeast?
How many unique (haploid) gametes are produced as the end result of meiosis in Baker’s yeast?
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What contributes to the new allele combinations in sexual reproduction?
What contributes to the new allele combinations in sexual reproduction?
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What increases the probability of survival and reproduction for individuals in a given environment?
What increases the probability of survival and reproduction for individuals in a given environment?
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What is the outcome of micro-evolution?
What is the outcome of micro-evolution?
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Which process in meiosis results in different allele combinations every time germ cells undergo meiosis?
Which process in meiosis results in different allele combinations every time germ cells undergo meiosis?
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During which phase of the cell cycle are chromosomes replicated?
During which phase of the cell cycle are chromosomes replicated?
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What is the function of the centromere during cell division?
What is the function of the centromere during cell division?
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Which phase of the cell cycle involves mitosis and cytokinesis?
Which phase of the cell cycle involves mitosis and cytokinesis?
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What is the main characteristic of chromosomes during mitotic cell division?
What is the main characteristic of chromosomes during mitotic cell division?
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In which phase of the cell cycle are the integrity of DNA and proper chromosome duplication assessed?
In which phase of the cell cycle are the integrity of DNA and proper chromosome duplication assessed?
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Which type of cells rarely or never enter the G0 phase of the cell cycle?
Which type of cells rarely or never enter the G0 phase of the cell cycle?
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What is the result of independent assortment of chromosomes during Meiosis I?
What is the result of independent assortment of chromosomes during Meiosis I?
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What does crossing over during Meiosis I lead to?
What does crossing over during Meiosis I lead to?
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What is the result of Meiosis II?
What is the result of Meiosis II?
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What does independent assortment of genes on different chromosomes mean?
What does independent assortment of genes on different chromosomes mean?
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What explains the differences in offspring's genetic information after Meiosis I?
What explains the differences in offspring's genetic information after Meiosis I?
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What affects the frequency of crossovers during Meiosis I?
What affects the frequency of crossovers during Meiosis I?
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What is the function of the M checkpoint in the cell cycle?
What is the function of the M checkpoint in the cell cycle?
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What is the consequence of a problem at the cell cycle checkpoints that can't be fixed?
What is the consequence of a problem at the cell cycle checkpoints that can't be fixed?
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What is the difference between asexual and sexual reproduction in terms of genetic variation?
What is the difference between asexual and sexual reproduction in terms of genetic variation?
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What is the difference between haploid and diploid organisms?
What is the difference between haploid and diploid organisms?
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What is the role of homologous chromosomes in genetic inheritance?
What is the role of homologous chromosomes in genetic inheritance?
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What is the process through which gametes are derived from diploid germ cells?
What is the process through which gametes are derived from diploid germ cells?
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What is the structure of chromosomes composed of, and how does it appear during mitosis?
What is the structure of chromosomes composed of, and how does it appear during mitosis?
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Define the term 'genome' and explain its significance in hereditary endowment.
Define the term 'genome' and explain its significance in hereditary endowment.
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What are the two definitions of a gene, and how do they differ in terms of specifying the primary structure of a protein?
What are the two definitions of a gene, and how do they differ in terms of specifying the primary structure of a protein?
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Explain the significance of independent assortment of chromosomes during Meiosis I, and how it contributes to genetic diversity in offspring.
Explain the significance of independent assortment of chromosomes during Meiosis I, and how it contributes to genetic diversity in offspring.
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Describe the process of crossing over during Meiosis I and its role in genetic recombination.
Describe the process of crossing over during Meiosis I and its role in genetic recombination.
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Explain the concept of genetic linkage and its impact on the segregation of genes during meiosis.
Explain the concept of genetic linkage and its impact on the segregation of genes during meiosis.
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Discuss the role of cell cycle checkpoints in maintaining genomic stability and preventing mutations. Provide examples of specific checkpoints and their functions.
Discuss the role of cell cycle checkpoints in maintaining genomic stability and preventing mutations. Provide examples of specific checkpoints and their functions.
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Explain the significance of meiotic cell division in generating genetic variation. Compare and contrast the genetic outcomes of asexual and sexual reproduction in terms of offspring diversity.
Explain the significance of meiotic cell division in generating genetic variation. Compare and contrast the genetic outcomes of asexual and sexual reproduction in terms of offspring diversity.
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Describe the differences between diploid and haploid organisms, and discuss the implications of these ploidy levels in terms of genetic diversity and inheritance.
Describe the differences between diploid and haploid organisms, and discuss the implications of these ploidy levels in terms of genetic diversity and inheritance.
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Explain the role of the centromere and kinetochores during mitotic cell division and their importance for genetic stability.
Explain the role of the centromere and kinetochores during mitotic cell division and their importance for genetic stability.
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Describe the significance of the G0 phase in the cell cycle and provide examples of cell types that may permanently enter this phase.
Describe the significance of the G0 phase in the cell cycle and provide examples of cell types that may permanently enter this phase.
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Discuss the implications of cell cycle mis-regulation in the context of cancer and the current focus of research in the field.
Discuss the implications of cell cycle mis-regulation in the context of cancer and the current focus of research in the field.
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What are the three sexual sources of genetic variation and how do they contribute to evolution?
What are the three sexual sources of genetic variation and how do they contribute to evolution?
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Explain the significance of the estimated ~6 crossovers per homologous pair in Baker’s yeast during meiosis.
Explain the significance of the estimated ~6 crossovers per homologous pair in Baker’s yeast during meiosis.
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How does sexual reproduction contribute to the reshuffling of genetic combinations and the potential for adaptation in changing environments?
How does sexual reproduction contribute to the reshuffling of genetic combinations and the potential for adaptation in changing environments?
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Study Notes
Cell Cycle, Checkpoints, and Genetics
- Cell division requires accurate DNA duplication and equal chromosome distribution to daughter cells
- Mistakes in duplication lead to mutations, which cells try to avoid
- Checkpoints in the cell cycle stop the cycle if there's a problem and trigger apoptosis if the problem can't be fixed
- The M checkpoint, or spindle checkpoint, ensures correct attachment of sister chromatids to spindle fibers
- Apoptosis is a tightly-regulated process for programmed cell death
- Cancer is often a result of cell cycle dis-regulation
- Model organisms like fission and baker's yeast are used to study cell cycle regulation
- Asexual reproduction through mitotic cell division leads to genetically identical offspring
- Sexual reproduction involves meiotic cell division, gamete formation, and genetic variation
- Diploid organisms have two sets of chromosomes, while haploid organisms have one set
- Homologous chromosomes have the same genes at the same loci, with alleles as alternative gene versions
- Gametes are haploid sex cells derived from diploid germ cells through meiosis; somatic cells undergo mitotic division
Cell Division and the Cell Cycle
- Different species have different numbers of chromosomes, with humans having 46, lake trout having 84, and hamsters having 22
- Cell Theory states that all cells come from pre-existing cells and have a genome, which is the total hereditary endowment of DNA
- Mitotic cell division results in genetically identical daughter cells with the same genome as the original cell
- Chromosomes spend most of their time in a non-condensed state, but condense during mitosis, always having sister chromatids
- Chromosome replication by DNA polymerases and associated enzymes is a prerequisite for cell division
- The cell cycle is a tightly regulated process, with interphase having three sub-phases (G1, S, G2) and the M phase involving mitosis and cytokinesis
- The centromere is a specialized zone of DNA where sister chromatids are held together, and kinetochores are produced during the M phase
- Some cells may enter the G0 phase, a resting phase, which can be temporary or permanent depending on the cell type
- Cell types that permanently enter G0 include neurons, some liver cells, and some kidney cells, while some, like epithelial cells, rarely or never enter G0
- Cancer is associated with cell cycle mis-regulation, and research focuses on cell cycle regulation and checkpoints
- The integrity of DNA, proper chromosome duplication, and attachment of kinetochores to spindle fibers are assessed at the G1, G2, and M checkpoints, respectively
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Description
Test your knowledge of the cell cycle, checkpoints, and genetics with this quiz. Explore the mechanisms of DNA duplication, chromosome distribution, and cell cycle regulation. Learn about the role of checkpoints in preventing mutations, the process of apoptosis, and how cell cycle dysregulation can lead to cancer. Delve into the differences between asexual and sexual reproduction, and understand the significance of meiotic cell division in creating genetic variation.