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Cell Cycle
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Cell Cycle

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Questions and Answers

What is the primary structure specified by a gene according to the 'one gene-one protein' definition?

  • Protein or polypeptide (correct)
  • Polysaccharides
  • Lipids
  • RNA
  • What are chromosomes composed of?

  • Polysaccharides
  • Nucleotides
  • DNA-protein complex (correct)
  • Lipids
  • What is the total hereditary endowment of DNA called?

  • Exome
  • Proteome
  • Metabolome
  • Genome (correct)
  • What serves to carry the genomic information from cell to cell?

    <p>Chromosomes</p> Signup and view all the answers

    What creates the appearance of 'beads on a string' in chromatin structure?

    <p>Histone proteins</p> Signup and view all the answers

    What is the characteristic feature of chromosome number within a species?

    <p>It is constant within species</p> Signup and view all the answers

    What is the estimated number of crossovers per homologous pair in Baker’s yeast during meiosis?

    <p>6</p> Signup and view all the answers

    How many unique (haploid) gametes are produced as the end result of meiosis in Baker’s yeast?

    <p>4</p> Signup and view all the answers

    What contributes to the new allele combinations in sexual reproduction?

    <p>Independent assortment of chromosomes</p> Signup and view all the answers

    What increases the probability of survival and reproduction for individuals in a given environment?

    <p>Possession of favourable alleles or allele combinations</p> Signup and view all the answers

    What is the outcome of micro-evolution?

    <p>A change in population allele frequency over time</p> Signup and view all the answers

    Which process in meiosis results in different allele combinations every time germ cells undergo meiosis?

    <p>Crossing over</p> Signup and view all the answers

    During which phase of the cell cycle are chromosomes replicated?

    <p>S phase</p> Signup and view all the answers

    What is the function of the centromere during cell division?

    <p>It holds together sister chromatids</p> Signup and view all the answers

    Which phase of the cell cycle involves mitosis and cytokinesis?

    <p>M phase</p> Signup and view all the answers

    What is the main characteristic of chromosomes during mitotic cell division?

    <p>They have sister chromatids</p> Signup and view all the answers

    In which phase of the cell cycle are the integrity of DNA and proper chromosome duplication assessed?

    <p>G2 phase</p> Signup and view all the answers

    Which type of cells rarely or never enter the G0 phase of the cell cycle?

    <p>Epithelial cells</p> Signup and view all the answers

    What is the result of independent assortment of chromosomes during Meiosis I?

    <p>Random division of chromosomes and a large number of possible chromosome combinations</p> Signup and view all the answers

    What does crossing over during Meiosis I lead to?

    <p>Genetic recombination and differences in gametes produced after Meiosis II</p> Signup and view all the answers

    What is the result of Meiosis II?

    <p>Formation of four haploid cells</p> Signup and view all the answers

    What does independent assortment of genes on different chromosomes mean?

    <p>They sort independently during meiosis</p> Signup and view all the answers

    What explains the differences in offspring's genetic information after Meiosis I?

    <p>Random assortment and independent assortment of chromosomes</p> Signup and view all the answers

    What affects the frequency of crossovers during Meiosis I?

    <p>It varies between species</p> Signup and view all the answers

    What is the function of the M checkpoint in the cell cycle?

    <p>Ensures correct attachment of sister chromatids to spindle fibers</p> Signup and view all the answers

    What is the consequence of a problem at the cell cycle checkpoints that can't be fixed?

    <p>Apoptosis is triggered</p> Signup and view all the answers

    What is the difference between asexual and sexual reproduction in terms of genetic variation?

    <p>Asexual reproduction leads to genetically identical offspring, while sexual reproduction involves genetic variation</p> Signup and view all the answers

    What is the difference between haploid and diploid organisms?

    <p>Diploid organisms have two sets of chromosomes, while haploid organisms have one set</p> Signup and view all the answers

    What is the role of homologous chromosomes in genetic inheritance?

    <p>Homologous chromosomes have the same genes at the same loci, with alleles as alternative gene versions</p> Signup and view all the answers

    What is the process through which gametes are derived from diploid germ cells?

    <p>Meiosis</p> Signup and view all the answers

    What is the structure of chromosomes composed of, and how does it appear during mitosis?

    <p>Chromosomes are composed of chromatin (DNA-protein complex) and appear as condensed threadlike structures during mitosis.</p> Signup and view all the answers

    Define the term 'genome' and explain its significance in hereditary endowment.

    <p>Genome refers to the total hereditary endowment of DNA and is significant as it carries the genomic information from cell to cell, maintaining genetic traits within a species.</p> Signup and view all the answers

    What are the two definitions of a gene, and how do they differ in terms of specifying the primary structure of a protein?

    <p>The two definitions of a gene are the 'one gene-one protein' definition and the 'one gene-one polypeptide' definition. They differ in terms of specifying the primary structure of a protein by indicating that a gene is a sequence of DNA/nucleotides/codons that specifies the primary structure of a protein (or a polypeptide), and also sections of DNA that code for a useful product, such as protein/polypeptide, tRNA, rRNA, or other forms of RNA.</p> Signup and view all the answers

    Explain the significance of independent assortment of chromosomes during Meiosis I, and how it contributes to genetic diversity in offspring.

    <p>Independent assortment of chromosomes during Meiosis I results in a random division of chromosomes, leading to a large number of possible chromosome combinations. This random assortment results in different genetic information in offspring, making each unique.</p> Signup and view all the answers

    Describe the process of crossing over during Meiosis I and its role in genetic recombination.

    <p>Crossing over during Meiosis I involves the exchange of genetic material between homologous chromosomes, leading to genetic recombination. This process contributes to the differences in gametes produced after Meiosis II.</p> Signup and view all the answers

    Explain the concept of genetic linkage and its impact on the segregation of genes during meiosis.

    <p>Genes on the same chromosome may be linked, with the probability of segregation being dependent on the degree of genetic linkage. This linkage affects the independent assortment of genes during meiosis.</p> Signup and view all the answers

    Discuss the role of cell cycle checkpoints in maintaining genomic stability and preventing mutations. Provide examples of specific checkpoints and their functions.

    <p>Cell cycle checkpoints play a crucial role in ensuring accurate DNA duplication and equal chromosome distribution to daughter cells. Examples of specific checkpoints include the M checkpoint, which ensures correct attachment of sister chromatids to spindle fibers, and the G1 checkpoint, which assesses the integrity of DNA and proper chromosome duplication. These checkpoints stop the cell cycle if there's a problem and trigger apoptosis if the problem can't be fixed, thus preventing the propagation of mutated cells.</p> Signup and view all the answers

    Explain the significance of meiotic cell division in generating genetic variation. Compare and contrast the genetic outcomes of asexual and sexual reproduction in terms of offspring diversity.

    <p>Meiotic cell division is significant in generating genetic variation as it involves the formation of haploid gametes with unique combinations of genetic material through processes such as independent assortment and crossing over. In contrast, asexual reproduction through mitotic cell division leads to genetically identical offspring, while sexual reproduction involves meiotic cell division, gamete formation, and genetic variation due to the combination of genetic material from two parents.</p> Signup and view all the answers

    Describe the differences between diploid and haploid organisms, and discuss the implications of these ploidy levels in terms of genetic diversity and inheritance.

    <p>Diploid organisms have two sets of chromosomes, while haploid organisms have one set. This difference in ploidy levels has implications for genetic diversity and inheritance, as diploid organisms possess homologous chromosomes with potential for genetic recombination and diversity through processes such as crossing over during meiosis, while haploid organisms have limited genetic variation due to the absence of homologous chromosomes.</p> Signup and view all the answers

    Explain the role of the centromere and kinetochores during mitotic cell division and their importance for genetic stability.

    <p>The centromere is a specialized zone of DNA where sister chromatids are held together, and kinetochores are produced during the M phase. The attachment of kinetochores to spindle fibers ensures proper chromosome segregation and genetic stability.</p> Signup and view all the answers

    Describe the significance of the G0 phase in the cell cycle and provide examples of cell types that may permanently enter this phase.

    <p>The G0 phase is a resting phase in the cell cycle. Some cell types, such as neurons, some liver cells, and some kidney cells, may permanently enter this phase. The G0 phase is significant as it allows cells to temporarily or permanently cease division, contributing to cellular diversity and specialized functions within an organism.</p> Signup and view all the answers

    Discuss the implications of cell cycle mis-regulation in the context of cancer and the current focus of research in the field.

    <p>Cell cycle mis-regulation is associated with cancer, highlighting the importance of understanding cell cycle regulation and checkpoints. Research in the field focuses on assessing the integrity of DNA, proper chromosome duplication, and attachment of kinetochores to spindle fibers at the G1, G2, and M checkpoints, respectively, to develop targeted cancer therapies and treatments.</p> Signup and view all the answers

    What are the three sexual sources of genetic variation and how do they contribute to evolution?

    <p>The three sexual sources of genetic variation are independent assortment of chromosomes, crossing over, and random fertilization. These sources contribute to evolution by creating new allele combinations, some of which may be more favorable in a given environment. Individuals possessing these favorable alleles have a higher probability of survival and reproduction, leading to an increase in their frequency in the population over time (micro-evolution).</p> Signup and view all the answers

    Explain the significance of the estimated ~6 crossovers per homologous pair in Baker’s yeast during meiosis.

    <p>The estimated ~6 crossovers per homologous pair in Baker’s yeast during meiosis contribute to genetic variation by creating new combinations of alleles. This increases the likelihood of producing unique gametes with different allele combinations, ultimately leading to increased genetic diversity within the population.</p> Signup and view all the answers

    How does sexual reproduction contribute to the reshuffling of genetic combinations and the potential for adaptation in changing environments?

    <p>Sexual reproduction reshuffles genetic combinations through processes such as independent assortment of chromosomes, crossing over, and random fertilization. This reshuffling generates new allele combinations, some of which may be more favorable in specific environments. Individuals carrying these favorable allele combinations have a higher probability of survival and reproduction, potentially leading to adaptation and increased frequency of these alleles in the population over time (micro-evolution).</p> Signup and view all the answers

    Study Notes

    Cell Cycle, Checkpoints, and Genetics

    • Cell division requires accurate DNA duplication and equal chromosome distribution to daughter cells
    • Mistakes in duplication lead to mutations, which cells try to avoid
    • Checkpoints in the cell cycle stop the cycle if there's a problem and trigger apoptosis if the problem can't be fixed
    • The M checkpoint, or spindle checkpoint, ensures correct attachment of sister chromatids to spindle fibers
    • Apoptosis is a tightly-regulated process for programmed cell death
    • Cancer is often a result of cell cycle dis-regulation
    • Model organisms like fission and baker's yeast are used to study cell cycle regulation
    • Asexual reproduction through mitotic cell division leads to genetically identical offspring
    • Sexual reproduction involves meiotic cell division, gamete formation, and genetic variation
    • Diploid organisms have two sets of chromosomes, while haploid organisms have one set
    • Homologous chromosomes have the same genes at the same loci, with alleles as alternative gene versions
    • Gametes are haploid sex cells derived from diploid germ cells through meiosis; somatic cells undergo mitotic division

    Cell Division and the Cell Cycle

    • Different species have different numbers of chromosomes, with humans having 46, lake trout having 84, and hamsters having 22
    • Cell Theory states that all cells come from pre-existing cells and have a genome, which is the total hereditary endowment of DNA
    • Mitotic cell division results in genetically identical daughter cells with the same genome as the original cell
    • Chromosomes spend most of their time in a non-condensed state, but condense during mitosis, always having sister chromatids
    • Chromosome replication by DNA polymerases and associated enzymes is a prerequisite for cell division
    • The cell cycle is a tightly regulated process, with interphase having three sub-phases (G1, S, G2) and the M phase involving mitosis and cytokinesis
    • The centromere is a specialized zone of DNA where sister chromatids are held together, and kinetochores are produced during the M phase
    • Some cells may enter the G0 phase, a resting phase, which can be temporary or permanent depending on the cell type
    • Cell types that permanently enter G0 include neurons, some liver cells, and some kidney cells, while some, like epithelial cells, rarely or never enter G0
    • Cancer is associated with cell cycle mis-regulation, and research focuses on cell cycle regulation and checkpoints
    • The integrity of DNA, proper chromosome duplication, and attachment of kinetochores to spindle fibers are assessed at the G1, G2, and M checkpoints, respectively

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    Test your knowledge of the cell cycle, checkpoints, and genetics with this quiz. Explore the mechanisms of DNA duplication, chromosome distribution, and cell cycle regulation. Learn about the role of checkpoints in preventing mutations, the process of apoptosis, and how cell cycle dysregulation can lead to cancer. Delve into the differences between asexual and sexual reproduction, and understand the significance of meiotic cell division in creating genetic variation.

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