Podcast
Questions and Answers
What is the significance of the metaphase plate in mitosis?
What is the significance of the metaphase plate in mitosis?
- It is the site where the spindle fibers originate.
- It is the location where the nuclear envelope reforms during telophase.
- It ensures the chromosomes are properly aligned before separation. (correct)
- It is the area where the cell membrane invaginates to form the cleavage furrow.
During which stage of mitosis do the sister chromatids separate?
During which stage of mitosis do the sister chromatids separate?
- Anaphase (correct)
- Prophase
- Metaphase
- Telophase
What is the role of the kinetochore microtubules in mitosis?
What is the role of the kinetochore microtubules in mitosis?
- They elongate the cell during telophase.
- They control the movement of the centrosomes during prophase.
- They form the cleavage furrow during cytokinesis.
- They attach to the centromeres of the chromosomes and pull them apart. (correct)
Which of the following conditions is NOT a potential cause of abnormalities in cell division?
Which of the following conditions is NOT a potential cause of abnormalities in cell division?
What is the primary function of the cell cycle control system?
What is the primary function of the cell cycle control system?
During which phase of the cell cycle does the cell grow and prepare for DNA replication?
During which phase of the cell cycle does the cell grow and prepare for DNA replication?
What is the primary difference between mitosis and meiosis?
What is the primary difference between mitosis and meiosis?
Which of the following is NOT a characteristic of the G0 phase of the cell cycle?
Which of the following is NOT a characteristic of the G0 phase of the cell cycle?
What is the role of cyclin-dependent kinase inhibitors (CKIs) in the cell cycle?
What is the role of cyclin-dependent kinase inhibitors (CKIs) in the cell cycle?
What is the primary function of the anaphase-promoting complex (APC) in the cell cycle?
What is the primary function of the anaphase-promoting complex (APC) in the cell cycle?
Which of the following is NOT a characteristic of the cell cycle checkpoints?
Which of the following is NOT a characteristic of the cell cycle checkpoints?
What is the role of growth factors in the cell cycle?
What is the role of growth factors in the cell cycle?
Which of the following is a correct pairing of a cyclin and its corresponding CDK?
Which of the following is a correct pairing of a cyclin and its corresponding CDK?
How do cyclin levels fluctuate during the cell cycle?
How do cyclin levels fluctuate during the cell cycle?
What is the primary reason for the irreversibility of events in the cell cycle?
What is the primary reason for the irreversibility of events in the cell cycle?
Which of the following is a checkpoint question asked during the G2 phase?
Which of the following is a checkpoint question asked during the G2 phase?
What is the role of tumor suppressor genes?
What is the role of tumor suppressor genes?
How do cancer cells typically respond to growth factors?
How do cancer cells typically respond to growth factors?
What happens when the p53 gene is mutated?
What happens when the p53 gene is mutated?
What is a characteristic behavior of cancer cells in the cell cycle?
What is a characteristic behavior of cancer cells in the cell cycle?
What is the role of the p53 protein in normal cells?
What is the role of the p53 protein in normal cells?
What is one primary reason cells need to divide?
What is one primary reason cells need to divide?
Which phase of the cell cycle involves the replication of the genome?
Which phase of the cell cycle involves the replication of the genome?
During which phase of the cell cycle does a cell primarily grow and prepare for division?
During which phase of the cell cycle does a cell primarily grow and prepare for division?
What happens during cytokinesis?
What happens during cytokinesis?
Which of the following is NOT a phase of interphase?
Which of the following is NOT a phase of interphase?
What is the significance of defects in cell division?
What is the significance of defects in cell division?
What type of cells are derived from the cell division in the bone marrow?
What type of cells are derived from the cell division in the bone marrow?
How many chromosomes do all normal human cells contain?
How many chromosomes do all normal human cells contain?
What type of cells undergo mitosis to produce identical daughter cells?
What type of cells undergo mitosis to produce identical daughter cells?
What is the primary outcome of meiosis in sexual reproduction?
What is the primary outcome of meiosis in sexual reproduction?
What is the role of proteins called condensins during mitosis?
What is the role of proteins called condensins during mitosis?
Which of the following correctly describes sister chromatids?
Which of the following correctly describes sister chromatids?
What type of cell division do prokaryotic organisms use?
What type of cell division do prokaryotic organisms use?
During which phase of the cell cycle does chromosome duplication occur?
During which phase of the cell cycle does chromosome duplication occur?
What is the main difference between somatic cells and gametes?
What is the main difference between somatic cells and gametes?
What structure is essential for chromosome movement during mitosis?
What structure is essential for chromosome movement during mitosis?
What is the primary function of kinetochores in the cell cycle?
What is the primary function of kinetochores in the cell cycle?
During which phase of mitosis do chromosomes condense into discrete structures?
During which phase of mitosis do chromosomes condense into discrete structures?
What occurs during the Metaphase stage of mitosis?
What occurs during the Metaphase stage of mitosis?
What characterizes Anaphase in the cell cycle?
What characterizes Anaphase in the cell cycle?
What happens during Telophase in animal cells?
What happens during Telophase in animal cells?
During G2 of Interphase, how many centrosomes are present in an animal cell?
During G2 of Interphase, how many centrosomes are present in an animal cell?
What is the structure formed by centrosomes that assists in chromosome movement?
What is the structure formed by centrosomes that assists in chromosome movement?
Which of the following describes the chromatin structure at the end of G2 of Interphase?
Which of the following describes the chromatin structure at the end of G2 of Interphase?
Flashcards
Cell Division
Cell Division
The process by which a single cell divides to produce two identical daughter cells.
Interphase
Interphase
The time period between cell divisions when a cell is growing and performing its normal functions.
Mitosis
Mitosis
The phase of the cell cycle where the cell's nucleus divides, resulting in two identical nuclei.
Cytokinesis
Cytokinesis
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G1 Phase
G1 Phase
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S Phase
S Phase
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G2 Phase
G2 Phase
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Diploid Cells
Diploid Cells
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Gametes
Gametes
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Binary fission
Binary fission
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Condensins
Condensins
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Centromere
Centromere
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Metaphase
Metaphase
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Metaphase plate
Metaphase plate
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Kinetochores
Kinetochores
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Kinetochore microtubules
Kinetochore microtubules
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Spindle
Spindle
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Telophase
Telophase
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Cell cycle control system
Cell cycle control system
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What is a centromere?
What is a centromere?
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What are kinetochores?
What are kinetochores?
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What is mitosis?
What is mitosis?
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What happens in Prophase?
What happens in Prophase?
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What happens in Metaphase?
What happens in Metaphase?
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What happens in Anaphase?
What happens in Anaphase?
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What happens in Telophase?
What happens in Telophase?
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What is cytokinesis?
What is cytokinesis?
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What is a checkpoint in the cell cycle?
What is a checkpoint in the cell cycle?
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What are cyclin-dependent kinases (CDKs)?
What are cyclin-dependent kinases (CDKs)?
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What are cyclins?
What are cyclins?
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What are cyclin-dependent kinase inhibitors (CKIs)?
What are cyclin-dependent kinase inhibitors (CKIs)?
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What is the anaphase-promoting complex (APC)?
What is the anaphase-promoting complex (APC)?
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What is proteolysis?
What is proteolysis?
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What are growth factors?
What are growth factors?
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What is the signal transduction pathway triggered by PDGF?
What is the signal transduction pathway triggered by PDGF?
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Cyclin-dependent kinases (CDKs)
Cyclin-dependent kinases (CDKs)
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Cdk-G1 cyclin
Cdk-G1 cyclin
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Cdk-Mitotic cyclin
Cdk-Mitotic cyclin
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p53 gene
p53 gene
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Cell cycle checkpoints
Cell cycle checkpoints
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Study Notes
Cell Division & Cell Cycle
- Cells need to divide for reproduction, growth, and tissue renewal.
- Cell division results in genetically identical daughter cells.
- Cells duplicate their genetic material (DNA) before division, ensuring each daughter cell receives an exact copy.
- DNA is the genetic information, packaged into chromosomes.
- The cell cycle consists of interphase (normal cell activity) and the mitotic phase (cell division).
- Interphase is divided into G1 (primary growth), S (genome replication), and G2 (secondary growth) phases.
- Mitosis (M phase) involves prophase, metaphase, anaphase, and telophase.
- Cytokinesis is the division of cytoplasm following mitosis.
- Prokaryotic cells (bacteria) divide by binary fission, a simpler process than mitosis.
- Eukaryotic cells, such as those in humans, go through a more complex cell cycle.
- The rate of cell division varies among different cell types (skin cells divide more frequently than nerve cells).
- Some cells are unlikely to divide (G0).
- Defects in cell division can lead to diseases like cancer.
- Cancer is uncontrolled cell proliferation, due to factors like faulty cell cycle checkpoints or mutations in genes that regulate cell division.
- Tumor suppressor genes normally slow down cell division and promote apoptosis (programmed cell death).
- A cell cycle checkpoint is a critical control point where stop and go signals regulate the cycle.
- Key checkpoints are located in G1, G2, and M phases.
- Control molecules (e.g., cyclin-dependent kinases, CDKs) pace the cell cycle; activity varies rhythmically.
- CDKs require cyclins to become active.
- Cell division is influenced by internal and external factors.
- Some are proteins called growth factors (e.g., PDGF) that trigger a signal transduction pathway leading to division.
Mitosis
- Mitosis is a process of cell division that produces two genetically identical daughter cells from a single parent cell. This is for growth (repair) in normal cells.
- There are four stages:
- Prophase: Condensation of chromosomes, disappearance of nucleolus, and spindle formation.
- Metaphase: Chromosomes align along the metaphase plate.
- Anaphase: Sister chromatids separate and move towards opposite poles.
- Telophase: Chromosomes decondense, and nuclear membrane reforms; two new nuclei are formed.
- Cytokinesis follows mitosis and involves the cytoplasmic division, creating two separate daughter cells.
Meiosis
- Meiosis is a special type of cell division that results in four haploid daughter cells from a single diploid cell. Used for sexual reproduction in the production of gametes (sperm and egg cells).
- It involves two rounds of cell division (Meiosis I and Meiosis II), reducing the chromosome number by half.
DNA and Chromosomes
- DNA, the genetic material, is packaged into chromosomes.
- Chromosomes are threadlike structures composed of DNA and protein.
- Each chromosome is made of two sister chromatids, joined at the centromere.
Functions of Cell Division
- Reproduction: Amoeba, a single cell eukaryote, can divide and form two new individual organisms.
- Growth and development: The process of fertilized eggs dividing to form new cells, essential for developing organisms.
- Tissue renewal: Bone marrow cells divide to give rise to new blood cells, replacing worn-out or damaged cells.
Eukaryotic Cell Cycle
- Major phases:
- Interphase: G1, S, G2 (condensed DNA).
- Cell Division (M): Mitosis and cytokinesis.
- Control system molecules that ensure cell cycle regulation.
Metaphase Chromosome
- Centromere: Constricted region, carries a specific DNA sequence and two discs of protein (kinetochores).
- Kinetochores: Attachment sites for microtubules that move chromosomes during cell division.
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