Cell Cycle and Mitosis Quiz

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Questions and Answers

What is the significance of the metaphase plate in mitosis?

  • It is the site where the spindle fibers originate.
  • It is the location where the nuclear envelope reforms during telophase.
  • It ensures the chromosomes are properly aligned before separation. (correct)
  • It is the area where the cell membrane invaginates to form the cleavage furrow.

During which stage of mitosis do the sister chromatids separate?

  • Anaphase (correct)
  • Prophase
  • Metaphase
  • Telophase

What is the role of the kinetochore microtubules in mitosis?

  • They elongate the cell during telophase.
  • They control the movement of the centrosomes during prophase.
  • They form the cleavage furrow during cytokinesis.
  • They attach to the centromeres of the chromosomes and pull them apart. (correct)

Which of the following conditions is NOT a potential cause of abnormalities in cell division?

<p>Proper separation of chromosomes (D)</p> Signup and view all the answers

What is the primary function of the cell cycle control system?

<p>To regulate the timing and order of events in the cell cycle. (B)</p> Signup and view all the answers

During which phase of the cell cycle does the cell grow and prepare for DNA replication?

<p>G1 (D)</p> Signup and view all the answers

What is the primary difference between mitosis and meiosis?

<p>Mitosis produces genetically identical daughter cells while meiosis produces genetically diverse daughter cells. (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of the G0 phase of the cell cycle?

<p>Cells in G0 are actively synthesizing DNA. (C)</p> Signup and view all the answers

What is the role of cyclin-dependent kinase inhibitors (CKIs) in the cell cycle?

<p>They inhibit the activity of CDKs by binding to CDK-cyclin complexes. (B)</p> Signup and view all the answers

What is the primary function of the anaphase-promoting complex (APC) in the cell cycle?

<p>It targets specific proteins for degradation by the proteasome. (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of the cell cycle checkpoints?

<p>They are only found in the G1, G2, and M phases of the cell cycle. (C)</p> Signup and view all the answers

What is the role of growth factors in the cell cycle?

<p>They stimulate cell division by binding to specific receptors on target cells. (A)</p> Signup and view all the answers

Which of the following is a correct pairing of a cyclin and its corresponding CDK?

<p>Cyclin E - CDK6 (C), Cyclin D - CDK4 (D)</p> Signup and view all the answers

How do cyclin levels fluctuate during the cell cycle?

<p>They increase and decrease in a cyclical pattern. (A)</p> Signup and view all the answers

What is the primary reason for the irreversibility of events in the cell cycle?

<p>The degradation of proteins by the proteasome. (C)</p> Signup and view all the answers

Which of the following is a checkpoint question asked during the G2 phase?

<p>Is DNA fully replicated? (B)</p> Signup and view all the answers

What is the role of tumor suppressor genes?

<p>To promote programmed cell death (D)</p> Signup and view all the answers

How do cancer cells typically respond to growth factors?

<p>They manufacture their own growth factors (A)</p> Signup and view all the answers

What happens when the p53 gene is mutated?

<p>Damaged cells may continue to divide uncontrollably (A)</p> Signup and view all the answers

What is a characteristic behavior of cancer cells in the cell cycle?

<p>They can divide at random points in the cycle (B)</p> Signup and view all the answers

What is the role of the p53 protein in normal cells?

<p>To repair DNA damage and induce apoptosis in severely damaged cells (B)</p> Signup and view all the answers

What is one primary reason cells need to divide?

<p>For reproduction (A)</p> Signup and view all the answers

Which phase of the cell cycle involves the replication of the genome?

<p>S phase (D)</p> Signup and view all the answers

During which phase of the cell cycle does a cell primarily grow and prepare for division?

<p>G1 phase (C)</p> Signup and view all the answers

What happens during cytokinesis?

<p>Cell divides into two daughter cells (A)</p> Signup and view all the answers

Which of the following is NOT a phase of interphase?

<p>M phase (C)</p> Signup and view all the answers

What is the significance of defects in cell division?

<p>They can lead to diseases (B)</p> Signup and view all the answers

What type of cells are derived from the cell division in the bone marrow?

<p>Blood cells (D)</p> Signup and view all the answers

How many chromosomes do all normal human cells contain?

<p>46 chromosomes (B)</p> Signup and view all the answers

What type of cells undergo mitosis to produce identical daughter cells?

<p>Somatic cells (A)</p> Signup and view all the answers

What is the primary outcome of meiosis in sexual reproduction?

<p>Formation of haploid gametes (C)</p> Signup and view all the answers

What is the role of proteins called condensins during mitosis?

<p>To condense and prepare chromosomes for duplication (D)</p> Signup and view all the answers

Which of the following correctly describes sister chromatids?

<p>They are identical copies of a duplicated chromosome (D)</p> Signup and view all the answers

What type of cell division do prokaryotic organisms use?

<p>Binary fission (C)</p> Signup and view all the answers

During which phase of the cell cycle does chromosome duplication occur?

<p>Interphase (D)</p> Signup and view all the answers

What is the main difference between somatic cells and gametes?

<p>Somatic cells are always diploid, gametes are haploid (D)</p> Signup and view all the answers

What structure is essential for chromosome movement during mitosis?

<p>Kinetochore (B)</p> Signup and view all the answers

What is the primary function of kinetochores in the cell cycle?

<p>To serve as attachment points for microtubules during chromosome movement (D)</p> Signup and view all the answers

During which phase of mitosis do chromosomes condense into discrete structures?

<p>Prophase (B)</p> Signup and view all the answers

What occurs during the Metaphase stage of mitosis?

<p>Chromosomes align and attach to spindle fibers (D)</p> Signup and view all the answers

What characterizes Anaphase in the cell cycle?

<p>Sister chromatids are pulled apart toward opposite poles (B)</p> Signup and view all the answers

What happens during Telophase in animal cells?

<p>The nuclear envelope reforms around the separated chromosomes (D)</p> Signup and view all the answers

During G2 of Interphase, how many centrosomes are present in an animal cell?

<p>Two centrosomes with two centriole pairs each (C)</p> Signup and view all the answers

What is the structure formed by centrosomes that assists in chromosome movement?

<p>Mitotic spindle (D)</p> Signup and view all the answers

Which of the following describes the chromatin structure at the end of G2 of Interphase?

<p>Chromatin is fully replicated but not yet condensed (D)</p> Signup and view all the answers

Flashcards

Cell Division

The process by which a single cell divides to produce two identical daughter cells.

Interphase

The time period between cell divisions when a cell is growing and performing its normal functions.

Mitosis

The phase of the cell cycle where the cell's nucleus divides, resulting in two identical nuclei.

Cytokinesis

The division of the cytoplasm to create two separate daughter cells after mitosis.

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G1 Phase

The first growth phase of interphase where the cell grows and synthesizes proteins.

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S Phase

The phase of interphase where the cell duplicates its DNA, ensuring each daughter cell gets a complete copy.

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G2 Phase

The second growth phase of interphase where the cell continues to grow and prepares for mitosis.

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Diploid Cells

Cells that contain two sets of chromosomes, one from each parent.

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Gametes

Specialized reproductive cells, such as sperm and egg cells, that contain only one set of chromosomes.

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Binary fission

The process by which prokaryotic cells (like bacteria) reproduce, where a single cell divides into two identical daughter cells without forming a nucleus.

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Condensins

Protein complexes that help to condense and prepare chromosomes for duplication during cell division.

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Centromere

The region on a chromosome where sister chromatids are joined together. It's the attachment point for microtubules during cell division.

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Metaphase

The longest stage of mitosis where chromosomes align at the center of the cell, ready for separation.

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Metaphase plate

An imaginary plane equidistant between the spindle poles, where chromosomes gather during metaphase.

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Kinetochores

Protein structures on chromosomes where microtubules attach during cell division.

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Kinetochore microtubules

Microtubules that connect to kinetochores, pulling chromosomes apart during anaphase.

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Spindle

The structure formed by microtubules during cell division, responsible for separating chromosomes.

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Telophase

The final stage of mitosis where two daughter nuclei form, and the cell begins to divide.

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Cell cycle control system

The controlled system that regulates cell cycle events, ensuring proper timing and order.

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What is a centromere?

A constricted region of a chromosome where two discs of protein (kinetochores) are attached. This region is involved in attaching microtubules that pull apart chromosomes during cell division.

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What are kinetochores?

Specialized protein structures found at the centromere of a chromosome that serve as attachment points for microtubules during cell division.

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What is mitosis?

The phase of the cell cycle where the cell's nucleus divides, resulting in two identical nuclei (daughter nuclei).

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What happens in Prophase?

The first stage of mitosis where the replicated chromosomes condense into visible structures. The nucleoli disappear and the mitotic spindle begins to form.

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What happens in Metaphase?

The stage of mitosis where the condensed chromosomes align themselves along the middle of the cell (metaphase plate).

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What happens in Anaphase?

The stage of mitosis where the sister chromatids of each duplicated chromosome separate and are pulled apart toward opposite poles of the cell.

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What happens in Telophase?

The final stage of mitosis where the nuclear envelope reforms around each set of chromosomes. The chromosomes relax into a less condensed chromatin state.

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What is cytokinesis?

The process of the cytoplasm dividing to create two separate daughter cells after mitosis.

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What is a checkpoint in the cell cycle?

A crucial control point in the cell cycle where signals determine if the cycle should proceed or stop.

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What are cyclin-dependent kinases (CDKs)?

Protein kinases that activate or deactivate other proteins by adding a phosphate group.

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What are cyclins?

Proteins that bind to CDKs and are essential for their activation.

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What are cyclin-dependent kinase inhibitors (CKIs)?

Proteins that specifically inhibit the kinase activity of CDKs by binding to the complex of CDKs and cyclins, effectively putting a brake on the cell cycle.

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What is the anaphase-promoting complex (APC)?

A complex of proteins activated during mitosis that initiates the separation of chromosomes, marking the start of anaphase.

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What is proteolysis?

A type of protein breakdown that is irreversible, used by cells to give the cell cycle directionality.

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What are growth factors?

Proteins released by cells that stimulate other cells to divide.

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What is the signal transduction pathway triggered by PDGF?

A signal transduction pathway triggered by platelet-derived growth factor (PDGF) that leads to cell division in fibroblasts.

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Cyclin-dependent kinases (CDKs)

A group of proteins that regulate the progression of the cell cycle by activating or inhibiting specific enzymes involved in cell division.

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Cdk-G1 cyclin

A type of CDK that is active during the G1 phase of the cell cycle and helps the cell commit to division.

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Cdk-Mitotic cyclin

A type of CDK that promotes entry into mitosis. It's also called maturation promoting factor (MPF).

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p53 gene

A tumor suppressor gene that plays a crucial role in controlling cell division and preventing cancer.

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Cell cycle checkpoints

A critical point in the cell cycle where the cell checks for errors and halts the cycle if issues are detected. These checkpoints ensure accurate DNA replication and proper chromosome segregation.

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Study Notes

Cell Division & Cell Cycle

  • Cells need to divide for reproduction, growth, and tissue renewal.
  • Cell division results in genetically identical daughter cells.
  • Cells duplicate their genetic material (DNA) before division, ensuring each daughter cell receives an exact copy.
  • DNA is the genetic information, packaged into chromosomes.
  • The cell cycle consists of interphase (normal cell activity) and the mitotic phase (cell division).
  • Interphase is divided into G1 (primary growth), S (genome replication), and G2 (secondary growth) phases.
  • Mitosis (M phase) involves prophase, metaphase, anaphase, and telophase.
  • Cytokinesis is the division of cytoplasm following mitosis.
  • Prokaryotic cells (bacteria) divide by binary fission, a simpler process than mitosis.
  • Eukaryotic cells, such as those in humans, go through a more complex cell cycle.
  • The rate of cell division varies among different cell types (skin cells divide more frequently than nerve cells).
  • Some cells are unlikely to divide (G0).
  • Defects in cell division can lead to diseases like cancer.
  • Cancer is uncontrolled cell proliferation, due to factors like faulty cell cycle checkpoints or mutations in genes that regulate cell division.
  • Tumor suppressor genes normally slow down cell division and promote apoptosis (programmed cell death).
  • A cell cycle checkpoint is a critical control point where stop and go signals regulate the cycle.
  • Key checkpoints are located in G1, G2, and M phases.
  • Control molecules (e.g., cyclin-dependent kinases, CDKs) pace the cell cycle; activity varies rhythmically.
  • CDKs require cyclins to become active.
  • Cell division is influenced by internal and external factors.
  • Some are proteins called growth factors (e.g., PDGF) that trigger a signal transduction pathway leading to division.

Mitosis

  • Mitosis is a process of cell division that produces two genetically identical daughter cells from a single parent cell. This is for growth (repair) in normal cells.
  • There are four stages:
    • Prophase: Condensation of chromosomes, disappearance of nucleolus, and spindle formation.
    • Metaphase: Chromosomes align along the metaphase plate.
    • Anaphase: Sister chromatids separate and move towards opposite poles.
    • Telophase: Chromosomes decondense, and nuclear membrane reforms; two new nuclei are formed.
  • Cytokinesis follows mitosis and involves the cytoplasmic division, creating two separate daughter cells.

Meiosis

  • Meiosis is a special type of cell division that results in four haploid daughter cells from a single diploid cell. Used for sexual reproduction in the production of gametes (sperm and egg cells).
  • It involves two rounds of cell division (Meiosis I and Meiosis II), reducing the chromosome number by half.

DNA and Chromosomes

  • DNA, the genetic material, is packaged into chromosomes.
  • Chromosomes are threadlike structures composed of DNA and protein.
  • Each chromosome is made of two sister chromatids, joined at the centromere.

Functions of Cell Division

  • Reproduction: Amoeba, a single cell eukaryote, can divide and form two new individual organisms.
  • Growth and development: The process of fertilized eggs dividing to form new cells, essential for developing organisms.
  • Tissue renewal: Bone marrow cells divide to give rise to new blood cells, replacing worn-out or damaged cells.

Eukaryotic Cell Cycle

  • Major phases:
    • Interphase: G1, S, G2 (condensed DNA).
    • Cell Division (M): Mitosis and cytokinesis.
  • Control system molecules that ensure cell cycle regulation.

Metaphase Chromosome

  • Centromere: Constricted region, carries a specific DNA sequence and two discs of protein (kinetochores).
  • Kinetochores: Attachment sites for microtubules that move chromosomes during cell division.

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