Cell Cycle and Mitosis Overview

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Questions and Answers

What is the name given to a fertilized egg?

Zygote

What is the primary method of reproduction for single-celled organisms?

  • Budding
  • Fragmentation
  • Cell division (correct)
  • Sexual reproduction

What is the term used to describe the stages in a cell's life from division to the production of two daughter cells?

Cell cycle

The mechanisms involved in the cell cycle are not regulated.

<p>False (B)</p> Signup and view all the answers

What is the term used for the genetic information packaged within a cell?

<p>Genome</p> Signup and view all the answers

What type of DNA molecule is found in prokaryotes?

<p>Single circular double-stranded DNA molecule</p> Signup and view all the answers

What are smaller non-essential DNA loops found in some prokaryotes called?

<p>Plasmids</p> Signup and view all the answers

What is the term used to describe the region in a prokaryotic cell that houses the genomic DNA?

<p>Nucleoid</p> Signup and view all the answers

What type of DNA molecule is found in eukaryotic cells?

<p>Double-stranded linear DNA molecule</p> Signup and view all the answers

How many chromosomes are present in human body cells?

<p>46 chromosomes</p> Signup and view all the answers

How many chromosomes are present in human gametes (sperm or eggs)?

<p>23 chromosomes</p> Signup and view all the answers

What is the term used to describe a typical body cell containing a full set of chromosomes, designated as 2n?

<p>Diploid</p> Signup and view all the answers

Flashcards

Cell Cycle

The orderly sequence of events describing a cell's life from division of a single parent cell to the production of two daughter cells.

Genome

The genetic material of a cell, packaged as double-stranded DNA molecules.

Nucleoid

The region in a prokaryotic cell containing the genetic material.

Plasmids

Small loops of non-essential DNA found in some prokaryotes.

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Plasmid Exchange

The process of transferring genetic material between bacteria, often resulting in traits like antibiotic resistance.

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Chromosomes

Linear double-stranded DNA molecules found in eukaryotic cells.

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Chromosome Number

The characteristic number of chromosomes in a species.

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Diploid

A cell containing two matched sets of chromosomes.

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Haploid

A cell containing one set of chromosomes, like sperm or egg cells.

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Homologous Chromosomes

Matched pairs of chromosomes in a diploid organism, having the same length and genes at the same locations.

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Genes

Functional units of chromosomes that code for specific proteins.

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Traits

Variations of characteristics determined by genes.

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Chromosomal Compaction

The process of tightly packaging DNA into compact chromosomes.

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S Phase

The phase of the cell cycle when DNA is replicated.

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Sister Chromatids

Identical pairs of DNA molecules that result from DNA replication.

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Centromere

The region where sister chromatids are connected.

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Mitotic Spindle

The structure responsible for organizing and moving chromosomes during mitosis.

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Centrioles

Rod-like objects found in animal cell centrosomes that help organize cell division.

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Interphase

The phase of the cell cycle where the cell prepares for division.

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G1 Phase

The first stage of interphase where the cell grows and accumulates resources.

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S Phase

The second stage of interphase when DNA is replicated.

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G2 Phase

The third stage of interphase where the cell grows further and prepares for mitosis.

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Mitosis

The stage of the cell cycle where the cell nucleus divides.

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Cytokinesis

The stage of the cell cycle where the cytoplasm divides.

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Prophase

The first stage of mitosis where chromosomes condense and the mitotic spindle forms.

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Prometaphase

The second stage of mitosis where the nuclear envelope breaks down and microtubules attach to chromosomes.

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Metaphase

The third stage of mitosis where chromosomes align at the center of the cell.

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Anaphase

The fourth stage of mitosis where sister chromatids separate and move to opposite poles of the cell.

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Telophase

The fifth and final stage of mitosis where the nuclear envelope reforms and chromosomes decondense.

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Cleavage Furrow

A contractile ring composed of actin filaments that helps divide the cytoplasm in animal cells.

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Phragmoplast

A vesicular structure formed during cytokinesis in plant cells, which eventually forms the cell wall.

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G0 Phase

The state where cells are not actively preparing to divide and are inactive.

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Internal Checkpoints

Control mechanisms within cells that ensure proper cell cycle progression.

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Checkpoint

A point in the cell cycle where progression is halted until conditions are favorable.

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G1 Checkpoint

The checkpoint in the cell cycle that assesses cell size, resources, DNA damage, and the commitment to division.

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G2 Checkpoint

The checkpoint in the cell cycle that ensures all chromosomes have been replicated and DNA is undamaged.

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M Checkpoint

The checkpoint in the cell cycle that ensures all sister chromatids are correctly attached to the spindle fibers.

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Study Notes

Cell Cycle and Mitosis

  • A human, like all sexually reproducing organisms, begins as a fertilized egg (zygote). Trillions of cell divisions, controlled, produce multicellular organisms. Single-celled organisms use cell division for reproduction.

DNA Organization and the Cell Cycle

  • The cell cycle is a series of events, describing a cell's life from one parent cell to two identical daughter cells. This cycle is highly regulated.

Genomic DNA

  • A cell's genetic information (genome) is DNA, packaged as double-stranded DNA molecules. This is called the cell's genome.
  • In prokaryotes, the genome is a single circular double-stranded DNA molecule within a nucleoid.
  • Some prokaryotes also have smaller DNA loops (plasmids) that aren't essential, but can carry beneficial genes, like antibiotic resistance. Bacteria can exchange plasmids.

Eukaryotic Chromosomal Structure and Compaction

  • DNA in eukaryotes (like humans) would measure meters if stretched out, but has to be compact for cells (approximately 10µm or 100,000 cells to equal one meter). The packaging allows for accessibility and expression of genes

  • DNA coils around histone proteins, forming nucleosomes. These nucleosomes coil into chromatin fibers, which further condense, becoming chromosomes.

  • Human somatic cells have 46 chromosomes, which are homologous pairs.

  • Gametes (sex cells) have 23 chromosomes each, representing one set of chromosomes (n). Thus, humans are considered 2n organisms (diploid).

The Mitotic Phase

  • The mitotic phase (M phase) includes mitosis and cytokinesis.
  • Mitosis is a series of phases: prophase, prometaphase, metaphase, anaphase, and telophase. Each one results in a division of the nucleus.
  • In animals, the division occurs at the midpoint (the metaphase plate). In plants, the new cell wall forms between daughter cells.

Interphase

  • During interphase, cells grow and prepare for division:
    • G1 phase (first gap): Cell grows, accumulating building blocks and energy for replication and protein synthesis.
    • S phase (synthesis): DNA replication occurs.
    • G2 phase (second gap): Cell replenishes energy and synthesizes proteins required for mitosis.

Cell Cycle Checkpoints

  • Internal controls prevent compromised cells from dividing. These checkpoints are critical control points (G1, G2, and M checkpoint) within the eukaryotic cell cycle. These checkpoints can pause or halt the progression of a cell into the next stage until certain conditions are met.
  • The G1 checkpoint assesses cell size and protein reserves.
  • The G2 checkpoint ensures all DNA has been replicated and is undamaged.
  • The M checkpoint checks for accurate chromosome attachment to the spindle fibers before proceeding.

Go Phase

  • Some cells, like mature muscle and nerve cells, permanently exit the cell cycle and enter a quiescent state called G0. They're not actively dividing but can be active in other ways.

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