Podcast
Questions and Answers
What is the name given to a fertilized egg?
What is the name given to a fertilized egg?
Zygote
What is the primary method of reproduction for single-celled organisms?
What is the primary method of reproduction for single-celled organisms?
- Budding
- Fragmentation
- Cell division (correct)
- Sexual reproduction
What is the term used to describe the stages in a cell's life from division to the production of two daughter cells?
What is the term used to describe the stages in a cell's life from division to the production of two daughter cells?
Cell cycle
The mechanisms involved in the cell cycle are not regulated.
The mechanisms involved in the cell cycle are not regulated.
What is the term used for the genetic information packaged within a cell?
What is the term used for the genetic information packaged within a cell?
What type of DNA molecule is found in prokaryotes?
What type of DNA molecule is found in prokaryotes?
What are smaller non-essential DNA loops found in some prokaryotes called?
What are smaller non-essential DNA loops found in some prokaryotes called?
What is the term used to describe the region in a prokaryotic cell that houses the genomic DNA?
What is the term used to describe the region in a prokaryotic cell that houses the genomic DNA?
What type of DNA molecule is found in eukaryotic cells?
What type of DNA molecule is found in eukaryotic cells?
How many chromosomes are present in human body cells?
How many chromosomes are present in human body cells?
How many chromosomes are present in human gametes (sperm or eggs)?
How many chromosomes are present in human gametes (sperm or eggs)?
What is the term used to describe a typical body cell containing a full set of chromosomes, designated as 2n?
What is the term used to describe a typical body cell containing a full set of chromosomes, designated as 2n?
Flashcards
Cell Cycle
Cell Cycle
The orderly sequence of events describing a cell's life from division of a single parent cell to the production of two daughter cells.
Genome
Genome
The genetic material of a cell, packaged as double-stranded DNA molecules.
Nucleoid
Nucleoid
The region in a prokaryotic cell containing the genetic material.
Plasmids
Plasmids
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Plasmid Exchange
Plasmid Exchange
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Chromosomes
Chromosomes
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Chromosome Number
Chromosome Number
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Diploid
Diploid
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Haploid
Haploid
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Homologous Chromosomes
Homologous Chromosomes
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Genes
Genes
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Traits
Traits
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Chromosomal Compaction
Chromosomal Compaction
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S Phase
S Phase
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Sister Chromatids
Sister Chromatids
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Centromere
Centromere
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Mitotic Spindle
Mitotic Spindle
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Centrioles
Centrioles
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Interphase
Interphase
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G1 Phase
G1 Phase
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S Phase
S Phase
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G2 Phase
G2 Phase
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Mitosis
Mitosis
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Cytokinesis
Cytokinesis
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Prophase
Prophase
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Prometaphase
Prometaphase
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Metaphase
Metaphase
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Anaphase
Anaphase
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Telophase
Telophase
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Cleavage Furrow
Cleavage Furrow
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Phragmoplast
Phragmoplast
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G0 Phase
G0 Phase
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Internal Checkpoints
Internal Checkpoints
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Checkpoint
Checkpoint
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G1 Checkpoint
G1 Checkpoint
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G2 Checkpoint
G2 Checkpoint
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M Checkpoint
M Checkpoint
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Study Notes
Cell Cycle and Mitosis
- A human, like all sexually reproducing organisms, begins as a fertilized egg (zygote). Trillions of cell divisions, controlled, produce multicellular organisms. Single-celled organisms use cell division for reproduction.
DNA Organization and the Cell Cycle
- The cell cycle is a series of events, describing a cell's life from one parent cell to two identical daughter cells. This cycle is highly regulated.
Genomic DNA
- A cell's genetic information (genome) is DNA, packaged as double-stranded DNA molecules. This is called the cell's genome.
- In prokaryotes, the genome is a single circular double-stranded DNA molecule within a nucleoid.
- Some prokaryotes also have smaller DNA loops (plasmids) that aren't essential, but can carry beneficial genes, like antibiotic resistance. Bacteria can exchange plasmids.
Eukaryotic Chromosomal Structure and Compaction
-
DNA in eukaryotes (like humans) would measure meters if stretched out, but has to be compact for cells (approximately 10µm or 100,000 cells to equal one meter). The packaging allows for accessibility and expression of genes
-
DNA coils around histone proteins, forming nucleosomes. These nucleosomes coil into chromatin fibers, which further condense, becoming chromosomes.
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Human somatic cells have 46 chromosomes, which are homologous pairs.
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Gametes (sex cells) have 23 chromosomes each, representing one set of chromosomes (n). Thus, humans are considered 2n organisms (diploid).
The Mitotic Phase
- The mitotic phase (M phase) includes mitosis and cytokinesis.
- Mitosis is a series of phases: prophase, prometaphase, metaphase, anaphase, and telophase. Each one results in a division of the nucleus.
- In animals, the division occurs at the midpoint (the metaphase plate). In plants, the new cell wall forms between daughter cells.
Interphase
- During interphase, cells grow and prepare for division:
- G1 phase (first gap): Cell grows, accumulating building blocks and energy for replication and protein synthesis.
- S phase (synthesis): DNA replication occurs.
- G2 phase (second gap): Cell replenishes energy and synthesizes proteins required for mitosis.
Cell Cycle Checkpoints
- Internal controls prevent compromised cells from dividing. These checkpoints are critical control points (G1, G2, and M checkpoint) within the eukaryotic cell cycle. These checkpoints can pause or halt the progression of a cell into the next stage until certain conditions are met.
- The G1 checkpoint assesses cell size and protein reserves.
- The G2 checkpoint ensures all DNA has been replicated and is undamaged.
- The M checkpoint checks for accurate chromosome attachment to the spindle fibers before proceeding.
Go Phase
- Some cells, like mature muscle and nerve cells, permanently exit the cell cycle and enter a quiescent state called G0. They're not actively dividing but can be active in other ways.
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