Cell Cycle and Chromosome Structure Quiz

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Questions and Answers

What are the main phases of the prokaryotic cell cycle?

The main phases are growth, DNA replication, and cell division.

Describe the process of binary fission in prokaryotic cells.

Binary fission involves DNA replication, attachment of chromosomes to cell membrane, and the formation of fibers that divide the cell.

What role do histone proteins play in DNA structure?

Histone proteins help in organizing DNA into nucleosomes, which supercoil to form a compact structure.

Identify the structure where sister chromatids are held together during cell division.

<p>The centromere holds sister chromatids together.</p> Signup and view all the answers

Why is the process of DNA replication critical before cell division?

<p>DNA replication is essential to ensure that each daughter cell receives an identical set of chromosomes.</p> Signup and view all the answers

What triggers the start of DNA replication in prokaryotic cells?

<p>DNA replication is triggered when prokaryotic cells reach a certain size.</p> Signup and view all the answers

How do prokaryotic and eukaryotic cell cycles differ fundamentally?

<p>Prokaryotic cell cycles are simpler and involve binary fission, while eukaryotic cell cycles include multiple phases of mitosis and cytokinesis.</p> Signup and view all the answers

What are the consequences if the cell cycle is disrupted?

<p>Disruption can lead to uncontrolled cell growth, resulting in conditions such as cancer.</p> Signup and view all the answers

What is the primary structural difference between prokaryotic and eukaryotic chromosomes?

<p>Prokaryotic chromosomes are typically circular and consist of a single chromosome, while eukaryotic chromosomes are linear and contain multiple chromosomes.</p> Signup and view all the answers

What role do histones play in the organization of eukaryotic DNA?

<p>Histones facilitate the coiling of DNA into a compact structure known as chromatin, allowing for efficient packaging of genetic material.</p> Signup and view all the answers

How do nucleosomes contribute to the structure of chromosomes?

<p>Nucleosomes, which are formed by DNA wrapped around histones, pack together to create thick fibers that characterize the structure of chromosomes.</p> Signup and view all the answers

Why is it important for cells to package their DNA into chromosomes during cell division?

<p>Packaging DNA into chromosomes ensures equal division of genetic material during cell division, preventing loss or damage to DNA.</p> Signup and view all the answers

Describe the composition of eukaryotic chromosomes.

<p>Eukaryotic chromosomes are composed of DNA tightly bound to proteins, specifically histones, forming structures known as chromatin.</p> Signup and view all the answers

What characterizes the chromosome shape commonly depicted in textbooks?

<p>The X-like shape commonly depicted represents a duplicated chromosome with supercoiled chromatin.</p> Signup and view all the answers

How does the amount of DNA in eukaryotic cells compare to that in prokaryotic cells?

<p>Eukaryotic cells generally contain much more DNA than prokaryotic cells due to their multiple chromosomes.</p> Signup and view all the answers

What initiates the process of chromosome coiling in eukaryotic cells?

<p>Chromosome coiling begins as a eukaryotic cell prepares for division, allowing for the DNA to form a compact structure.</p> Signup and view all the answers

What role does cell cycle control play in the development of cancer?

<p>Cell cycle control is essential; when it's disrupted, it can lead to uncontrolled cancer cell growth.</p> Signup and view all the answers

How do muscle and nerve cells differ from blood-producing cells in terms of division?

<p>Muscle and nerve cells typically do not divide after development, while blood-producing cells continuously divide throughout life.</p> Signup and view all the answers

What happens to cell division when cells come into contact with one another?

<p>Cell division usually stops when cells make contact with each other.</p> Signup and view all the answers

Describe the effect of removing neighboring cells in a laboratory cell culture.

<p>If neighboring cells are removed, the remaining cells will start dividing again until they come into contact with other cells.</p> Signup and view all the answers

What occurs at the edges of an injury like a cut or fracture in the skin?

<p>Cells at the edges are stimulated to divide rapidly to initiate the healing process.</p> Signup and view all the answers

What happens to the rate of cell division as the healing process nears completion?

<p>The rate of cell division slows, and controls on growth are restored.</p> Signup and view all the answers

Why is maintaining control over cell division important in organisms?

<p>Maintaining control over cell division prevents excessive growth, which can lead to diseases like cancer.</p> Signup and view all the answers

What is indicated by the rapid division of cells in response to injury?

<p>It indicates that cell growth regulation can be modulated by external stimuli such as injury.</p> Signup and view all the answers

What is the primary purpose of the S phase in the cell cycle?

<p>The primary purpose of the S phase is to synthesize new DNA, resulting in the replication of chromosomes.</p> Signup and view all the answers

Describe the roles of G2 phase in preparation for cell division.

<p>During the G2 phase, the cell produces many organelles and molecules necessary for cell division.</p> Signup and view all the answers

What are the two main stages of cell division in eukaryotes?

<p>The two main stages of cell division in eukaryotes are mitosis and cytokinesis.</p> Signup and view all the answers

How does cytokinesis relate to mitosis during the cell cycle?

<p>Cytokinesis often begins while mitosis is still taking place, indicating an overlap between the two stages.</p> Signup and view all the answers

What phases are included in the mitosis process as defined by biologists?

<p>The phases of mitosis are prophase, metaphase, anaphase, and telophase.</p> Signup and view all the answers

Why is interphase considered a lengthy period in the cell cycle?

<p>Interphase is considered lengthy because it encompasses processes like DNA replication and preparation for division.</p> Signup and view all the answers

What does the term 'kinesis' imply in the context of cell division?

<p>'Kinesis' refers to 'movement' or 'motion', relating to the movement involved during cytokinesis.</p> Signup and view all the answers

How long might the mitosis process take, depending on cell type?

<p>Mitosis can last anywhere from a few minutes to several days, depending on the type of cell.</p> Signup and view all the answers

What defines a totipotent cell in the context of embryonic development?

<p>A totipotent cell is defined as a cell that can develop into any type of cell in the body, including those that form extra-embryonic tissues like the placenta.</p> Signup and view all the answers

How does pluripotency differ from totipotency in stem cells?

<p>Pluripotent cells can develop into many different types of cells but not all, particularly they cannot form extra-embryonic tissues like totipotent cells can.</p> Signup and view all the answers

What is the significance of the inner cell mass in a blastocyst?

<p>The inner cell mass is significant because it contains pluripotent cells that will eventually differentiate into the various tissues of the body.</p> Signup and view all the answers

At what developmental stage does a human embryo first form a blastocyst?

<p>A human embryo first forms a blastocyst about four days after fertilization.</p> Signup and view all the answers

What role does the fertilized egg play in the differentiation of cells?

<p>The fertilized egg acts as the starting point for differentiation, being totipotent and capable of developing into all necessary cell types.</p> Signup and view all the answers

How does cell differentiation in mammals differ from that in other organisms?

<p>In mammals, cell differentiation is controlled by a complex interaction of factors in the embryo, while other organisms may follow more rigid pathways.</p> Signup and view all the answers

What happens to adult cells once they reach complete differentiation?

<p>Once adult cells reach complete differentiation, they generally cannot convert into other types of cells.</p> Signup and view all the answers

What triggers the process of differentiation in zygote-derived cells?

<p>The differentiation in zygote-derived cells is triggered by various interacting factors in the embryo, although the exact mechanisms remain largely misunderstood.</p> Signup and view all the answers

What ethical concerns are raised by human embryonic stem cell research?

<p>The ethical concerns include the opposition from groups who consider it unethical to use human embryos for research, versus the support from others who argue it is essential for saving lives.</p> Signup and view all the answers

What breakthrough did Shinya Yamanaka achieve in stem cell research?

<p>Shinya Yamanaka achieved the conversion of human fibroblasts into induced pluripotent stem cells (iPS cells) that resemble embryonic stem cells.</p> Signup and view all the answers

How do induced pluripotent stem cells (iPS cells) differ from embryonic stem cells?

<p>iPS cells are generated from adult cells and reprogrammed to an embryonic-like state, unlike embryonic stem cells which are derived from embryos.</p> Signup and view all the answers

What was the significance of John Gurdon's work related to iPS cells?

<p>John Gurdon's work demonstrated that the nucleus of an adult cell can be reprogrammed to develop into an embryo, paving the way for iPS cell research.</p> Signup and view all the answers

What are the potential applications of iPS cells in research?

<p>iPS cells can potentially be used in regenerative medicine, disease modeling, and drug testing, offering insights into human development and disease.</p> Signup and view all the answers

What was the major recognition received by Yamanaka and Gurdon for their work on stem cells?

<p>Yamanaka and Gurdon were awarded the Nobel Prize in Physiology or Medicine in 2012 for their contributions to stem cell science.</p> Signup and view all the answers

What are some arguments presented by supporters of embryonic stem cell research?

<p>Supporters argue that restricting embryonic stem cell research would hinder potential medical breakthroughs and improve treatments for various diseases.</p> Signup and view all the answers

Why is the field of stem cell research considered controversial?

<p>Stem cell research is controversial due to the conflicting ethical viewpoints concerning the moral implications of using human embryos.</p> Signup and view all the answers

Flashcards

Prokaryotic Chromosome

A single, circular molecule of DNA that contains most of the genetic information in prokaryotic cells.

Eukaryotic Chromosome

Multiple, linear molecules of DNA that contain the genetic information of eukaryotic cells.

Chromatin

A complex of DNA and proteins, primarily histones, found in eukaryotic cells.

Nucleosomes

Bead-like structures formed by DNA tightly coiled around histone proteins in eukaryotic cells.

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Duplicated Chromosome

A duplicated chromosome with supercoiled chromatin, often seen as an 'X' shape during cell division.

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Chromosomal Condensation

The process of tightly packing DNA into chromosomes, which helps to ensure equal division of genetic material during cell division.

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Chromosomal Separation

The process of separating chromosomes evenly into two daughter cells during cell division.

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Prokaryotic vs. Eukaryotic Chromosomes

The difference in chromosome structure between prokaryotic and eukaryotic cells.

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Cell Cycle

The process by which a cell grows, prepares for division, and then divides to form two daughter cells.

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Binary Fission

A type of asexual reproduction in prokaryotes where a single cell divides into two identical daughter cells.

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Chromosome

The genetic material of a cell, composed of a long, double-stranded molecule of DNA.

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Sister Chromatids

Two identical copies of a chromosome that are joined together at the centromere.

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Centromere

The constricted region of a chromosome where the two sister chromatids are joined together.

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Supercoils

Coiled structures formed when nucleosomes are packed together even more tightly.

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Histone proteins

Proteins that help package and organize DNA into chromosomes.

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Interphase

The stage in the cell cycle where the cell grows and copies its DNA before dividing.

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S phase (Synthesis)

The phase of interphase when DNA is replicated, creating two identical copies of each chromosome.

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G2 phase

The phase of interphase after DNA replication, where the cell prepares for mitosis.

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Mitosis

The phase of the cell cycle during which the cell divides its nucleus into two identical nuclei.

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Prophase

The first stage of mitosis where the chromosomes condense and become visible.

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Metaphase

The stage of mitosis where the chromosomes line up in the middle of the cell.

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Anaphase

The stage of mitosis where the sister chromatids, the replicated chromosomes, are pulled apart to opposite poles of the cell.

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Telophase

The final stage of mitosis where the nuclei form around the chromosomes at each pole, resulting in two identical nuclei.

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Cell division

The process by which cells divide and produce new cells.

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Control of the cell cycle

The regulation of the cell cycle ensures that cells divide in an orderly and controlled manner.

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Consequences of uncontrolled cell cycle

Disruption of normal cell cycle control can lead to uncontrolled cell growth, such as in cancer.

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Cell division in different tissue types

Certain cells, like muscle and nerve cells, stop dividing after they mature, while others, such as blood cells, skin cells, and digestive tract cells, continue dividing throughout life.

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Contact inhibition

When cells in a culture come into contact with each other, they usually stop dividing.

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Contact inhibition in a cell culture

When cells are scraped off a culture dish, the remaining cells start dividing again until they make contact with other cells.

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Cell division in wound healing

Injury triggers rapid cell division at the damaged site, leading to tissue repair.

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Cell division control after healing

After the healing process is complete, the rate of cell division slows down and control is restored to normal.

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Totipotency

The ability of a cell to develop into any kind of cell in the body, including those that form the placenta and extra-embryonic membranes.

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Blastocyst

A hollow ball of cells that forms during early human development, containing an inner cell mass.

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Inner Cell Mass

The cluster of cells inside the blastocyst that will eventually develop into the embryo.

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Differentiation

The process by which a cell becomes specialized and acquires a specific function.

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Pluripotent

Cells that can develop into many, but not all, types of cells in the body.

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Terminally Differentiated

Cells that have reached a point where they cannot further differentiate into other cell types.

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Zygote

A fertilized egg cell, the first cell of a new organism.

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Development

The process by which a single fertilized egg cell develops into various specialized cells.

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Ethical Debate on Embryonic Stem Cell Research

Stem cell research using human embryos is considered unethical by some due to concerns about the moral status of an embryo, while others support it as essential for advancing medical treatments and saving lives.

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Induced Pluripotent Stem Cells (iPS Cells)

Induced pluripotent stem cells (iPS cells) are created by reprogramming adult cells (e.g., fibroblasts) to behave like embryonic stem cells. This breakthrough eliminates the need for embryonic stem cells and addresses ethical concerns.

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Why iPS Cells are Important

iPS cell research is considered a significant advancement in cell biology, as it allows scientists to study and potentially treat diseases without relying on embryonic stem cells, addressing ethical issues related to their use.

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Yamanaka's Nobel Prize-Winning Discovery

Shinya Yamanaka's work in reprogramming adult cells into iPS cells is considered groundbreaking and was awarded the Nobel Prize in Physiology or Medicine in 2012. His research paved the way for new therapeutic approaches and ethical solutions in stem cell research.

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Link between Gurdon's Frog Cloning and iPS Cells

The discovery of iPS cells is a direct outcome of John Gurdon's work on cloning frogs. Gurdon showed that the nucleus of an adult cell can be reprogrammed to develop into an embryo. Yamanaka's work built upon this by finding the specific conditions for reprogramming adult cells into iPS cells.

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Possible Replacement for Embryonic Stem Cells

iPS cells can potentially replace embryonic stem cells in research and therapy, offering a more ethical and readily available source for studying and treating diseases.

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How iPS Cells Are Made

The reprogramming process involves introducing specific transcription factors (genes) into adult cells, which then alter the expression of genes and ultimately change the cell's identity.

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Potential Medical Applications of iPS Cells

iPS cells hold promise for treating a wide range of diseases, including Parkinson's disease, Alzheimer's disease, diabetes, and spinal cord injuries, as they can differentiate into various cell types needed for repair and regeneration.

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Study Notes

Cell Growth, Division, and Reproduction

  • Cells increase in size but become less efficient at moving nutrients and waste.
  • Cells also place increasing demands on their DNA.
  • Cells divide to maintain an efficient surface area to volume ratio, and to reduce the demands on their DNA.
  • Asexual reproduction creates genetically identical offspring from a single parent.
  • Sexual reproduction produces offspring with genetic diversity through the fusion of reproductive cells.

The Process of Cell Division

  • Genetic information is packaged into chromosomes

  • Prokaryotic cells have a single, circular chromosome.

  • Eukaryotic cells have multiple linear chromosomes.

  • DNA tightly coils around histone proteins in chromatin to form nucleosomes. This structure compacts the DNA.

  • Chromosomes are duplicated and condense into sister chromatids, then separate to form two daughter cells.

  • The cell cycle consists of four stages: G1, S, G2, and M (mitosis).

  • Mitosis includes four phases: prophase, metaphase, anaphase, and telophase; cytokinesis follows mitosis.

  • Prophase: Chromatin condenses, chromosomes become visible, nuclear envelope breaks down, spindle fibers form.

  • Metaphase: Chromosomes align in the center of the cell, spindle fibers attach to centromeres.

  • Anaphase: Sister chromatids separate and move to opposite poles.

  • Telophase: Chromosomes uncoil, nuclear envelopes reform, spindle breaks down.

  • Cytokinesis: Cytoplasm divides, creating two new daughter cells.

Regulating the Cell Cycle

  • Cells regulate their growth and division carefully.
  • Growth factors and cyclins are proteins that regulate the cell cycle.
  • Internal regulators respond to events inside the cell.
  • External regulators respond to events outside the cell.
  • Apoptosis is programmed cell death.
  • Cancer is uncontrolled cell growth.
  • Cancer cells don't respond to signals that regulate growth and division.
  • Cancer cells form tumors.

Cell Differentiation

  • Cell differentiation is the process by which specialized cells are produced from a single fertilized egg.
  • Stem cells are unspecialized cells that have the potential to develop into different cell types.
  • Totipotent cells can differentiate into any cell type in the body.
  • Pluripotent cells can differentiate into many cell types, but not all.
  • Multipotent cells can differentiate into a limited subset of cell types.
  • Embryonic stem cells are pluripotent.
  • Adult stem cells are multipotent.
  • Induced pluripotent stem cells can be created from already differentiated cells.
  • Stem cells are important in medical research for treating injuries or disorders.

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