Cell Communication and Signaling

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Questions and Answers

What are the possible genotypes of the parents if their child has phenylketonuria (PKU), a recessive disorder?

  • F2, F1, P (correct)
  • F1, F2, P (correct)
  • F1, F1
  • F1, F2 (correct)

Cytokinesis occurs in plants by furrow formation.

False (B)

How many chromosomes are in each of the chicken’s gametes?

39

Humans have _________ pair of autosomes.

<p>22</p> Signup and view all the answers

Match the following stages of the signal transduction pathway:

<p>Receptor binds signal = Stage 1 Signal travels to target cell = Stage 2 Signal transduced within cell = Stage 3 Effects from signal transduction occur = Stage 4</p> Signup and view all the answers

Which of the following is necessary for a cell to respond to a signal molecule?

<p>Receptor (B)</p> Signup and view all the answers

Quorum sensing is a process used only by yeast cells for cell signaling.

<p>False (B)</p> Signup and view all the answers

What are the three stages of cell signaling?

<p>Reception, Transduction, Response</p> Signup and view all the answers

Intracellular receptors typically bind to __________ ligands.

<p>hydrophobic</p> Signup and view all the answers

Match the following types of receptors with their descriptions:

<p>G-protein coupled receptors = Activate pathways via G-proteins Tyrosine kinase receptors = Phosphorylate tyrosine residues Ion channel receptors = Open channels in response to a signal</p> Signup and view all the answers

What advantage does signal amplification provide during glycogen breakdown?

<p>It allows for more energy production. (B)</p> Signup and view all the answers

All cells will respond the same way to the same signaling molecule.

<p>False (B)</p> Signup and view all the answers

Describe the significance of scaffolding proteins in signal transduction.

<p>Scaffolding proteins organize signaling pathways and facilitate the interaction between various proteins.</p> Signup and view all the answers

What is the primary purpose of cell division in multicellular organisms?

<p>To grow and repair tissues (A)</p> Signup and view all the answers

All somatic cells are diploid.

<p>True (A)</p> Signup and view all the answers

What occurs during the S phase of interphase?

<p>DNA replication occurs during the S phase.</p> Signup and view all the answers

During metaphase, the chromosomes align at the __________.

<p>metaphase plate</p> Signup and view all the answers

Match the following phases of the cell cycle to their descriptions:

<p>G1 phase = Cell grows and prepares for DNA replication S phase = DNA is replicated G2 phase = Cell prepares for mitosis M phase = Cell divides into two daughter cells</p> Signup and view all the answers

What is the function of the mitotic spindle?

<p>To separate sister chromatids during mitosis (B)</p> Signup and view all the answers

Cytokinesis occurs simultaneously with mitosis.

<p>True (A)</p> Signup and view all the answers

What is apoptosis and its significance?

<p>Apoptosis is programmed cell death, important for development and maintaining tissue homeostasis.</p> Signup and view all the answers

What are the two structures present in a replicated chromosome?

<p>Sister chromatids and centromeres (C)</p> Signup and view all the answers

Mitosis results in the production of four genetically identical daughter cells.

<p>False (B)</p> Signup and view all the answers

List one process associated with sexual reproduction that produces genetic variation.

<p>Crossing over</p> Signup and view all the answers

During meiosis, the chromosome number is __________ in the resulting gametes.

<p>halved</p> Signup and view all the answers

Match the following terms related to Mendel's experiments with their definitions:

<p>Character = A heritable feature that varies among individuals Trait = A specific variant of a character True-breeding = Organisms that produce offspring identical to themselves Hybridization = Mating two contrasting, true-breeding varieties</p> Signup and view all the answers

What would likely happen if homologous chromosomes fail to separate during anaphase I of meiosis?

<p>Some gametes will have an abnormal chromosome number (A)</p> Signup and view all the answers

A stable environment favors asexual reproduction over sexual reproduction for well-adapted organisms.

<p>True (A)</p> Signup and view all the answers

What is the haploid number for pea plants?

<p>7</p> Signup and view all the answers

Which of the following traits is an example of a disorder caused by a recessive allele?

<p>Cystic fibrosis (D)</p> Signup and view all the answers

A carrier of a genetic disorder will always express the disorder's traits.

<p>False (B)</p> Signup and view all the answers

What is amniocentesis?

<p>A prenatal diagnostic procedure to sample amniotic fluid.</p> Signup and view all the answers

The expected phenotypic ratio of a monohybrid cross between two heterozygous individuals (Aa) is ___ : ___.

<p>3:1</p> Signup and view all the answers

Match the following genetic testing methods with their descriptions:

<p>Carrier testing = Determines if an individual carries a recessive allele for a genetic disorder Fetal testing = Assessing the fetus for genetic disorders Amniocentesis = Sampling amniotic fluid to test for genetic conditions Chorionic villus sampling (CVS) = Sampling the placenta to evaluate for genetic disorders</p> Signup and view all the answers

Which of the following best describes pleiotropy?

<p>One gene influencing multiple traits (C)</p> Signup and view all the answers

Epistasis is when one gene's allele masks the effects of another gene's alleles.

<p>True (A)</p> Signup and view all the answers

Explain the concept of polygenic inheritance using human skin color.

<p>Polygenic inheritance involves multiple genes contributing to a trait, resulting in a range of phenotypes, as seen in human skin color.</p> Signup and view all the answers

Which of the following human aneuploidies is associated with Down syndrome?

<p>Trisomy 21 (D)</p> Signup and view all the answers

Klinefelter syndrome is caused by an individual having three sex chromosomes.

<p>False (B)</p> Signup and view all the answers

What is the definition of mitochondrial replacement therapy?

<p>A technique used to prevent mitochondrial diseases by replacing defective mitochondria with healthy ones.</p> Signup and view all the answers

During ______ of mitosis, chromosomes line up at the equator of the cell.

<p>metaphase</p> Signup and view all the answers

What is the probability that a son will inherit an X-linked recessive disorder from an unaffected mother and affected father?

<p>0% (A)</p> Signup and view all the answers

Match the genetic conditions with their corresponding characteristics:

<p>Trisomy 21 = Down syndrome XYY syndrome = Male with an extra Y chromosome XXY = Klinefelter syndrome X0 = Turner syndrome</p> Signup and view all the answers

What are three types of cell membrane receptors?

<p>G-protein coupled receptors, ion channel receptors, and receptor tyrosine kinases.</p> Signup and view all the answers

Flashcards

Cell Signaling

The process by which cells communicate with each other through signals and receptors, initiating intracellular responses.

Quorum Sensing

A process where bacteria coordinate their behavior in response to cell density using signaling molecules.

Receptor Protein

A protein that binds to a specific signaling molecule (ligand) to initiate a cellular response.

Ligand

A signaling molecule that binds to a specific receptor.

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Cell-Surface Receptor

A receptor protein embedded in the cell membrane, receiving signals from outside the cell.

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Intracellularreceptor

A receptor protein located inside the cell, often responding to hydrophobic ligands.

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Signal Transduction

The process by which a signal from outside the cell is converted into a cellular response.

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Second Messenger

Small, non-protein molecules that amplify and relay signals inside the cell.

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Phosphorylation Cascade

A series of enzyme activations where each enzyme phosphorylates the next in the sequence.

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Cellular Response

The change in cellular activity brought about by cell signaling.

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Signal Amplification

A process where a small initial signal triggers a large response.

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Scaffolding Proteins

Proteins that organize signaling molecules in space and time to regulate cellular responses.

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Apoptosis

Programmed cell death that is essential for development and maintenance in animals.

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Cell Division in Unicellular Organisms

Cell division is reproduction, making more cells of the same type in unicellular organisms.

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Cell Division in Multicellular Organisms

Cell division in multicellular organisms is for growth, development, and repair.

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Genome

The entire set of genetic instructions in an organism.

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Chromosomes

Structures containing DNA and protein.

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Genes

Units of heredity that carry instructions for traits.

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Chromatin

DNA and proteins together.

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Chromosome Condensation

Packing chromosomes tightly.

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Sister chromatids

Identical copies of a chromosome.

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Centromere

Region where sister chromatids join.

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Mitosis

Division of genetic material.

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Cytokinesis

Division of the cytoplasm.

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Gametes

Reproductive cells (sperm/egg).

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Somatic cells

Body cells.

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Homologs

Pairs of chromosomes with similar genes.

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Sister Chromatids

Identical copies of a chromosome.

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Interphase

The part of the cell cycle where the cell is not dividing actively.

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M Phase

The 'M' stands for mitosis, or the mitotic phase of the cell cycle.

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G1 phase

Cell growth and normal function.

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S phase

DNA replication.

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G2 Phase

Preparation for mitosis.

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Cell-cycle checkpoints

Control points that asses if a cell is ready to move to the next phase of the cycle.

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G0 phase

Non-dividing state.

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Cell checkpoints in regulating cell division

Inspect the state of a cell to ensure that DNA is correct and ready for the next action.

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Cytokinesis in animal cells

Forms a cleavage furrow that pinches the cell in two.

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Cytokinesis in plant cells

Forms a cell plate across the center of the cell, which will eventually develop into a cell wall.

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Mitotic spindle

A structure composed of microtubules that help guide chromosome segregation during mitosis.

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Kinetochore

A protein structure on a chromosome that makes contact with the spindle apparatus.

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Metaphase plate

Midline of the cell where the chromosomes are arranged at metaphase stage of mitosis

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Cleavage furrow

A groove in the plasma membrane during cytokinesis in animal cells that eventually divides the cell.

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Cell plate

Structure formed during cytokinesis in plant cells that will form the cell wall.

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G1 checkpoint

Cell-cycle checkpoint to assess cell growth.

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Possible outcomes if a cell does not pass the G1 checkpoint

The cell may enter G0 phase, undergo apoptosis, or continue if condition are met.

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Aneuploidy Examples

Examples of aneuploidy are Trisomy 21 (Down syndrome), XXY (Klinefelter syndrome), XYY syndrome, XXX syndrome, and X0 (Turner syndrome).

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Mitochondrial Inheritance

Mitochondrial DNA is passed down exclusively from the mother.

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Mitochondrial Disease Example

A mitochondrial disease is a disorder caused by defects in mitochondrial DNA.

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3-Parent Babies

Mitochondrial replacement therapy is a technique that allows a child to inherit healthy mitochondria.

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Blood Type A x B Offspring

Offspring can have blood types A, B, AB, or O.

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Polygenic Inheritance Light Skin

Medium-dark skin parents may have a child with light skin, but the probability depends on the genes.

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X-Linked Recessive Disorder

A son of a mother with an X-linked recessive disorder has a 50% chance of inheriting the disorder.

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XX Inheritance Condition

XX inheritance (two X chromosomes) associated with disorders if one X chromosome is inactivated.

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Mitosis Metaphase

During metaphase of mitosis, chromosomes align at the cell's equator.

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Gamete Production AaBbCCDdEE

Independent assortment produces 16 possible gamete types from genotype AaBbCCDdEE.

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Chromosome Composition

Chromosomes are composed of DNA and proteins.

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Cell Membrane Receptors Types

Cell membrane receptors include channel, enzymatic, and G protein-linked receptors.

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Vitamin D Receptor Location

Vitamin D's receptor is located inside the cell because it is lipid-soluble.

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Mendel's Crosses Order

Mendel's crosses follow a specific order, but the exact order is not provided.

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Recessive Alleles

Two copies of the allele are needed to express the trait.

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Dominant Alleles

Only one copy of the allele is needed to express the trait.

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Carrier

A person with one recessive allele for a disorder but doesn't show it.

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Carrier Testing

Screening for carrier status for genetic disorders.

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Fetal Testing

Testing a fetus for genetic disorders during pregnancy.

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Amniocentesis

Procedure to collect amniotic fluid for fetal genetic testing.

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Chorionic Villus Sampling (CVS)

Procedure to get a tissue sample from the placenta for testing.

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Newborn Screening

Genetic testing performed within days of birth to detect genetic disorders.

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Monohybrid Cross

Cross between two heterozygous individuals for one trait.

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Phenotypic Ratio

Ratio of different phenotypes in offspring.

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Genotypic Ratio

Ratio of different genotypes in offspring.

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Incomplete Dominance

Heterozygotes show an intermediate phenotype.

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Codominance

Both alleles are fully expressed in heterozygotes.

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Multiple Alleles

More than two alleles for a gene.

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Pleiotropy

One gene influencing multiple traits.

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Epistasis

One gene influencing the expression of another gene.

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Polygenic Inheritance

Multiple genes influencing a single trait.

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Independent Assortment

Genes for different traits are sorted independently during meiosis.

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PKU Parent Genotypes

Parents' genotypes for a child with a recessive inherited disorder (like PKU) must be heterozygous (carrying one copy of the affected gene and one normal copy).

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Biofilm Response

Biofilm formation is stimulated by cell signaling, leading to coordinated bacterial behaviors.

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G2 vs. G1 Nucleus

A nucleus in G2 phase has replicated chromosomes, while a nucleus in G1 has unreplicated chromosomes.

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Meiosis Variation

Crossing over and independent assortment during meiosis create genetic variation.

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Plant Cytokinesis

Plant cytokinesis forms a cell plate during division.

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Chicken Gametes

A chicken's gamete (egg/sperm) has half the number of chromosomes as its somatic cells.

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Chicken Offspring Somatic Cells

Chicken offspring somatic cells have the same number of chromosomes as the parent (78).

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Signal Transduction Pathway

The sequential steps where a signal triggers a response inside a cell; receptor binding, conformational change, signal transduction, and cellular response.

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Human Autosomes

Humans have 22 pairs of autosomes.

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Metaphase I vs. Mitosis

In Metaphase I of meiosis, homologous chromosomes pair up at the metaphase plate, while in mitosis individual chromosomes line up.

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Metaphase I Chromosomes

The differently shaded chromosomes in Metaphase I represent homologous chromosomes.

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Sister Chromatids

Identical copies of a chromosome formed by DNA replication, joined at the centromere.

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Chromosome vs. Sister Chromatids

A chromosome, before replication, is one DNA molecule. After replication, it exists as two identical sister chromatids, joined together.

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Mitosis vs. Meiosis

Mitosis creates identical diploid cells for growth and repair; Meiosis creates genetically unique haploid cells for sexual reproduction.

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Mitosis Divisions

One round of division (one cell becomes two identical cells)

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Meiosis Divisions

Two rounds of division (one cell becomes four genetically unique cells)

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Sexual Reproduction Genetic Variation

Three processes (crossing over, independent assortment, random fertilization) create diversity in offspring

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Stable Environment and Reproduction

Asexual reproduction is advantageous in a stable environment because it doesn't require the pairing and fusion of gametes and results in offspring identical to the parent.

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Homologous Chromosome Non-Disjunction

A failure of homologous chromosomes to separate during anaphase I, leading to gametes with abnormal chromosome numbers

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Cytokinesis Failure in Meiosis II

Without completing cytokinesis in meiosis, there will be one cell containing more than two complete sets of chromosomes.

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Crossing Over Impact

Crossing over in meiosis I shuffles genetic material between homologous chromosomes, increasing genetic diversity in gametes

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Pea Plant Ideal Organism

Pea plants are easy to grow, have readily identifiable traits, and are easily self-and cross-pollinated.

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Mendel's Experimental Approach

Mendel's controlled breeding experiments and systematic data collection led to the discovery of inheritance laws.

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Study Notes

Cell Communication

  • Cells use signaling mechanisms for two general reasons: survival and reproduction.
  • Cell signaling, in evolutionary terms, is quite old.
  • Quorum sensing is a bacterial cell signaling process where bacteria communicate with one another through chemical signals. This process is significant because it allows bacteria to coordinate their responses and behave collectively.
  • Quorum sensing differs between bacteria and yeast cells in its signaling mechanisms.
  • A cell's response to a signal molecule depends on the existence of a specific receptor protein. Receptor proteins typically are found within or on a cell's membrane.
  • Cell signaling has three stages: reception, transduction, and response.

Reception

  • A receptor protein and its ligand interact.
  • Receptor proteins are often located within or on a cell's membrane.
  • Three major types of cell-surface transmembrane receptors exist.
  • Intracellular receptors bind to hydrophobic ligands like steroid hormones.

Signal Transduction

  • Signaling molecules binding to protein kinases initiate phosphorylation cascades.
  • These cascades involve a sequence of phosphorylation and dephosphorylation events, ultimately leading to a cellular response.
  • Signal transduction pathways involving G-protein coupled receptors (GPCRs) are important for cell functions.
  • Second messengers, such as cAMP, amplify signals within cells and are advantageous in signal transduction.

Response

  • Cellular responses to signaling molecules can include processes like changes in enzyme activity, gene expression, or cytoskeletal rearrangements.
  • Signal amplification can be advantageous, such as in glycogen breakdown.
  • Different cells can have different responses to the same signaling molecule.
  • Scaffolding proteins organize signaling pathways, promoting efficient signal transduction.
  • Cells terminate signals to prevent uncontrolled responses.
  • Apoptosis is a programmed cell death process significant for proper development where cells undergo apoptosis to maintain balance.

Cell Cycles & Mitosis

  • Cell division is essential for unicellular and multicellular organisms.
  • Genetic material in eukaryotic cells is organized within chromosomes. Chromatin makes up the chromosomes.
  • Gametes are reproductive cells, and somatic cells are body cells.
  • Homologous chromosomes are paired chromosomes, while sister chromatids are identical copies of a chromosome.
  • Interphase precedes mitosis, and consists of G1, S, and G2 phases, where cells grow and DNA replicates.
  • The M-phase consists of mitosis and cytokinesis, leading to cell division.
  • Each phase of mitosis occurs in a specific order.
  • Cytokinesis occurs differently in animal and plant cells.
  • Checkpoints regulate the cell cycle, preventing errors in cell replication. Malfunctions in checkpoints may lead to cancer.
  • Cells can exit the cell cycle, entering a non-dividing state called G0.

Meiosis & Reproduction

  • Sexual reproduction involves meiosis and fertilization.
  • Meiosis results in genetic variation in offspring through crossing over.
  • The processes of meiosis and fertilization alternate in sexual life cycles.
  • Chromosome numbers change through meiosis and fertilization.
  • Haploid cells can't undergo mitosis, whereas haploid cells can undergo meiosis.

Mendelian Genetics

  • Inheritance involves genes, located on chromosomes, and are characterized by observable traits.
  • There are different types of inheritance with respect to the traits.
  • True-breeding organisms produce offspring with the same traits as the parent.
  • Hybridization involves breeding organisms with different traits to study their offspring's traits. (eg., parent 1 is tall, parent 2 is short, the offspring's characteristics are studied)
  • Mendel's experimental work on pea plants is a model for studying inheritance patterns.
  • Mendel's results demonstrated that inheritance is particulate, and not blending.
  • The laws of segregation and independent assortment explain inheritance patterns.

Complex Inheritance

  • Inheritance patterns are more complex, including incomplete dominance, codominance, multiple alleles, pleiotropy, and epistasis.
  • Epistasis involves cases where the expression of one gene affects the expression of another gene.
  • Polygenic inheritance explains traits such as human skin color with multiple genes being involved.
  • Environmental conditions play a role in some traits, in conjunction with genes.

Human Genetics & Sex Determination

  • Multiple alleles and multiple genes can determine human traits, like blood type.
  • Incomplete dominance and codominance affect inheritance patterns.
  • Pedigree analysis tracks inheritance patterns in families.
  • Sex determination and inheritance patterns vary among organisms.
  • Genetic disorders can arise due to chromosomal alterations including nondisjunction and aneuploidy.
  • Examples of human genetic disorders are Down syndrome, Turner syndrome, and Klinefelter syndrome.

Mitochondrial Inheritance

  • Genes in mitochondria and chloroplasts are inherited maternally.
  • Mitochondrial diseases can affect organisms.

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