Cell Biology Quiz on Membrane Dynamics
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Questions and Answers

Which molecule crosses the membrane most easily by simple diffusion?

  • H2O
  • Amino acid
  • CO2 (correct)
  • Ca+2

Which statement about receptor-mediated endocytosis is FALSE?

  • Clathrin binds directly to membrane receptors. (correct)
  • A triskelion is composed of three large and three small subunits.
  • Multivesicular bodies are derived from endosomes.
  • Some receptors are recycled while others are degraded.

What effect does decreasing cholesterol have on membrane fluidity?

  • Increases fluidity (correct)
  • Increases membrane rigidity
  • No effect on fluidity
  • Decreases fluidity

Where does the assembly of collagen molecules into fibers occur?

<p>Rough endoplasmic reticulum (A)</p> Signup and view all the answers

Which protein functions as an integral membrane protein participating in cell-matrix adhesion?

<p>Integrin (C)</p> Signup and view all the answers

Which statement about the origin and evolution of cells is correct?

<p>The first biological membrane had specialized regions for signaling. (D)</p> Signup and view all the answers

Regarding the extracellular matrix (ECM), which statement is correct?

<p>Fibronectin and elastin are components of the ECM. (A)</p> Signup and view all the answers

Which component does NOT increase membrane fluidity?

<p>Increase in long fatty acid chains (D)</p> Signup and view all the answers

Which statement about biological membranes is true?

<p>They exhibit very different structures in various organelles or cell types. (C)</p> Signup and view all the answers

During receptor-mediated endocytosis, where does the receptor and ligand separate?

<p>In a low pH endosomal compartment. (C)</p> Signup and view all the answers

What mechanism does Na+ use to move from a more concentrated environment to a less concentrated one?

<p>Ion channels. (B)</p> Signup and view all the answers

Which mechanism does Na+ utilize to move from a less concentrated environment to a more concentrated one?

<p>Na+/K+ pump. (D)</p> Signup and view all the answers

Which statement regarding endocytosis is true?

<p>Receptor-mediated endocytosis allows specific incorporation of molecules into vesicles. (A)</p> Signup and view all the answers

Which statement about the extracellular matrix (ECM) is true?

<p>Elastin protein is part of elastic fibers. (A)</p> Signup and view all the answers

What is a typical property of collagen fibers?

<p>They provide mechanical resistance. (C)</p> Signup and view all the answers

What is the function of the glycocalyx in relation to the plasma membrane?

<p>It is a collection of carbohydrates attached to the external face of the plasma membrane. (B)</p> Signup and view all the answers

Which statement about membrane permeability is incorrect?

<p>Proteins are not capable of lateral movement in the membrane. (D)</p> Signup and view all the answers

Which of the following proteins is NOT typically found in the extracellular matrix?

<p>Myosin (D)</p> Signup and view all the answers

Which cell type is specialized for the process of phagocytosis?

<p>Macrophages and neutrophils (A)</p> Signup and view all the answers

Which statement regarding viruses is TRUE?

<p>They contain genetic material but can replicate only within host cells. (B)</p> Signup and view all the answers

What might be the consequence of mice lacking a collagen gene?

<p>Brittle bones. (D)</p> Signup and view all the answers

Which of the following is a FALSE statement regarding the transport of micromolecules across membranes?

<p>Ionic channels permit the passage of all ions, regardless of charge. (C)</p> Signup and view all the answers

Which statement about clathrin is FALSE?

<p>It functions primarily in exocytosis. (B)</p> Signup and view all the answers

What characteristic defines membrane lipids?

<p>They have a hydrophilic head and one or two hydrophobic tails. (A)</p> Signup and view all the answers

Which statement is true regarding the extracellular matrix (ECM)?

<p>Fibronectin and elastin are proteins present in the ECM. (A)</p> Signup and view all the answers

Which statement about the asymmetry of cell membranes is FALSE?

<p>Phosphatidylserine is mainly located on the outer face of the plasma membrane. (A)</p> Signup and view all the answers

Regarding the glucose transporter, which statements are correct?

<p>All three statements are correct. (B)</p> Signup and view all the answers

What is required for the exocytosis of vesicles?

<p>It is regulated and requires ATP. (B)</p> Signup and view all the answers

Which statement is true about the properties of cell membranes?

<p>Membrane semipermeability allows lipids to move laterally with ease. (A)</p> Signup and view all the answers

Which of the following is NOT a component of the extracellular matrix?

<p>Keratin (C)</p> Signup and view all the answers

What does the presence of sugar residues on the membrane indicate?

<p>They primarily serve as recognition sites. (A)</p> Signup and view all the answers

What is the process called when a cell emits pseudopodia to surround and engulf a solid particle?

<p>Phagocytosis (C)</p> Signup and view all the answers

Which statement regarding caveolae-mediated endocytosis is TRUE?

<p>Caveolae play a role in cholesterol homeostasis. (C)</p> Signup and view all the answers

Which of the following statements about endocytosis is FALSE?

<p>Phagocytosis occurs in all cell types. (D)</p> Signup and view all the answers

Endocytosis exclusively incorporates which type of material?

<p>Both solid and liquid (B)</p> Signup and view all the answers

What is the probability that Guillermo has 47 chromosomes given the context of Down syndrome in his family?

<p>Guillermo has 47 chromosomes. (D)</p> Signup and view all the answers

Based on her family history, what is the probability that the woman with a sister who died of Tay-Sachs is a carrier?

<p>1/2 (A)</p> Signup and view all the answers

How many chromosomes would Antia's father have had if he died from SCA36?

<p>46 chromosomes. (C)</p> Signup and view all the answers

Which of the following statements about Tay-Sachs disease is TRUE?

<p>It is an autosomal recessive condition. (B)</p> Signup and view all the answers

What is true about sickle cell anemia?

<p>It has pleiotropic effects on various organs and tissues. (D)</p> Signup and view all the answers

Which statement accurately describes nonsense mutations?

<p>They introduce a stop codon in place of a regular codon. (A)</p> Signup and view all the answers

Which of the following genetic alterations is NOT associated with cancer induction?

<p>Inversions that activate oncogenes. (C)</p> Signup and view all the answers

Which chromosomal formula is likely to result in the most severe phenotype due to a deletion?

<p>46,XX,del(X)(q23) (C)</p> Signup and view all the answers

What genetic phenomenon is represented by a child with muscular dystrophy showing a deletion not found in either parent?

<p>Germline mutation. (C)</p> Signup and view all the answers

How will a mutation in the alpha-globin gene affect hemoglobin?

<p>It will cause the red blood cells to form a sickle shape. (D)</p> Signup and view all the answers

What is the pattern of inheritance of sickle cell anemia?

<p>Autosomal recessive inheritance. (D)</p> Signup and view all the answers

What effect does gene amplification have in cancers?

<p>It leads to an increase in oncogene products. (C)</p> Signup and view all the answers

Flashcards

Simple Diffusion

Molecules move across the membrane without energy input, from high to low concentration.

Receptor-mediated Endocytosis

A type of endocytosis where specific molecules bind to receptors on the cell membrane, triggering their internalization.

Membrane Fluidity

Increases in unsaturated fatty acids and short-chain fatty acids, as well as a decrease in cholesterol, contribute to membrane fluidity.

Collagen Fiber Formation

The process of collagen molecules assembling into fibers, occurring outside the cell in the extracellular space.

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Integrin

A transmembrane protein that plays a crucial role in cell-matrix adhesion.

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Early Cell Membranes

The first cell membrane was simple and lacked specialized regions for signaling.

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Extracellular Matrix

The extracellular matrix (ECM) provides structural support and influences cell behavior.

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ECM Components

Fibronectin and elastin are two major proteins found in the extracellular matrix (ECM).

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What is the glycocalyx?

The glycocalyx is a layer of carbohydrates attached to the outer surface of the plasma membrane. It plays a role in cell recognition and communication.

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What does semipermeability mean in the context of the cell membrane?

The plasma membrane's selective permeability allows certain molecules, such as lipids, to move laterally within the membrane more easily than others.

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Describe active transport.

Active transport mechanisms move molecules against their concentration gradient, requiring energy. This process is usually very specific, meaning a particular transporter protein is responsible for moving a specific type of molecule.

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Which protein is NOT typically found in the extracellular matrix?

Myosin is a protein primarily found in muscle cells, responsible for muscle contraction, not in the extracellular matrix (ECM).

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What type of cells are specialists in phagocytosis?

Macrophages and neutrophils, types of white blood cells, are specialized cells in the immune system that carry out phagocytosis - the engulfment of foreign particles and cellular debris.

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What are viruses?

Viruses are not cells; they are acellular particles that require a host cell to replicate. They possess genetic material (either DNA or RNA) but lack the complex machinery needed for independent life.

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What deficiency would you expect to find in mice lacking a collagen gene?

Collagen is a fibrous protein responsible for providing structure and strength to tissues, including bones. A deficiency in collagen can cause fragile bones, leading to increased risk of fractures.

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What is true about the transport of small molecules across the membrane?

Small, nonpolar molecules like oxygen (O2) and carbon dioxide (CO2) can easily pass through the cell membrane without any special transport mechanism.

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Protein Variability in Membranes

Different biological membranes contain varying amounts of proteins, influencing their specific functions.

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Receptor-Ligand Separation

During receptor-mediated endocytosis, the receptor and its bound ligand (molecule) are internalized together within a vesicle. This vesicle then travels to an endosome, where the lower pH environment leads to the separation of the receptor and ligand.

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Sodium Ions: Against the Gradient

The sodium-potassium pump, a type of active transport, moves sodium ions from a low concentration area to a higher concentration area, requiring energy expenditure.

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Clathrin's Role in Endocytosis

Clathrin is a protein that forms a cage-like structure around vesicles during endocytosis. This helps to create a more controlled and efficient internalization process.

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ECM: Structural Support

The extracellular matrix (ECM) provides structural support and helps to create a framework for cells. It is found in all animal tissues, but its composition and density can vary.

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Collagen: Strength and Resistance

Collagen fibrils, composed of assembled collagen molecules, are strong and resist stretching. They contribute to the overall mechanical strength of tissues.

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Integrin and ECM Interaction

The ECM interacts with cells through integrins, which are transmembrane proteins that connect the cytoskeleton to the ECM. This interaction helps to regulate cell behavior and movement.

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ER: Protein Processing Factory

The endoplasmic reticulum (ER) is an extensive network of interconnected membrane-bound sacs and tubules that plays a vital role in protein synthesis, processing, and folding.

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Nonsense mutation

A mutation that changes a codon for a specific amino acid into a stop codon, leading to a truncated and often non-functional protein.

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Frameshift mutation

A type of mutation that causes the insertion or deletion of a small number of nucleotides in the DNA sequence, leading to a frameshift in the reading frame.

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Pleiotropy

A mutation that affects multiple phenotypic traits.

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Allelic heterogeneity

A condition where different mutations in the same gene can cause the same or similar phenotypes.

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Genetic alterations leading to cancer

Genetic alterations that can lead to uncontrolled cell growth and tumor development.

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Deletion mutation

The loss of chromosomal DNA.

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Mutation affecting muscle function

A type of genetic mutation that affects the production of a specific protein that plays a role in muscle function.

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Epigenetic alteration

The process of gene expression being modified without changes in the DNA sequence.

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What makes lipids amphipathic?

Lipids in cell membranes are amphipathic, meaning they have both a hydrophilic head (attracted to water) and one or two hydrophobic tails (repelled by water). This structure allows them to form the bilayer, where the heads face the watery environment and the tails hide inside.

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What is the extracellular matrix and what does it contain?

The extracellular matrix (ECM) is a complex network of molecules outside the cell's membrane. It's not just a support structure, but also influences cell behavior. This is due to the presence of various proteins like fibronectin and elastin, which play crucial roles in cell adhesion and tissue elasticity.

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Why are cell membranes asymmetrical?

The distribution of lipids and proteins within a cell membrane is asymmetrical. For instance, phosphatidylserine is mainly found on the inner leaflet of the cell membrane, while sugar residues are primarily on the outer surface.

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What are the characteristics of glucose transporters?

The transporter proteins responsible for glucose transport across the cell membrane are integral membrane proteins. This means they are embedded within the membrane, allowing them to move molecules across. They also undergo conformational changes to facilitate this transport. Importantly, they are specific for glucose, meaning they don't transport just any molecule.

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Describe exocytosis and what it requires.

Exocytosis is the process where cells release substances outside their membrane by fusing vesicles (small sacs) with the cell membrane. This is a regulated process, meaning it requires energy (ATP) and specific signals. One important signal is the presence of calcium ions, which trigger the fusion of vesicles.

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Why is the cell membrane called semipermeable?

The plasma membrane is semipermeable, allowing some molecules to pass through easier than others. This is particularly true for lipids. Their hydrophobic tails allow them to move laterally within the membrane, making it more fluid.

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What is phagocytosis?

A process where a cell uses pseudopods to engulf solid particles, enclosing them in a vesicle that then fuses with lysosomes for digestion.

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What is caveolae-mediated endocytosis?

Caveolae-mediated endocytosis is characterized by small, flask-shaped invaginations of the plasma membrane that are rich in caveolin, a specific protein.

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What is FALSE about endocytosis?

It is FALSE to say that phagocytosis occurs in all types of cells. Only specialized cells, like macrophages and neutrophils, are capable of this.

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What is endocytosis?

Endocytosis is the process by which cells take in materials from the extracellular space. This process can involve both solid and liquid substances.

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Who is most likely to carry the extra chromosome 21?

Down syndrome is caused by having an extra copy of chromosome 21. Since Guillermo's brother and sister both have Down syndrome, it is likely that Guillermo also has the extra chromosome 21, making him a carrier for Down syndrome.

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What is the probability of a woman being a carrier of Tay-Sachs disease?

Since her sister died from Tay-Sachs disease, an autosomal recessive disorder, there is a 2/3 chance that the woman is a carrier. This is because she has a 1/2 chance of inheriting the faulty gene from her mother and a 1/2 chance of inheriting it from her father. Since her sister was affected, both parents must have been carriers. This means she has a 2/3 chance of being a carrier.

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What is the probability of being a carrier for ataxia cerebelosa?

Autosomal recessive disorders require two copies of the faulty gene to cause the disease. Since Antia's father had the condition, he must have been homozygous for the faulty gene. This means that Antia has a 50% chance of inheriting a copy of the faulty gene from her father and a 50% chance of being a carrier. The probability depends on whether her mother was also a carrier.

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Test your knowledge on cell membranes, diffusion, and endocytosis with this comprehensive quiz. You'll explore the various mechanisms involved in cell-matrix adhesion, as well as the roles of cholesterol and the extracellular matrix. Perfect for students studying cell biology or related fields.

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