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Questions and Answers
What is the primary structural component of the lipid bilayer?
What is the primary structural component of the lipid bilayer?
- Amphiphilic lipids (correct)
- Carbohydrates
- Proteins
- Nucleic acids
Which part of the amphiphilic lipids faces the aqueous solution?
Which part of the amphiphilic lipids faces the aqueous solution?
- Polar head groups (correct)
- Nonpolar heads
- Hydrophobic tails
- Fatty acid chains
What characteristic describes the distribution of lipids in the lipid bilayer?
What characteristic describes the distribution of lipids in the lipid bilayer?
- Uniform distribution
- Asymmetric distribution (correct)
- Symmetric distribution
- Random distribution
What type of lipid is predominant in the outer layer of the membrane?
What type of lipid is predominant in the outer layer of the membrane?
Which cellular structure is responsible for synthesizing components of the membrane?
Which cellular structure is responsible for synthesizing components of the membrane?
What is the primary difference in cell structure between prokaryotic and eukaryotic cells?
What is the primary difference in cell structure between prokaryotic and eukaryotic cells?
Which organisms are classified as prokaryotes?
Which organisms are classified as prokaryotes?
What best describes the size difference between prokaryotic and eukaryotic cells?
What best describes the size difference between prokaryotic and eukaryotic cells?
Which statement is true regarding unicellular organisms?
Which statement is true regarding unicellular organisms?
What distinguishes multicellular organisms from unicellular organisms?
What distinguishes multicellular organisms from unicellular organisms?
What type of molecules are membranes almost impermeable to?
What type of molecules are membranes almost impermeable to?
Which component of the membrane helps to increase its fluidity?
Which component of the membrane helps to increase its fluidity?
What role do cholesterol and glycolipids play in membrane fluidity?
What role do cholesterol and glycolipids play in membrane fluidity?
The fluidity of the lipid bilayer is affected by which of the following?
The fluidity of the lipid bilayer is affected by which of the following?
Which statement accurately describes the permeability of membranes?
Which statement accurately describes the permeability of membranes?
What is one function of the cell membrane related to cell organelles?
What is one function of the cell membrane related to cell organelles?
How does the cell membrane assist in signal transduction?
How does the cell membrane assist in signal transduction?
What is the primary purpose of the glycocalyx in cells?
What is the primary purpose of the glycocalyx in cells?
What is the role of glycoproteins on the cell membrane?
What is the role of glycoproteins on the cell membrane?
Which of the following best describes the structure of the glycocalyx?
Which of the following best describes the structure of the glycocalyx?
What occurs during the electrical excitability function of the cell membrane?
What occurs during the electrical excitability function of the cell membrane?
What are cell junctions primarily formed by?
What are cell junctions primarily formed by?
How does the glycocalyx contribute to the immune response?
How does the glycocalyx contribute to the immune response?
Which of the following is NOT a component of the glycocalyx?
Which of the following is NOT a component of the glycocalyx?
What role does the glycocalyx play in red blood cells (RBCs)?
What role does the glycocalyx play in red blood cells (RBCs)?
What type of diffusion allows individual lipid molecules to move freely within the lipid bilayer?
What type of diffusion allows individual lipid molecules to move freely within the lipid bilayer?
Which mechanism involves the transport of glucose via specific transport proteins?
Which mechanism involves the transport of glucose via specific transport proteins?
What is required for transverse diffusion to occur in the membrane?
What is required for transverse diffusion to occur in the membrane?
Which of the following substances is specifically transported through aquaporin channels in the kidney?
Which of the following substances is specifically transported through aquaporin channels in the kidney?
What process is involved in bicarbonate reabsorption in the kidney?
What process is involved in bicarbonate reabsorption in the kidney?
What is the function of ribosomes in eukaryotic cells?
What is the function of ribosomes in eukaryotic cells?
Which statement correctly describes the DNA structure in prokaryotic cells?
Which statement correctly describes the DNA structure in prokaryotic cells?
Which of the following statements is true about mitochondria?
Which of the following statements is true about mitochondria?
What feature distinguishes the cell wall in prokaryotes from that of eukaryotes?
What feature distinguishes the cell wall in prokaryotes from that of eukaryotes?
What is the role of plasmids in prokaryotic cells?
What is the role of plasmids in prokaryotic cells?
What is a key characteristic of integral membrane proteins?
What is a key characteristic of integral membrane proteins?
Which of the following best describes peripheral membrane proteins?
Which of the following best describes peripheral membrane proteins?
What percentage of membrane protein content can be found in the lipid bilayer?
What percentage of membrane protein content can be found in the lipid bilayer?
What is true regarding the binding of integral membrane proteins?
What is true regarding the binding of integral membrane proteins?
Which function does NOT typically describe membrane proteins?
Which function does NOT typically describe membrane proteins?
Flashcards
Prokaryotic Cells
Prokaryotic Cells
Single-celled organisms, like bacteria, encased by a cell membrane containing cytoplasm.
Eukaryotic Cells
Eukaryotic Cells
Multicellular organisms and some single-celled organisms, like protozoa, containing a nucleus and other membrane-bound organelles.
Lipid Bilayer
Lipid Bilayer
A double layer of lipids and proteins that forms the boundary of all cells.
Lipid Bilayer Structure
Lipid Bilayer Structure
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Lateral Diffusion
Lateral Diffusion
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Transverse Diffusion
Transverse Diffusion
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Facilitated Diffusion
Facilitated Diffusion
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Glucose Transport
Glucose Transport
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Water Transport
Water Transport
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Membrane Permeability
Membrane Permeability
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Membrane Fluidity
Membrane Fluidity
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Factors Increasing Fluidity
Factors Increasing Fluidity
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Factors Stabilizing Fluidity
Factors Stabilizing Fluidity
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Cell Compartmentalization
Cell Compartmentalization
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Substance Transport
Substance Transport
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Signal Transduction
Signal Transduction
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Cell Identification
Cell Identification
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Membrane Potential
Membrane Potential
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Cell Junctions
Cell Junctions
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Glycocalyx
Glycocalyx
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Glycocalyx Function
Glycocalyx Function
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Membrane Proteins
Membrane Proteins
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Integral Membrane Proteins
Integral Membrane Proteins
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Peripheral Membrane Proteins
Peripheral Membrane Proteins
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Transmembrane Proteins
Transmembrane Proteins
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Membrane Transport
Membrane Transport
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Selective Permeability
Selective Permeability
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Membrane Fluidity Change
Membrane Fluidity Change
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Signal Reception
Signal Reception
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Cell Adhesion
Cell Adhesion
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Study Notes
Prokaryotic Cells
- Single-celled organisms including bacteria
- Encased by a cell membrane containing cytoplasm
Eukaryotic Cells
- Multicellular organisms and some single-celled organisms (e.g., protozoa)
- Contain a nucleus and other membrane-bound organelles
- Significantly larger than prokaryotic cells (100 to 10,000 times larger)
Lipid Bilayer
- Composed of lipids and proteins
- Synthesized within the smooth endoplasmic reticulum (SER)
Lipid Bilayer Structure
- Consists of amphiphilic lipids like phospholipids and sphingolipids
- Amphiphilic lipids have a polar head group and a hydrophobic tail
- Hydrophobic tails face inward, while polar heads form a boundary with water molecules
Transport Mechanisms
- Lateral (parallel) diffusion: Individual lipid molecules move freely within the lipid bilayer
- Transverse diffusion: Very slow and requires enzymatic support
- Facilitated diffusion: Diffusion of molecules across the cell membrane using carrier proteins, channel proteins, or ions
- Glucose and fructose transport into cells via GLUT transporters
- Transport of glucose from the blood into the pancreatic beta cell via GLUT2
- Water transport via aquaporin channels in principal cells of the kidney
- Glucose and fructose transport into cells via GLUT transporters
- Bicarbonate reabsorption in the early proximal convoluted tubule
Membrane Characteristics
- Permeability: The cell membrane is permeable to nonpolar molecules and water, but almost impermeable to polar molecules
- Fluidity: Can change depending on the composition of the bilayer and the temperature
- Factors increasing fluidity: Unsaturated fatty acids
- Factors stabilizing fluidity: Cholesterol and glycolipids
Cell Membrane Functions
- Separates cell compartments within the cytosol
- Transports substances into and out of the cell
- Converts extracellular signals into intracellular reactions
- Enables cell identification through specific proteins on its surface, mostly glycosylated glycoproteins
- Generates an electrochemical gradient across the membrane, creating a membrane potential
- Forms cell junctions using anchor proteins (cell adhesion molecules) connected to the cytoskeleton
Glycocalyx
- Loose glycoprotein-polysaccharide layer covering the outside of the cell membrane
- Contains a long, branching network of polysaccharides, covalently bound to proteins or lipids
- Functions: protects the cell from dehydration, enables immune cells to differentiate between host cells and foreign organisms, differentiates blood groups
Overview of Eukaryote and Prokaryote Cell Structure
Feature | Eukaryotes | Prokaryotes |
---|---|---|
Nucleus | Present | Absent |
Location of DNA | Nucleus | Cytoplasm |
DNA Storage Form | In several chromosomes (double-stranded), Contains histones | Circular bacterial chromosome (termed "chromosome equivalent"), located in the cytoplasm.Plasmids (small additional DNA rings) |
Amount of noncoding DNA | 70-98% (lower gene density) | 5-25% (higher gene density) |
Mitochondria | Present | Absent |
Ribosomes | 80S | 70S |
Cell Membrane | Lipid bilayer | Present |
Cell Wall | Only in plants, fungi, and algae | Present in most bacteria; exceptions include Mycoplasma which lack a cell wall |
Compartmentalization | Membranes separate cellular compartments within the cytosol | No compartmentalization |
Locomotive Structures (flagellum) | Consist of bundles of microtubules and the motor protein dynein, surrounded by a plasma membrane | Consist of repeating subunits of the protein flagellin (filament), a hook, and a motor complex that is anchored in the cell membrane |
Membrane Proteins
- Proteins embedded in the lipid bilayer of membranes
- Usually glycoproteins
- Membrane protein content in the lipid bilayer: 20-80%
Integral Membrane Proteins
- Strongly bind to the lipid bilayer
- Partially penetrate into the membrane
- Transmembrane proteins: completely penetrate the lipid double layer (e.g., Na+/K+-ATPase)
Peripheral Membrane Proteins
- Poor binding to the lipid bilayer
- Usually bind via electrostatic affinity or hydrogen bonds between a peripheral and an integral membrane protein
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