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Questions and Answers
What type of junction is described by a continuous, belt-like connection between cells?
What type of junction is described by a continuous, belt-like connection between cells?
- Desmosomes
- Zona adherens (correct)
- Gap junctions
- Tight junctions
Which junction is primarily responsible for providing strength between cells subjected to mechanical stress?
Which junction is primarily responsible for providing strength between cells subjected to mechanical stress?
- Gap junctions
- Desmosomes (correct)
- Zona adherens
- Tight junctions
What is the primary role of gap junctions in cellular interactions?
What is the primary role of gap junctions in cellular interactions?
- Forming a barrier to prevent leakage
- Connecting the cell to the extracellular matrix
- Facilitating direct communication between cells (correct)
- Providing structural support
In the context of cell-matrix interactions, what does the zona adherens primarily involve?
In the context of cell-matrix interactions, what does the zona adherens primarily involve?
Which of the following plays a critical role in the stability of desmosomes?
Which of the following plays a critical role in the stability of desmosomes?
What is the primary function of tight junctions in epithelial cells?
What is the primary function of tight junctions in epithelial cells?
Which type of junction is characterized by its role as an anchoring junction?
Which type of junction is characterized by its role as an anchoring junction?
Which proteins are primarily involved in the formation of tight junctions?
Which proteins are primarily involved in the formation of tight junctions?
Which of the following statements about gap junctions is accurate?
Which of the following statements about gap junctions is accurate?
What distinguishes zona adherens from desmosomes in terms of function?
What distinguishes zona adherens from desmosomes in terms of function?
Which type of junction would be least effective at providing mechanical strength between epithelial cells?
Which type of junction would be least effective at providing mechanical strength between epithelial cells?
In epithelial tissue, how do gap junctions facilitate cell-cell interactions?
In epithelial tissue, how do gap junctions facilitate cell-cell interactions?
Which of the following junction types primarily contributes to the attachment of epithelial cells to the extracellular matrix?
Which of the following junction types primarily contributes to the attachment of epithelial cells to the extracellular matrix?
What role do gap junctions primarily serve in cellular communication?
What role do gap junctions primarily serve in cellular communication?
Which type of junction is primarily responsible for creating a strong adhesive connection between adjacent cells?
Which type of junction is primarily responsible for creating a strong adhesive connection between adjacent cells?
Which statement accurately describes cell-cell recognition?
Which statement accurately describes cell-cell recognition?
In the context of cell-matrix interactions, what is the primary function of integrins?
In the context of cell-matrix interactions, what is the primary function of integrins?
Which of the following components is characteristic of gap junctions?
Which of the following components is characteristic of gap junctions?
What is the primary purpose of tight junctions in epithelial tissue?
What is the primary purpose of tight junctions in epithelial tissue?
Which of the following best describes the extracellular matrix?
Which of the following best describes the extracellular matrix?
What is a key function of the zona adherens in cell junctions?
What is a key function of the zona adherens in cell junctions?
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Study Notes
Intercellular Connections
- Tight junctions are occluding junctions that close the gaps between cells.
- Tight junctions act as a diffusion barrier.
- Tight junctions contain claudins and occludins.
- Zona adherens are anchoring junctions that tightly connect cells in a continuous, belt-like manner.
- Zona adherens contain cadherins and vinculin.
- Desmosomes are anchoring junctions that connect two cells subjected to high levels of mechanical stress via intermediate filaments.
- Desmosomes contain cadherins.
- Gap junctions are communication junctions that provide intercellular channels allowing the passage of electrical or chemical signals, including Ca2+ and IP3.
- Gap junctions consist of connexins.
Cell-Cell Recognition
- Cell-cell recognition allows a cell to distinguish one type of neighbouring cell from another.
- This process involves a receptor on one cell surface binding to a specific ligand on a nearby cell.
Functions of Cell-Cell Recognition
- Pathogen recognition in the immune system.
- Response to injury: recruitment of cells (e.g. platelets, immune cells) to damaged areas.
- Growth and development.
Cell-Matrix Interactions
- Extracellular matrix is a network consisting of secreted proteins and proteoglycans.
- Extracellular matrix provides structural support to surrounding cells.
- Integrins bind to the extracellular matrix.
- Epithelial cells form the boundary between an organism's external and internal environments.
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