Cell Biology: Intercellular Communication and Transport

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Questions and Answers

What characterizes ungated or leak channels?

  • They respond to mechanical stimuli.
  • They can only open with a change in voltage.
  • They require a specific ligand to open.
  • They are always open. (correct)

What is the primary function of neurohormones in the body?

  • To transport nutrients into the cells
  • To regulate temperature within the body
  • To release hormones into the bloodstream for distant target cells (correct)
  • To facilitate communication between neurons only

Which type of channel opens in response to changes in electrical potential?

  • Ligand-gated channels
  • Voltage-gated channels (correct)
  • Leak channels
  • Mechanically gated channels

Which mechanism requires no energy for the transport of substances?

<p>Facilitated diffusion (A)</p> Signup and view all the answers

How do ligand-gated channels function?

<p>They open in response to hormonal substances. (A)</p> Signup and view all the answers

Which type of diffusion occurs through the lipid bilayer of the cell membrane?

<p>Simple diffusion only (D)</p> Signup and view all the answers

What triggers mechanically gated channels to open?

<p>Physical pressure or deformation (D)</p> Signup and view all the answers

Which type of transport is facilitated by protein channels in cell membranes?

<p>Facilitated diffusion without energy (C)</p> Signup and view all the answers

What characterizes passive transport mechanisms?

<p>They can occur through both lipid bilayer and protein channels. (A)</p> Signup and view all the answers

What is a characteristic of simple diffusion through the lipid bilayer?

<p>It is influenced by the solubility of substances in lipids. (D)</p> Signup and view all the answers

What role do intercellular communications play in multicellular organisms?

<p>They enable cells to make life-sustaining exchanges with the external environment. (A)</p> Signup and view all the answers

Which type of intercellular communication involves physical contact between cells?

<p>Direct communication through gap junctions (C)</p> Signup and view all the answers

What characterizes the action of paracrine chemical messengers?

<p>They exert their effects on neighboring cells in the immediate environment. (B)</p> Signup and view all the answers

What distinguishes neurotransmitters from hormones in terms of their action range?

<p>Neurotransmitters act on local target cells, while hormones act systemically. (D)</p> Signup and view all the answers

What is the main function of hormones in the context of intercellular communication?

<p>To transmit signals to other sites in the body via the bloodstream. (B)</p> Signup and view all the answers

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Study Notes

Intercellular Communication

  • Most cells are not in direct contact with the external environment.
  • Direct communication: Cells are physically connected through structures like gap junctions.
  • Indirect communication: Cells use extracellular chemical messengers, which are secreted by cells and act on target cells to exert their effects.
  • Paracrine messengers: These messengers act locally on neighboring cells.
  • Neurotransmitters: Released by nervous cells in response to electrical signals. They act on nearby target cells, including other neurons, muscles, and glands.
  • Hormones: Long-range messengers secreted by endocrine glands into the bloodstream. They travel to distant target cells to elicit responses.
  • Neurohormones: Hormones released by neurosecretory neurons into the blood.

Transport Across Cell Membrane

  • Cells need to exchange substances with their environment.
  • Passive transport: Movement of substances along concentration or electrical gradients (downhill). It does not require energy.
    • Simple diffusion: Substances move directly through the lipid bilayer or protein channels of the cell membrane.
    • Facilitated diffusion: Substances are transported across the membrane with the help of carrier proteins.
  • Active transport: Movement of substances against concentration, electrical, or electrochemical gradients (uphill). It requires energy.
    • Primary active transport: Energy is directly obtained from the breakdown of ATP.
    • Secondary active transport: Energy for the movement of one substance is obtained from the movement of a second substance, often coupled through a carrier protein.

Homeostasis

  • Homeostasis: Maintaining a stable internal environment within a narrow range, despite external fluctuations, is vital for life.
  • Components of a homeostatic control system:
    • Sensors (receptors): Detect changes in the internal environment.
    • Control center: Receives information from sensors and sends out commands to effectors.
    • Effectors: Carry out the adjustments to correct deviations from the set point.
  • Negative feedback: The response opposes the initial stimulus, bringing the system back towards a set point.
  • Positive feedback: The response amplifies the initial stimulus.

Examples of Homeostatic Mechanisms

  • Negative feedback examples: Regulation of blood pressure, body temperature, and blood glucose levels.
  • Positive feedback examples: Blood coagulation, labor, and membrane excitation.

Homeostasis Disturbance Example: Fever (Pyrexia)

  • Pyrogens: Substances that trigger fever. They can be released by bacteria or from degenerating tissues.
  • Macrophages: These immune cells engulf pyrogens and release interleukin-1 (an endogenous pyrogen).
  • Prostaglandins (PGE2): Interleukin-1 stimulates the formation of prostaglandins, which raise the set point of the body's internal thermostat.
  • The higher set point triggers heat production mechanisms, leading to a fever.

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