Cell Biology Chapter 4 Quiz
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Questions and Answers

Which of the following is NOT involved in the process of protein degradation within a cell?

  • Ribosomes (correct)
  • Peroxisomes
  • Proteasomes
  • Lysosomes
  • What is the primary function of mitochondria in a cell?

  • Protein synthesis
  • Energy production (correct)
  • DNA storage
  • Lipid production
  • Which cellular component is responsible for modifying proteins for transportation?

  • Endoplasmic reticulum
  • Nucleus
  • Golgi apparatus (correct)
  • Mitochondria
  • What is the key difference between rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER)?

    <p>RER processes proteins, while SER is involved in lipid production. (C)</p> Signup and view all the answers

    Which of the following is NOT a function of the cytoskeleton?

    <p>Synthesizing DNA (D)</p> Signup and view all the answers

    What is the role of lysosomes in cellular function?

    <p>Degrading macromolecules (D)</p> Signup and view all the answers

    Which of these cellular components is directly involved in apoptosis?

    <p>Mitochondria (D)</p> Signup and view all the answers

    What is the main function of the plasma membrane in a cell?

    <p>Regulated movement of solutes (B)</p> Signup and view all the answers

    Which of the following statements accurately describes the difference between neutrophils and macrophages in terms of their response to inflammation?

    <p>Neutrophils are more potent and arrive faster, while macrophages are slower but their response is more prolonged. (C)</p> Signup and view all the answers

    How does the prolonged inflammatory response mediated by macrophages contribute to chronic inflammation?

    <p>Macrophages release substances that promote collagen formation, leading to tissue fibrosis and scarring. (A)</p> Signup and view all the answers

    What is a potential negative consequence of the potent activity of leukocytes, particularly neutrophils, during an acute inflammatory response?

    <p>Excessive leukocyte activity can lead to the destruction of healthy tissue, causing collateral damage. (A)</p> Signup and view all the answers

    In the context of tuberculosis (TB) and hepatitis, how can prolonged host response lead to more damage than the causative microbe?

    <p>The prolonged presence of leukocytes, especially macrophages, in these diseases can worsen the inflammatory response, leading to tissue destruction and scarring. (B)</p> Signup and view all the answers

    What is one mechanism by which the physiological role of leukocytes in eliminating microbes can have pathological consequences for normal tissues?

    <p>Leukocytes can release granule enzymes and antimicrobial proteins into the extracellular space, causing damage to surrounding tissues. (C)</p> Signup and view all the answers

    What is the role of selectins and integrins in the inflammatory process?

    <p>They are involved in the adhesion and margination of leukocytes to the vessel walls. (D)</p> Signup and view all the answers

    What distinguishes the migration process of leukocytes in inflammation from their typical movement in the bloodstream?

    <p>Leukocytes normally attach to the vessel walls and move through them, but inflammation reduces blood flow, allowing for this process. (C)</p> Signup and view all the answers

    Which molecule is responsible for recruiting leukocytes to the site of inflammation through chemotaxis?

    <p>Complement system (B)</p> Signup and view all the answers

    What is the main function of leukocytes recruited to the site of inflammation?

    <p>To eliminate the offending agents causing inflammation (A)</p> Signup and view all the answers

    Which of the following is NOT a mechanism involved in the recruitment of leukocytes during inflammation?

    <p>Vasodilation (A)</p> Signup and view all the answers

    The stage of inflammation that involves the recruitment of leukocytes and plasma proteins is known as:

    <p>Response of vascular tissues to insult (B)</p> Signup and view all the answers

    What are the two main types of molecules that contribute to the adherence and margination of leukocytes during inflammation?

    <p>Selectins and integrins (A)</p> Signup and view all the answers

    What is the role of chemoattractants in the inflammatory process?

    <p>They guide leukocytes to the site of inflammation. (D)</p> Signup and view all the answers

    What are the two main categories of mediators involved in inflammation?

    <p>Cell-derived and plasma-derived (D)</p> Signup and view all the answers

    What is a key characteristic of chronic inflammation?

    <p>Proliferation of blood vessels (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of acute inflammation?

    <p>Dominant presence of macrophages (A)</p> Signup and view all the answers

    Which specific chemical mediator is released by mast cells in response to physical injury, causing vasodilation and increased vascular permeability?

    <p>Histamine (D)</p> Signup and view all the answers

    What is the main function of histamine in the inflammatory response?

    <p>Vasodilation and increased vascular permeability (C)</p> Signup and view all the answers

    Which group of mediators is involved in vascular and smooth muscle reactions, as well as leukocyte recruitment, during inflammation?

    <p>Leukotrienes (D)</p> Signup and view all the answers

    Which two cytokines are particularly key in the systemic response to inflammation?

    <p>Tumor necrosis factor and interleukin-1 (D)</p> Signup and view all the answers

    What is the role of macrophages in inflammation?

    <p>Phagocytose pathogens and cellular debris (B)</p> Signup and view all the answers

    What is the primary outcome of acute inflammation when the offending agent is successfully destroyed?

    <p>Resolution and tissue repair (B)</p> Signup and view all the answers

    Which of the following is NOT a step of inflammation as described by the 'R's' mnemonic?

    <p>Replication of the offending agent (D)</p> Signup and view all the answers

    What is the primary role of complement proteins in inflammation?

    <p>Activate and recruit leukocytes to the site of inflammation (D)</p> Signup and view all the answers

    Which of the following is a possible outcome of chronic inflammation?

    <p>Tissue healing by connective tissue replacement (scarring) (B)</p> Signup and view all the answers

    How do prostaglandins contribute to the inflammatory response?

    <p>They are involved in vascular and systemic reactions of inflammation (A)</p> Signup and view all the answers

    What is the main distinction between COX-1 and COX-2 in relation to inflammation?

    <p>COX-2 is primarily involved in inflammatory responses, while COX-1 is involved in other tissues (D)</p> Signup and view all the answers

    What are the two major side effects associated with the use of prostaglandins in clinical settings?

    <p>Peptic ulcer and acute/chronic kidney disease (B)</p> Signup and view all the answers

    What is the primary mechanism by which Tylenol affects fever?

    <p>Its mechanism of action regarding fever is unclear. (A)</p> Signup and view all the answers

    Which of the following cellular processes is NOT directly involved in tissue repair by scar formation?

    <p>Apoptosis (programmed cell death) (D)</p> Signup and view all the answers

    Which of the following contributes to the development of chills during inflammation?

    <p>Shunting of blood away from the skin to conserve heat. (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of leukopenia?

    <p>Characterized by an increase in the number of immature neutrophils. (D)</p> Signup and view all the answers

    Which of the following conditions is characterized by an increase in the number of eosinophils?

    <p>Allergic reactions (B)</p> Signup and view all the answers

    Which of the following is a key difference between regeneration and scar formation in tissue repair?

    <p>Regeneration occurs in tissues with a high proliferative capacity, while scar formation occurs in tissues with a limited proliferative capacity. (A)</p> Signup and view all the answers

    What is the primary function of NSAIDs in fever management?

    <p>To inhibit the production of prostaglandins, which are involved in fever development. (D)</p> Signup and view all the answers

    Which of the following is a characteristic of the 'left shift' in a blood test?

    <p>An increase in the number of immature neutrophils. (D)</p> Signup and view all the answers

    What is the primary way that a cell presenting a 'death receptor' initiates the process of apoptosis?

    <p>The cell binds to a specific protein molecule, triggering a cascade of caspases. (B)</p> Signup and view all the answers

    Which of the following scenarios is an example of the intrinsic pathway of apoptosis?

    <p>A cell undergoes DNA damage due to exposure to radiation. (A)</p> Signup and view all the answers

    What is the role of BCL2 in the intrinsic apoptosis pathway?

    <p>BCL2 inhibits the formation of pores in the mitochondrial membrane, preventing the release of cytochrome c. (D)</p> Signup and view all the answers

    Which of the following describes the role of caspases in apoptosis?

    <p>Caspases are a group of enzymes that dismantle the cell's components in a controlled manner. (B)</p> Signup and view all the answers

    Which of the following is a characteristic of the inflammatory response?

    <p>It involves a complex series of cellular and vascular changes. (B)</p> Signup and view all the answers

    Which of the following are considered cardinal signs of inflammation?

    <p>Redness, heat, swelling, and pain. (D)</p> Signup and view all the answers

    What is the main role of antigen-presenting cells in the immune system?

    <p>To present antigens to other immune cells, triggering an immune response. (A)</p> Signup and view all the answers

    Flashcards

    Cell Components

    Essential parts of a cell, each with distinct functions like energy production and protein synthesis.

    Mitochondria

    Organelles responsible for energy production and initiating apoptosis through oxidative phosphorylation.

    Ribosomes

    Cellular structures that synthesize proteins by translating mRNA.

    Lysosomes

    Organelles containing digestive enzymes to break down macromolecules for cell recycling.

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    Apoptosis

    Programmed cell death that is a regulated process necessary for development and homeostasis.

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    Stem Cells

    Undifferentiated cells capable of self-renewal and giving rise to various cell types, crucial in regeneration.

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    Necrosis

    Uncontrolled cell death due to injury or disease, leading to inflammation.

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    Inflammation

    A response to injury or infection characterized by redness, heat, swelling, and pain; involves leukocytes.

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    Phagocytosis

    The process by which cells ingest or destroy bacteria and debris.

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    Neutrophils

    White blood cells that respond quickly to infection and are the first line of defense.

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    Macrophages

    White blood cells that have a slower response but last longer and aid in tissue repair.

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    Collateral damage in inflammation

    Tissue damage caused by intense immune responses from leukocytes.

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    Impact of leukocytes on chronic diseases

    Extended activation of leukocytes can cause more damage than the microbes themselves.

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    Extrinsic Pathway

    Apoptosis pathway activated by death receptors recognizing antigens.

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    Intrinsic Pathway

    Apoptosis pathway activated internally due to stress or damage.

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    Caspase Cascade

    Series of proteolytic enzymes activated during apoptosis.

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    Inflammation Causes

    Triggers include infections, toxins, necrosis, and immune reactions.

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    Fluid Accumulation in Inflammation

    Increased fluid delivery to injury site during inflammation.

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    Cell and Protein Mediated Damage

    Cells act to clear insults during inflammation.

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    Signs of Inflammation

    Redness, heat, swelling, and pain indicating inflammation.

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    Cell Necrosis

    Cell death due to injury or lack of blood supply.

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    Lymphangitis

    Inflammation of lymphatic vessels, often due to infection.

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    Inflammation Stages

    Phases include recognition, response, recruitment, destruction, termination, and repair.

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    Vascular Response

    Blood vessels respond to injury by increasing blood flow and permeability.

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    Leukocyte Adhesion

    Leukocytes stick to endothelial cells to move out of blood vessels.

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    Diapedesis

    Movement of leukocytes through blood vessel walls into tissues.

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    Chemotaxis

    Movement of leukocytes towards chemical signals from pathogens.

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    Leukocyte Functions

    Leukocytes are recruited to eliminate pathogens and debris.

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    Acute Inflammation

    Rapid response lasting hours to days, causing fluid exudation and edema.

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    Chronic Inflammation

    Long-lasting inflammation leading to tissue destruction and repair attempts.

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    Resolution of Inflammation

    Outcome where the offending agent is eliminated, leading to healing.

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    Fibrosis

    Healing by connective tissue replacement, resulting in scarring.

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    Mediators of Inflammation

    Substances that trigger and regulate inflammatory responses like vasodilation.

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    Cytokines

    Proteins released by cells to communicate and recruit more immune cells.

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    Prostaglandins

    Arachidonic acid derivatives involved in inflammation and pain responses.

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    Leukotrienes

    Mediators that promote vasodilation and recruit white blood cells.

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    Histamine

    Vasoactive amine from mast cells causing vasodilation and increased permeability.

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    Tumor Necrosis Factor

    Cytokine involved in systemic inflammation and leukocyte recruitment.

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    Complement Proteins

    Plasma-derived proteins aiding in immune responses, activating inflammation.

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    Leukemia Indicators

    Workup is indicated if there is an ↑ in immature neutrophils (left shift).

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    Lymphocytosis

    An increase in lymphocytes usually caused by viral infections.

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    Eosinophilia

    An increase in eosinophils, often related to allergic reactions.

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    Leukopenia Causes

    A decrease in white blood cells that can be due to infections such as typhoid fever or certain viruses.

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    Effects of Inflammation

    Symptoms like ↓ sweating, ↑ heart rate, and chills occur during inflammation.

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    Tissue Repair Mechanisms

    Repair of tissue occurs through either regeneration or scar formation depending on the tissue's ability to regenerate.

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    Cytokines in Liver Repair

    Regeneration of the liver is promoted by cytokines and growth factors following tissue loss.

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    Study Notes

    Pathogen 3.1: Cells and Inflammation

    • Objectives:
      • Analyze the fundamental components of a typical cell and their functions.
      • Analyze how the functions of cells are coordinated and integrated.
      • Interpret the roles of growth factors in cellular activity.
      • Illustrate the characteristics of stem cells and their involvement in regenerative medicine.
      • Demonstrate reversible and irreversible cellular injury, encompassing cytoplasmic and nuclear changes.
      • Analyze the key causes of cellular injury.
      • Differentiate between various types of cellular adaptations.
      • Distinguish between metaplasia and dysplasia.
      • Examine the process of cellular aging.
      • Compare and contrast necrosis and apoptosis, two forms of cell death.
      • Compare different forms of necrosis, providing examples for each.
      • Analyze the cellular and events of inflammation.
      • Distinguish the distinct vascular changes in acute inflammation.
      • Debate the terms associated with leukocytes' participation in inflammation (margination, diapedesis, emigration, exudation, chemotaxis, phagocytosis, and microbicidal substances).
      • Analyze the functions of complement system proteins, cytokines, and the clotting system in inflammation.
      • Compare and contrast the potential outcomes of acute and chronic inflammation.
      • Describe granuloma formation and its characteristics.
      • Analyze various pathological terms related to inflammation (serous, fibrinous, purulent, abscess, ulcer, wound, scar, and keloid).
      • Debate the typical localized and systemic symptoms of inflammation.
      • Analyze the pathogenesis of fever.

    The Cell as a Unit of Health and Disease

    • Key concepts:
      • Cells are the fundamental units of health and disease.
      • Understanding cell structure and function is crucial for comprehending health and disease processes.

    Essential Components of Animal Cells

    • Nucleus: DNA storage, transcription, and mRNA processing
    • Ribosomes: protein synthesis
    • Mitochondria: energy production; apoptosis
    • Endoplasmic reticulum (ER):
      • Rough ER: protein folding and processing
      • Smooth ER: lipid synthesis and calcium storage
    • Golgi apparatus: protein modification and sorting
    • Lysosomes: intracellular digestion
    • Peroxisomes: oxidation and detoxification
    • Cytoskeleton: cell shape and structure
    • Plasma membrane: regulated transport of molecules

    Lysosomes/Proteasomes

    • Lysosomes: contain enzymes that break down various macromolecules.
    • Formed via pinocytosis, receptor-mediated endocytosis, and autophagy.
    • Proteasomes: degrade misfolded or denatured proteins.

    Plasma Membrane

    • Permeable to very small particles (water, oxygen, carbon dioxide, etc) and non-polar molecules.
    • Impermeable to polar molecules and ions.
    • Methods for transport across the membrane:
      • Passive transport: diffusion through channels or carriers
      • Active transport: pumps using ATP
      • Endocytosis: engulfing large molecules or particles
      • Exocytosis: releasing molecules from the cell
      • Receptor-mediated endocytosis: targeted uptake of specific molecules

    ER/Golgi

    • Rough ER modifies and folds proteins.
    • Smooth ER synthesizes lipids, metabolizes certain molecules, and stores calcium.
    • Golgi apparatus processes and packages proteins for transport.

    Mitochondria

    • Role in cellular respiration and energy production (oxidative phosphorylation).
    • Critical role in apoptosis (programmed cell death).

    Receptors

    • Extracellular and intracellular receptors.
    • Ligands bind to receptors, initiating intracellular responses.
    • Receptors can influence DNA transcription directly.

    Kinase Activity

    • Kinases are molecules which phosphorylate other molecules to initiate cellular activity.
    • Receptor tyrosine kinases (RTKs) involved in signalling pathways (insulin, epidermal growth factor).

    A few Receptor Types

    • G-Protein coupled receptors (GPCRs): bind to signaling molecules
    • Steroid receptors: enter into the cell to initiate changes and regulate genes

    Transcription Factors

    • Transcription factors bind to specific DNA sequences.
    • They control gene expression and regulate cellular processes.
    • Can bind to promoter region or enhancers.

    Growth Factors

    • Promote cell entry into cell cycle, replication, and biosynthesis of cellular components (nucleic acids, proteins, lipids, carbohydrates).
    • Necessary to create daughter cells, and to prevent apoptosis.

    Stem Cells

    • Totipotent stem cells give rise to all types of cells in the body.
    • Adult stem cells have a limited capacity; able to replace damaged cells of the same type.
    • The use of stem cells in regenerative medicine is still evolving.

    Cell Injury

    • Causes of cellular injury:
      • Hypoxia/ischemia
      • Infectious agents (bacteria, virus, fungi)
      • Toxins
      • Autoimmune diseases
      • Genetic abnormalities
      • Immunologic reactions
      • Physical agents
      • Nutritional imbalances

    Toxic Cell Injury

    • Direct-acting toxins bind to essential cellular components, disrupting normal function.
    • Some toxins are latent, becoming reactive metabolites.
    • Reactive oxygen species (ROS) are highly reactive chemicals that cause damage.

    Reversible Cell Injury

    • Signs of reversible cell injury:
      • Increased intracellular swelling Mitochondrial and ER swelling Plasma membrane blebbing Clumping of chromatin in the nucleus

    Irreversible Cell Injury

    • Symptoms of irreversible injury include:
      • Inability to restore mitochondrial function Loss of structure and function of the plasma membrane. Loss of DNA and chromatin integrity

    Apoptosis vs. Necrosis

    • Necrosis: uncontrolled cell death causing inflammation, and is generally caused by extracellular stimuli
    • Apoptosis: regulated process of cell death without inflammations; is intracellularly mediated; often from intracellular stimuli

    Adapting to Cellular Injury

    • Types of adaptation: hypertrophy, hyperplasia, atrophy, and metaplasia

    Hypertrophy

    • Increased cell size; usually in response to increased workload; it is available in many cell types.
    • Can be pathologic, as in heart muscle

    Hyperplasia

    • Increased cell number; usually in physiologic situations.
    • Can be pathologic, leading to various diseases including cancer.

    Atrophy

    • Decreased cell size; often due to decreased workload, blood supply, or loss of stimulation.
    • Can be caused by changes in nutrition.

    Metaplasia

    • Change in cell type; a reversible adaptation to stress, possibly in response to ongoing injury
    • Can be a precursor to cancerous changes.

    Metaplasia vs. Dysplasia

    • Dysplasia refers to abnormal cell proliferation, development and maturation.
    • Dysplasia isn't always an indicator of cancer; however it is a risk factor for developing cancer.

    Necrosis

    • Coagulative, liquefactive, caseous, and fat necrosis each have distinct characteristics, cellular appearances, and origins.
    • Coagulative is frequently seen in organs like the heart.
    • Liquefactive necrosis is characteristic of the brain, as it is highly metabolic and actively functioning.
    • Caseous necrosis is commonly observed in TB, and occurs when walled off by macrophages.
    • Fat necrosis involves the breakdown of triglycerides in the pancreas.
    • Fibrinoid necrosis results from immune complex deposits in blood vessels

    Key signs of Necrosis

    • Increased eosinophilia
    • Nuclear changes (pyknosis, karyorrhexis, karyolysis)

    Fate of Cells in Coagulative Necrosis

    • Cells don't completely autodigest.
    • Leukocytes are recruited and digest debris.
    • Can result in dry gangrene.

    Fate of Liquefactive Necrosis

    • Cells are completely digested, leading to a liquid solution.
    • Inflammation frequently ensues.
    • "Wet gangrene" is a possibility.

    Fate of Caseous Necrosis

    • Tissue architecture is disrupted.
    • Macrophages and other inflammatory cells are commonly observed
    • Lesions are commonly seen in clusters, or nodules.

    Fate of Fat Necrosis

    • Enzymes and fatty acids are involved.
    • Calcium may bind resulting in soap formation.

    Fate of Fibrinoid Necrosis

    • Hypersensitivity reactions are involved
    • Complex deposits are seen in blood vessels
    • RBCs are often affected.

    Biomarkers in Necrosis

    • Intracellular proteins released due to cell lysis are found in specific bodily fluid tests, used to locate the source of damage.

    Apoptosis

    • Programmed cell death; a regulated and controlled cell dismantling process.
    • Intracellular contents aren't released; so inflammation doesn't occur.
    • It is used in development and in purging self-reactive cells of the immune system.

    Apoptosis: 2 Categories

    • Physiological apoptosis is necessary for embryonic development and immune system regulation.
    • Pathological apoptosis occurs in response to severe or irreversible damage.

    Apoptosis: 2 Pathways

    • Intrinsic pathway - activated by the intracellular, internal cellular conditions, and results from damaged mitochondria
    • Extrinsic pathway - activated by extracellular signals and triggers the activation of death-receptor pathway.

    Intrinsic Pathway

    • The intrinsic pathway is triggered mainly from intracellular damage or stress.
    • The cell must activate its pathway to trigger programmed cell death.
    • It is a crucial process that enables proper maturation.
    • P53 protein (a tumor suppressor) plays a vital role, regulating DNA damage and cellular responses.

    Extrinsic Pathway

    • The extrinsic pathway is triggered by stimuli from outside the damaged cell and results in the activation of death-receptor pathways.
    • The cell is induced to self-destruct.
    • Primarily, self-reactive cells are killed in the thymus.

    Inflammation: Recognition

    • Microbes and necrotic cells activate immune responses.
    • Internal cellular sensors (DAMPs) signal cellular distress.
    • Circulating proteins (e.g., complement) can trigger inflammation.

    Inflammation: Stages

    • Recognition of threat
    • Response of vascular tissues to insult.
    • Recruitment of leukocytes and plasma proteins.
    • Destruction of offending substance.
    • Termination of sequence.
    • Tissue repair.

    Phagocytes, dendritic cells

    • These specialized cells are capable of capturing foreign invaders and sensing the presence of an invading microorganism.
    • Trigger protein secretions like inflammation cytokines, anti-viral cytokines (interferons), and other cytokines and membrane proteins that activate lymphocytes to initiate inflammation

    Internal Cellular Sensors

    • Intracellular damage triggers a signal cascade.
    • Excessive uric acid, deficient ATP, and reduced K+ levels within a cell indicate intracellular damage.
    • These substances (DAMPs) are released to activate the inflammatory response.
    • The inflammasome, a protein cascade, is activated to regulate the inflammatory response to the damage.

    Complement System

    • Complement proteins operate with the immune system and contribute to the inflammatory process.
    • These proteins are produced in the liver, and circulate freely in the bloodstream.
    • They recognize microbes and mark them for destruction by phagocytes.
    • They directly kill microbes by forming membrane attack complexes (MACs), which cause cell lysis.

    Mediators: Others

    • Platelet-activating factor (PAF) participates in platelet aggregation and inflammation.
    • Kinins (like bradykinin) increase vascular permeability and induce pain.

    Mediators: Suppressing Inflammation

    • Lipoxins: suppress inflammation by deterrents of protein release and leukocyte recruitment
    • NSAIDs (non-steroidal anti-inflammatory drugs)
    • COX-2 inhibitors (e.g. some NSAIDS): particularly important for pain and fever reduction.

    Mediators: Recap

    • Many mediators with distinctive characteristics act upon vascular systems and cellular systems
    • Including histamine, prostaglandins, leukotrienes, cytokines, chemokines and complement proteins, each with individual contributions to the inflammatory process

    Morphologic Patterns of Acute Inflammation

    • Serous inflammation involves the exudation of fluid that is low in cell content.
    • Fibrinous inflammation involves excessive fibrinogen.
    • Purulent inflammation features a large number of neutrophils and a pus-like exudate.

    Ulcers

    • Ulcers are local defects in tissue surfaces resulting from inflamed and necrotic tissue sloughing.

    Granulomatous Inflammation

    • Characterized by the accumulation of macrophages, often with T lymphocytes.
    • Granulomatous inflammation is a specific type of chronic inflammation often encountered when the initial stimuli causing inflammation cannot be resolved.

    Systemic Inflammation

    • Fever, elevated body temperatures.
    • Elevated blood counts; with immature neutrophils.
    • Other effects include: chills, anorexia, somnolence, and malaise
    • Septic shock: a life-threatening systemic inflammatory response caused by massive bacterial infections, which can lead to cardiovascular collapse, multiple organ failures or death.

    Fever Pathogenesis

    • Cytokines (like TNF and IL-1) from inflammatory responses stimulate the hypothalamus to increase body set point and temperature.
    • Non-steroidal anti-inflammatory medications inhibit prostaglandins to reduce fever reaction.
    • Mechanisms regulating and maintaining temperature response is still not fully elucidated

    Tissue Repair

    • Regeneration (re-growth of new tissue) vs. Scar tissue regeneration (a less functional substitute of the original tissue).
    • Factors that inhibit tissue repair: infection, diabetes, reduced nutrition, use of glucocorticoids, poor tissue blood supply, and the degree of tissue injury.

    Cutaneous Wound Healing

    • Inflammation, granulation tissue formation, and ECM remodeling are phases.
    • Excessive ECM production can cause keloids.

    Cellular Aging

    • Accumulations of errors in DNA (ROS, mutations).
    • Decreased cellular replication
    • Limited capacity for replication.

    Intracellular Accumulations

    • Steatosis (fatty change) is the accumulation of triglycerides.
    • Cholesterol accumulation can be observed in atherosclerosis.
    • Excess glycogen storage is seen in some metabolic disorders.
    • Other substances like pigments will accumulate in the affected tissue(s).

    Fatty Liver Changes

    • Steatosis: Accumulation of triglycerides in liver cells.
    • Causes: Alcohol abuse, diabetes, obesity, and NASH (non-alcoholic steatohepatitis).

    Atherosclerosis

    • Cholesterol accumulation in arterial walls.

    Exogenous Carbon

    • Anthracosis (coal dust in the lungs, commonly seen in coal miners lungs).

    Lipofuscin

    • Wear and tear of cells; yellow-brown pigment.
    • Accumulation of free-radicals peroxidation of lipids in damaged tissues, and the by-products of oxidation accumulate lipids inside cells.

    Calcification

    • Mineralization in tissues.
    • Seen in aortic valve.

    Conclusion:

    • Comprehensive understanding of cells, inflammation, and related processes is crucial for comprehending health and disease.
    • Various mechanisms and factors influence these processes.

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    Test your knowledge of key concepts in cell biology with this quiz focused on cellular components and their functions. Explore the roles of mitochondria, lysosomes, and the cytoskeleton, along with the differences between various types of cells. Perfect for students studying cell biology.

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