Cell Biology and Growth Factors Quiz

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Questions and Answers

What is the primary function of growth factors in cell division and proliferation?

  • They directly stimulate DNA replication and cell division.
  • They inhibit cell cycle entry and promote cell death.
  • They act as signaling molecules that activate pathways leading to cell cycle entry. (correct)
  • They regulate the production of proteins that directly initiate cell division.

Which of the following is NOT a key characteristic of growth factors' action within a cell?

  • They can promote cell survival through various signaling pathways.
  • They can directly initiate DNA replication. (correct)
  • They can regulate cell division and proliferation.
  • They can influence cell migration and differentiation.

Which type of signaling is characterized by communication between adjacent cells?

  • Endocrine signaling
  • Synaptic signaling
  • Autocrine signaling
  • Paracrine signaling (correct)

Which of the following components of the Extracellular Matrix is responsible for providing tensile strength and recoil properties to tissues?

<p>Collagens and elastin (B)</p> Signup and view all the answers

In what way does the Extracellular Matrix contribute to tissue repair?

<p>It creates a scaffold for cell migration and attachment. (C)</p> Signup and view all the answers

Which type of collagen is predominantly found in basement membranes?

<p>Type IV collagen (D)</p> Signup and view all the answers

Which of the following is NOT a component of the interstitial matrix?

<p>Laminin (D)</p> Signup and view all the answers

Which of the following accurately describes the role of integrins in the Extracellular Matrix?

<p>They connect the ECM to cells and other matrix elements. (B)</p> Signup and view all the answers

What is the primary role of re-epithelialization in wound healing?

<p>Building new epithelium through keratinocyte migration and proliferation (B)</p> Signup and view all the answers

Which growth factor is NOT typically involved in the early stages of angiogenesis?

<p>Epidermal Growth Factor (EGF) (D)</p> Signup and view all the answers

What characterizes granulation tissue in the context of wound healing?

<p>Proliferation of fibroblasts and delicate new capillaries (C)</p> Signup and view all the answers

What initiates endothelial cell migration during angiogenesis?

<p>Proteolytic degradation of the basement membrane (B)</p> Signup and view all the answers

What is the implication of newly formed vessels being leaky during the healing process?

<p>Edematous appearance of repairing tissue (A)</p> Signup and view all the answers

How long after wounding do fibroblasts typically appear in the wound site?

<p>After 24 hours (A)</p> Signup and view all the answers

Which process aids in the supply of nutrients and oxygen to newly formed tissues during wound healing?

<p>Angiogenesis (C)</p> Signup and view all the answers

What are the main histological components of granulation tissue?

<p>Endothelial cells and fibroblasts, along with inflammatory cells (A)</p> Signup and view all the answers

Which factor is known to facilitate the healing of wounds?

<p>UV light exposure (B)</p> Signup and view all the answers

What type of scar is characterized by excessive collagen accumulation within the wound boundaries?

<p>Hypertrophic scar (A)</p> Signup and view all the answers

Which complication arises from excessive granulation tissue blocking re-epithelialization?

<p>Exuberant granulation (B)</p> Signup and view all the answers

What systemic factor can significantly impair wound healing in older individuals?

<p>Poor blood supply (C)</p> Signup and view all the answers

What is a potential consequence of infection in chronic wounds?

<p>Osteomyelitis (C)</p> Signup and view all the answers

What is dehiscence commonly associated with in wound healing?

<p>Increased abdominal pressure (B)</p> Signup and view all the answers

Which vitamin is essential for proper wound healing?

<p>Vitamin C (B)</p> Signup and view all the answers

Marjolin’s ulcer is a rare complication that can occur due to which process?

<p>Scar tissue resulting in carcinoma (C)</p> Signup and view all the answers

What is the main function of pro-inflammatory cytokines during the inflammatory phase of wound healing?

<p>They prevent infection and regulate inflammatory responses. (B)</p> Signup and view all the answers

Which process immediately follows hemostasis in wound healing?

<p>Inflammation (B)</p> Signup and view all the answers

Which of the following is NOT a mechanism involved in hemostasis?

<p>Extracellular matrix deposition (C)</p> Signup and view all the answers

What initiates the healing process immediately after an injury to a wound?

<p>Clotting of blood at the wound site (B)</p> Signup and view all the answers

Which cells replace polymorphs in the wound by the third day after injury?

<p>Macrophages (D)</p> Signup and view all the answers

What role do macrophages play during the inflammatory phase of wound healing?

<p>They remove apoptotic PMNs via debridement. (B)</p> Signup and view all the answers

During which phase of wound healing do fibroblasts predominantly rebuild the wound with collagen?

<p>Proliferation (B)</p> Signup and view all the answers

What forms the scar tissue during the healing process?

<p>Collagen fibrils predominating over time (D)</p> Signup and view all the answers

Which phase involves the formation of granulation tissue due to fibroblast proliferation?

<p>Granulation phase (D)</p> Signup and view all the answers

What is the consequence of interruptions in the wound healing process?

<p>Delayed wound healing or chronic non-healing wounds (B)</p> Signup and view all the answers

During healing by second intention, which structure is likely to be permanently lost?

<p>Hair follicles and sweat glands (B)</p> Signup and view all the answers

Which of the following cytokines is a major source during the inflammatory phase?

<p>Interleukin-6 (IL-6) (C)</p> Signup and view all the answers

What is the main function of the extracellular matrix during the proliferation phase of wound healing?

<p>Provide mechanical support and a scaffold for new tissue (C)</p> Signup and view all the answers

What important feature distinguishes secondary healing from primary healing?

<p>Wound contraction (C)</p> Signup and view all the answers

What color change occurs in scar tissue upon maturation?

<p>From deep red to pale and white due to collagen increase (C)</p> Signup and view all the answers

What is the primary role of myofibroblasts in the healing process?

<p>Contracting the wound site (D)</p> Signup and view all the answers

What is the primary role of fibroblasts in wound healing?

<p>Synthesis of collagen and elastin, and organizing the extracellular matrix (C)</p> Signup and view all the answers

Which cytokine is NOT produced by fibroblasts during the remodeling phase of wound healing?

<p>Epidermal growth factor (EGF) (B)</p> Signup and view all the answers

What is the effect of a lack of oxygen during collagen formation?

<p>Improper hydroxylation of proline and lysine, affecting collagen stability (C)</p> Signup and view all the answers

What defines healing by secondary intention?

<p>Extensive tissue loss requiring granulation tissue formation (B)</p> Signup and view all the answers

How does the remodeling phase affect the cellular makeup of the scar tissue?

<p>Reduces cellularity resulting in a mature scar (A)</p> Signup and view all the answers

What is the primary mechanism of wound contraction during healing?

<p>Activity of myofibroblasts (B)</p> Signup and view all the answers

Which of the following contributes to the persistent cellularity leading to hypertrophic scars or keloids?

<p>Ongoing inflammatory response in the wound area (D)</p> Signup and view all the answers

What is a key difference between primary and secondary intention healing?

<p>Primary intention typically results in less scarring than secondary intention (A)</p> Signup and view all the answers

Flashcards

Growth Factors

Proteins that stimulate cell survival, proliferation, and migration.

Autocrine Signaling

Cell responds to substances it releases, affecting itself.

Paracrine Signaling

Signaling between adjacent cells.

Endocrine Signaling

Long-distance signaling via hormones in the bloodstream.

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Extracellular Matrix (ECM)

A complex of proteins that surrounds cells, providing support.

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Fibrous Structural Proteins

Proteins like collagen and elastin that provide strength and elasticity to tissues.

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Interstitial Matrix

Matrix found in spaces between cells in various tissues.

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Basement Membrane

Thin layer produced by epithelial and mesenchymal cells that supports cell surfaces.

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Collagen Formation

Collagen requires oxygen for hydroxylation of proline and lysine residues.

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Fibroblasts

Fibroblasts produce elastin and organize the extracellular matrix (ECM).

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Wound Remodeling

Scar formation involves ECM composition change and long-term modifications.

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Cytokines in Healing

Key cytokines like TNF-α, IL-1, PDGF, and TGF-β are crucial during remodeling.

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Myofibroblasts

Contractile fibroblasts that aid in wound contraction during healing.

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Hypertrophic Scars

Persistent cellularity at wound site leads to hypertrophic scars or keloids.

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Healing by First Intention

A clean, surgical wound with limited tissue loss that heals with minimal scarring.

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Function ECM

Extracellular matrix provides mechanical support and regulates cell functions.

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Stages of Wound Healing

Wound healing consists of four overlapping phases: Hemostasis, Inflammation, Proliferation, Remodeling.

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Hemostasis

Immediate response that includes vascular constriction and clot formation after injury.

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Inflammation Phase

The phase where inflammatory cells influx, promoting healing and preventing infection.

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Pro-inflammatory Cytokines

Molecules released that stimulate inflammation, including IL-1, IL-6, and TNF-α.

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PMN Debridement

Process where macrophages remove dying PMNs to clear the wound.

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Proliferation Phase

Phase where new tissue, collagen, and extracellular matrix rebuild the wound.

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Platelet Activation

Process where platelets aggregate to form a plug at the injury site.

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Wound contraction

The process where a wound shrinks as new tissues form.

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Re-epithelialization

Recovery of a wound with new epithelial tissue through keratinocyte migration and proliferation.

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Angiogenesis

Formation of new blood vessels from existing ones during the healing process.

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Granulation tissue

Pink, soft tissue that forms during healing, rich in new capillaries and fibroblasts.

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Endothelial cell migration

The movement of endothelial cells to form new blood vessels post-wounding.

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Collagen deposition

The process where fibroblasts produce collagen for tissue strength during healing.

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VEGF

Vascular Endothelial Growth Factor, a key protein that stimulates angiogenesis.

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Immediate post-injury response

Blood fills the wound space, clotting occurs to seal it.

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Acute inflammatory response

Within 24 hours, polymorphs appear at the incision site, replaced by macrophages by day 3.

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Epithelial migration

Basal epidermal cells migrate from wound margins, covering it within 48 hours.

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Scar formation

Occurs after necrotic tissue separation, forming a multilayered new epidermis.

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Fibroblast invasion

By day 3, fibroblasts invade the wound area; collagen fibril formation begins by day 5.

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Healing by second intention

Occurs with large tissue loss and heavy contamination, involving granulation and contraction.

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Local Factors

Factors that affect wound healing at the site, like infection and blood supply.

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Systemic Factors

Body-wide influences on healing such as age, nutrition, and diseases.

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Deficient Scar Formation

Inadequate scar tissue leading to poor wound healing or rupture.

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Keloid

A type of excessive scar that extends beyond original wound boundaries.

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Osteomyelitis

Bone infection that can occur due to a chronic wound infection.

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Marjolin’s Ulcer

Rare skin cancer that develops in scar tissue over time, usually after burns.

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Related Documents

Healing and Repair PDF

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