Cell Biology and Growth Factors Quiz

<p>Collagens and elastin (B)</p> Signup and view all the answers

<p>It creates a scaffold for cell migration and attachment. (C)</p> Signup and view all the answers

<p>Type IV collagen (D)</p> Signup and view all the answers

<p>Laminin (D)</p> Signup and view all the answers

<p>They connect the ECM to cells and other matrix elements. (B)</p> Signup and view all the answers

<p>Building new epithelium through keratinocyte migration and proliferation (B)</p> Signup and view all the answers

<p>Epidermal Growth Factor (EGF) (D)</p> Signup and view all the answers

<p>Proliferation of fibroblasts and delicate new capillaries (C)</p> Signup and view all the answers

<p>Proteolytic degradation of the basement membrane (B)</p> Signup and view all the answers

<p>Edematous appearance of repairing tissue (A)</p> Signup and view all the answers

<p>After 24 hours (A)</p> Signup and view all the answers

<p>Angiogenesis (C)</p> Signup and view all the answers

<p>Endothelial cells and fibroblasts, along with inflammatory cells (A)</p> Signup and view all the answers

<p>UV light exposure (B)</p> Signup and view all the answers

<p>Hypertrophic scar (A)</p> Signup and view all the answers

<p>Exuberant granulation (B)</p> Signup and view all the answers

<p>Poor blood supply (C)</p> Signup and view all the answers

<p>Osteomyelitis (C)</p> Signup and view all the answers

<p>Increased abdominal pressure (B)</p> Signup and view all the answers

<p>Vitamin C (B)</p> Signup and view all the answers

<p>Scar tissue resulting in carcinoma (C)</p> Signup and view all the answers

<p>They prevent infection and regulate inflammatory responses. (B)</p> Signup and view all the answers

<p>Inflammation (B)</p> Signup and view all the answers

<p>Extracellular matrix deposition (C)</p> Signup and view all the answers

<p>Clotting of blood at the wound site (B)</p> Signup and view all the answers

<p>Macrophages (D)</p> Signup and view all the answers

<p>They remove apoptotic PMNs via debridement. (B)</p> Signup and view all the answers

<p>Proliferation (B)</p> Signup and view all the answers

<p>Collagen fibrils predominating over time (D)</p> Signup and view all the answers

<p>Granulation phase (D)</p> Signup and view all the answers

<p>Delayed wound healing or chronic non-healing wounds (B)</p> Signup and view all the answers

<p>Hair follicles and sweat glands (B)</p> Signup and view all the answers

<p>Interleukin-6 (IL-6) (C)</p> Signup and view all the answers

<p>Provide mechanical support and a scaffold for new tissue (C)</p> Signup and view all the answers

<p>Wound contraction (C)</p> Signup and view all the answers

<p>From deep red to pale and white due to collagen increase (C)</p> Signup and view all the answers

<p>Contracting the wound site (D)</p> Signup and view all the answers

<p>Synthesis of collagen and elastin, and organizing the extracellular matrix (C)</p> Signup and view all the answers

<p>Epidermal growth factor (EGF) (B)</p> Signup and view all the answers

<p>Improper hydroxylation of proline and lysine, affecting collagen stability (C)</p> Signup and view all the answers

<p>Extensive tissue loss requiring granulation tissue formation (B)</p> Signup and view all the answers

<p>Reduces cellularity resulting in a mature scar (A)</p> Signup and view all the answers

<p>Activity of myofibroblasts (B)</p> Signup and view all the answers

<p>Ongoing inflammatory response in the wound area (D)</p> Signup and view all the answers

<p>Primary intention typically results in less scarring than secondary intention (A)</p> Signup and view all the answers

Proteins that stimulate cell survival, proliferation, and migration.

Cell responds to substances it releases, affecting itself.

Signaling between adjacent cells.

Long-distance signaling via hormones in the bloodstream.

A complex of proteins that surrounds cells, providing support.

Proteins like collagen and elastin that provide strength and elasticity to tissues.

Matrix found in spaces between cells in various tissues.

Thin layer produced by epithelial and mesenchymal cells that supports cell surfaces.

Collagen requires oxygen for hydroxylation of proline and lysine residues.

Fibroblasts produce elastin and organize the extracellular matrix (ECM).

Scar formation involves ECM composition change and long-term modifications.

Key cytokines like TNF-α, IL-1, PDGF, and TGF-β are crucial during remodeling.

Contractile fibroblasts that aid in wound contraction during healing.

Persistent cellularity at wound site leads to hypertrophic scars or keloids.

A clean, surgical wound with limited tissue loss that heals with minimal scarring.

Extracellular matrix provides mechanical support and regulates cell functions.

Wound healing consists of four overlapping phases: Hemostasis, Inflammation, Proliferation, Remodeling.

Immediate response that includes vascular constriction and clot formation after injury.

The phase where inflammatory cells influx, promoting healing and preventing infection.

Molecules released that stimulate inflammation, including IL-1, IL-6, and TNF-α.

Process where macrophages remove dying PMNs to clear the wound.

Phase where new tissue, collagen, and extracellular matrix rebuild the wound.

Process where platelets aggregate to form a plug at the injury site.

The process where a wound shrinks as new tissues form.

Recovery of a wound with new epithelial tissue through keratinocyte migration and proliferation.

Formation of new blood vessels from existing ones during the healing process.

Pink, soft tissue that forms during healing, rich in new capillaries and fibroblasts.

The movement of endothelial cells to form new blood vessels post-wounding.

The process where fibroblasts produce collagen for tissue strength during healing.

Vascular Endothelial Growth Factor, a key protein that stimulates angiogenesis.

Blood fills the wound space, clotting occurs to seal it.

Within 24 hours, polymorphs appear at the incision site, replaced by macrophages by day 3.

Basal epidermal cells migrate from wound margins, covering it within 48 hours.

Occurs after necrotic tissue separation, forming a multilayered new epidermis.

By day 3, fibroblasts invade the wound area; collagen fibril formation begins by day 5.

Occurs with large tissue loss and heavy contamination, involving granulation and contraction.

Factors that affect wound healing at the site, like infection and blood supply.

Body-wide influences on healing such as age, nutrition, and diseases.

Inadequate scar tissue leading to poor wound healing or rupture.

A type of excessive scar that extends beyond original wound boundaries.

Bone infection that can occur due to a chronic wound infection.

Rare skin cancer that develops in scar tissue over time, usually after burns.