Podcast
Questions and Answers
What is the primary function of growth factors in cell division and proliferation?
What is the primary function of growth factors in cell division and proliferation?
- They directly stimulate DNA replication and cell division.
- They inhibit cell cycle entry and promote cell death.
- They act as signaling molecules that activate pathways leading to cell cycle entry. (correct)
- They regulate the production of proteins that directly initiate cell division.
Which of the following is NOT a key characteristic of growth factors' action within a cell?
Which of the following is NOT a key characteristic of growth factors' action within a cell?
- They can promote cell survival through various signaling pathways.
- They can directly initiate DNA replication. (correct)
- They can regulate cell division and proliferation.
- They can influence cell migration and differentiation.
Which type of signaling is characterized by communication between adjacent cells?
Which type of signaling is characterized by communication between adjacent cells?
- Endocrine signaling
- Synaptic signaling
- Autocrine signaling
- Paracrine signaling (correct)
Which of the following components of the Extracellular Matrix is responsible for providing tensile strength and recoil properties to tissues?
Which of the following components of the Extracellular Matrix is responsible for providing tensile strength and recoil properties to tissues?
In what way does the Extracellular Matrix contribute to tissue repair?
In what way does the Extracellular Matrix contribute to tissue repair?
Which type of collagen is predominantly found in basement membranes?
Which type of collagen is predominantly found in basement membranes?
Which of the following is NOT a component of the interstitial matrix?
Which of the following is NOT a component of the interstitial matrix?
Which of the following accurately describes the role of integrins in the Extracellular Matrix?
Which of the following accurately describes the role of integrins in the Extracellular Matrix?
What is the primary role of re-epithelialization in wound healing?
What is the primary role of re-epithelialization in wound healing?
Which growth factor is NOT typically involved in the early stages of angiogenesis?
Which growth factor is NOT typically involved in the early stages of angiogenesis?
What characterizes granulation tissue in the context of wound healing?
What characterizes granulation tissue in the context of wound healing?
What initiates endothelial cell migration during angiogenesis?
What initiates endothelial cell migration during angiogenesis?
What is the implication of newly formed vessels being leaky during the healing process?
What is the implication of newly formed vessels being leaky during the healing process?
How long after wounding do fibroblasts typically appear in the wound site?
How long after wounding do fibroblasts typically appear in the wound site?
Which process aids in the supply of nutrients and oxygen to newly formed tissues during wound healing?
Which process aids in the supply of nutrients and oxygen to newly formed tissues during wound healing?
What are the main histological components of granulation tissue?
What are the main histological components of granulation tissue?
Which factor is known to facilitate the healing of wounds?
Which factor is known to facilitate the healing of wounds?
What type of scar is characterized by excessive collagen accumulation within the wound boundaries?
What type of scar is characterized by excessive collagen accumulation within the wound boundaries?
Which complication arises from excessive granulation tissue blocking re-epithelialization?
Which complication arises from excessive granulation tissue blocking re-epithelialization?
What systemic factor can significantly impair wound healing in older individuals?
What systemic factor can significantly impair wound healing in older individuals?
What is a potential consequence of infection in chronic wounds?
What is a potential consequence of infection in chronic wounds?
What is dehiscence commonly associated with in wound healing?
What is dehiscence commonly associated with in wound healing?
Which vitamin is essential for proper wound healing?
Which vitamin is essential for proper wound healing?
Marjolin’s ulcer is a rare complication that can occur due to which process?
Marjolin’s ulcer is a rare complication that can occur due to which process?
What is the main function of pro-inflammatory cytokines during the inflammatory phase of wound healing?
What is the main function of pro-inflammatory cytokines during the inflammatory phase of wound healing?
Which process immediately follows hemostasis in wound healing?
Which process immediately follows hemostasis in wound healing?
Which of the following is NOT a mechanism involved in hemostasis?
Which of the following is NOT a mechanism involved in hemostasis?
What initiates the healing process immediately after an injury to a wound?
What initiates the healing process immediately after an injury to a wound?
Which cells replace polymorphs in the wound by the third day after injury?
Which cells replace polymorphs in the wound by the third day after injury?
What role do macrophages play during the inflammatory phase of wound healing?
What role do macrophages play during the inflammatory phase of wound healing?
During which phase of wound healing do fibroblasts predominantly rebuild the wound with collagen?
During which phase of wound healing do fibroblasts predominantly rebuild the wound with collagen?
What forms the scar tissue during the healing process?
What forms the scar tissue during the healing process?
Which phase involves the formation of granulation tissue due to fibroblast proliferation?
Which phase involves the formation of granulation tissue due to fibroblast proliferation?
What is the consequence of interruptions in the wound healing process?
What is the consequence of interruptions in the wound healing process?
During healing by second intention, which structure is likely to be permanently lost?
During healing by second intention, which structure is likely to be permanently lost?
Which of the following cytokines is a major source during the inflammatory phase?
Which of the following cytokines is a major source during the inflammatory phase?
What is the main function of the extracellular matrix during the proliferation phase of wound healing?
What is the main function of the extracellular matrix during the proliferation phase of wound healing?
What important feature distinguishes secondary healing from primary healing?
What important feature distinguishes secondary healing from primary healing?
What color change occurs in scar tissue upon maturation?
What color change occurs in scar tissue upon maturation?
What is the primary role of myofibroblasts in the healing process?
What is the primary role of myofibroblasts in the healing process?
What is the primary role of fibroblasts in wound healing?
What is the primary role of fibroblasts in wound healing?
Which cytokine is NOT produced by fibroblasts during the remodeling phase of wound healing?
Which cytokine is NOT produced by fibroblasts during the remodeling phase of wound healing?
What is the effect of a lack of oxygen during collagen formation?
What is the effect of a lack of oxygen during collagen formation?
What defines healing by secondary intention?
What defines healing by secondary intention?
How does the remodeling phase affect the cellular makeup of the scar tissue?
How does the remodeling phase affect the cellular makeup of the scar tissue?
What is the primary mechanism of wound contraction during healing?
What is the primary mechanism of wound contraction during healing?
Which of the following contributes to the persistent cellularity leading to hypertrophic scars or keloids?
Which of the following contributes to the persistent cellularity leading to hypertrophic scars or keloids?
What is a key difference between primary and secondary intention healing?
What is a key difference between primary and secondary intention healing?
Flashcards
Growth Factors
Growth Factors
Proteins that stimulate cell survival, proliferation, and migration.
Autocrine Signaling
Autocrine Signaling
Cell responds to substances it releases, affecting itself.
Paracrine Signaling
Paracrine Signaling
Signaling between adjacent cells.
Endocrine Signaling
Endocrine Signaling
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Extracellular Matrix (ECM)
Extracellular Matrix (ECM)
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Fibrous Structural Proteins
Fibrous Structural Proteins
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Interstitial Matrix
Interstitial Matrix
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Basement Membrane
Basement Membrane
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Collagen Formation
Collagen Formation
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Fibroblasts
Fibroblasts
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Wound Remodeling
Wound Remodeling
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Cytokines in Healing
Cytokines in Healing
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Myofibroblasts
Myofibroblasts
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Hypertrophic Scars
Hypertrophic Scars
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Healing by First Intention
Healing by First Intention
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Function ECM
Function ECM
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Stages of Wound Healing
Stages of Wound Healing
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Hemostasis
Hemostasis
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Inflammation Phase
Inflammation Phase
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Pro-inflammatory Cytokines
Pro-inflammatory Cytokines
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PMN Debridement
PMN Debridement
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Proliferation Phase
Proliferation Phase
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Platelet Activation
Platelet Activation
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Wound contraction
Wound contraction
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Re-epithelialization
Re-epithelialization
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Angiogenesis
Angiogenesis
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Granulation tissue
Granulation tissue
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Endothelial cell migration
Endothelial cell migration
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Collagen deposition
Collagen deposition
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VEGF
VEGF
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Immediate post-injury response
Immediate post-injury response
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Acute inflammatory response
Acute inflammatory response
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Epithelial migration
Epithelial migration
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Scar formation
Scar formation
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Fibroblast invasion
Fibroblast invasion
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Healing by second intention
Healing by second intention
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Local Factors
Local Factors
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Systemic Factors
Systemic Factors
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Deficient Scar Formation
Deficient Scar Formation
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Keloid
Keloid
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Osteomyelitis
Osteomyelitis
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Marjolin’s Ulcer
Marjolin’s Ulcer
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