Cell Adhesion Structures Quiz
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Questions and Answers

What is the primary function of zonula adherens in cellular structures?

  • Facilitates nutrient uptake
  • Provides mechanical stability (correct)
  • Acts as a selective barrier
  • Allows rapid communication between cells

Which protein complex is associated with cadherins in zonula adherens?

  • Catenin (correct)
  • Collagen
  • Integrin
  • Fibronectin

Which type of cell primarily contains fascia adherens?

  • Cardiac muscle cells (correct)
  • Epithelial cells
  • Connective tissue cells
  • Skin cells

What characterizes desmosomes in terms of structure?

<p>They have attachment plaques containing desmoplakins and plakoglobins (B)</p> Signup and view all the answers

What role do intermediate filaments play in macula adherens (desmosome)?

<p>They interact with desmoplakins and plakoglobins (D)</p> Signup and view all the answers

What is a defining physical characteristic of fascia adherens compared to zonula adherens?

<p>It forms a sheet-like structure. (A)</p> Signup and view all the answers

Which protein is known to bind the cytoplasmic part of cadherin in zonula adherens?

<p>Catenin (B)</p> Signup and view all the answers

What do desmoplakins and plakoglobins primarily contribute to in macula adherens?

<p>They form attachment plaques. (D)</p> Signup and view all the answers

What is the mechanical role of zonula adherens in cellular structure?

<p>It provides mechanical stability. (A)</p> Signup and view all the answers

Which type of junction does macula adherens primarily represent?

<p>A spot-like junction (B)</p> Signup and view all the answers

Which of the following is true regarding the intermediate filaments in macula adherens?

<p>They integrate into attachment plaques. (C)</p> Signup and view all the answers

What is the function of cadherins in zonula adherens?

<p>They create a junction between membranes. (B)</p> Signup and view all the answers

The fuzzy plaque found in zonula adherens corresponds to which of the following?

<p>Cadherin-catenin complex (A)</p> Signup and view all the answers

What distinguishes the intercellular space in macula adherens?

<p>It displays an intermediate line. (B)</p> Signup and view all the answers

Which type of cells predominantly contain fascia adherens?

<p>Cardiac muscle cells (D)</p> Signup and view all the answers

Flashcards

Zonula Adherens

A belt-like junction that provides mechanical stability. It involves cadherin proteins, which are transmembrane and calcium-dependent. Cadherins interact with intracellular proteins like catenin, vinculin, and alpha-actinin, linking to actin filaments.

Fascia Adherens

A sheet-like junction found in non-epithelial cells like cardiac muscle. It provides cell-to-cell adhesion but it is not a belt-like structure like zonula adherens.

Macula Adherens (Desmosome)

A spot-like junction that resists shearing forces and dissipates physical forces. It features attachment plaques that are made of desmoplakins and plakoglobins, linked to intermediate filaments.

Desmoglein and Desmocollin

Transmembrane proteins that are components of desmosomes. They bind to desmoplakins and plakoglobins in the attachment plaques.

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Attachment Plaque

The intracellular region of a desmosome where desmoplakins and plakoglobins bind to intermediate filaments, providing structural support and anchoring.

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What is the purpose of a zonula adherens (adherens junction)?

A strong, belt-like junction that holds cells together, often found in epithelial tissues. It's made of cadherin proteins that are linked to the cytoskeleton through intracellular proteins like catenin, vinculin, and alpha-actinin.

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What is the function of cadherin in zonula adherens?

A transmembrane protein that plays a key role in cell-cell adhesion. It's calcium-dependent and found in zonula adherens junctions. It interacts with intracellular proteins like catenin to anchor the junction to the cytoskeleton.

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What is the function of the cadherin-catenin complex?

A complex of proteins that connects cadherins to the cytoskeleton. It's found in zonula adherens and helps distribute mechanical stress to the cell.

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What is fascia adherens?

A sheet-like junction that's found in non-epithelial cells, particularly in cardiac muscle. It helps connect cells for strong contraction but isn't a belt-like structure.

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What is the function of a macula adherens (desmosome)?

A strong, spot-like junction that provides resistance against shearing forces. It's characterized by dense 'attachment plaques' that link to intermediate filaments for extra strength.

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What are 'attachment plaques' in desmosomes?

Special protein structures within desmosomes that anchor intermediate filaments to the plasma membrane. They're made of desmoplakins and plakoglobins.

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What are desmoglein and desmocollin?

Transmembrane proteins found in desmosomes that help connect adjacent cells. They are part of the cadherin family and contribute to the strong, spot-like nature of these junctions.

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What is the 'intermediate line' in desmosomes?

A dense, continuous line observed in the intercellular space of a desmosome. It represents the extracellular domain of desmoglein and desmocollin, proteins that bind adjacent cells together.

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What is the function of desmosomes?

Structures that provide mechanical stability to epithelial cells by acting like 'rivets' to resist pulling forces. They contain attachment plaques made of proteins like desmoplakins and plakoglobins that connect to intermediate filaments.

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What is the difference between the 'fascia adherens' and a 'zonula adherens'?

They are similar in structure to zonula adherens, but they are found in non-epithelial tissues, like cardiac muscle. Their sheet-like structure allows for strong cell-to-cell connections.

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Study Notes

Zonula Adherens

  • Provides mechanical stability to cells.
  • Forms a belt-like junction between adjacent cells.
  • The intercellular space contains extracellular portions of cadherin proteins.
  • Cadherin is a calcium-dependent transmembrane protein.
  • Intracellular protein, catenin, binds to the cytoplasmic part of cadherin, creating a complex.
  • The E-cadherin/catenin complex interacts with vinculin.
  • Vinculin interacts with alpha-actinin, linking to actin filaments.
  • A "fuzzy plaque" contains the cadherin/catenin complex, vinculin, and alpha-actinin at the cytoplasmic side, corresponding to a terminal bar at the light microscopic level.
  • Actin filaments are part of the terminal web.

Fascia Adherens

  • Structure is sheet-like, not belt-like.
  • Found in non-epithelial cells, such as cardiac muscle cells.

Macula Adherens (Desmosome)

  • Resists shearing forces and distributes physical forces within the cell.
  • Forms a spot-like junction.
  • Desmosomes have characteristic attachment plaques.
  • Desmoplakins and plakoglobins are key proteins within attachment plaques, which also contain cytoplasmic parts of desmogleins and desmocollins.
  • Intermediate filaments insert into attachment plaques, interacting with desmoplakins and plakoglobins, forming a loop and returning.
  • Desmoglein and desmocollin (cadherins) are transmembrane glycoproteins connecting the plasma membranes of adjacent cells.
  • The intercellular space shows a distinctive intermediate line, corresponding to the extracellular portions of desmoglein and desmocollin.

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Description

Test your knowledge on the various types of cell adhesion structures, including zonula adherens, fascia adherens, and macula adherens (desmosomes). This quiz covers the functions, locations, and characteristics of these critical cellular junctions. Perfect for students studying cell biology and physiology.

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