21 Questions
What is the recommended regimen for Lymphogranuloma Venereum?
doxycycline 100 mg orally 2x/day for 21 days
In what order are the recommended therapeutic regimens presented in the CDC's Sexually Transmitted Infections Treatment Guidelines?
Alphabetical order
What is an essential component of STI treatment according to the CDC's guidelines?
Partner management
What is an alternative regimen for Bacterial Vaginosis?
secnidazole 2 gm orally in a single dose
What is the recommended regimen for Cervicitis?
doxycycline 100 mg orally 2x/day for 7 days
What is the primary purpose of the CDC's Sexually Transmitted Infections Treatment Guidelines?
To serve as a source of clinical guidance
Where can healthcare providers find complete guidelines for STI treatment?
What is the recommended regimen for Nongonococcal Urethritis (NGU)?
doxycycline 100 mg orally 2x/day for 7 days
What is an alternative regimen for Lymphogranuloma Venereum?
erythromycin base 500 mg orally 4x/day for 21 days
Under what circumstances can alternative regimens be considered?
In instances of substantial drug allergy or other contraindications
What is the recommended regimen for Persistent or Recurrent Nongonococcal Urethritis (NGU)?
test for Mycoplasma genitalium: If M. genitalium is detected
What is an alternative regimen for Cervicitis?
azithromycin 1 gm orally in a single dose
What is an alternative regimen for Bacterial Vaginosis?
metronidazole gel 0.75%, one 5 gm applicator intravaginally, 1x/day for 5 days
What is the recommended treatment for adults and adolescents when M.genitalium is detected but moxifloxacin cannot be used?
doxycycline 100 mg orally 2x/day for 7 days, followed by azithromycin 1 gm orally on first day, followed by azithromycin 500 mg orally 1x/day for 3 days
What is the recommended treatment for pregnant women?
amoxicillin 500 mg orally 3x/day for 7 days
What is the recommended treatment for infants and children?
not specified in the provided content
What is the recommended duration of treatment for adults and adolescents when M.genitalium is detected but moxifloxacin cannot be used?
7 days
What is the recommended follow-up test for pregnant women after completion of therapy?
test-of-cure 21 days after completion of therapy
What is the recommended treatment for adults and adolescents when M.genitalium is detected and resistance testing is available?
doxycycline 100 mg orally 2x/day for 7 days, followed by moxifloxacin 400 mg 1x/day for 7 days
What is the recommended dose of azithromycin for pregnant women?
1 gm orally in a single dose
What is the recommended treatment for adults and adolescents when M.genitalium is detected but resistance testing is unavailable?
doxycycline 100 mg orally 2x/day for 7 days, followed by azithromycin 1 gm orally on first day, followed by azithromycin 500 mg orally 1x/day for 3 days
Study Notes
STI Treatment Guidelines, 2021
Bacterial Vaginosis
- Recommended regimen: metronidazole 500 mg orally 2x/day for 7 days
- Alternative regimens: clindamycin 300 mg orally 2x/day for 7 days, metronidazole gel 0.75%, one 5 gm applicator intravaginally, 1x/day for 5 days, clindamycin ovules 100 mg intravaginally at bedtime for 3 days, secnidazole 2 gm orally in a single dose
Lymphogranuloma Venereum
- Recommended regimen: doxycycline 100 mg orally 2x/day for 21 days
- Alternative regimens: azithromycin 1 gm orally 1x/week for 3 weeks, erythromycin base 500 mg orally 4x/day for 21 days
Nongonococcal Urethritis (NGU)
- Recommended regimen: doxycycline 100 mg orally 2x/day for 7 days
- Alternative regimens: azithromycin 1 gm orally in a single dose, tinidazole 2 gm orally 1x/day for 2 days, azithromycin 500 mg orally in a single dose, THEN 250 mg 1x/day for 4 days
Cervicitis
- Recommended regimen: doxycycline 100 mg orally 2x/day for 7 days
- Alternative regimen: azithromycin 1 gm orally in a single dose
Chlamydial Infections
- Recommended regimen for adults and adolescents: doxycycline 100 mg orally 2x/day for 7 days
- Alternative regimens for adults and adolescents: azithromycin 1 gm orally in a single dose, levofloxacin 500 mg orally 1x/day for 7 days
- Recommended regimen for pregnancy: azithromycin 1 gm orally in a single dose
- Alternative regimen for pregnancy: amoxicillin 500 mg orally 3x/day for 7 days
Persistent or Recurrent NGU
- Test for Mycoplasma genitalium: doxycycline 100 mg orally 2x/day for 7 days, FOLLOWED BY moxifloxacin 400 mg 1x/day for 7 days
- For settings without resistance testing and when moxifloxacin cannot be used: doxycycline 100 mg orally 2x/day for 7 days, FOLLOWED BY azithromycin 1 gm orally on first day, FOLLOWED BY azithromycin 500 mg orally 1x/day for 3 days and a test-of-cure 21 days after completion of therapy
Summary of CDC's 2021 Sexually Transmitted Infections Treatment Guidelines, providing recommended regimens for clinical guidance.
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