3.5 Respiratory Pathophys
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Questions and Answers

What are the two main causes of CO2 retention mentioned in the text?

  • Diffusion impairment and shunt
  • Hypoventilation and ventilation-perfusion inequality (correct)
  • Obstructive sleep apnea and central sleep apnea
  • Ventilation-perfusion inequality and low FiO2
  • Which condition causes hypoxemia due to impaired diffusion across the alveolar-capillary unit?

  • Diseases of respiratory muscles
  • Spinal cord abnormalities
  • Pneumonia (correct)
  • Hemorrhage
  • Which condition results in mental confusion, tachycardia, lactic acidosis, and proteinuria when PaO2 falls below 50 mmHg?

  • Diffusion impairment
  • Hypoventilation (correct)
  • Obstructive sleep apnea
  • Ventilation-perfusion inequality
  • What is the characteristic feature of Right-to-Left Shunt?

    <p>Blood reaches arterial system without passing through ventilated regions of the lung</p> Signup and view all the answers

    In which condition would administering 100% O2 not correct the hypoxemia?

    <p>Right-to-Left Shunt</p> Signup and view all the answers

    Which type of sleep apnea involves apnea due to obstruction during inspiration?

    <p>Obstructive sleep apnea</p> Signup and view all the answers

    Which of the following exacerbates Ventilation-Perfusion Inequality?

    <p>Decreased cardiac output</p> Signup and view all the answers

    What is the common finding associated with central sleep apnea?

    <p>Small periods of no respiratory effort</p> Signup and view all the answers

    What is the primary cause of hypoxemia in patients with COPD?

    <p>Ventilation-Perfusion Inequality</p> Signup and view all the answers

    Which condition can double PCO2 to 80 mmHg but only decrease PAO2 from 100 to 60 mmHg?

    <p>Hypoventilation</p> Signup and view all the answers

    What PFT result would you expect in the 63-year-old woman with a 30 pack-year smoking history, FEV1 of 59%, FEV1/FVC ratio of 0.62, and large lung volumes on CXR?

    <p>Increased residual volume</p> Signup and view all the answers

    Apart from rapid, shallow breathing, what is a characteristic of pulmonary edema with alveolar filling?

    <p>Arterial hypoxemia cannot be abolished by inspiring 100% O2</p> Signup and view all the answers

    In the 65-year-old female with hemorrhagic shock and a drop in blood pressure after intubation, what is the most likely cause of her hypotension?

    <p>Decrease in venous return</p> Signup and view all the answers

    Which of the following is a common feature of all COPDs?

    <p>Dynamic compression of airways</p> Signup and view all the answers

    What is the strongest predisposing factor for asthma?

    <p>Production of IgE antibodies to allergens (atopy)</p> Signup and view all the answers

    What is a characteristic feature of chronic bronchitis in COPD?

    <p>Hypertrophy of mucous glands in larger airways</p> Signup and view all the answers

    Which of the following is a type of emphysema usually caused by cigarettes?

    <p>Centriacinar</p> Signup and view all the answers

    What contributes to luminal narrowing in chronic bronchitis?

    <p>Patchy squamous metaplasia</p> Signup and view all the answers

    What is a characteristic of asthma related to smooth muscle tone?

    <p>Increased airway inflammation</p> Signup and view all the answers

    What is a common feature of emphysema in COPD?

    <p>Alveolar destruction with loss of elastic recoil</p> Signup and view all the answers

    What is the most common etiology of chronic bronchitis in COPD?

    <p>Cigarette smoking</p> Signup and view all the answers

    What contributes to ventilation-perfusion inequality in all COPDs?

    <p>Hypoxemia with or without CO2 retention</p> Signup and view all the answers

    Which type of emphysema results from alpha 1-antitrypsin deficiency?

    <p>Panacinar</p> Signup and view all the answers

    Which cells play a crucial role in clearing inhaled particles in the terminal airways and alveoli?

    <p>Macrophages</p> Signup and view all the answers

    What is the primary function of the mucociliary escalator in the respiratory tract?

    <p>To propel particles towards the pharynx for removal</p> Signup and view all the answers

    Which pollutant is predominantly removed from the respiratory tract by impaction or sedimentation?

    <p>Large aerosol particles</p> Signup and view all the answers

    What effect does cigarette smoke have on alveolar macrophages?

    <p>Inhibits their function in ingesting foreign particles</p> Signup and view all the answers

    How do alveolar macrophages contribute to innate immunity in the lung?

    <p>Clearing substances through phagocytosis</p> Signup and view all the answers

    Which component of cigarette smoke can bind preferentially to hemoglobin?

    <p>Carbon monoxide</p> Signup and view all the answers

    What is the primary function of the upper viscous gel layer in the mucociliary escalator?

    <p>Trapping particles to be moved towards pharynx</p> Signup and view all the answers

    What is a common function of masks, such as N95 respirators, in reducing respiratory exposure to pollutants?

    <p>Reducing shedding and contamination through physical barriers</p> Signup and view all the answers

    In emphysema, the primary pathogenesis involves hypertrophy of mucous glands and increased mucous hypersecretion.

    <p>False</p> Signup and view all the answers

    A patient with chronic bronchitis may exhibit excessive expectoration of sputum due to diminished mucociliary clearance function.

    <p>True</p> Signup and view all the answers

    Asthma is characterized by a non-inflammatory process primarily affecting the airway smooth muscle tone.

    <p>False</p> Signup and view all the answers

    Ventilation-perfusion inequality in COPDs can lead to hypoxemia with or without CO2 retention.

    <p>True</p> Signup and view all the answers

    COPD encompasses chronic bronchitis and asthma, both of which are characterized by airway inflammation and reversible airway obstruction.

    <p>False</p> Signup and view all the answers

    Mechanical ventilation can only be delivered invasively with positive pressure ventilation.

    <p>False</p> Signup and view all the answers

    Continuous positive airway pressure (CPAP) maintains airway pressure below zero cm H2O.

    <p>False</p> Signup and view all the answers

    Oxygen therapy can lead to absorption atelectasis when high FiO2 is administered.

    <p>True</p> Signup and view all the answers

    Positive end-expiratory pressure (PEEP) is not commonly used during mechanical ventilation.

    <p>False</p> Signup and view all the answers

    Volume control mode in mechanical ventilation delivers a preset volume regardless of changes in lung compliance or airway resistance.

    <p>True</p> Signup and view all the answers

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